Current world literature

Current world literature

121 Bibliography Current World Literature This bibliography is compiled by biotechnologists from the journals listed at the end of this publication...

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121

Bibliography Current World Literature

This bibliography is compiled by biotechnologists from the journals listed at the end of this publication. It is based on literature entered into our database between 1st October 1995 and 30th September 1996 (articles are generally added to the database about two and a half months after publication). In addition, the bibliography contains every paper annotated by reviewers; these references were obtained from a variety of bibliographic databases and published between the beginning of the review period and the time of going to press. The bibliography has been grouped into topics that relate to the reviews in this issue.

Current Opinion in Biotechnology

Contents

123

Automation and computer-aided analysis

== Papers considered by the reviewers to be of outstanding interest

125

Calorimetry

The number in square brackets following a selected paper, e.g. [7], refers to its number in the annotated references of the corresponding review.

125

Sequencing and PCR

127

Fluorescence resonance energy transfer spectroscopy

Analytical

with Long-time Molecular Dynamics Calculations in Explicit Water. Proteins 1996, 24:304-313. Brown RS, Lennon JJ: Mass Resolution Improvement by • Incorporation of Pulsed ion Extraction/ionization Unear Time-of-flight Mass Spectrometry. Anal Chem 1995, 67:1998-2003. [18]. Brummel CL, Vickerman JC, Carr SA, Hemling ME, Roberts GD, Johnson W, Weinstock J, Gaitanopoulos D, Bankovic SJ, Winograd N: Evaluation of Mass Spectrometric Methods Applicable to the Direct Analysis of Non-peptide Bead-bound Combinatorial Libredes. Anal Chem 1996, 68:237-242. Budzynski DM, Gao X, Benight AS: Isolation, • • Characterization, and Magnesium-induced Self-assodation Kinetics of Discrete Aggregates of RecA Protein from EscheHchia Coil Biopolymers 1996, 38:47 t -491. [22"~]Bulons D, San Biagio PL: Mesoscopic Gel at Low • • Agarosa Concentration in Water: a Dynamic Ught Scattering Study. Biophys J 1995, 68:1569-1573. [26~]. Burlingame AL, Boyd RK, Gaskell SJ: Mass Spectrometry. • Anal Chem 1996, 68:599R-651R. [41]. Busch NA, Chiew YC, Yarmush ML, Wertheim MS: • Development and Validation of a Simple Antigen-antibody Model. AIChE J 1995, 41:974-984. [24~']. Casset F, Hamelryck 1", Loris R, Brisson JR, TeHierC, Daothi MH, Wyns L, Poortmans F, Perez S, Imberty A: NMR, Molecular Modeling, and Crystallographic Studies of Lentil Lectin-sucrose Interaction. J Biol Chem 1995, 270:25619-25628. Chang XH, Chen RD, Bruce JE, Schwartz BL, Anderson GA, Hofstadler SA, Gale DC, Smith RD, Gao JM, Sigal GB, Mammen M, Whitesides GM: Using Bectrospray Ionization FTICR Mass Spectrometry to Study Competitive Binding of Inhibitors to Carbonic Anhydrase. J Am Chem Soc 1995, 117:8859-8860. Cheng XH, Harms AC, Goudreau PN, TerwilligerTC, Smith RD: Direct Measurement of Oligonuclootide Binding Stoichiomel~'~/of Gene V Protein by Moss Spectrometer. Proc Nat/Acad Sci USA 1996, 93:7022-7027. Cheng XH, Morin PE, Harms AC, Bruce JE, Bendavid Y. Smith RD: Mass Spectrometric Characterization of Sequence-specific Complexes of DNA and Transcription Factor PU.1 DNA Binding Domain. Anal Biochem 1996, 239:35-40.

Related reviews: Mass spectrometry in protein studies from genome to function (pp 6-13); Static and dynamic light scattering of biological macromolecules-what can we learn? (pp 25-30)t Aime S, Ascenzi P, Comoglio E, Fasano M, Paoletti S: Molecular Recognition of R- and T-states of Human Adult Hemoglobin by a Parsmagnetic Gd(lll) Complex by Means of the Measurement of Solvent Water Proton Relaxation Rate. J Am Chem Soc 1995, 117:9365-9366. Andersen JS, Svensson B, Roepstorff P: Bectrospray Ionization and Matrix Assisted Laser Desorption/ionization Mass Spectrometry: Powerful Analytical Tools in Recombinant Protein Chemistry. Nat Biotechnol 1996, 14:449-457. Banks JF, Dresch T: DetecUon of Fast Capillary Eledrophoresis Peptide and Protein Separations Using Bectrospray Ionization with a Time-of-flight Mass Spectrometer. Anal Chem 1996, 68:1480-1485. Bean MF, Annan RS, Hemling ME, Mentzer M, Huddleston • MJ, Cart SA: LC-MS Methods for Selective Detection of Post Translational Modifications in Proteins: Glycosylation, Phosphorylation, Sulfation and Acylation. in Techniquesin Protein Chemistry VI. Edited by Crabbe J. San Diego: Academic Press. 1995:107-116. [59]. Beck HC, Lanritsen FR, Patrick JS, Cooks RG: Metabolism of Helogeneted Compounds in the White Rot Fungus Bjetkandera Adusta Studied by Membrane Inlet Mass Spectrometry and Tandem Mass Spectrometry. Biotechnol Bioeng 1996, 51:23-32. Behm JM, Hemminger JC, Lykke KR: Microscopic Laser Desorption Postionization Fourier Transform Mass Spectrometry. Ana/Chem 1996, 68:713-719. Bemdt KD, Guntert P, Wuthrich K: Conformational Sampling by NMR Solution Structures Calculated with the Program DIANA Evaluated by Comparison

Microscopy

135

Analyzing protein interactions in vivo

135

Genome mapping, hybridization techniques and immobilization

138

Chromatography and electrophoresis

140

Oligonucleotides, antisense and ribozymes

140

Peptide libraries and phage display

141

Immunotechniques

142

Molecular imprinting

142

Miscellaneous

Analytical biotechnology

Papers considered by the reviewers to be of special interest

Mass spectrometry and NMR analysis

134

© Current Biology Ltd ISSN 0958-1669

Mass spectrometry and NMR analysis

biotechnology

Surface plasmon resonance spectroscopy and infrared spectroscopy, biosensors and flow-injection analysis

1997, 8 : 1 9 1 - 1 4 4

121

=

128

Chiou AJ, Ong GT, Wang KT, Chiou SH, Wu SH: Conforrnetional Study of Two Linear Hexapeptides by Two-dimensional NMR and Computer-simulated Modeling: Implication for Peptide Cyclization in Solution. Bicchem Biophys Res Cornmun 1996, 219:572-579. Clark K, Dugad LB, Bartsch RG, Cusanovich MA, Lamar GN: An Interpretive Basis of the Proton Nuclear Magnetic Resonance Hyperfine Shifts for Structure Determination of High-spin Ferric Hernoproteins. Implications for the Reversible Thermal Unfolding of Ferricytechrome C" from Rhodopseudomonas Pelustris. J Am Chem Soc 1996, 118:4654-4664. Coen CJ, Blanch HW, Prausnitz JM: Salting-out • , of Aqueous Proteins: Phase Equilibda and Intermolecular Potentials. A/ChE J 1995, 41:996-1004. [23tl Corr JJ, A~aclato JF: Analysis of Inorganic Species by Capillary Electrophoresla Mass Spectrometry and Ion Exchange Chromatography Mass Spectrometry Using an Ion Spray Source. Anal Chem 1996, 68:2155-2163. Davis MT, Stahl DC, Hefta SA, Lee TD: A Mlcroscale Electrospray Interface for On-line, Capillary Liquid Chromatography Tandem Mass Spectrometry of Complex Peptide Mixtures. AnN Chem 1995, 67:4549-4556. Decagny B, Ergan F, Sarazin C, Barbotin JN, Seguin JP: Activity by H-1 Nuclear Magnetic Resonance Spectroscopy: Application to the Study of Water Exchange in Biphasic Media. Anal Biochem 1996, 234:142-148. Dekoster CG, Heerma W, Pepermans HAM, Groenewegen A, Peters H, HaverkampJ: Tandem Mass Spec~ometry and Nuclear Magnetic Resonance Spectroscopy Studies of Candida Bombicola Sophorolipids and Product Formed on Hydrolysis by Cutinase. Anal Biochem 1995, 230:135-148. Dharmasiri K, Smith DL: Mass Spectrometdc Determination of Isotopic Exchange Rates of Amide Hydrogens Located on the Surfaces of Proteins. AnaJ Chem 1998, 68:2340-2344. Dotsch V, W~det G: Exchange Rates of Internal Water Molecules in Proteins Measured Using Pulsed Reid Gradients. J Am Chem Soc 1995, 117:5064-6070. Dybowski C, Bruch MD: Nuclear Magnetic Resonance Spectrometry. Anal Chem 1996, 68:R161 -R168. Eliasson R, Reichard P, Mulliez E, Ollagnier S, Fontecave M, LJepinsh E, Offing G: The Mechanism of

