Current world literature

Current world literature

121 Bibliography Current World Literature This bibliography is compiled by biotechnologists from the journals listed at the end of this publication...

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Bibliography Current World Literature

This bibliography is compiled by biotechnologists from the journals listed at the end of this publication. It is based on literature entered into our database between 1st October 1995 and 30th September 1996 (articles are generally added to the database about two and a half months after publication). In addition, the bibliography contains every paper annotated by reviewers; these references were obtained from a variety of bibliographic databases and published between the beginning of the review period and the time of going to press. The bibliography has been grouped into topics that relate to the reviews in this issue.

Current Opinion in Biotechnology



Automation and computer-aided analysis

== Papers considered by the reviewers to be of outstanding interest



The number in square brackets following a selected paper, e.g. [7], refers to its number in the annotated references of the corresponding review.


Sequencing and PCR


Fluorescence resonance energy transfer spectroscopy


with Long-time Molecular Dynamics Calculations in Explicit Water. Proteins 1996, 24:304-313. Brown RS, Lennon JJ: Mass Resolution Improvement by • Incorporation of Pulsed ion Extraction/ionization Unear Time-of-flight Mass Spectrometry. Anal Chem 1995, 67:1998-2003. [18]. Brummel CL, Vickerman JC, Carr SA, Hemling ME, Roberts GD, Johnson W, Weinstock J, Gaitanopoulos D, Bankovic SJ, Winograd N: Evaluation of Mass Spectrometric Methods Applicable to the Direct Analysis of Non-peptide Bead-bound Combinatorial Libredes. Anal Chem 1996, 68:237-242. Budzynski DM, Gao X, Benight AS: Isolation, • • Characterization, and Magnesium-induced Self-assodation Kinetics of Discrete Aggregates of RecA Protein from EscheHchia Coil Biopolymers 1996, 38:47 t -491. [22"~]Bulons D, San Biagio PL: Mesoscopic Gel at Low • • Agarosa Concentration in Water: a Dynamic Ught Scattering Study. Biophys J 1995, 68:1569-1573. [26~]. Burlingame AL, Boyd RK, Gaskell SJ: Mass Spectrometry. • Anal Chem 1996, 68:599R-651R. [41]. Busch NA, Chiew YC, Yarmush ML, Wertheim MS: • Development and Validation of a Simple Antigen-antibody Model. AIChE J 1995, 41:974-984. [24~']. Casset F, Hamelryck 1", Loris R, Brisson JR, TeHierC, Daothi MH, Wyns L, Poortmans F, Perez S, Imberty A: NMR, Molecular Modeling, and Crystallographic Studies of Lentil Lectin-sucrose Interaction. J Biol Chem 1995, 270:25619-25628. Chang XH, Chen RD, Bruce JE, Schwartz BL, Anderson GA, Hofstadler SA, Gale DC, Smith RD, Gao JM, Sigal GB, Mammen M, Whitesides GM: Using Bectrospray Ionization FTICR Mass Spectrometry to Study Competitive Binding of Inhibitors to Carbonic Anhydrase. J Am Chem Soc 1995, 117:8859-8860. Cheng XH, Harms AC, Goudreau PN, TerwilligerTC, Smith RD: Direct Measurement of Oligonuclootide Binding Stoichiomel~'~/of Gene V Protein by Moss Spectrometer. Proc Nat/Acad Sci USA 1996, 93:7022-7027. Cheng XH, Morin PE, Harms AC, Bruce JE, Bendavid Y. Smith RD: Mass Spectrometric Characterization of Sequence-specific Complexes of DNA and Transcription Factor PU.1 DNA Binding Domain. Anal Biochem 1996, 239:35-40.

Related reviews: Mass spectrometry in protein studies from genome to function (pp 6-13); Static and dynamic light scattering of biological macromolecules-what can we learn? (pp 25-30)t Aime S, Ascenzi P, Comoglio E, Fasano M, Paoletti S: Molecular Recognition of R- and T-states of Human Adult Hemoglobin by a Parsmagnetic Gd(lll) Complex by Means of the Measurement of Solvent Water Proton Relaxation Rate. J Am Chem Soc 1995, 117:9365-9366. Andersen JS, Svensson B, Roepstorff P: Bectrospray Ionization and Matrix Assisted Laser Desorption/ionization Mass Spectrometry: Powerful Analytical Tools in Recombinant Protein Chemistry. Nat Biotechnol 1996, 14:449-457. Banks JF, Dresch T: DetecUon of Fast Capillary Eledrophoresis Peptide and Protein Separations Using Bectrospray Ionization with a Time-of-flight Mass Spectrometer. Anal Chem 1996, 68:1480-1485. Bean MF, Annan RS, Hemling ME, Mentzer M, Huddleston • MJ, Cart SA: LC-MS Methods for Selective Detection of Post Translational Modifications in Proteins: Glycosylation, Phosphorylation, Sulfation and Acylation. in Techniquesin Protein Chemistry VI. Edited by Crabbe J. San Diego: Academic Press. 1995:107-116. [59]. Beck HC, Lanritsen FR, Patrick JS, Cooks RG: Metabolism of Helogeneted Compounds in the White Rot Fungus Bjetkandera Adusta Studied by Membrane Inlet Mass Spectrometry and Tandem Mass Spectrometry. Biotechnol Bioeng 1996, 51:23-32. Behm JM, Hemminger JC, Lykke KR: Microscopic Laser Desorption Postionization Fourier Transform Mass Spectrometry. Ana/Chem 1996, 68:713-719. Bemdt KD, Guntert P, Wuthrich K: Conformational Sampling by NMR Solution Structures Calculated with the Program DIANA Evaluated by Comparison



Analyzing protein interactions in vivo


Genome mapping, hybridization techniques and immobilization


Chromatography and electrophoresis


Oligonucleotides, antisense and ribozymes


Peptide libraries and phage display




Molecular imprinting



Analytical biotechnology

Papers considered by the reviewers to be of special interest

Mass spectrometry and NMR analysis


© Current Biology Ltd ISSN 0958-1669

Mass spectrometry and NMR analysis


Surface plasmon resonance spectroscopy and infrared spectroscopy, biosensors and flow-injection analysis

