4705848 Isolation of bioactive, monomeric growth hormone

4705848 Isolation of bioactive, monomeric growth hormone

226 PATENT ABSTRACTS 4705752 PROCESS FOR THE ENZYMATIC HYDROLYSIS OF D- ALPHAAMINO-ACID AMIDES Wilhelmus H J Boesten, Maria J Cals, Sittard, Netherl...

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226

PATENT ABSTRACTS 4705752

PROCESS FOR THE ENZYMATIC HYDROLYSIS OF D- ALPHAAMINO-ACID AMIDES Wilhelmus H J Boesten, Maria J Cals, Sittard, Netherlands assigned to Stamicarbon B V Process for the enzymatic hydrolysis of a Dalpha-amino-acid amide to the corresponding D- alpha-amino-acid, wherein an aqueous solution of the D- alpha-amino-acid amide is contacted with an aminoacylamidase-containing preparation obtained from a culture of Rhodococcus erythropolis or a mutant thereof and the D- alpha-amino-acid is subsequently recovered from the hydrolysate obtained.

4705848 ISOLATION OF BIOACTIVE, MONOMERIC GROWTH HORMONE Ren-De Yang, Edwin J Hamilton, Larry D Taber assigned to International Minerals & Chemical Corp Monomeric, biologically active growth hormone is isolated from microbially-produced insoluble inclusion bodies by solubilizing and denaturing the growth hormone by extraction of the inclusion bodies into a guanidine salt solution such as guanidine hydrochloride and subsequently renaturing at least a portion of the growth hormone in the solution by replacing the guanidine salt solution with a denaturant-free buffer solution and removing precipitated impurities and growth hormone aggregates. The renatured growth hromone is then purified by ion-exchange chromatography.

4706192 INPUT APPARATUS FOR ENTERING BASE SEQUENCE INFORMATION OF THE GENE Hisanori Nasu, Satoru Suzuki, Hiroak Yoshida, Tomoich Fukuda, Eiichi Soeda, Yokohama, Japan assigned to Hitachi Software Engineering Co Ltd An input apparatus for entering base sequence information of the gene, comprises a computer

for analyzing the base sequence of the gene, an input apparatus for entering base sequence information of the gene to the computer which successively stores the base sequence information entered by the input apparatus and produces the stored base sequence information, and a speech sounding apparatus supplied with the base sequence information produced from the computer for sounding speech corresponding to the base sequence information produced from the computer. 4707167 AIR STERILIZATION

FILTER

Kenichiro Saito, Chikao Kanaoka, Shigeyuki Aoyama, Tokyo, Japan assigned to Aoki Corporation An air sterilization filter for the containment of leakage prevention of biologically contaminated air in space for a biotechnological performance, such as a genetic engineering work. The filter comprises a heat durable sheet filter for collecting microorganisms suspended in air and a heater for heating the sheet filter and sterilizing the collected microorganisms. The filter of the invention is also useful for providing a clean room. 4707357 IMMUNOLOGICALLY ACTIVE PEPTIDES CAPABLE OF INDUCING IMMUNIZATION AGAINST MALARIA AND GENES ENCODING THEREFOR John B Dame, Jackie Williams, Thomas F McCutchan, Imogen Schneider assigned to The United States of America as represented by the Secretary of the Army An immunologically active substantially pure peptide capable of inducing in a human an immune response which is cross reactive with and protective against infection by a malaria parasite, wherein the peptide contains at least 2 consecutive repeats of a sequence Asn-X-Y-Pro wherein X is Ala or Val and Y is Ash or Asp or a sequence of the formula Thr-Glu-Trp-Z-ProCys-Ser-Val-Thr-Cys-Gly-Asn-Glywherein Z is Ser or Thr or the formula Lys-Pro-S-T-S-LysLeu-Lys-Gln-Pro-U-V-Gly-W-Pro wherein S is Lys or Asn, T is His or Glu, U is Gly or Asn, V is As or Glu, and W is Asn or Gin is disclosed along