122

Analytical biotechnology Mass spectrometry and NMR analysis

the Anaerobic Eschericha Coil Ribonucteotide Reductese Investigated with Nuclear Magnetic Resonance Spectroscopy. Biochem Biophys Res Commun 1995, 214:28-35. Evans UA, Cooper A, Lakey JH: Direct Measurement of the Association of a Protein with a Family of Membrane Receptors. J Me/Biol 1996, 255:559-563. Fan F, Mayo KH: Effect of PH on the Conformation and Backbone Dynamics of a 27-residue Peptide in Trifluoroethanol - an NMR and CD Study. J BiG/ Chem 1995, 270:24693-24701. Figeys D, Vanoostveen I, Ducret A, Aebersold R: Protein Identification by Capillary Zone Bectrophorosis/microelectrospray Ionizstion-tandem Mass Spectrometry at the Subfemtomole Level. Anal Chem 1996, 58:1822-1828. Rshman DM, Patterson GD: Light Scattering Studies of • . Supercoiled and Nicked DNA. Biopo/ymers 1996, 38:535-552. [15~;]. Fitzgerald MC, Chernushevich I, Standing KG, Whitman CP, Kent SBH: Probing the Oligomeric Structure of an Enzyme by Electrospray Ionization Time-of-flight Mass Spectrometry. Proc Nat/Acad Sci USA 1996, 93:6851-6856. Frassineti C, Ghelli S, Cans P, Sabatini A, Moruzzi MS, Vacca A: Nuclear Magnetic Resonance as a Tool for Determining Protonation Constants of Natural Polyprotic Bases in Solution. Anal Biochem 1995, 231:374-382. Fregeau NL, Wang YQ, Pen RT, Wylie WA, Lown JW: Charactedzation of a CPHexitropsin Conjugate OIIgonucleotide Covalent Complex by H-1 NMR and Restrained Molecular Dynamics Simulation. J Am Chem Soc 1995, 117:8917-8925. Friedrichs MS, Stouch TR, Bruccoleri RE, Mueller L, Constantine KL: Structural and Dynamic Properties of a Beta-hairpin-forming Uneer Peptide. 2. C-13 NMR Relaxation Analysis. J Am Chem Soc 1995, 117:10855-10864. Gehri9 PM, Krzyzaniak A, Barciszewsk; J, Biemann K: Mass Spectrometdc Amino Acid Sequencing of a Mixture of Seed Storage Proteins (napin) from Brassica Napus, Products of a multigene Family. Proc Nat/ Acad Sci USA 1996, 93:3647-3652. Ghosh S, Reed WF: New Characteristic Signatures from =- Time-dependent Static Ught Scattering Dudn9 Polymer Depolymefizstion, with Application to Proteoglycan Subunit Degradation. Biopolymers 1995, 35:435-450, [33t]. Girault S, Chassaing G, Blais JC, Brunet A, Bolbach G: Coupling of MALDi-TOF Mess Analysis to the Separation of Biotinylsted Peptidea by Magnetic Streptavidin Beads. Anal Chem 1996, 60:2122-2126. Goshe MB, Anderson VE: Determination of Amino Acid Isotope Ratios by Bectrospmy Ionization Mass Spectrometry. Anal Biochem 1995, 231:38"7-392. Green BN, Suzuki 1", Gotoh T, Kuchumov AR, Vinogradov SN: Bectrosproy Ionization Mass Spectrometdc Determination of the Complete Polypeptide Chain Composition of "rylorrhynchos Heterochaetos Hemoglobin. J Biol Chem 1995, 270:18209-18211+ Guy P, Remigy H, Jaquinod M, Bersch B, Blanchard L, Della A, Forest E: Study of the New Stability Properties Induced by Amino Acid Replacement of Tyrosine 64 in Cytochromo C(553) from Desulfovibrio Vulgaris Hildenborough Using Etactrospray Ionization Mass Spectrometry. Biochem Biophys Res Commun 1996, 218:97-103. Hagenhoff B: Surface Mass Spectrometry: Application to Biosensor Charactedzation. Biosens Bioelectron 1995, 10:885-894. Hoogstraten CO, Markley JL: Effects of Expedrnentally Achievable Improvements in the Quality of NMR Distance Constraints on the Accuracy of Calculated Protein Structures. J Mol Biol 1996, 258:334-348. Jarvie TR Went GT, Mueller KT: Simultaneous Multiple Distance Measurements in Peptides Via Solid-state NMR. JAm Chem Soc 1996, 118:5330-5331. Jansen O, Poteletejnikov A, Mann M: Delayed Extraction • Improves Specificity in Database Searches by MALDI Peptide Maps. Rapid Commun Mass Spectrom 1996, 10:1371-1378. [20]. Juge N, Andersen JS, Tuff D, Roepstorff P, Svensson B: • Overexpression, Purification and Characterization of Recombinant Bsdey c(-amylases 1 and 2 Secreted by the Methylotrophic Yeast Picas Pastoris. Protein Expr Puff/1996, 8:204-214. [57]. Jurinke C, Vandenboom D, Jacob A, Tang K, Wed R, Koster H: Analysis of Ligase Chain Reaction Products Via Matrix-assisted Laser Desorption/ionization Time-of-flight-mass Spectrometry. Anal Biochem 1996, 237:174-181. Kalman A, Thunecke F, Schmidt R, Schiller PW, Horvath C: Isolation and Identification of Peptide Conformers

by Reversed-phase High-performance Liquid Chromatography and NMR at Low Temperature. J Chromatogr A 1996, 729:155-171. Kaufmann R: Mstdx-assisted Laser Desorption Ionization (MALDI) Mass Spectrometry: a Novel Analytical Tool in Molecular Biology and Biotechnology. J Biotechno11995,41:155-175. Kelly JA, Feigon J, Yeates TO: Reconciliation of the X-ray and NMR Structures of the Thrombin-binding Aptamer D(GGTTGGTGTGGTTGG).J Mol Biol 1996, 256:417-422. Klatt R Pfeiffer S. List BM, Lehner D. Clatter O, Bachinger • HP, Werner ER, Schmidt K, Mayer B: Characterization of Home-deficient Neuronal Nitric-oxide Synthase Reveals a Role for Home in Subunit Dimerizstion and Binding of the Amino Acid Substrate and Tetrahydrobiopterin. J Biol Chem 1996, 271:7336-7342, [5t]. Kofman V, Fewer O, Pecht I, Goldfarb D: Two-dimensional Pulsed EPR Spectroscopy of the Copper Protein Azudn. JAm Chem Soc 1996, 118:1201-1206. K~rner R, Wilm M, Monrad K, Schubert M, Mann M: • Combining Nano Etactrosprsy with Quadrupole Ion Trap for the Analysis of Peptides and Proteins. J Am Soc Mass Spectrom 1996, 7:150-156. [39]. Kriwacki RW, Wu J, Siuzdak G, Wright PE: Probing Protain/protein Interactions with Mass Spectrometry and Isotopic Labeling: Analysis of the P21/Cdk2 Complex. J Am Chem Sac 1996, 118:5320-5321. Krock KA, Wilkins CL: Qualitative Analysis of Contaminated Environmental Extracts by Multidimensional Gas Chromatography with Infrared and Mass Spectral Detection (MDGC-IR-MS). J ChromatogrA 1996, 726:167-178. Kuwata K, Ueki S, Era S, Sogaml M, Watari H: Spin-lattice Relaxation Times of Water in Polarized and Depolarized Rabbit Vagus Nerves. Biechem Biophys Res Commun 1995, 215:459-466. Lafitte D, Capony JP, Grassy G, Haiech J, Calas B: Analysis of the Ion Binding Sites of Ceimodutin by Electrospray Ionization Mass Spectrometry. Biochemistry 1995, 34:13825-13832, Lee MS, Cao BL: Nuclear Magnetic Resonance Chemical Shift: Comparison of Estimated Secondary Structures in Peptides by Nuclear Magnetic Resonance and Circular Dichroism. Protein Eng 1996, 9:15-25. Li/U, Daggett V: Investigation of the Solution Structure of Chymotrypsin Inhibitor 2 Using Molecular Dynamics: Compadson to X-my Crystallographic and NMR Data. Protein Eng 1995, 8:1117-1128. Li X, Galanekis D, Gabdel DA: Transient intermediates in • the Thrombin Activation of Fibrinogen. J Biol Chem 1996, 271:11767-11771. [39~']. Li YZ, Little DP, Koster H, Hunter RL, Mclver RT: High-resolution MALDI Fourier Transform Mass Spectrometry of Oligonucleotides. Anal Chem 1996, 68:2090-2096. Licklider L, Kuhr WG, Lacey MP, Keough T, Purdon MP, Taklgiku R: On-Une Microreectors Capillary Bectrophoresis Mass Spectrometry for the Analysis of Proteins and Peptides. Anal Chem 1995, 67:4170-4177+ Little DP, McLafferty FW: Sequencing 50-mar DNAs Using Bectrospray Tandem Mass Spectrometw and Complementary Fragmentation Methods. J Am Chem Soc 1995, 117:6783-6784. Liu YH, Bai J, Liang XO, Lubman DM, Venta PJ: Use of a Nitrocellulose Film Substrata in Matrix-assisted Laser Desorption/ionization Mass Spectrometry for DNA Mapping and Screening. Anal Chem 1995, 67:3482-3490. Lohmeiervogel EM, Mclntyre DD, Vogel HJ: Phosphorus-31 and Carbon-13 Nuclear Magnetic Resonance Studies of Glucose and Xylose Metabolism in Cell Suspensions and Agarose-immobilized Cultures of Pichia Stipitis and Saccharomyces Cerevisiae. Appl Environ Microbiol 1996, 62:2832-2838. Leo JA: Observation of Large Subunit Protein Complexes by Electrospray Ionization Mass Spectrometry. J Mass Spectrom 1995, 30:180-183. [92]. Lopezbeltran EA, Mate MJ, Cerdan S: Dynamics and Environment of Mitochondrial Water as Detected by H-1 NMR. J Biol Chem 1996, 271:10648-10653. Lutz NW. Yahi N, Fantini J, Cozzone PJ: New Method for the Determination of Specific C-13 Enrichment in Phosphorylated [1-C-13]glucoea Metabolitea C-13-coupled, H-1 -decouptad P-31-NMR Spectroscopy of Tissue Perchloric Acid Extracts. Eur J Biochem 1996, 238:470-475. Lyles DS, McKenzie Me, H~tgan RR: Stopped+flow, -, Classical, and Dynamic Light Scattering Analysis of Matrix Protein Binding to Nucleocapsids of Vesicular Stomatitis Virus. Biochemistry 1996, 35:6508-6518. [31f].