1997, 8 : 1 9 1 - 1 4 4




Chiou AJ, Ong GT, Wang KT, Chiou SH, Wu SH: Conforrnetional Study of Two Linear Hexapeptides by Two-dimensional NMR and Computer-simulated Modeling: Implication for Peptide Cyclization in Solution. Bicchem Biophys Res Cornmun 1996, 219:572-579. Clark K, Dugad LB, Bartsch RG, Cusanovich MA, Lamar GN: An Interpretive Basis of the Proton Nuclear Magnetic Resonance Hyperfine Shifts for Structure Determination of High-spin Ferric Hernoproteins. Implications for the Reversible Thermal Unfolding of Ferricytechrome C" from Rhodopseudomonas Pelustris. J Am Chem Soc 1996, 118:4654-4664. Coen CJ, Blanch HW, Prausnitz JM: Salting-out • , of Aqueous Proteins: Phase Equilibda and Intermolecular Potentials. A/ChE J 1995, 41:996-1004. [23tl Corr JJ, A~aclato JF: Analysis of Inorganic Species by Capillary Electrophoresla Mass Spectrometry and Ion Exchange Chromatography Mass Spectrometry Using an Ion Spray Source. Anal Chem 1996, 68:2155-2163. Davis MT, Stahl DC, Hefta SA, Lee TD: A Mlcroscale Electrospray Interface for On-line, Capillary Liquid Chromatography Tandem Mass Spectrometry of Complex Peptide Mixtures. AnN Chem 1995, 67:4549-4556. Decagny B, Ergan F, Sarazin C, Barbotin JN, Seguin JP: Activity by H-1 Nuclear Magnetic Resonance Spectroscopy: Application to the Study of Water Exchange in Biphasic Media. Anal Biochem 1996, 234:142-148. Dekoster CG, Heerma W, Pepermans HAM, Groenewegen A, Peters H, HaverkampJ: Tandem Mass Spec~ometry and Nuclear Magnetic Resonance Spectroscopy Studies of Candida Bombicola Sophorolipids and Product Formed on Hydrolysis by Cutinase. Anal Biochem 1995, 230:135-148. Dharmasiri K, Smith DL: Mass Spectrometdc Determination of Isotopic Exchange Rates of Amide Hydrogens Located on the Surfaces of Proteins. AnaJ Chem 1998, 68:2340-2344. Dotsch V, W~det G: Exchange Rates of Internal Water Molecules in Proteins Measured Using Pulsed Reid Gradients. J Am Chem Soc 1995, 117:5064-6070. Dybowski C, Bruch MD: Nuclear Magnetic Resonance Spectrometry. Anal Chem 1996, 68:R161 -R168. Eliasson R, Reichard P, Mulliez E, Ollagnier S, Fontecave M, LJepinsh E, Offing G: The Mechanism of


Analytical biotechnology Mass spectrometry and NMR analysis

the Anaerobic Eschericha Coil Ribonucteotide Reductese Investigated with Nuclear Magnetic Resonance Spectroscopy. Biochem Biophys Res Commun 1995, 214:28-35. Evans UA, Cooper A, Lakey JH: Direct Measurement of the Association of a Protein with a Family of Membrane Receptors. J Me/Biol 1996, 255:559-563. Fan F, Mayo KH: Effect of PH on the Conformation and Backbone Dynamics of a 27-residue Peptide in Trifluoroethanol - an NMR and CD Study. J BiG/ Chem 1995, 270:24693-24701. Figeys D, Vanoostveen I, Ducret A, Aebersold R: Protein Identification by Capillary Zone Bectrophorosis/microelectrospray Ionizstion-tandem Mass Spectrometry at the Subfemtomole Level. Anal Chem 1996, 58:1822-1828. Rshman DM, Patterson GD: Light Scattering Studies of • . Supercoiled and Nicked DNA. Biopo/ymers 1996, 38:535-552. [15~;]. Fitzgerald MC, Chernushevich I, Standing KG, Whitman CP, Kent SBH: Probing the Oligomeric Structure of an Enzyme by Electrospray Ionization Time-of-flight Mass Spectrometry. Proc Nat/Acad Sci USA 1996, 93:6851-6856. Frassineti C, Ghelli S, Cans P, Sabatini A, Moruzzi MS, Vacca A: Nuclear Magnetic Resonance as a Tool for Determining Protonation Constants of Natural Polyprotic Bases in Solution. Anal Biochem 1995, 231:374-382. Fregeau NL, Wang YQ, Pen RT, Wylie WA, Lown JW: Charactedzation of a CPHexitropsin Conjugate OIIgonucleotide Covalent Complex by H-1 NMR and Restrained Molecular Dynamics Simulation. J Am Chem Soc 1995, 117:8917-8925. Friedrichs MS, Stouch TR, Bruccoleri RE, Mueller L, Constantine KL: Structural and Dynamic Properties of a Beta-hairpin-forming Uneer Peptide. 2. C-13 NMR Relaxation Analysis. J Am Chem Soc 1995, 117:10855-10864. Gehri9 PM, Krzyzaniak A, Barciszewsk; J, Biemann K: Mass Spectrometdc Amino Acid Sequencing of a Mixture of Seed Storage Proteins (napin) from Brassica Napus, Products of a multigene Family. Proc Nat/ Acad Sci USA 1996, 93:3647-3652. Ghosh S, Reed WF: New Characteristic Signatures from =- Time-dependent Static Ught Scattering Dudn9 Polymer Depolymefizstion, with Application to Proteoglycan Subunit Degradation. Biopolymers 1995, 35:435-450, [33t]. Girault S, Chassaing G, Blais JC, Brunet A, Bolbach G: Coupling of MALDi-TOF Mess Analysis to the Separation of Biotinylsted Peptidea by Magnetic Streptavidin Beads. Anal Chem 1996, 60:2122-2126. Goshe MB, Anderson VE: Determination of Amino Acid Isotope Ratios by Bectrospmy Ionization Mass Spectrometry. Anal Biochem 1995, 231:38"7-392. Green BN, Suzuki 1", Gotoh T, Kuchumov AR, Vinogradov SN: Bectrosproy Ionization Mass Spectrometdc Determination of the Complete Polypeptide Chain Composition of "rylorrhynchos Heterochaetos Hemoglobin. J Biol Chem 1995, 270:18209-18211+ Guy P, Remigy H, Jaquinod M, Bersch B, Blanchard L, Della A, Forest E: Study of the New Stability Properties Induced by Amino Acid Replacement of Tyrosine 64 in Cytochromo C(553) from Desulfovibrio Vulgaris Hildenborough Using Etactrospray Ionization Mass Spectrometry. Biochem Biophys Res Commun 1996, 218:97-103. Hagenhoff B: Surface Mass Spectrometry: Application to Biosensor Charactedzation. Biosens Bioelectron 1995, 10:885-894. Hoogstraten CO, Markley JL: Effects of Expedrnentally Achievable Improvements in the Quality of NMR Distance Constraints on the Accuracy of Calculated Protein Structures. J Mol Biol 1996, 258:334-348. Jarvie TR Went GT, Mueller KT: Simultaneous Multiple Distance Measurements in Peptides Via Solid-state NMR. JAm Chem Soc 1996, 118:5330-5331. Jansen O, Poteletejnikov A, Mann M: Delayed Extraction • Improves Specificity in Database Searches by MALDI Peptide Maps. Rapid Commun Mass Spectrom 1996, 10:1371-1378. [20]. Juge N, Andersen JS, Tuff D, Roepstorff P, Svensson B: • Overexpression, Purification and Characterization of Recombinant Bsdey c(-amylases 1 and 2 Secreted by the Methylotrophic Yeast Picas Pastoris. Protein Expr Puff/1996, 8:204-214. [57]. Jurinke C, Vandenboom D, Jacob A, Tang K, Wed R, Koster H: Analysis of Ligase Chain Reaction Products Via Matrix-assisted Laser Desorption/ionization Time-of-flight-mass Spectrometry. Anal Biochem 1996, 237:174-181. Kalman A, Thunecke F, Schmidt R, Schiller PW, Horvath C: Isolation and Identification of Peptide Conformers

