5156957 Follicle stimulating hormone

5156957 Follicle stimulating hormone

133 PATENT ABSTRACTS nding, detecting expression, drug screening, and treatment involving the human 5-HTID receptor. membrane protein of Bordetella ...

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133

PATENT ABSTRACTS nding, detecting expression, drug screening, and treatment involving the human 5-HTID receptor.

membrane protein of Bordetella pertussis. The invention also relates to host cells and vectors comprising the nucleotide sequence, as well as a vaccine composition comprising the substantially pure protein.

5156955 NUCLEOSIDE OXIDASE AND ASSAY METHOD UTILIZING SAME Yoshikaz Isono, Masami Hoshino, Otsu, Japan assigned to Otsuka Foods Co Ltd The present invention provides a novel nucleoside oxidase YT-1 serving as an enzyme for catalyzing oxidation reaction o f a nucleoside, and oxidase being characterized in that the oxidase causes the nucleoside to react with molecular oxygen to produce a nucleoside-5'earboxylic acid via a nucleoside-5'-aldehyde without producing hydrogen peroxide, a process for producing the enzyme, a novel microorganism having ability to produce the enzyme, and a novel analysis or assay method for nucleosides and the like utilizing the enzyme.

5156959 METHOD TO EXPORT GENE PRODUCTS TO THE GROWTH MEDIUM OF GRAM NEGATIVE BACTERIA Lars Abrahmsen, Tomas Moks, Bjorn Nilsson, Mathias Uhlen, Stockholm, Sweden assigned to KabiGen AB

Biologically active heterodimeric human FSH composed of an alpha subunit and a beta subunit, each subunit being synthesized by a cell having an expression vector containing heteroIogous DNA encoding the subunit.

A process for expressing proteins in Gram(-) bacteria and providing for extracellular secretion thereof, comprising the steps: a) introducing into a Gram(-) bacterium a recombinant DNA construction comprising a promoter, a signal sequence enabling translocation and processing, and a structural gene encoding the desired protein to be expressed; b) cultivating the bacterium under conditions resulting in filamentous growth; and c) recovering the extraceUularly secreted protein; a recombinant DNA construction comprising: a promoter, a signal sequence and a structural gene including a cleavage region, wherein the structural gene is of the formula: See Patent for Tabular Presentation PS where n is an integer ) or = 1, m is an integer, Y is a DNA sequence encoding a desired protein and E and B are the genes corresponding to the protein A regions E and B, with the proviso that the structural gene is different from that encoding natural protein A; a plasmid vector comprising such recombinant DNA construction; a Gram(-) bacterium harbouring said recombinant DNA construction; and proteins obtained by such process.

5156958

5156968

5156957 FOLLICLE STIMULATING HORMONE Vemuri Reddy, Nancy Hsiung, Anton K Beck, Edward G Berstine assigned to Genzyme Corporation

G E N E E N C O D I N G A 30 KILODALTON OUTER MEMBRANE P R O T E I N O F BORDETELLA PERTUSSIS AND METHOD OF RECOMBINANT PRODUCTION OF SAID PROTEIN Patricia A Reilly assigned to Cyanamid Company

American

The present invention relates to a nucleotide and amino acid sequence of a 30 kilodalton outer

PURIFIED YEAST UBIQUITIN HYDROLASE Chung-Cheng Liu assigned to Genentech Inc Ubiquitin hydrolase is provided having a purity of at least 70% homogeneity based on the weight of the total protein in the composition, which hydrolase hydrolyzes a ubiquitin-polypeptide conjugate at the amide bond linking the ubiquitin and polypeptide, thereby yielding intact polypeptide with an unconjugated, mature N-