Lynch NJ, Kitpatrick PK, Carbonell RG: Aggregation of • Ligsnd-modified Liposomes by Specific interactions with Proteins. I. Biotinylsted Uposomes and Avidin. Biotechnol Bioeng 1996, 50:151-168. [341"]. Lynch NJ, FJIpatdck PK, Carbonell RG: Aggregation of • Ligand-modified Uposomes by Specific interactions with Proteins. II. Biotinylated Lipsomes and Antibiotin Antibody. Biotechnol Bioeng 1996, 50:169-183. [35~]. Ma C, Sun L, Bloomfield VA: Condensation of Plasmids • Enhanced by Z-DNA Conformation of D(CG)n Inserts. Biochemistr/1995, 34:3521-3528. [14t]. Mander~lle RA, Ellena JF, Hecht SM: Interaction of Zn(il).Bleomycin with D(CGCTAGCG)2. A binding Model Based on NMR Experiments and Restrained Molecular Dynamics Calculations. J Am Chem Soc 1995, 117:7891-7903, Mann M, Talbo G: Developments in Mstrix-assisted Laser • Desorption/ionizstion Mass Spectrometry. Curt Opin Biotechnol 1996, 7:11-19. [15]. Mattiello DL, Warren WS, Mueller L, Farmer BT: Minimizing the Wafer Resonance in Biological NMR: Charsctedzation and Suppression of Intermoleculer Dipolar Interactions by Multiple-axis Gradients. J Am Chem Soc 1996, 118:3253-3261. McGuire JM, Lynch CC: Characterization of Nonmicrobiological Paper Mill Deposits by Simultaneous TG-IR-MS. Anal Chem 1996, 80:2459-2463+ Met G, Hietter H, Lefevre JF: Stabilization of Proteins by Glycosylation Examined by NMR Analysis of a Fucosylated Proteinese Inhibitor. Nature 1996, 3:45-53. Mirza UA, Chait BT, Lander HM: Monitoring Reactions of Nitric Oxide with Peptides and Proteins by Electrospray Ionizstion-mass Spectrometry. J Biol Chem 1995, 270:17185-17188. Mortz E, Seraneva T, Haebel S, Julkunen I, Roepstorff • P: Mass Spectrometric Characterization of Glycosyleted Interferon-y Variants Separated by Gel Electrophoresis. Electrophoresis 1996, 17:1493-1502. [64]. Morris HR, PaxtonT, Dell A, Langhorne J, Berg • M, Bordoll RS, Hoyes J, Batemann RH: High Sensitivity Collisionally-activsted Decomposition Tandem Mass Spectrometry on a novel Ouadrupole/orihogonal-acceierstion Time-of-flight Mass Spectrometer. Rapid Commun Mass Spectrom 1996, 10:889-896, [40]. Moser MJ, Lee SY, Klevit RE, Davis TN: Ca2+ Binding to Ceimodulin and Its Role in Schizossccharomyces Pombe as Revealed by Mutaganasis and NMR Spectroscopy. J BiG/Chem f 995, 270:20643-20652. Mueller L, Legault P, Pardi A: Improved RNA Structure Determination by Detection of NeE Contacts to Exchange-broadened Amino Protons. J Am Chem Soc 1995, 117:11043-11048. Nakayama H, Uchida K, Shinkai F, Shinoda 1", Okuyama T, Seta K, Isobe T: Capillary Column High-performance Liquid Chromatographic Electrospray Ionization Triple-stage Quadrupole Mass Spectrometric Analysis of Proteins Separated by Two-dimensional Polyecrylamide Gel Electrophoresis - Application to Cerebeiler Protein Mapping. J ChromatogrA 1996, 730:279-287. Nelson RW, Krone JR, Bieber AL, Williams P: Mass • e Spectrometric Immunoassay. Anal Chem 1995, 34:1153-1158. [89]. Nestle NFEI, Kimmich R: NMR imaging of Heavy Metal Absorption in Alginete, Immobilized Calls, and Kombu Algal Biosorbents. Biotechnel Bioeng 1996, 51:538-543. Ni JS, Pomerantz SC, Rozenski J, Zhang YH, McCIoskey JA: Interpretation of Oligonuctaottde Mass Spectre for Determination of Sequence Using Electrospray Ionization and Tandem Mass Spectrometry. Anal Chem 1996, 68:1989-1999, Nielsen NC, Thogersen H, Sorensen OW: Doubling the Sensitivity of INADEQUATE for Tracing Out the Carbon Skeleton of Molecules by NMR. J Am Chem Soc 1995, 117:11365-11366. Nietlispach D, Clowes RT, Broadhurst RW, Ire Y, Kealer J, Kelly M, Ashurst J, Oschkinat H, Domaifle PJ, Laue ED: An Approach to the Structure Determination of Larger Proteins Using Triple Resonance NMR Experiments in Conjunction with Random Fractional Deuteration. J Am Chem Soc 1996, 118:407-415. Noy A, Frisbie CD, Rozsnyai LF, Wrighton MS, Lieber CM: Chemical Force Microscopy: Exploiting Chemically-modified Tips to Quantify Adhesion, Friction. and Functional Group Distributions in Molecular Assemblies, J Am Chem Soc 1995, 117:7943-7951. O'Connor PB, McLaflerty FW: Oligomer Charactedzation of 4-23 KDa Polymers by Electrospray Fourier

Analytical biotechnology Automation and computer-aided analysis

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Analytical biotechnology Calorimetry • Sequencing and PCR

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Calorimetry Related review: Characterization of binding interactions by isothermal titration calorimetry (pp 31-35) Baker BM, Murphy KP: Evaluation of Unked Protonation • Effects in Protein Binding Reactions Using Isothermal Titration calorimetry. Biophye J 1996, 71:2049-2055. [50]. Bhetnagar RS, Gordon Jl: Thermodynamic Studies of • Myfistoyl-CoA-proteln N-myristoyfttansferase Using Isothermal Titration Calorimetry. Methods Enzymo/ 1995, 250:467-486. [41]. Doyle ML, Hensley P: Experimental Dissection of • Protein-protein Interactions in Solution, Adv Mol Cell Bio11997, 21 :in press. [48]. Evans UA, Cooper A, Lekey JH: Direct Measurement • of the Association of e Protein with a Family of Membrane Receptors. J Mol Biol 1996, 255:559-563. [11]. Fisher HI=,Singh N: Cbiodmetric Methods for Interpreting • Protein-ligend Interactions. Methods Enzymol 1995, 259:194-22t. [38]. Fradette S, Rho D, Samson R, Leduy A: Microcalorimetry as a Diagnostic end Analytical Tool for the Assessment of Biodogrsdation of 2,4-D in a Liquid Medium and in Soil (vol 42, Pg 432, 1995). Appl Microbiol Biotechnol 1995, 43:387. Garcia-Fuentes L, Reche P, Lopez-Mayorga O, Senti DV, • Gonzalez-PacanowskaD, Baron C: Thermodynamic Analysis of the Binding of 5-fluoro-2'-deoxyuridine 5"-monophosphate to Thymidylate Synthetase Over • Range of Temperatures. Eur J Biochem 1995, 232:641-645. [34]. Gill DS, Roueh DJ, Shick KA, Willson RC: Mlcrocalodmetrlc Characterization of the Anion-exchange Adsorption of Recombinant Cytechrome B(5) and Its Surfece-cherge Mutants. J ChromatogrA 1995. 715:81-93. Gomez J, Freire E: Thermodynamic Mapping of • * the Inhibitor Site of the Aspartic Protease Endothlapepsin. J Mol B/o/1995, 252:337-350. [6]. Kamiys M, Torigoe H, Shindo H, Sarai A: Temperature Dependence and Sequence Specificity of DNA Triplex Formation: an Analysis Using Isothermal Titration Calorimetry. J Am Chem Soc 1996, 118:4532-4538. Lin Z, Schwarz FP, Eisenstein E: The Hydrophobic Nature • of GroEL-substrete Binding. J Biol Chem 1995, 270:1011-1014. [27]. Liu Y, Sturtevant JM: Significant Discrepancies Between • Van't Hoff and Calodmatric Enthalpies II. Protein Sci 1995, 4:2559-2561. [47]. Lohman TM, Overman LB, Ferrari ME, Kozlov AG: A Highly • • Salt-deqendent Enthalpy Change for Escherichie Cola SSB Protein-nucleic Acid Binding Due to Ion-protein Interactions. Biochemistry 1996, 35:5272-5279. [22]. Luque I, Mayorga OL, Freire E: Structuro-based • • Thermodynamic Scale of Alpha-helix Propensities in Amino Acids. Biochemistry 1996, 35:13681-13688. [52]. Marzabadi MR, Gruys KJ, Pansegrau PD, Walker MC, • YuenHK, Sikorski JA: An EPSP Synthetase Inhibitor Joining Shikimate 3-phosphata with Glyphosate: Synthesis and Ugand Binding Studies. Biochemistry 1996, 35:4199-4210. [37]. Merabet E, Ackers GK: Calorimetric Analysis of Lambda • el Represser Binding to DNA Operator Sites. Biochemistry 1995, 34:8554-8563. [25]. Murphy KP, Freire E, Paterson Y: Conflgurationel Effects • in Antibody-antigen Interactions Studied by Microcelorimetry. Proteins 1995, 21:83-90. [1]. Ohyama 1", Cowan JA: Calorimetric Studies of Metal • Binding to Tetracycline. Role of Solvent Structure in Defining the Selectivity of Metal Ion-drug Interactions./norg Chem 1995, 34:3083-3086. [53].