by Reversed-phase High-performance Liquid Chromatography and NMR at Low Temperature. J Chromatogr A 1996, 729:155-171. Kaufmann R: Mstdx-assisted Laser Desorption Ionization (MALDI) Mass Spectrometry: a Novel Analytical Tool in Molecular Biology and Biotechnology. J Biotechno11995,41:155-175. Kelly JA, Feigon J, Yeates TO: Reconciliation of the X-ray and NMR Structures of the Thrombin-binding Aptamer D(GGTTGGTGTGGTTGG).J Mol Biol 1996, 256:417-422. Klatt R Pfeiffer S. List BM, Lehner D. Clatter O, Bachinger • HP, Werner ER, Schmidt K, Mayer B: Characterization of Home-deficient Neuronal Nitric-oxide Synthase Reveals a Role for Home in Subunit Dimerizstion and Binding of the Amino Acid Substrate and Tetrahydrobiopterin. J Biol Chem 1996, 271:7336-7342, [5t]. Kofman V, Fewer O, Pecht I, Goldfarb D: Two-dimensional Pulsed EPR Spectroscopy of the Copper Protein Azudn. JAm Chem Soc 1996, 118:1201-1206. K~rner R, Wilm M, Monrad K, Schubert M, Mann M: • Combining Nano Etactrosprsy with Quadrupole Ion Trap for the Analysis of Peptides and Proteins. J Am Soc Mass Spectrom 1996, 7:150-156. [39]. Kriwacki RW, Wu J, Siuzdak G, Wright PE: Probing Protain/protein Interactions with Mass Spectrometry and Isotopic Labeling: Analysis of the P21/Cdk2 Complex. J Am Chem Sac 1996, 118:5320-5321. Krock KA, Wilkins CL: Qualitative Analysis of Contaminated Environmental Extracts by Multidimensional Gas Chromatography with Infrared and Mass Spectral Detection (MDGC-IR-MS). J ChromatogrA 1996, 726:167-178. Kuwata K, Ueki S, Era S, Sogaml M, Watari H: Spin-lattice Relaxation Times of Water in Polarized and Depolarized Rabbit Vagus Nerves. Biechem Biophys Res Commun 1995, 215:459-466. Lafitte D, Capony JP, Grassy G, Haiech J, Calas B: Analysis of the Ion Binding Sites of Ceimodutin by Electrospray Ionization Mass Spectrometry. Biochemistry 1995, 34:13825-13832, Lee MS, Cao BL: Nuclear Magnetic Resonance Chemical Shift: Comparison of Estimated Secondary Structures in Peptides by Nuclear Magnetic Resonance and Circular Dichroism. Protein Eng 1996, 9:15-25. Li/U, Daggett V: Investigation of the Solution Structure of Chymotrypsin Inhibitor 2 Using Molecular Dynamics: Compadson to X-my Crystallographic and NMR Data. Protein Eng 1995, 8:1117-1128. Li X, Galanekis D, Gabdel DA: Transient intermediates in • the Thrombin Activation of Fibrinogen. J Biol Chem 1996, 271:11767-11771. [39~']. Li YZ, Little DP, Koster H, Hunter RL, Mclver RT: High-resolution MALDI Fourier Transform Mass Spectrometry of Oligonucleotides. Anal Chem 1996, 68:2090-2096. Licklider L, Kuhr WG, Lacey MP, Keough T, Purdon MP, Taklgiku R: On-Une Microreectors Capillary Bectrophoresis Mass Spectrometry for the Analysis of Proteins and Peptides. Anal Chem 1995, 67:4170-4177+ Little DP, McLafferty FW: Sequencing 50-mar DNAs Using Bectrospray Tandem Mass Spectrometw and Complementary Fragmentation Methods. J Am Chem Soc 1995, 117:6783-6784. Liu YH, Bai J, Liang XO, Lubman DM, Venta PJ: Use of a Nitrocellulose Film Substrata in Matrix-assisted Laser Desorption/ionization Mass Spectrometry for DNA Mapping and Screening. Anal Chem 1995, 67:3482-3490. Lohmeiervogel EM, Mclntyre DD, Vogel HJ: Phosphorus-31 and Carbon-13 Nuclear Magnetic Resonance Studies of Glucose and Xylose Metabolism in Cell Suspensions and Agarose-immobilized Cultures of Pichia Stipitis and Saccharomyces Cerevisiae. Appl Environ Microbiol 1996, 62:2832-2838. Leo JA: Observation of Large Subunit Protein Complexes by Electrospray Ionization Mass Spectrometry. J Mass Spectrom 1995, 30:180-183. [92]. Lopezbeltran EA, Mate MJ, Cerdan S: Dynamics and Environment of Mitochondrial Water as Detected by H-1 NMR. J Biol Chem 1996, 271:10648-10653. Lutz NW. Yahi N, Fantini J, Cozzone PJ: New Method for the Determination of Specific C-13 Enrichment in Phosphorylated [1-C-13]glucoea Metabolitea C-13-coupled, H-1 -decouptad P-31-NMR Spectroscopy of Tissue Perchloric Acid Extracts. Eur J Biochem 1996, 238:470-475. Lyles DS, McKenzie Me, H~tgan RR: Stopped+flow, -, Classical, and Dynamic Light Scattering Analysis of Matrix Protein Binding to Nucleocapsids of Vesicular Stomatitis Virus. Biochemistry 1996, 35:6508-6518. [31f].

