1666 Quality of life in motor handicap of neurological origin: validation of quality of life assessment questionnaire

1666 Quality of life in motor handicap of neurological origin: validation of quality of life assessment questionnaire

$522 Poster Abstracts Friday, November 11, 2005 1664 Quantitative proton MR Spectroscopy and the aging brain Semnic, R ~, Selilnic, M 2, Kozic, D ~...

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$522

Poster Abstracts

Friday, November 11, 2005

1664 Quantitative proton MR Spectroscopy and the aging brain Semnic, R ~, Selilnic, M 2, Kozic, D ~, Ostojic, J~, Ocic, G 1, Djilas 1-valiovic, D 1, Popovic, S ~, Bogdaliovic, D 1, Miucili Vukadiliovic, I ~, Prvulovic, N 1. 1Institute Of Oncology, Yugoslavia; 2.institute of

Neurology, Novi Sad, Je2~goslavia The purpose of this study was to determine the early effect of normal aging on the regional distribution of brain metabolite concentrations, including N-acetylaspartate (NAA), choline (Cho) and creatilie (Cr). Methods: Eighty nine volunteers, ages 16 to 75 years, were examilied by localized single-voxel proton M R spectroscopy at 1.5T using PRESS 135 sequence. Voxels 2 × 2 × 2 taxi were placed in the middle white matter (SVM) o f the centrum semiovale in the left hemisphere and in the occipital gray IIlatter (GM) of posterior parietal lobes. Tile ratio of NAA/Cho were calculated, as well as absolute concentrations of NAA, Cr and Cho. Quantification was perforlited using IIlethod of external standard. Results: Absolute concentrations (mM/kg) of Cho increased with age both in W M (r -- 0.42, P < 0.05) and in G M (r -- 0.57, P < 0.05). Cr concentrations were higher in G M than in W M and significantly higher in tile old than yomlg subjets (r -- 0.41, P < 0.05). The change of W M Cr with age failed to meet P < 0.05 criteria. N A A colicelitration was higher in G M than in W M and did not differ between young and old subjects. The age dependency of G M NAA/Cho ratio was steeper (r - 0.68, P < 0.001) comparing to W M (r -- 0.49, P < 0.05) and almost negatively linear. Conclusion: Our study suggest that brain aging is characterized by reduction in neuronal viability with accelerated IIlelilbralie degradation and increase of the IIUlilbers of glial cells. Aging effects on IIletabolite concentrations are more pronounced in the GM. Detennination of absolute metabolite concentrations, rather than use of ratios only, is essential for characterizing age-related changes ill brain IIletabolites. 1665 Refsmn Syndxoiii with abnormally increased Pipecolic acid Slassi, I l, Rafai, M A a , El Moutawakkil, B ~, Benchekroun, S ~, Kissani, N ~, Fadel, H 1, Hamdani, M a, Abdelouafi, A 3. 1Service de

Neurologie CHU Ibn Rochd, Casablanca; 2Service d'Ophtabnologie, [email protected] Aofft, Casablanca; 3Service de Radiologie Centrale, CHU Ibn Rochd, Casablanca - MAROC Background: Refsum disease is a rare inborn peroxysomale disease, with disorder o f lipid metabolism, inherited as autosomal recessive trait, described primarly in the Scandinavian countries then in zones of Viking strong migration, but never in tile Maghreb. The cardinal IIlanifestatiolis' syndromeare peripheral IIeuropathy, retiliitis pigmelitosa, cerebellar ataxia, and elevated cerebrospilial fluid protein colicelitratioli. It translates a Phytaliyl CoA-hydroxylase deficit with phytunic a d d accumulation. The responsible gene is located on chromosom 10. However, typically Refsum syndrom without increase on phytunic add were described and raises some interrogations. Results: We report eight cases of Refsmli syndrolil frolil two Moroccan falililies (C and L), with first degree colisaliguinity. The symptolilatology's beginning was progressive, between 10 and 20 years age and visual disturbance was the most frequent mode of onset. All the patients present, with variable degrees, a peripheral neuropathy, a pigliielitosa retinitis and ataxia. Increased protein in cerebrospinal fluid was found in one patient troll1 each falililies. Other IIlanifestatiolis are all auditive disturbance and a dySlilovphic syndroli1. Tile serum level of phytanic acid and the very long chain fatty acids were normal among all patients. But the pipecolic acid was abnormally increased in one of them without clinical signs of pipecolic acidemia. The increase of the pipecolic acid signs a peroxysomal nature o f this affection. Conclusion: The Association of a typically Refsulil syndroli1 without phytanic acid acculimlatioli and with increased pipecolic acid level was