Orban J, Alexander R Bryan P, Khare D: Assessment of Stability Differences in the Protein G B1 and B2 Domains from Hydrogen-deuterium Exchange: Compadson with Calorimetric Data. Biochemistry 1995, 34:15291-15300. Pearce KH, Ulisch MH, Kelley RF, De Vos AM, Wells JA: • Structural and Mutational Analysis of Affinity-inert Contact Residues at the Growth Hormone-receptor Interface. Biochemistry 1996, 35:10300-10307. [15]. Plum GR, Breslauer KJ: Calorimetry of Proteins • and Nucleic Acids. Curr Opin Struct Biol 1995, 5:682-690. [21]. Privalov G, Kavina V, Freire E, Privalov PL: Precise Scanning Calorimeter for Studying Thermal Properties of Biological Macromolecules in Dilute Solution. Anal Biochem 1995, 232:79-85. Raman CS, Allen MJ, Nail ST: Enthalpy of * Antibody-cytochrome c Binding. Biochemistry 1995, 34:5831-5838. [4]. Reedstrom RJ, Royer CA: Evidence for Coupling of • Folding and Function in trp Represser: Physical Characterization of the Superropressor Mutant AV77. J Mol Biol 1995, 253:266-276. [24]. Schwarz FP, Tello D, Goldbaum FA, Mariuzza RA. Poljak *, RJ: Thermodynamics of Antigen-antibody Binding Using Specific Anti-lysozyme Antibodies. Eur J Biochem 1995, 228:388-394. [2]. Torlgoe H, NakayamaT, Imszato M, Shimada I. Arata Y, Sarai A: The Affinity Maturation of Anti-4-hydroxy-3-nifrophenylacetyl Mouse Monoclonal Antibody - a calorimetric Study of the Antigen-antibody Interaction. J Bio/Chem 1995, 270:22218-22222. Wu J, Li J, Li G, Long DG, Weiss RM: The Receptor • Binding Site for the Mathyffransferese of Bacterial Chemotaxis is Distinct from the Sites of Methylation. Biochemistry 1996, 35:4984-4993. [30]. Xu Y, Johnson CR, Beckett D: Thermodynamic Analysis • of Small Ligand Binding to the Escherichia Cola Represser of Biotin Synthesis. Biochemistry 1996, 35:5509-5517. [35].

Sequencing and PCR Related reviews: Quantitative nucleic a c i d s f o o t p r i n t i n g - t h e r m o d y n a m i c a n d kinetic a p p r o a c h e s (pp 3 6 - 4 4 ) ; H i g h - s p e e d D N A s e q u e n c i n g in ultrathin slab gels (pp 107-113)-~ Alvarez AJ, Buttner MP, Stetzenbach LD: PCR for Bioeerosol Monitoring: Sensitivity and Environmental Interference. Appl Environ Microbiol 1995, 61:3639-3644. Anazawa T, Takahashi S, Kambara H: A Capillary Array Gel Bectrophoresis System Using Multiple Laser Focusing for DNA Sequencing. Anal Chem 1996, 68:2699-2704. Andersson B, Lu J, Edwards KE, Muzny DM, Gibbs RA: Method for 9S-well M13 DNA Template Preparations for Large-scale Sequencing. Biotechniques 1996, 20:1022-1027 Ansarilari MA, Jones SN. Timms KM, Gibbs RA: Improved Ligation-anchored PCR Strategy for:Identification of 5" Ends of Transcripts. Biotechniqu~s 1996, 21:34, Arias CR, Garay E, Aznar R: Nested PCR~Mathod for Rapid and Sensitive Detection of Vibdo Vulelficus in Fish, Sediments. and Water. App/Eriviron Microbiol 1995, 61:3476-3478. Atrnar RL, Neill FH, Woodley CM, Manger R, Fout GS, Burkhardt W, Leja L, McGovern ER, Leguyader F, Metcaff TG, Estes MK: Collaborative Evaluation of a Method for the Detection of Norwalk Virus in Shellfish Tissues by PCR. Appl Environ Microbiol 1996, 62:254-258. Balavoine G: Identification of Members of Several Homeobox Genes in a Planerian Using a Ligation-mediated~Polymerase Chain Reaction Technique. Nucleic Acids Roe 1996, 24:1547-1553. Banff S, Borsani G, Roesi E, Bernard L, Guffanti A. • , Rubboli F, Marchitiello A. Giglio S, Coluccia E, Zollo Met aL: Identification and Mapping of Human CDNAs Homologous to Drosophila mutant Genes Through EST Database Seamhing. Nat Ganet 1996, 13:167-174. [56,~]. Bassler HA. Rood SJA. Livak KJ, Marrnaro J, Knorr R, Bat1 CA: Use of a Fiuorogenic Probe in a PCR-based Assay for the Detection of Listeria Monocytogenes. App/ Environ Microblol 1995, 61:3724-3728. Backer A. Reith A. Napiwotzki J, Kadenbach B: A Quantitative Method of Determining Initial Amounts of DNA by Polymerese Chain Reaction Cycle Titration Using Digital Imaging and a Novel DNA Stain. Anal Biochem 1996, 237;204-207.

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Beg OU: Use of Polylysine in Solid Phase Protein Sequencing. Biotechniquee 1995, 19:876. Bentzley CM, Johnston MV, Larsen BS, Gutteridge S: Oligonucleotide Sequence and Composition Determined by Metdx-assieted Laser Desorption Ionization. Anal Chem 1996, 68:2141-2146. Beraswill S, Bugert P, Brochmuller I, Geider K: Identification of the fire Blight Pathogen, Erwinla Amylovora, by PCR Assays with Chromosomal DNA. Appl Environ Microbiol 1995, 61:2636-2642. Berndt C, Bebenroth M, Oehlschlegel K, Hiepe F, Schossler W: Quantitative Polymerese Chain Reaction Using a DNA Hybddization Assay Based on Surface-activated Mlctoplates. Anal Biochem 1995, 225:252-257. Betz C, Papadopoulos T, Buchwald J, Dammdch J, Mullerhermelink HK: Surfactant Protein Gene Expression in Metastatic and Micrometastatic Pulmonary AdenocarcJnornas and Other Non-small Cell Lung Carcinomas: Detection by Reverse Transcdptase-polymerase Chain Reaction. Cancer Res 1995, 55:4283-4286. Bokal AJ IV, Rose W, Gourse RL: The Trenecdptionel • Activator Protein FIS: DNA Interactions and Cooperative Interactions with RNA Polymerese a the Escherichie ColaRmB P1 Promoter. J Mol B/o/ 1995, 245:197-207. [28l Bonfield JK, Staden R: The Application of Numerical Estimates of Base Calling Accuracy to DNA Sequencing Projects. Nucleic Acids Ras 1995, 23:1406-1410. Bordello F, Lederer J: Construction of Quantitative RT-PCR MIMICs. Biotechniquas 1995, 19:580. Bortolin S, Christopoulos TK, Verhaegan M: Quantitative Polymerese Chain Reaction Using a Recombinant DNA Internal Standard and Time Resolved Ruorometry. Anal Chem 1996, 88:834-840. Briglia M, Eggen RIL Devos WM, Vanelsas JD: Rapid and Sensitive Method for the Detection of Mycobacterium Chlorophenolicum PCP-I in Soil Based on 1ES RRNA Gene-targated PCR. Appl Environ Microbiol 1996, 62:1478-1480. Brossart P, Schmier JW, Kruger S, Wil~hsuck M, Scheibenbogen C, Mohler 1", Keilholz U: A Polymerese Chain Reaction-based Semiquantitative Assessment of Malignant Melanoma Cells in Peripheral Blood. Cancer Ras 1995, 55:4065-4068. Bult CJ, White O, Olsen GJ, Zhou L, Reischmann RD, • • Sutton GG, Blake JA. RtzGerald LM, C~ayton RA. Gocayne JD et aJ.: Complete Genome Sequence of the Methanogenic Archaeon, Methenococcus Jannaschii. Science 1996, 273:1058-1073. [49"~]. Cascon A, Anguita J, Hernanz C, Ssnchez M, Femandez M, Naharro G: Identification of Aeromona$ Hydrophlla Hybridization Group 1 by PCR Assays. Appl Environ Microbiol 1996, 62:1167-1170. Chadwick RB, Conrad MR McGinnie MD, Johneton-Dow • * L, Spurgeon SL, Kronick MN: Haterozygete and Mutation Detection by Direct Automated Ruorescent DNA Sequencing Using • Mutant Teq DNA Polymerase, Biotechniques 1996, 20:676-683. [57~]. Cheng J, Shoffner MA, Hvichia GE, Kricka II, Wilding P: Chip PCR. 2. Investigation of Different PCR Amplification Systems in MIcrotahriceted Silicon-glass Chips. Nucleic Acids Ras 1996, 24:380-385. Clinton M, ScougaLI RK: Detection and Capture of S-35-1abeled Gas Released from Reaction Tubes During Differential Display PCR - Lab Safety Tip. Biotechniques 1995, 19:798-799. Craig ML, Sub W-C, Record MT Jr: HO. and DNase I • Probing of F_~70RNA Polymereae-~.PR promoter Open Complexes: Mg2+ Binding and Its Structural Consequences at the Transcription Start Site, Biochemistry 1995, 34:15624-15632. [52]. Dalma-Weiszhausz DD, Brenowitz M: Interaction Between • RNA Polymerase and the Positive and Negative Regulators of Transcription at the Escherlchia Cola Gel operon. Biochemistry 1996, 35:3735-3745. [27]. Day DJ, Spe;ser PW, White PC, Barany F: Detection of Steroid 21-hydroxylase Alleles Using Gene-specitlc PCR and a Multiplexed Ligation Detection Reaction. Genomics 1995, 29:152-162. Desalle R, Birstein VJ: PCR Identification of Black Caviar [Letter]. Nature 1996, 381:197-198. Oi Cera E: Thermodynamic Theory of Site-Specific • Binding Processes in Biological Mecromolecules. New York: Cambridge University Press; 1995. [t I]. Ericsson H, Stalhandske P, Danielssontham ML Bannen~an E, Bille J, Janquet C, Rocourt J, Tham W: Division of Listaria Monocytogenes Serovar 4b Strains into Two Groups by PCR and Restriction Enzyme Analysis. Appl Environ Microbiol 1995, 61:3872-3874. Fasol G: Room-temperature Blue Gallium Nitdde Laser • • Diode. Science 1996, 272:1751-1752. [32"~].