Lynch NJ, Kitpatrick PK, Carbonell RG: Aggregation of • Ligsnd-modified Liposomes by Specific interactions with Proteins. I. Biotinylsted Uposomes and Avidin. Biotechnol Bioeng 1996, 50:151-168. [341"]. Lynch NJ, FJIpatdck PK, Carbonell RG: Aggregation of • Ligand-modified Uposomes by Specific interactions with Proteins. II. Biotinylated Lipsomes and Antibiotin Antibody. Biotechnol Bioeng 1996, 50:169-183. [35~]. Ma C, Sun L, Bloomfield VA: Condensation of Plasmids • Enhanced by Z-DNA Conformation of D(CG)n Inserts. Biochemistr/1995, 34:3521-3528. [14t]. Mander~lle RA, Ellena JF, Hecht SM: Interaction of Zn(il).Bleomycin with D(CGCTAGCG)2. A binding Model Based on NMR Experiments and Restrained Molecular Dynamics Calculations. J Am Chem Soc 1995, 117:7891-7903, Mann M, Talbo G: Developments in Mstrix-assisted Laser • Desorption/ionizstion Mass Spectrometry. Curt Opin Biotechnol 1996, 7:11-19. [15]. Mattiello DL, Warren WS, Mueller L, Farmer BT: Minimizing the Wafer Resonance in Biological NMR: Charsctedzation and Suppression of Intermoleculer Dipolar Interactions by Multiple-axis Gradients. J Am Chem Soc 1996, 118:3253-3261. McGuire JM, Lynch CC: Characterization of Nonmicrobiological Paper Mill Deposits by Simultaneous TG-IR-MS. Anal Chem 1996, 80:2459-2463+ Met G, Hietter H, Lefevre JF: Stabilization of Proteins by Glycosylation Examined by NMR Analysis of a Fucosylated Proteinese Inhibitor. Nature 1996, 3:45-53. Mirza UA, Chait BT, Lander HM: Monitoring Reactions of Nitric Oxide with Peptides and Proteins by Electrospray Ionizstion-mass Spectrometry. J Biol Chem 1995, 270:17185-17188. Mortz E, Seraneva T, Haebel S, Julkunen I, Roepstorff • P: Mass Spectrometric Characterization of Glycosyleted Interferon-y Variants Separated by Gel Electrophoresis. Electrophoresis 1996, 17:1493-1502. [64]. Morris HR, PaxtonT, Dell A, Langhorne J, Berg • M, Bordoll RS, Hoyes J, Batemann RH: High Sensitivity Collisionally-activsted Decomposition Tandem Mass Spectrometry on a novel Ouadrupole/orihogonal-acceierstion Time-of-flight Mass Spectrometer. Rapid Commun Mass Spectrom 1996, 10:889-896, [40]. Moser MJ, Lee SY, Klevit RE, Davis TN: Ca2+ Binding to Ceimodulin and Its Role in Schizossccharomyces Pombe as Revealed by Mutaganasis and NMR Spectroscopy. J BiG/Chem f 995, 270:20643-20652. Mueller L, Legault P, Pardi A: Improved RNA Structure Determination by Detection of NeE Contacts to Exchange-broadened Amino Protons. J Am Chem Soc 1995, 117:11043-11048. Nakayama H, Uchida K, Shinkai F, Shinoda 1", Okuyama T, Seta K, Isobe T: Capillary Column High-performance Liquid Chromatographic Electrospray Ionization Triple-stage Quadrupole Mass Spectrometric Analysis of Proteins Separated by Two-dimensional Polyecrylamide Gel Electrophoresis - Application to Cerebeiler Protein Mapping. J ChromatogrA 1996, 730:279-287. Nelson RW, Krone JR, Bieber AL, Williams P: Mass • e Spectrometric Immunoassay. Anal Chem 1995, 34:1153-1158. [89]. Nestle NFEI, Kimmich R: NMR imaging of Heavy Metal Absorption in Alginete, Immobilized Calls, and Kombu Algal Biosorbents. Biotechnel Bioeng 1996, 51:538-543. Ni JS, Pomerantz SC, Rozenski J, Zhang YH, McCIoskey JA: Interpretation of Oligonuctaottde Mass Spectre for Determination of Sequence Using Electrospray Ionization and Tandem Mass Spectrometry. Anal Chem 1996, 68:1989-1999, Nielsen NC, Thogersen H, Sorensen OW: Doubling the Sensitivity of INADEQUATE for Tracing Out the Carbon Skeleton of Molecules by NMR. J Am Chem Soc 1995, 117:11365-11366. Nietlispach D, Clowes RT, Broadhurst RW, Ire Y, Kealer J, Kelly M, Ashurst J, Oschkinat H, Domaifle PJ, Laue ED: An Approach to the Structure Determination of Larger Proteins Using Triple Resonance NMR Experiments in Conjunction with Random Fractional Deuteration. J Am Chem Soc 1996, 118:407-415. Noy A, Frisbie CD, Rozsnyai LF, Wrighton MS, Lieber CM: Chemical Force Microscopy: Exploiting Chemically-modified Tips to Quantify Adhesion, Friction. and Functional Group Distributions in Molecular Assemblies, J Am Chem Soc 1995, 117:7943-7951. O'Connor PB, McLaflerty FW: Oligomer Charactedzation of 4-23 KDa Polymers by Electrospray Fourier

Analytical biotechnology Automation and computer-aided analysis

Transform Mass Spectrometry. J Am Chem Sac t 995, 117:12826-12831, Okumura T, Nishikawa Y: Determination Of Organophosphorus Pesticides in Environmental Samples by Capillary Gas Chromatography Mass Spectrometry. J ChromatogrA 1995, 709:319-331, Orban J, Alexander P, Bryan P, Khare D: Assessment of Stability Differences in the Protein G B1 and B2 Domains from Hydrogen-deuterium Exchange: Comparison with Calorimetric Data. Biochemistry 1995, 34:15291-15300. Peek SH, Kim JH: Generation of Calorimetric. Dual Signals from Two Different Enzymes by Using Catalytic PH Shift. Biotechnol Bioeng 1996, 51:591-596. Park JT, Railings JE: Effects of Substrata Branching • Charectedstics on Kinetics of Enzymatic Depolymerizetion of Mixed Linear and Branched Polyseccherides. II. Amylase/glycogen c~-amylolysis. Biotechnol Bioeng 1995, 46:36-42. [37";']. Patterson DH, Tart GE, Regnier FE, Martin SA: C-terminal • Ladder Sequencing Via Metrix-assisfed Laser Desorption/ionization Mass Spectrometry Coupled with Cerboxypeptidese Y Time-dependent and Concentration-dependent Digestions, Anal Chem 1995, 67:3971-3978. [25]. Pearson JG, Wang JF, Merkley JL, Le HB, Oldfield E: Protein Structure Refinement Using Carbon-13 Nuclear Magnetic Resonance Spectroscopic Chemical Shifts and Quantum Chemistry, J Am Chem Sac 1995, 117:8823-8829. Perrin CL, Fabian MA: Multicomponent NMR Titration for Simultaneous Measurement of Relative PK(a)s..Anal Chem 1996, 68:2127-2134. Poon GK, Raynaud R, Mistry P, Odell DE, Ketland LR, Harrap KR, Bamard CFJ, Murrer BA: Metabolic Studies of an Orally Active Platinum Ant°cancer Drug by Uquid Chromatography Electrospray Ionization Mass Spectrometry. J ChromatogrA 1995, 712:61-66. Pot°or N, Bert P, Trisch D, Biellmann J-F, Van Doersselaer • • A: Study of Non-covalent Enzyme-inhibitor Complexes of AIdose Reductase by Electrospray Mass Spectrometry. Eur J Biochem t 996, in press. [93]. Price WD, Schnier PD, Williams ER: Tandem Mass Spectrometry of Large Biomolecule Ions by Blackbody Infrared Radiative Dissociation. Anal Chem 1996, 68:859-866. Qin J, Chait BT: Matrix-assisted Laser Desorption Ion Trap Mass Spectrometry: Efficient Isolation and Effective Fragmentation of Pep°ida Ions. Anal Chem 1996, 88:2108-2112. Qin J, S.teenvoorden PJJM, Chait BT: A Practical Ion Trap Mass Spectrometer for the Analysis of Peptides by Matrix Assisted Laser Desorption-ionization. Anal Che/n 1996, 68:1784-1791. Rae TD, Gaff HM: Lactoparoxidase Homo Structure Characterized by Paremegnetic Proton NMR Spectroscopy. J Am Chem Sac 1996, 118:2103-2f 04. Ran H, Szpylka J, Anderson LB: Electrochemical Modulation of the Sample Stream in Mass Spectrometry. Anal Chem 1996, 68:243-249. Rider MH, Puype M, VandammeJ, Gevaert K, Deboeck S, Dslayer J, Rasmussen HH, Celis JE, Vandekerckhove J: An Agerose-based Gel-concentration System for Mierosequenco and Mass Spectrometric Characterization of Proteins Previously Purified in Polyscrylamide Gels Starting at Low Picomole Levels. Eur J Biochem 1995, 230:258-265. Robinson CV, Chung EW, Kragelund BB, Knudsen J, ApSin ** RT, Poulsen FM, Dobson CM: Probing the Nature of Non-covalent Interactions by Mass Spectrometry. A Study of Protoin-CoA Ugand Binding and Assembly. J Am Chem Sac 1gg6. 118:8646-8653. [95]. Roskey MT, Juhasz P, Smimov IP, Takach EJ, Martin SA, Haft LA: DNA Sequencing by Delayed Extraction Metrix-essisted Laser Desorption/ionizetion Time of Right Mass Spectrometry. Proc Natl Acad Scl USA 1996, 93:4724-4729. Sarkar SK, Garigipati RS, Adams JL, Keifer PA: An NMR Method to Identify Nondestructively Chemical Compounds Bound to a Single Solid-phase-synthesis Bead for Combinatorial Chemistry Applications. J Am Chem Sac 1996, 118:2305-2306. Schmeer K, Behnke B, Bayer E: Capillary Electrochromatography Bectrospmy Mass Spectrometry: a Micmer.lllysis Technique. Anal Chem t 995, 67:3666-3658. Schoberth SM, Chapman BE, Kuchel PW, Wittg RM, Grotendorst J, Jansen P, Degraaf AA: Ethanol Transport in Zymomonas Mobilis Measured by Using in viva Nuclear Magnetic Resonance Spin Transfer? J Bacterial 1996, 178:1756-1761.