never, to our knowledge, described. The authors discuss the probable etiologic heterogeneity of the Refsum syndrom and the persistence of many unknown peroxysom fmlctiolis. 1666 Quality of liie in Motor Handicap of Neurological origin: validation of quality of life assessment questionnaire Slassi, I ~, Hassoune, S2, Rafai, M A 1, El Moutawakkil, B 1, Beliiialii-Otlmlani, M 2, Gain, 11, Fadel, H 1, Hakim, K 1, Maaroufi, A ~, Mechakra Tahiri, 82. 1Service de Neurologie - Explorations Fonction-

nelles Chu ibn Rochd, Casablanca, Morocco; 2Laboratoire de Biostatisfique- Epidemiologie- Informatique Medicale, Casablanca, Morocco Background: Actually, quality o f life (QOL) of patients occupies a considerable place in decision IIlakilig coliceruilig their health state. Many QOL questionnaires were developed to study tiffs aspect. Study purposes were to tralislatioli-validatioli of the short foml health survey (SF36) to Arabic and to evaluate the impact of motor handicap of neurological origin (MHNO). Methods: The translation has been done following Gnillemin guidetines recommended by. A study of tile face validity has been done using a pretest. Coefficient alpha of Crolibach was calculated. After tralislatioli-validatioli, we did a cross sectional study in 55 patients and 55 controls. Wile translating SF36, some sentences that were not adapted to the Moroccan context have been replaced, the mean length for scale admiuistratioli was 13 IIliliutes. The coefficient alpha of Crolibach was equal to 0.80. Results: Patients and controls were comparable concerning age, sex and marital statute. The mean of patient's age was 40.8 years with a feminine predominance. The mean of illness evolution length was 3.4 years. The most affected dimensions o f QOL were physical function, [imitations due to the physical state and limitatiolis due to tile psychic state whose IIleali scores were respectively 41"/o, 13% and 42"/0. Discussion: QOL wasn't influenced by age, sex, school level and marital statute. Nevertheless, patients who took a symptomatic treatment had better scores o f general health and mental health. Conehision: This study provided a scale for evaluation of QOL in Moroccan people, and showed that M H N O affect physical and psychological dililelisions of QOL and tile interest of IIlakilig a prospective evaluation for each etiology. 1667 P300 auditory potential in patients with Ischaemic Cerebral Lesion Slotwinsld, K l, Podelilski, R a, Pokryszko-Dragali, A a. 1Departmem Of

Neurology, lk?oclav Medical University, Poland Background: Endogenous P300 potential reflects efficiency of cognitive processess taking place mainly at cortical level. The purpose of our study was clinical and electrophysiological assessment of cognitive decline in patients with dominant or non-dominant hemispheric ischaemic cerebral lesion. Methods: Tile study comprised 17 patients (19 male, 8 felilale), aged 46-74, with focal ischaemic cerebral lesion in dominant (19 subjects) or non-dominant hemisphere (18 subjects), shown in computerized tomography (CT) head scan. Control group consisted of 18 persons (10 male, 8 felilale), aged 40-71, with normal CT head scan and without coguitive decline. P300 potential was performed using "oddball paradigm" , with responses recorded in Fz, Cz, Pz (110-20 system) by means of Nicolet System. Cognitive abilities in patients were assessed by means o f Wechsler Adult Intelligence Scale, Trail Making Test, Auditory Verbal Lean-ring Test. Results: Significant prolongation of P300 latency was found only in patients with iScllaeliffc lesion in domilialit hemisphere. Mean P300 latelicies differed siguificalitly between the patients with lesion in IIolidominant and dolirilialit hemisphere. Tile differences of IIleali P300