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Analytical biotechnology Sequencing and PCR

Relschmann RD, Adams MD, White O, Clayton RA, • . Kirkness EF, Kedavage AR, Bull CJ, Tomb JF, Dougherty BA, Merrick JM et at.: Whole-ganome Random Sequencing and Assembly of Haemophilu$ Influenzae Rd. Science 1995, 269:496-512. [47"~]. Fraser CM, Gocayne JD, White O, Adams MD, Clayton • - RA, Fleischmann RD, Bull CJ, Kedavage AR, Sutton G, Kelley JM et at.: The Minimal Gana Complement of Mycoplasma Genitelium. Science 1995, 270:397-403. [481]. Fujita 1", Kiyama M: Identification of DNA Polymorphism by Asymmatric-PCR SSCP. Biotechniques 1995, 19:532. Gatlin J, Campbell LH, Schmidt MG, Arrigo SJ: Direct-rspid (DR) Mutagenesis of Large Plasmids Using PCR. Biotechniquea 1995, 19:559. Gautvik KM, Delecea L, Gautvik VT, Danielson PE, Tranque P, Dopazo A, Bloom FE, Sutcliffe JG: Overview of the Most Prevalent Hypothalamus-spedfic MRNAs, as Identified by Directional Tag PCR Subtraction. Proc Nat/Acad Sci U S A 1996, 93:8733-8738. Ghosh S: A Novel Ligation Medisted-PCR Based Strategy for Construction of Subtraction Libraries from Limiting Amounts of MRNA. Nucleic Acids Res 1996, 24:795-796, Gibbs RA: Pressing Ahead with Human Genoma • Sequencing. Nat Genet 1995, 11:121-125. [53"P]. Gilchrist CA, Streets HL, Ackers JP, Hall R: PCR-based Quantitation of Transtected Luciferase DNA: Evaluation Using an Entamoeba Histolytica Reporter Construct. Biotechniques 1996, 20:764. Gingrich JC, Boehrer DM, Basu SB: Partial CviJI Digestion as an Aitemstive Approach to Generate Cosmid Sublibrariec for Large-scale Sequencing Projects. Biotechniques 1996, 21:99-104. Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, • • FeldmannH, Galibert F, Hoheisel JD, Jacq C, Johnston Met AI.: Life with 6000 Genes. Science 1996, 274:546-567. [50"~]. Gotz A, Pukall R, Smit E, Tietze E, Prager R, Tschape H, Vanelsas JD, Smalla K: Detection and Characterization of Broad-hoar-range Plasmids in Environmental Bacteria by PCR.Appl Environ Microbiol 1996, 62:2621-2628. Gow JW, McGill MM, Behan WMH, Behan PO: Long RT-PCR Amplification of Full-length Enterovirus Genome. Biotechniques 1996, 20:582, Gruber A, ZJngeles B: One-base Double-stranded DNA Sequencing Reaction Using Commercial Kits. Biotechniques 1995, 19:748. Gurtler V, Barde HD: Typing of Staphylococcus Aureus Strains by PCR-emplification of Variable-length 16S-23S RDNA Spacer Regions: Characterization of Spacer Sequences. Microbiology 1995, 141:1255-1266. Hegiware K, Harris CC: 'Long Distance Sequencer' Method; a Novel Strategy for Large DNA Sequencing Projects. Nucleic Acids Res 1996, 24:2460-2461. Hales BA, Edwards C, Ritchie DA, Hall G, Pickup RW, Saunders JR: Isolation and Identification of Methanogen-speclfic DNA from Blanket Bog Feat by PCR Amplification and Sequence Analysis. App/ Environ Microbiol 1996, 62:668-675. Havukkale I, Ichimurs H, Nagemure Y. Sasaki T: Rice Genome Analysis by Integration of Sequencing and Mapping Data. J Biotechnol 1995, 41:139-148, Haywardlester A, Oefner PJ, Doris PA: Rapid Quantification of Gone Expression by Competitive RT-PCR and Ion-pair Reversed-phase HPLC. Biotechniques 1996, 20:250-257. Herman LMF, Deblock JHGE Waes GMAVJ: A Direct PCR Detection Method for Cloatridium Tyrobutyricum Spores in Up to 100 Milliliters of Raw Milk. Appl Environ MicrobJot 1995, 51:4141-4148+ Hill JM, Halford WP, Wen RJ, Engel LS, Green LC, Gebhardt BM: Quantitative Analysis of Polymerase Chain Reaction Products by Dot Blot. Anal Biochem 1996, 235:44-48. Hiller 1", Snell L, Watson PH: Microdissection RT-PCR Analysis of Gone Expression in Pathologically Defined Frozen Tissue Sections. Biotechniques 1996, 21:38. Hodson RE, Dustman WA, Garg RP. Moran MA: In Situ PCR for Visualization of Microscale Dis~bution of Specific Genes and Gene Products in Prokaryotic Communities. Appl Environ Microbiol 1995, 61:4074-4082. Hsieh M, Brenowitz M: Quantitative Kinetics Footprinting • • of Protoin-DNA Association Reactions. Methods Enzymo11996, 274:478-492. [78]. Hutchison W, Dahl HHM: Detergent-enhanced Sequencing of Heat-denatured PlasmidDNA. Biotechniques 1995, 19:554. Ibeas JI, Lozano I, Perdigones F, J;menezJ: Detection of Dekkera=Brettanomyces Strains in Sherry by a

nested PCR Method. Appl Environ Microbiol 1996, 62:998-1003. Jacobsen CS: Microscale Detection of Specific Bacterial DNA in Soil with a Magnetic Capture-hybridlzation and PCR Amplification Assay. Appl Environ Microbiol 1995, 61:3347-3352. Johnston SL, Strausbauch M, Sarkar G, Wettstein PJ: A Novel Method for Sequencing Members of Multi-gene Families. Nucleic Acids Res 1995, 23:3074-3075. Jurinke C, Vandenboom D, Jacob A, Tang K, Worl R, Koster H: Analysis of Ligase Chain Reaction Products Via Matrix-assisted Laser Desorption/ionization Time-of-flight-mass Spectrometry. Anal Biochem 1996, 237:174-181. Kaufman RI, Nixon BT: Use of PCR to Isolate Genes Encoding Sigma 54-dependent Activators from Diverse Bacteria. J Bacteriol 1996, 178:3967-3970. Keen G, Burton J, Crowley D, Dickinson E, Espinosalujan A, Franks E, Harger C, Manning M, March S, McLeod M, Oneill J, Power A, Pumilia M, Reinert R, Rider D, Rohrlich J, Schwertfeger J, Smyth L, Thayer N, Troup C, Retds C: The Genome Sequence DataBase (GSDB): Meeting the Challenge of Genomic Sequencing. Nucleic Acids Res 1996, 24:13-16. Kilvington S, Beeching J: Development of a PCR for Identification of Naegleda Fowled from the Environment Appl Environ Microbio/1995, 81:3764-3767. Kim S, Yoo HJ, Hahn .IH: Postelectrophoresis Capillary Scanning Method for DNA Sequencing. Anal Chem 1996, 68:936-939. Kim Y, Eom SH, Wang J, Lee D-S, Suh SW, Steitz TA: -. Crystal Structure of Thermus Aquaticus DNA Polymerase. Nature 1995, 376:612-616. [131]. Koonin EV, Musheg~anAR, Rudd KE: Sequencing and Analysis of Bacterial Genomes` Curr BiD/1996, 5:404-416. Korolev S, Nayal M, Barnes WM, De Cere E, Waksman G: • . Crystal Structure of the Large Fragment of Thermus Aquaticus DNA Polymerase I at 2.5/~ Resolution: Structural Basis for Thermostability. Proc Nat/Acad Sci USA 1995, 92:9264-9268. [14~']. Krejinovic M, Richer C, Labuda D, Sinnett D: Detection of a Mutstor Phenotype in Cancer Cells by Inter-alu Polymerase Chain Reaction. Cancer Res 1996, 56:2733-273?. Krekowski K, Bunville J, Said J, Baskln D, Seto D: Rapid Purification of Fluorescent Dye-labeled Products in a 9E-well Format for High-throughput Automated DNA Sequencing. Nucleic Acids Res 1995, 23:4930-4931. Kumeda Y, Asao T: Single-strand Conformation Polymorphism Analysis of PCR-amplified Ribosomal DNA Internal Transcribed Spacers to Differentiate Species of Aspergillus Section Ravi. Appl Environ Microbio11996, 62:2947-2952. Kuo WS, Chak KF: Identification of Novel Cry-type Genes from Bacillus Thuringiensis Strains on the Basis of Restriction Fragment Length Polymorphism of the PCR-amplified DNA. Appl Environ Microbiol 1996, 62:1369-1377, Lai ACK, Chambers TM: Rapid Protucol for Sequencing RNA Virus Using Delta Taq(R) Version 2.0 DNA Polymersse. Biotechniques 1995, 19:704. Lees DN, Henshilwood K, Green J, Gallimom CI, Brown DWG: Detection of Small Round Structured Viruses in Shellfish by Reverse Transcription PCR. Appl Environ Microbiol 1995, 51:4418-4424. Leng XG, Mosier DA, Oberst RD: Simplified Method for Recovery and PCR Detection of Cryptospoddium DNA from Bovine Feces. Appl Environ Microbiol 1996, 62:643-64?. Librizzi MD, Moir R, Brenowitz M, Willis h Expression and += Purification of the RNA Poiymerase I1| Transcription Specificity Factor nlBTo and Its Cooperative Binding with TBR J Biol Chem 1996, in press. [33]. Ling MF, Robinson BH: A One-step Polymerase Chain Reaction Site-directed Mutsgenesis Method for Large Gene-cassettes with High Efficiency, Yield, and Fidelity. Anal Biochem 1995, 230:167-172. Little DP, McLafferty FW: Sequencing 5O-mer DNAs Using Elecfrospray Tandem Mass Spectrometry and Complementary Fragmentation Methods. J Am Chem Soc 1995, 117:6783-6784. Liu DY, Daubendiek SL, Zillman MA, Ryan K, Kool ET: Rolling Circle DNA Synthesis: Small Circular Oligonucleotides as Efficient Templates for DNA Polymerases. J Am Chem Soc 1996, 118:1587-1594. Loewen PC, Switala J: Template Secondary Structure can Increase the Error Frequency of the DNA Polymerase from Thermus Aquaticus. Gene 1995, 164:59-63. Makino SI, Okada Y, Maruyama T: A New Method for Direct Detection of Listada Monocytogenes from