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Analytical biotechnology Calorimetry • Sequencing and PCR

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Calorimetry Related review: Characterization of binding interactions by isothermal titration calorimetry (pp 31-35) Baker BM, Murphy KP: Evaluation of Unked Protonation • Effects in Protein Binding Reactions Using Isothermal Titration calorimetry. Biophye J 1996, 71:2049-2055. [50]. Bhetnagar RS, Gordon Jl: Thermodynamic Studies of • Myfistoyl-CoA-proteln N-myristoyfttansferase Using Isothermal Titration Calorimetry. Methods Enzymo/ 1995, 250:467-486. [41]. Doyle ML, Hensley P: Experimental Dissection of • Protein-protein Interactions in Solution, Adv Mol Cell Bio11997, 21 :in press. [48]. Evans UA, Cooper A, Lekey JH: Direct Measurement • of the Association of e Protein with a Family of Membrane Receptors. J Mol Biol 1996, 255:559-563. [11]. Fisher HI=,Singh N: Cbiodmetric Methods for Interpreting • Protein-ligend Interactions. Methods Enzymol 1995, 259:194-22t. [38]. Fradette S, Rho D, Samson R, Leduy A: Microcalorimetry as a Diagnostic end Analytical Tool for the Assessment of Biodogrsdation of 2,4-D in a Liquid Medium and in Soil (vol 42, Pg 432, 1995). Appl Microbiol Biotechnol 1995, 43:387. Garcia-Fuentes L, Reche P, Lopez-Mayorga O, Senti DV, • Gonzalez-PacanowskaD, Baron C: Thermodynamic Analysis of the Binding of 5-fluoro-2'-deoxyuridine 5"-monophosphate to Thymidylate Synthetase Over • Range of Temperatures. Eur J Biochem 1995, 232:641-645. [34]. Gill DS, Roueh DJ, Shick KA, Willson RC: Mlcrocalodmetrlc Characterization of the Anion-exchange Adsorption of Recombinant Cytechrome B(5) and Its Surfece-cherge Mutants. J ChromatogrA 1995. 715:81-93. Gomez J, Freire E: Thermodynamic Mapping of • * the Inhibitor Site of the Aspartic Protease Endothlapepsin. J Mol B/o/1995, 252:337-350. [6]. Kamiys M, Torigoe H, Shindo H, Sarai A: Temperature Dependence and Sequence Specificity of DNA Triplex Formation: an Analysis Using Isothermal Titration Calorimetry. J Am Chem Soc 1996, 118:4532-4538. Lin Z, Schwarz FP, Eisenstein E: The Hydrophobic Nature • of GroEL-substrete Binding. J Biol Chem 1995, 270:1011-1014. [27]. Liu Y, Sturtevant JM: Significant Discrepancies Between • Van't Hoff and Calodmatric Enthalpies II. Protein Sci 1995, 4:2559-2561. [47]. Lohman TM, Overman LB, Ferrari ME, Kozlov AG: A Highly • • Salt-deqendent Enthalpy Change for Escherichie Cola SSB Protein-nucleic Acid Binding Due to Ion-protein Interactions. Biochemistry 1996, 35:5272-5279. [22]. Luque I, Mayorga OL, Freire E: Structuro-based • • Thermodynamic Scale of Alpha-helix Propensities in Amino Acids. Biochemistry 1996, 35:13681-13688. [52]. Marzabadi MR, Gruys KJ, Pansegrau PD, Walker MC, • YuenHK, Sikorski JA: An EPSP Synthetase Inhibitor Joining Shikimate 3-phosphata with Glyphosate: Synthesis and Ugand Binding Studies. Biochemistry 1996, 35:4199-4210. [37]. Merabet E, Ackers GK: Calorimetric Analysis of Lambda • el Represser Binding to DNA Operator Sites. Biochemistry 1995, 34:8554-8563. [25]. Murphy KP, Freire E, Paterson Y: Conflgurationel Effects • in Antibody-antigen Interactions Studied by Microcelorimetry. Proteins 1995, 21:83-90. [1]. Ohyama 1", Cowan JA: Calorimetric Studies of Metal • Binding to Tetracycline. Role of Solvent Structure in Defining the Selectivity of Metal Ion-drug Interactions./norg Chem 1995, 34:3083-3086. [53].