Foods by PCR. Appl Environ Microbiol 1995, 61:3745-3747, Matioli SR, Debrito RA: Obtaining Genetic Markers by Using Double-stringency PCR with Microaatellites and Arbitrary Pdmers` Biotechniques 1995, 19:752, Mauro JM, CaD LK, Kondrecki LM, Walz SE, Campbell JR: Fiber-optic Fluoromatric Sensing of Polymerase Chain Reaction-amplified DNA Using an Immobilized DNA Capture Protein. Anal Biochem 1996, 235:61-72. McKendree WL, Naim CJ, Bausher MG: Differential Display from Plant Leaves Using Oligo(dT) Magnetic Bead MRNA Isolation end Hot Air PCR. Biotechniques 1995, 19:715. Metzker ML, Lu J, Gibbs RA: Electrophoretically Uniform Fluorescent Dyes for Automated DNA Sequencing. Science 1996, 271:1420-1422. Millard D, Decouat HG: Preparation of Glass Plates with Cerium Oxide for DNA Sequencing. Biotechniques 1995, 19:576. Minami M, Poussin K, Brechot C, Patedini P: Novel PCR Technique Using Alu-apecific Primers to Identity U~known Flanking Sequences from the Human Genome. Genomics 1995, 29:403-408. Naeve CW, Buck GA, Niece RL, Pon RT, Robertson M, • Smith/U: Accuracy of Automated DNA Sequencing: a multi-laboratory Comparison of Sequencing Results. Biotechniques 1995, 19:448-453. [441]. Nicoletti A, Sassyprigent C: An Alternative Quantitative Polymerase Chain Reaction Method. Anal Biochem 1996, 236:229-241, Noble D: Forensic PCR - Primed, Amplified, end Ready for Court. Anal Chem 1995, 67:A613-A615. Olson MV: A Time to Sequence. Science 1995, • 270:394-396. [52"P]. Ossewaerde JM, Dewies A, Beatebroer T, Angulo AF: Application of a Mycoplasma Group-specific PCR for Monitoring Decontamination of Mycoplasma-infected Chlamydla Sp Strains. Appl Environ Microbio/1996, 62:328-331. Ozoline ON, Tsyganov MA: Structure of Open Promoter • Complexes with EscheHchia Col/RNA Polymerase as Revealed by the DNase I Footpdnting Technique: Compilation Analysis. Nucleic Acids Res 1995, 22:4533-4541. [38], Parks ME, Baird EE, Dervan PB: Recognition of • . 5"-(A,T)GG(A,T)2-3'SequencesIn the Minor Groove of DNA by Hairpin Polyamides` J Am Chem Soc 1996, 118:6153-6159. [36]. Patten TE, Xia J, Abernathy T, Matyjaszewski K: Polymers • . with Very Low Polydispersittes from Atom Transfer Radical Polymerization. Science 1996, 272:866-868. [241]. Peacock A, Verhoeve P, Rando N. Van Dordrecht A, Taylor • • BG, Erd C, Pemjman MAC, Venn R, Howlatt J, Goldie DJ et el.: Single Optical Photon Detection with a super-conducting Tunnel Junction. Nature 1996, 381 : 135-137. [341]. Perini LT, Doherty F_A,Wemer E, Senear DF: Multiple -. Spadfic CytR Binding Sites at the E. Coil DeoP2 promoter Mediate Both Cooperative and Competitive Interactions Between CytR and CRP. Biochemistry 1996, in press, [29]. Patti V, Hsieh M, Brenowitz M: Thermodynamic and +• Kinetic Characterization of the Binding of the TATA Binding Protein to the Adenovirus 54 Promoter. Biochemistry 1995, 34:9977-9984. [32]. Pohl TM, Maier E: Sequencing 500 Kb of Yeast DNA Using a GATC(R) 1500 Direct Blotting Elecfrophoresis System. Biotechniques 1995, 19:482-486. Powers T, Noller HF: Hydroxyl Radical Footpdnting of • Ribosomal Proteins on 18S RRNA. RNA 1995, 1: 194-209. [63]. Purendare SM, Breidenbach HH, ~ Y, Zhu XL, Sawada S, Nell SM, Brothman A, White R, C~wthon R, Viskochil D: Identification of Neurofibromatosis 1 (NF1) Homologous Loci by Direct Sequencing, Ruomscence in Situ Hybridization, and PCR Amplification of Somatic Cell Hybrids` Genomics 1995, 30:476-485. Radovich P, Bortolin S, Christopoulos TK: Time-resolved Ruorometdc Hybddizstion Assays with RNA Probes Synthesized from Polyrnerase Chain Reaction-generated DNA Templates. Anal Chem 1995, 67:2644-2649. Reddy P, McKenney K: Improved Method for the Production of M13 Phage and Single-stranded DNA for DNA Sequencing. Biotechniques 1996, 20:854. Reeve MA, Fuller CW: A Novel Thermostable Polymerase for DNA Sequencing. Nature 1995, 376:796-797. Reynolds KA, Gerba CP, Pepper IL: Detection of Infectious Enteroviruses by an Integrated Cell Culture PCR Procedure. Appl Environ Microbiol 1996, 62:1424-1427.

Analytical biotechnology Fluorescence resonance energy transfer spectroscopy

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Analytical biotechnology Surface plasmon resonancespectroscopy and infrared spectroscopy, biosensorsand flow-injectionanalysis

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S u r f a c e p l a s m o n r e s o n a n c e s p e c t r o s c o p y and infrared s p e c t r o s c o p y , biosensors and flow-injection analysis

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GaD XP, White HS: Rotating Microdisk Voltammetry. Anal Chem 1995, 67:4057-4064. Gardiol AE, Hernandez RJ, Reinhammar B, Harte BR: Development of a Gas-phase Oxygen Biosensor Using a Blue Copper-containing Oxidase. Enzyme Microb Technol 1996, 18:347-352. Gatto*Menking DL, Yu H. Bruno JG, Goode MT, Miller M, Zulich AW: Sensitive Detection of Biotoxoids and Bacterial Spores Using an Immunomagnetic Electrochemiluminescence Sensor, Biosens Bioe/ectron 1995, 10:501-508. Gilbert BA, Rando RR: Modular Design of Biotinylated Photoaffinity Probes: Synthesis and Utilization of a biotinylated Pepstatin Photoprobe. J Am Chem Soc 1995, 117:8061-8066. Gondo S, Kirn C, Morishita M, Kawakami M: Frequency Response of the Glucose Sensor Based on Immobilized Glucose Oxidase Membrane. App/ Biochem Biotechno11996, 57-8:8?7-884. Goodacre R, Kell DB: Correction of Mass Spectral Drift Using Artificial Neural Networks. Anal Chem 1996, 68:271-280. Goodman MS, Jubian V, Linton B, Hamilton AD: A Combinatorial Library Approach to Artificial Receptor Design. J Am Chem Soc 1995, 117:11610-11611. Goodwin DC, Yamazaki I, Aust SD, Grover TA: Determination of Rate Constants for Rapid Peroxidase Reactions. Anal Biochem 1995, 231:333-338. G6pel W: Introduction: 'Interfacing Biology with Electronics'. Biosens Bioelectron 1995, 9:iii. G?pel W: Controlled Signal TransducUon Across Interfaces of 'intelligent' Molecular Systems. Biosens Bioelectron 1995, 10:35-60. G6pel W, Heiduschka P: Interface Analysis in Biosensor Design. Biosens Bioelectron 1995, 10:853-884. Grate JW, McGill RA: Dewetting Effects on Polymer-coeted Surface Acoustic Wave Vapor Sensors. Anal Chem 1995, 67:4015-4019. Grate JW, Patrash SJ, Abraham MH, Du CM: Selective Vapor Sorption by Polymers and Cavitands on Acoustic Wave Sensors: is This Molecular Recognition? [Letter]. Anal Chem 1996, 68:913-917 Groom CA, Luong JHT, Thafipalmala R: Dual Functionalities of 4-aminodlphenylamine in Enzymatic Assay and Mediated Biosensor Construction. Anal Biochern 1995, 231:393-399. Gross GW, Rhoades BK, Azzazy HME, Wu MC: The use of Neuronal Networks on Multielectrode Arrays as Biosensors. Biosens Bioelectron 1995, 10:553-568. Guilbault GG, Palleschi G, Lubrano G: Non-invasive Biosensors in Clinical Analysis. Biosens Bioelectron 1995, 10:379-392. Guthrie GD, Nichotsonguthrie CS, Shuck CS: Bacterial Assay for Quantitative Measurement of Nanomolar Concentrations of a Metabolite. Anal Biochem 1995, 225:283-285. Hagenhoff B: Surface Mass Spectrometry: Application to Biosensor Characterization. Biosens Bioelectron 1995, 10:685-894. Hale ZM, Payne FP, Marks RS, Lowe CR, Levine MM: The Single Mode Tapered Optical Fibre Loop Immunosensor. Biosens Bioelectron 1996, 11:137-148. Hall DR, Cann JR, Winzor DJ: Demonstration of an Upper Umit to the Range of Association Rate Constants Amenable to Study by Biosensor Technology Based on Surface Plasmon Resonance. Anal Biochem 1996, 235:175-184. Hammerle H, Egert U, Mohr A, Nisch W: Extrecellular Recording in Neuronal Networks with Substrate Integrated Microelectrode Arrays. Biosens Bioelectron 1995, 9:691-696. Haromerle M, Halt EAH, Cade N, Hodgins D: Electrochemical Enzyme Sensor for Formaldehyde Operating in the Gas Phase. Biosens Bioe/ectron 1996, 11:239-246. Hart AL, Turner APF, Hopcroft D: On the use of Screen- and Ink-jet Printing to Produce Amperometric Enzyme Electrodes for Lactate. Biosens Bioelectron 1996, 11:263-270. Hartsock CE. Lewis JK, Leslie I, Pope JA, Tsal LB, Sachdev R, Meng SY: Assessing Post-induction Cellular Response in a Recombinant E-coil Lactose-inducible System by Monitoring Beta-galactosidase Levels. Biotechnol Lett 1995, 17:1025-1030. Hastings JW: Chemistries and Colors of Bioluminescent Reactions: a Review. Gene 1996, 173:5-11. Hatazawa T, Terrill RH, Murray RW: Microelectrode VoRammetry and Electron Transport in an Undiluted Room Temperature Melt of an Oligo(ethylene Glycot)-tailed Viologen. Anal Chern 1996, 68:597-603.