Orban J, Alexander R Bryan P, Khare D: Assessment of Stability Differences in the Protein G B1 and B2 Domains from Hydrogen-deuterium Exchange: Compadson with Calorimetric Data. Biochemistry 1995, 34:15291-15300. Pearce KH, Ulisch MH, Kelley RF, De Vos AM, Wells JA: • Structural and Mutational Analysis of Affinity-inert Contact Residues at the Growth Hormone-receptor Interface. Biochemistry 1996, 35:10300-10307. [15]. Plum GR, Breslauer KJ: Calorimetry of Proteins • and Nucleic Acids. Curr Opin Struct Biol 1995, 5:682-690. [21]. Privalov G, Kavina V, Freire E, Privalov PL: Precise Scanning Calorimeter for Studying Thermal Properties of Biological Macromolecules in Dilute Solution. Anal Biochem 1995, 232:79-85. Raman CS, Allen MJ, Nail ST: Enthalpy of * Antibody-cytochrome c Binding. Biochemistry 1995, 34:5831-5838. [4]. Reedstrom RJ, Royer CA: Evidence for Coupling of • Folding and Function in trp Represser: Physical Characterization of the Superropressor Mutant AV77. J Mol Biol 1995, 253:266-276. [24]. Schwarz FP, Tello D, Goldbaum FA, Mariuzza RA. Poljak *, RJ: Thermodynamics of Antigen-antibody Binding Using Specific Anti-lysozyme Antibodies. Eur J Biochem 1995, 228:388-394. [2]. Torlgoe H, NakayamaT, Imszato M, Shimada I. Arata Y, Sarai A: The Affinity Maturation of Anti-4-hydroxy-3-nifrophenylacetyl Mouse Monoclonal Antibody - a calorimetric Study of the Antigen-antibody Interaction. J Bio/Chem 1995, 270:22218-22222. Wu J, Li J, Li G, Long DG, Weiss RM: The Receptor • Binding Site for the Mathyffransferese of Bacterial Chemotaxis is Distinct from the Sites of Methylation. Biochemistry 1996, 35:4984-4993. [30]. Xu Y, Johnson CR, Beckett D: Thermodynamic Analysis • of Small Ligand Binding to the Escherichia Cola Represser of Biotin Synthesis. Biochemistry 1996, 35:5509-5517. [35].

Sequencing and PCR Related reviews: Quantitative nucleic a c i d s f o o t p r i n t i n g - t h e r m o d y n a m i c a n d kinetic a p p r o a c h e s (pp 3 6 - 4 4 ) ; H i g h - s p e e d D N A s e q u e n c i n g in ultrathin slab gels (pp 107-113)-~ Alvarez AJ, Buttner MP, Stetzenbach LD: PCR for Bioeerosol Monitoring: Sensitivity and Environmental Interference. Appl Environ Microbiol 1995, 61:3639-3644. Anazawa T, Takahashi S, Kambara H: A Capillary Array Gel Bectrophoresis System Using Multiple Laser Focusing for DNA Sequencing. Anal Chem 1996, 68:2699-2704. Andersson B, Lu J, Edwards KE, Muzny DM, Gibbs RA: Method for 9S-well M13 DNA Template Preparations for Large-scale Sequencing. Biotechniques 1996, 20:1022-1027 Ansarilari MA, Jones SN. Timms KM, Gibbs RA: Improved Ligation-anchored PCR Strategy for:Identification of 5" Ends of Transcripts. Biotechniqu~s 1996, 21:34, Arias CR, Garay E, Aznar R: Nested PCR~Mathod for Rapid and Sensitive Detection of Vibdo Vulelficus in Fish, Sediments. and Water. App/Eriviron Microbiol 1995, 61:3476-3478. Atrnar RL, Neill FH, Woodley CM, Manger R, Fout GS, Burkhardt W, Leja L, McGovern ER, Leguyader F, Metcaff TG, Estes MK: Collaborative Evaluation of a Method for the Detection of Norwalk Virus in Shellfish Tissues by PCR. Appl Environ Microbiol 1996, 62:254-258. Balavoine G: Identification of Members of Several Homeobox Genes in a Planerian Using a Ligation-mediated~Polymerase Chain Reaction Technique. Nucleic Acids Roe 1996, 24:1547-1553. Banff S, Borsani G, Roesi E, Bernard L, Guffanti A. • , Rubboli F, Marchitiello A. Giglio S, Coluccia E, Zollo Met aL: Identification and Mapping of Human CDNAs Homologous to Drosophila mutant Genes Through EST Database Seamhing. Nat Ganet 1996, 13:167-174. [56,~]. Bassler HA. Rood SJA. Livak KJ, Marrnaro J, Knorr R, Bat1 CA: Use of a Fiuorogenic Probe in a PCR-based Assay for the Detection of Listeria Monocytogenes. App/ Environ Microblol 1995, 61:3724-3728. Backer A. Reith A. Napiwotzki J, Kadenbach B: A Quantitative Method of Determining Initial Amounts of DNA by Polymerese Chain Reaction Cycle Titration Using Digital Imaging and a Novel DNA Stain. Anal Biochem 1996, 237;204-207.