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Analytical biotechnology Surface plasmon resonance spectroscopy and infrared spectroscopy, biosensors and flow-injection analysis

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Analytical biotechnology

S u r f a c e p l a s m o n r e s o n a n c e s p e c t r o s c o p y and infrared s p e c t r o s c o p y , b i o s e n s o r s and f l o w - i n j e c t i o n analysis

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S u r f a c e p l a s m o n r e s o n a n c e s p e c t r o s c o p y and infrared s p e c t r o s c o p y , b i o s e n s o r s and flow-injection analysis

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Genome mapping, hybridization techniques and immobilization Related reviews: Optical mapping approaches to molecular genomics (pp 70-74); RecA-mediated Achilles' heel cleavage (pp 75-81)t Akopian AN, Wood JN: Pedpherel Nervous System-specific Genes Identified by Subtractive CDNA Cloning. J Biol Chem 1995, 270:21264-21270. Albertin G, Rossi GP, Majone F, Tiso N, Matters A, Danieli GA, PessinaAC, Palu G: Rne Mapping of the Human Endothelin-converting Enzyme Gene by Ruoreacent in Situ Hybridization and Rediation Hybdds. Biochem Biophys Res Commun 1996, 221:682-687, Alkorta I, Garbisu C, Llama MJ, Serfs JL: Immobilization of Pectin Lyesefrom Penictlllum Itslicum by Covalent Binding to Nylon. Enzyme Microb Technol 1996, 10:141-146. Alters DL: Critical Issues in Applications of Self-assembled Monelayers.Biosens Bioelectron 1995, 10:771-784. Asselbergs FAM, Widmer R: Use of the Eecherichia Coil Chromosomal DHFR Gone as Selection Marker in Mammalian Cells. J Biotechnol 1995, 43:133-138. Baldocchi RA, Tartaglia KE, Bryda EC, RahertyL: Recovery of Probes Unked to the Jcpk Locus on Mouse Chromosome 10 by the use of an Improved Representstionel Difference Analysis Technique.. Genomics 1996, 33:193-198. Bevedoo HB, LeconiatM, Wljsman J, Lillington DM, Bernard O, Deklein A, Vsnwering E, Welborn J, Young BD; Hagemeijer A, Berger R: Breakpoint Heterogeneity in T(10;11) Transloca6on in AML-M4/M5 Resulting in Fusion of AFrO and MLL is Resolved by Ruorescent in Situ Hybridization Analysis. Cancer Res 1995, 58:4220-4224. Bier FF, ScheUerFW: Label-free Observation of DNA-hybddisation and Endonuclease Activity on a Wave Guide Surface Using a GraUng Coupler. Biosens Bioelectran 1996, 11:669-674. Bloch CA, Rode CK, Obreque VH, Mahillon J: Purification of Eechadchls Coil Chromosomal Segments Without Cloning• Biochem Biophys Res Commun 1996, 223:104-111. Bonnington LS, Henderson W, Petach HH: P(CH2OH)3-polyetheramine-dedved Polymedc Rims for Enzyme Immobilization. Enzyme Microb Techno/1g95, 17:746-750. Borodovsky M, Mclninch ]D, Koonin EV, Rudd KE, Medigue C, Danchin A: Detection of New Genes in a Bacterial Genome Using Markov Models for Three Gone Classes. Nucleic Acids Res 1995, 23:3554-3562. Brayward P, Menninger.I, LiamanJ, Desai 1", MokadyN, Banks A, Ward DC: Integration of the Cytogeneti¢, Genetic, and Physical Maps of the Human Genome by FISH Mapping of CEPH YAC Clones. Genomics 1996, 32:1-14. Brunk CF, Avanissaghajani E, Brunk CA: A Computer Analysis of Primer and Probe Hybridization

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Analytical biotechnology G e n o m e

mapping, hybridization t e c h n i q u e s a n d immobilization

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Analytical biotechnology Genome mapping, hybridization techniques and immobilization

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Analytical biotechnology Chromatography and electrophoresis

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Analytical

Desiderio C, Fanali S: Use of Negatively Charged Sulfobutyl Ether-beta-cyclodextrin for Enantiomeric Separation by Capillary Electrophorasis. J Chmmatogr A 1995, 715:183-196. Dot M: Introduction to Polymer Physics. Oxford: • Clarendon Press; 1996. [42]. Dorsey JG, Cooper ~NT,Siles BA, Foley JP, Berth HG: Uquid Chromatography: Theory and Methodology. Anal Chem 1996, 68:R515-R568. Eiceman GA, Hill HH, Davani B, Gardeatorresday J: Gas Chromatography. Anal Chem 1996, 58:R291-R308, Fanali S: Identification of Chiral Drug Isomers by Capillary Elecfrophorasis. J Chromatogr A 1996, 735:77-121, Favier JP, Bicanic D, VandebovenkampP, Chirtoc M, Helander P: Detection of Total Trans Fatty Acids Content in Margarine: an Intarcompadson Study of GLC,GLC+TLC,FT-IR. and Optothermei Window (open Photoncoustic Ceil). Anal Chem 1996, 58:729-733. Felmlee TA, Ode RP, Parsing DA, Landers JP: Capillary Elecb'ophoresis of DNA. Potential Utility for Clinical Diagnoses. J Chromatogr A 1995, 717:127-137. Fernandez C, Egginger G, Wainer IW, Lloyd DK: Separation of Tastoeterone Metabolites in Microsornel Incubates Using a New Capillary Electrophorasis Assay. J Chromatogr B BJomed Appl 1996, 677:363-368, Rgeys D, Vanoostveen I, Ducret A, Aebersold R: Protein Identtficetton by Capillary Zone Electrophoresis/microeiectrospray Ionizetion-tsndem Mass Spectrometry at the Subferntomole Level. Anal Chem 1996, 68:1822-1828. Rshman HA, Orwar O, Scheller RH, Zare RN: Identification of Receptor Ugands and Receptor Subtypes Using Antagonists in a Capillary Electrophorasls Single-celt Biosensor Separation System. Proc Natl Acad Sci USA 1995, 92:7877-7881. Flaischmsnn RD, Adams MD, White O, Clayton RA, • Kirkness EF, Kerlava9e AR, Bult CJ, Tomb J-F, Dougherty BA, Merrick JM et at,: Whole-genome Random Sequencing and Assembly of Hsemophilus Influenzae rdo Science 1995, 269:496-512. [1]` Foster MD, Synovec RE: Liquid Chromatographic Sensing in Water on s Thin Clad Optical Rber by Mode-filtered Light Detection. Anal Chem 1996, 68:1456-1463, Friedman Y, Higgins EA: A Method for Monitoring the Glycosyletion of Recombinant Glycoprotains from Conditioned Medium, Using Ruorophore-assisted Carbohydrate Electrophoresis. Anal Biochem 1995, 228:221-225. Fung EN, Yeung ES: High-speed DNA Sequencing by • Using Mixed Poly(ethylene Oxide) Solutions in Uncoated Capillary Columns. Anal Chem 1995, 67:1913-1919. [11]. Gasper MP, Bedhod A, Nair UB, Armstrong DW: Comparison and Modeling Study of Vancomyctn, RlstocaUn A, and Teicoplanin for CE Enantioseperetions. Anal Chem 1996, 56:2501-2514. Glatz CE, Ford CF: Genetic Engineering to Enhance the Selectivity of Protein Separations. App/Biochem Biotechnol 1995, 54:173-191. Gondo S, Kim C, Morishita M, Kawakami M: Frequency Response of the Glucose Sensor Based on Immobilized Glucose Oxidase Membrane. Appl Biochem Biotechno/1996, 57-8:877-884. Haab BB, Mathies RA: Single Molecule Ruorascence Burst Detection of DNA Fragments Separated Capillary Bncfrophoresis. Anal Chem 1995, 67:3253-3260. Haupt K, Roy F, Vijayalakshmi MA: Immobilized Metal ton Affinity Capillary Elecfrophoresis of Proteins - a Model for Affinity Capillary Electrophorosis Using Soluble Polymer-suppoded Ugands. Anal Biochem 1996, 234:149-154. Haywsrdlaster A, Oeiner PJ, Doris PA: Rapid QuantiFm.ation of Gene Expression by Compet~ive RT-PCR and ion-pair Reversed-phase HPLC. Biotechnlques 1996, 20:250-257. Heller C: Capillary Elecfrophorasia of Proteins and • Nucleic Acids in Gels and Entangled Polymer Solutions. J Chmmatogr A 1995, 598:19-31. [17]. Hentz NG, Vukasinovic V, Daunert S: Affinity Chromatography of Recombinant Peptides Proteins Based on a calmodulin Fusion Tail. Anal Chem 1996, 68:1550-1555. Herraezhemandez R, C~mpinsfalco P, Sevillanocabeza A: On-line Derivatizetion into Prncotumns for the Determination of Drugs by Liquid Chromatography and Column Switching: Determination of Amphetamines in Udne` Anal Chem 1996, 68:?34-739.

biotechnology

Hsieh FYL, Tong X, Wachs T, Ganem B, Henion J: Kinetic Monitoring of Enzymatic Reactions in Real Time by Quantitative High-performance Liquid Chromatography-mass Specb'ometry. Anal Biochem 1995, 229:20-25. Johnson BF, Oaks FN, Menchen SM: DNA Sequencing in • Uncoated Capillaries Using a New Sieving Medium on the ABI Prism 310 Genetic Analyzer. In Eighth International Genome Sequencing and Analysis Conference: 1996 Oct 5-6; Hilton Head, SC. Hilton Head, SC: TIGR Science Foundation Inc; 1996. [7], Johnson JH, Mclntyre P, Zdunek J: Automated Sample Preparation for Cholesterol Determination in Foods. J Chromatogr A 1995, 718:371-381. Johnson RD, Todd RJ, Arnold FH: MuItipoint Binding in Metei-affinity Chromatography. 2. Effect of PH and Imidazole on Chromatographic Retention of Engineered Histidine-containlng Cytnchromes C. J Chromatogr A 1996, 725:225-235. Kalman A, Thunecke F, Schmidt R, Schiller PW, Horvath C: Isolation and Identification of Peptide Conformers by Reversed-phase High-performance Liquid Chromatography and NMR at Low Temperature. J Chromatogr A 1996, 729:155-171. Katsivela E, Hofle MG: Low-molecular-mess RNA Rngerpdnting of Bacteria by capillary Elecfrophorasis Using Entangled Polymer Solutions. J Chromatogr A 1995, 717:91-103. Kaufman SL, Skogen JW, Dorman FD, Zarrin F, Lewis KC: Mecromolecule Analysis Based on Electrophoretic Mobility in Air: Globular Proteins. Anal Chem 1996, 58:1895-1904. Kempe M: Antibody-Mimicking Polymers as Chiral Stationary Phases in HPLC. Anal Chem 1996, 68:1948-1953. Kerherve P, Charriere B, Gadel F: Determination of Marine Monoseccharidas by High-pH Anion-exchange Chromatography with Pulsed AmperometHc Detection. J Chrornatogr A 1995, 718:283-269, KJeparnik K, Foret F, Barks J, Goetzinger W, Miller • AW, Karger BL: The use of Elevated Column Temperature to Extend DNA Sequencing Read Lengths in Capillary Electrophorasis with Replaceable Polymer Metdces, Electrophoresis 1996, in press. [52]. Koegler WS, Ivory CF: Focusing Proteins in an Electdc Field Gradient. J Chromatogr A 1996, 726:229-236. Koppenhoefer B, Epperlein U, Christlsn B, Ji YB, Chen YY, Lin BC: Separation of Enantiomers of Drugs by Capillary Electrophoresis. 1. Gamma-cyclodexfrin as Chiral Solveting Agenk J Chromatogr A 1995, 717:181-190. Koutny LB, Schmalzing D, Taylor TA, Fuchs M: Microchip Electrophoretic Immunoassay for Serum CodlsoL Anal Chem 1996, 68:18-22. Krock KA, Wilkins CL: Qualitative Analysis of Contaminated Environmental Extracts by Multidimensional Gas Chromatography with Infrared and Mass Spectral Detection (MDGC-IR-MS). J Chromatogr A 1996, 725:167-178. Kuffner CA, Marchi E, Morgado JM, Ruble CR: Capillary Electrophoresis and Daubed: Time for Admission. Anal Chem 1996, 68:A241-A246. Labrou NE, Clonis YD: Biomimetic-dye Affinity Chromatography for the Purification of Mitochondrial L-meiete Dehydrogenese from Bovine Heart. J Biotechno11996, 45:185-194. IJckJider L, Kuhr WG, Lacey MP, Keough T, Pun:Ion MP, Takigiku R: On-Line Microreactors Capillary Electrophorasis Mass Spectrometry for t~a Analysis of Proteins and Paptides. Anal Chem 1995, 67:4170-417?. Liu YM, Sweedler JV: Channel Electrophoresis for Kinetic Assays. Anal Chem 1996, 68:2471-2476. Loidlstahlhofen A. Kaufmann S, Braunsohweig T, Bayed TM: The Thermodynamic Control of Protein Binding to Lipid Bllayers for Protein Chromatography. Nat Biotechnol t996, 14:999- t002. Loun B, Hage DS: Chiral Separation Mechanisms in Protein-based HPLC Columns. 2. Kinetic Studies of (R)-and (S)-wadarin Binding to Immobilised Human Serum/~bOl:hin. Anal Chem 1996, 68:1218-1225. Malavasi B, Locatell; M, Ripamonti M, Ascalone V: Determination of Amisulpride, a New Benzamide Derivative, in Human Plasma end Urine by Uquid-liquid Extraction or Solid-phase Extraction in Combination with High-per/ormance Liquid Chromatography and Ruorescence Detection - Application to Pharmacokinetics. J Chromatogr B Biomed App11996, G71i:107-115. Mammen M, Gomez FA, Whitesides GM: Determinetion of the Binding of Ligands Containing the N-2,4-dini~ophenyl Group to Bivalent Monodonal Rat Anti-DNP Antibody Using Affinity Capillary Electrophoresis. Anal Chem 1995, 67:3526-3535.

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Menchen S, Johnson B, Madabhushi R, Winnik M: The • Design of Separation Media for DNA Sequencing in Capillaries. in Progress in Biomedical Optics: Proceedings of Ultroseosltive Biochemical Diagnostics: 1996 Jan 31-Feb 2: San Jose, CA. Sen Jose, CA: SPlE - the International Society for Optioal Engineering; 1996:294-303. [8]. Menchen S, Johnson B, Winnik MA, Xu B: Rowabta • Networks as Equilibrium DNA Sequencing Media in Capillary Columns. Chem Mater 1996, 8:2205-2208. [54]` Matting HJ, Coenegracht PIVU:Neural Networks in High-performance Liquid Chromatography Optimization: Response Surface Modeling. J Chromatogr A 1996, 728:47-53. Minarik M, Groiss F, Gas B, Bless D, Kermdler E: Dispersion Effects Accompanying Pressurized Zone Mobillsetion in Capillary Isoelecfric Focusing of Proteins. J Chromatogr A 1996, 738:123-128. Mitnik L, Sslome L, Viovy JL, HeUer C: Systematic Study • of Reid and Concentration Effects in capillary Bncfrophorasis of DNA in Polymer Solutions. J Chromatogr A 1995, 710:309-321. [30]Moore AW, Jacobsen SC, Ramsay JM: MIcrochlp Separations of Neutral Species Via Miceilar Electrokinetic Capillary Chromatography. Anal Chem 1995, 67:4184-4189. Moore AW, Jorgenson JW: Rapid Comprehensive Two Dimensional Separations of Peptidas Via RPLC Optically Gated capillary Zone Electrophoresls. Anal Chem 1995, 67:3448-3455. Nakaysma H, Uchida K, Shinkai F, Shinoda T, Okuysma T, Seta K, Isobe T: Capillary Column High-performance Liquid Chromatographic Bectrospray Ionization Triple-stage Qusdrupole Mass Spectrometric Analysis of Proteins Separated by Two-dimensional Polyacrytemide Gel Electrophoresis - Application to Cerabeller Protein Mapping. J Chromatogr A 1996, 730:279-287, Nishi H: Ensntiomer Separation of Drugs by Bectrokinatic Chromatography. J Chromatogr A 1996, 735:57-76. Nishi H, Terabe S: Micaller Bectrokineti¢ Chromatography Perspectives in Drug Analysis. J Chromatogr A 1996, 735:3-27. Ohara T, Shlbukawa A, Nakagawa T: Capillary Etecfrophoresis Frontal Analysis for Microanalysis of Enantioseiective Protein Binding of a Basic Drug. Anal Chem 1995, 67:3520-3525. Okumura 1", Nishikawa Y: Determination of Organophosphorus Pesticides in Environmental Samples by Capillary Gas Chromatography Mass Specb'omatry. J Chromatogr A 1995, 709:319-331. Oravcova J, Bohs B, Undner W: Drug-protein Binding Studies - New Trends in Analytical and Experimental Methodology. J Chromatogr B Biomed App11996, 677:1-28. Patterson DH, Harmon BJ, Regnier FE: Dynamic Modeling of Bectrophoretically Mediated Microanalysls. J Chromatogr A 1996, 732:119-132. Pinto CG, Pavan JLP, Corders BM: Cloud Point Prnconcentratlon and High-performance Uquid Chromatographic Determination of Organophosphorus Pesticides with Dual Electrochemical Detection. Anal Chem 1995, 67:2606-2612. Pirkle WH, Welch CJ: Some Thoughts on the Coupling of Dissimilar Chirei Columns or the Mixing of Chirel Stationary Phases for the Separation of Enantiomers. J Chromatogr A 1996, 731:322-326. Peon GK, Rayneud R, Mistry P, Odell DE, Kelland LR, Harrap KR, Bamard CFJ, Morrer BA: Metabolic Studies of an Orally Active Platinum Anticancer Drug by Liquid Chromatography Electrospray ionization Mass Spectrometry. J Chromatogr A 1995, 712:61-66. Pritchett T, Evangelists RA, Chen FTA: capillary Elecb'ophoresis-based Immunoassays - a Speedy Alternative to Seiid-phase Immunoassays. Biotechnology 1995, 13:1449-1450. Raymond DE, Manz A, Widmer HM: Condnuous Separation of High Molecular Weight Compounds Using a microllter Volume Froe-fiow Becfrophoresis Microstructure` Anal Chem 1996, 68:2515-2522. RizzJ AM, Cladrowarunge S, Jonsson H, asia S: Enantiomeric Resolution of Derivatized DL-emino Acids by High-performance Uquid Chromatography Using a Bats-cyciodextrin Chiral Stationery Phase: a Comparison Between Derivatizetion Labels. J Chromatogr A 1995, 710:287-295, Roobolboza M. Andersson B: Isolation of Hydrophobia Membrane Proteins by Perfusion Chromatography -Purification of Photosystem II Reaction Centers from Spinach Chloroplasts. Anal Biochem 1996, 235:127-t 33.

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Analytical biotechnology Oligonucleotides,antisenseand ribozymes • Peptide librariesand phage display

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Oligonucleotides, antisense and ribozymes Delumleywoodyear 1", Campbell CN, Heller A: Direct Enzyme-amplified Electrical RecogniUon of a 30-bese Model Oligonuclentide. J Am Chem Soc 1996, t 18:5504-5505. Drolet DW, Moonmcdermott L, Romig TS: An Enzyme-linked Oligonucleotide Assay. Nat Biotechno11996, 14:1021-1025. Frank P, Albert S, Cazenave C, Touline JJ: Pudtication and Charectedzat~on of Human Ribonucleese HIL Nucleic Acids Res 1994, 22:5247-5254. Haynes CA, Sherwood CS, Turner RFB: Charactedzetion of an Oligonucleotide-blnding Ruorescent Ligand for Application in Affinity Purification of DsDNA. Biotechnol Bioeng 1995, 48:25-35. Hung WC, Huang JS, Chuang LY: Antisense Oligodeoxynucleotides Targeted Against Different Regions of CyclinD1 MRNA May Exert Different Inhibitory Effects on Cell Growth and Gene E~pression. Biochem BJophysRes Commun 1996, 720 71 rJ-?23.

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