Beg OU: Use of Polylysine in Solid Phase Protein Sequencing. Biotechniquee 1995, 19:876. Bentzley CM, Johnston MV, Larsen BS, Gutteridge S: Oligonucleotide Sequence and Composition Determined by Metdx-assieted Laser Desorption Ionization. Anal Chem 1996, 68:2141-2146. Beraswill S, Bugert P, Brochmuller I, Geider K: Identification of the fire Blight Pathogen, Erwinla Amylovora, by PCR Assays with Chromosomal DNA. Appl Environ Microbiol 1995, 61:2636-2642. Berndt C, Bebenroth M, Oehlschlegel K, Hiepe F, Schossler W: Quantitative Polymerese Chain Reaction Using a DNA Hybddization Assay Based on Surface-activated Mlctoplates. Anal Biochem 1995, 225:252-257. Betz C, Papadopoulos T, Buchwald J, Dammdch J, Mullerhermelink HK: Surfactant Protein Gene Expression in Metastatic and Micrometastatic Pulmonary AdenocarcJnornas and Other Non-small Cell Lung Carcinomas: Detection by Reverse Transcdptase-polymerase Chain Reaction. Cancer Res 1995, 55:4283-4286. Bokal AJ IV, Rose W, Gourse RL: The Trenecdptionel • Activator Protein FIS: DNA Interactions and Cooperative Interactions with RNA Polymerese a the Escherichie ColaRmB P1 Promoter. J Mol B/o/ 1995, 245:197-207. [28l Bonfield JK, Staden R: The Application of Numerical Estimates of Base Calling Accuracy to DNA Sequencing Projects. Nucleic Acids Ras 1995, 23:1406-1410. Bordello F, Lederer J: Construction of Quantitative RT-PCR MIMICs. Biotechniquas 1995, 19:580. Bortolin S, Christopoulos TK, Verhaegan M: Quantitative Polymerese Chain Reaction Using a Recombinant DNA Internal Standard and Time Resolved Ruorometry. Anal Chem 1996, 88:834-840. Briglia M, Eggen RIL Devos WM, Vanelsas JD: Rapid and Sensitive Method for the Detection of Mycobacterium Chlorophenolicum PCP-I in Soil Based on 1ES RRNA Gene-targated PCR. Appl Environ Microbiol 1996, 62:1478-1480. Brossart P, Schmier JW, Kruger S, Wil~hsuck M, Scheibenbogen C, Mohler 1", Keilholz U: A Polymerese Chain Reaction-based Semiquantitative Assessment of Malignant Melanoma Cells in Peripheral Blood. Cancer Ras 1995, 55:4065-4068. Bult CJ, White O, Olsen GJ, Zhou L, Reischmann RD, • • Sutton GG, Blake JA. RtzGerald LM, C~ayton RA. Gocayne JD et aJ.: Complete Genome Sequence of the Methanogenic Archaeon, Methenococcus Jannaschii. Science 1996, 273:1058-1073. [49"~]. Cascon A, Anguita J, Hernanz C, Ssnchez M, Femandez M, Naharro G: Identification of Aeromona$ Hydrophlla Hybridization Group 1 by PCR Assays. Appl Environ Microbiol 1996, 62:1167-1170. Chadwick RB, Conrad MR McGinnie MD, Johneton-Dow • * L, Spurgeon SL, Kronick MN: Haterozygete and Mutation Detection by Direct Automated Ruorescent DNA Sequencing Using • Mutant Teq DNA Polymerase, Biotechniques 1996, 20:676-683. [57~]. Cheng J, Shoffner MA, Hvichia GE, Kricka II, Wilding P: Chip PCR. 2. Investigation of Different PCR Amplification Systems in MIcrotahriceted Silicon-glass Chips. Nucleic Acids Ras 1996, 24:380-385. Clinton M, ScougaLI RK: Detection and Capture of S-35-1abeled Gas Released from Reaction Tubes During Differential Display PCR - Lab Safety Tip. Biotechniques 1995, 19:798-799. Craig ML, Sub W-C, Record MT Jr: HO. and DNase I • Probing of F_~70RNA Polymereae-~.PR promoter Open Complexes: Mg2+ Binding and Its Structural Consequences at the Transcription Start Site, Biochemistry 1995, 34:15624-15632. [52]. Dalma-Weiszhausz DD, Brenowitz M: Interaction Between • RNA Polymerase and the Positive and Negative Regulators of Transcription at the Escherlchia Cola Gel operon. Biochemistry 1996, 35:3735-3745. [27]. Day DJ, Spe;ser PW, White PC, Barany F: Detection of Steroid 21-hydroxylase Alleles Using Gene-specitlc PCR and a Multiplexed Ligation Detection Reaction. Genomics 1995, 29:152-162. Desalle R, Birstein VJ: PCR Identification of Black Caviar [Letter]. Nature 1996, 381:197-198. Oi Cera E: Thermodynamic Theory of Site-Specific • Binding Processes in Biological Mecromolecules. New York: Cambridge University Press; 1995. [t I]. Ericsson H, Stalhandske P, Danielssontham ML Bannen~an E, Bille J, Janquet C, Rocourt J, Tham W: Division of Listaria Monocytogenes Serovar 4b Strains into Two Groups by PCR and Restriction Enzyme Analysis. Appl Environ Microbiol 1995, 61:3872-3874. Fasol G: Room-temperature Blue Gallium Nitdde Laser • • Diode. Science 1996, 272:1751-1752. [32"~].


Analytical biotechnology Sequencing and PCR

Relschmann RD, Adams MD, White O, Clayton RA, • . Kirkness EF, Kedavage AR, Bull CJ, Tomb JF, Dougherty BA, Merrick JM et at.: Whole-ganome Random Sequencing and Assembly of Haemophilu$ Influenzae Rd. Science 1995, 269:496-512. [47"~]. Fraser CM, Gocayne JD, White O, Adams MD, Clayton • - RA, Fleischmann RD, Bull CJ, Kedavage AR, Sutton G, Kelley JM et at.: The Minimal Gana Complement of Mycoplasma Genitelium. Science 1995, 270:397-403. [481]. Fujita 1", Kiyama M: Identification of DNA Polymorphism by Asymmatric-PCR SSCP. Biotechniques 1995, 19:532. Gatlin J, Campbell LH, Schmidt MG, Arrigo SJ: Direct-rspid (DR) Mutagenesis of Large Plasmids Using PCR. Biotechniquea 1995, 19:559. Gautvik KM, Delecea L, Gautvik VT, Danielson PE, Tranque P, Dopazo A, Bloom FE, Sutcliffe JG: Overview of the Most Prevalent Hypothalamus-spedfic MRNAs, as Identified by Directional Tag PCR Subtraction. Proc Nat/Acad Sci U S A 1996, 93:8733-8738. Ghosh S: A Novel Ligation Medisted-PCR Based Strategy for Construction of Subtraction Libraries from Limiting Amounts of MRNA. Nucleic Acids Res 1996, 24:795-796, Gibbs RA: Pressing Ahead with Human Genoma • Sequencing. Nat Genet 1995, 11:121-125. [53"P]. Gilchrist CA, Streets HL, Ackers JP, Hall R: PCR-based Quantitation of Transtected Luciferase DNA: Evaluation Using an Entamoeba Histolytica Reporter Construct. Biotechniques 1996, 20:764. Gingrich JC, Boehrer DM, Basu SB: Partial CviJI Digestion as an Aitemstive Approach to Generate Cosmid Sublibrariec for Large-scale Sequencing Projects. Biotechniques 1996, 21:99-104. Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, • • FeldmannH, Galibert F, Hoheisel JD, Jacq C, Johnston Met AI.: Life with 6000 Genes. Science 1996, 274:546-567. [50"~]. Gotz A, Pukall R, Smit E, Tietze E, Prager R, Tschape H, Vanelsas JD, Smalla K: Detection and Characterization of Broad-hoar-range Plasmids in Environmental Bacteria by PCR.Appl Environ Microbiol 1996, 62:2621-2628. Gow JW, McGill MM, Behan WMH, Behan PO: Long RT-PCR Amplification of Full-length Enterovirus Genome. Biotechniques 1996, 20:582, Gruber A, ZJngeles B: One-base Double-stranded DNA Sequencing Reaction Using Commercial Kits. Biotechniques 1995, 19:748. Gurtler V, Barde HD: Typing of Staphylococcus Aureus Strains by PCR-emplification of Variable-length 16S-23S RDNA Spacer Regions: Characterization of Spacer Sequences. Microbiology 1995, 141:1255-1266. Hegiware K, Harris CC: 'Long Distance Sequencer' Method; a Novel Strategy for Large DNA Sequencing Projects. Nucleic Acids Res 1996, 24:2460-2461. Hales BA, Edwards C, Ritchie DA, Hall G, Pickup RW, Saunders JR: Isolation and Identification of Methanogen-speclfic DNA from Blanket Bog Feat by PCR Amplification and Sequence Analysis. App/ Environ Microbiol 1996, 62:668-675. Havukkale I, Ichimurs H, Nagemure Y. Sasaki T: Rice Genome Analysis by Integration of Sequencing and Mapping Data. J Biotechnol 1995, 41:139-148, Haywardlester A, Oefner PJ, Doris PA: Rapid Quantification of Gone Expression by Competitive RT-PCR and Ion-pair Reversed-phase HPLC. Biotechniques 1996, 20:250-257. Herman LMF, Deblock JHGE Waes GMAVJ: A Direct PCR Detection Method for Cloatridium Tyrobutyricum Spores in Up to 100 Milliliters of Raw Milk. Appl Environ MicrobJot 1995, 51:4141-4148+ Hill JM, Halford WP, Wen RJ, Engel LS, Green LC, Gebhardt BM: Quantitative Analysis of Polymerase Chain Reaction Products by Dot Blot. Anal Biochem 1996, 235:44-48. Hiller 1", Snell L, Watson PH: Microdissection RT-PCR Analysis of Gone Expression in Pathologically Defined Frozen Tissue Sections. Biotechniques 1996, 21:38. Hodson RE, Dustman WA, Garg RP. Moran MA: In Situ PCR for Visualization of Microscale Dis~bution of Specific Genes and Gene Products in Prokaryotic Communities. Appl Environ Microbiol 1995, 61:4074-4082. Hsieh M, Brenowitz M: Quantitative Kinetics Footprinting • • of Protoin-DNA Association Reactions. Methods Enzymo11996, 274:478-492. [78]. Hutchison W, Dahl HHM: Detergent-enhanced Sequencing of Heat-denatured PlasmidDNA. Biotechniques 1995, 19:554. Ibeas JI, Lozano I, Perdigones F, J;menezJ: Detection of Dekkera=Brettanomyces Strains in Sherry by a

nested PCR Method. Appl Environ Microbiol 1996, 62:998-1003. Jacobsen CS: Microscale Detection of Specific Bacterial DNA in Soil with a Magnetic Capture-hybridlzation and PCR Amplification Assay. Appl Environ Microbiol 1995, 61:3347-3352. Johnston SL, Strausbauch M, Sarkar G, Wettstein PJ: A Novel Method for Sequencing Members of Multi-gene Families. Nucleic Acids Res 1995, 23:3074-3075. Jurinke C, Vandenboom D, Jacob A, Tang K, Worl R, Koster H: Analysis of Ligase Chain Reaction Products Via Matrix-assisted Laser Desorption/ionization Time-of-flight-mass Spectrometry. Anal Biochem 1996, 237:174-181. Kaufman RI, Nixon BT: Use of PCR to Isolate Genes Encoding Sigma 54-dependent Activators from Diverse Bacteria. J Bacteriol 1996, 178:3967-3970. Keen G, Burton J, Crowley D, Dickinson E, Espinosalujan A, Franks E, Harger C, Manning M, March S, McLeod M, Oneill J, Power A, Pumilia M, Reinert R, Rider D, Rohrlich J, Schwertfeger J, Smyth L, Thayer N, Troup C, Retds C: The Genome Sequence DataBase (GSDB): Meeting the Challenge of Genomic Sequencing. Nucleic Acids Res 1996, 24:13-16. Kilvington S, Beeching J: Development of a PCR for Identification of Naegleda Fowled from the Environment Appl Environ Microbio/1995, 81:3764-3767. Kim S, Yoo HJ, Hahn .IH: Postelectrophoresis Capillary Scanning Method for DNA Sequencing. Anal Chem 1996, 68:936-939. Kim Y, Eom SH, Wang J, Lee D-S, Suh SW, Steitz TA: -. Crystal Structure of Thermus Aquaticus DNA Polymerase. Nature 1995, 376:612-616. [131]. Koonin EV, Musheg~anAR, Rudd KE: Sequencing and Analysis of Bacterial Genomes` Curr BiD/1996, 5:404-416. Korolev S, Nayal M, Barnes WM, De Cere E, Waksman G: • . Crystal Structure of the Large Fragment of Thermus Aquaticus DNA Polymerase I at 2.5/~ Resolution: Structural Basis for Thermostability. Proc Nat/Acad Sci USA 1995, 92:9264-9268. [14~']. Krejinovic M, Richer C, Labuda D, Sinnett D: Detection of a Mutstor Phenotype in Cancer Cells by Inter-alu Polymerase Chain Reaction. Cancer Res 1996, 56:2733-273?. Krekowski K, Bunville J, Said J, Baskln D, Seto D: Rapid Purification of Fluorescent Dye-labeled Products in a 9E-well Format for High-throughput Automated DNA Sequencing. Nucleic Acids Res 1995, 23:4930-4931. Kumeda Y, Asao T: Single-strand Conformation Polymorphism Analysis of PCR-amplified Ribosomal DNA Internal Transcribed Spacers to Differentiate Species of Aspergillus Section Ravi. Appl Environ Microbio11996, 62:2947-2952. Kuo WS, Chak KF: Identification of Novel Cry-type Genes from Bacillus Thuringiensis Strains on the Basis of Restriction Fragment Length Polymorphism of the PCR-amplified DNA. Appl Environ Microbiol 1996, 62:1369-1377, Lai ACK, Chambers TM: Rapid Protucol for Sequencing RNA Virus Using Delta Taq(R) Version 2.0 DNA Polymersse. Biotechniques 1995, 19:704. Lees DN, Henshilwood K, Green J, Gallimom CI, Brown DWG: Detection of Small Round Structured Viruses in Shellfish by Reverse Transcription PCR. Appl Environ Microbiol 1995, 51:4418-4424. Leng XG, Mosier DA, Oberst RD: Simplified Method for Recovery and PCR Detection of Cryptospoddium DNA from Bovine Feces. Appl Environ Microbiol 1996, 62:643-64?. Librizzi MD, Moir R, Brenowitz M, Willis h Expression and += Purification of the RNA Poiymerase I1| Transcription Specificity Factor nlBTo and Its Cooperative Binding with TBR J Biol Chem 1996, in press. [33]. Ling MF, Robinson BH: A One-step Polymerase Chain Reaction Site-directed Mutsgenesis Method for Large Gene-cassettes with High Efficiency, Yield, and Fidelity. Anal Biochem 1995, 230:167-172. Little DP, McLafferty FW: Sequencing 5O-mer DNAs Using Elecfrospray Tandem Mass Spectrometry and Complementary Fragmentation Methods. J Am Chem Soc 1995, 117:6783-6784. Liu DY, Daubendiek SL, Zillman MA, Ryan K, Kool ET: Rolling Circle DNA Synthesis: Small Circular Oligonucleotides as Efficient Templates for DNA Polymerases. J Am Chem Soc 1996, 118:1587-1594. Loewen PC, Switala J: Template Secondary Structure can Increase the Error Frequency of the DNA Polymerase from Thermus Aquaticus. Gene 1995, 164:59-63. Makino SI, Okada Y, Maruyama T: A New Method for Direct Detection of Listada Monocytogenes from

Foods by PCR. Appl Environ Microbiol 1995, 61:3745-3747, Matioli SR, Debrito RA: Obtaining Genetic Markers by Using Double-stringency PCR with Microaatellites and Arbitrary Pdmers` Biotechniques 1995, 19:752, Mauro JM, CaD LK, Kondrecki LM, Walz SE, Campbell JR: Fiber-optic Fluoromatric Sensing of Polymerase Chain Reaction-amplified DNA Using an Immobilized DNA Capture Protein. Anal Biochem 1996, 235:61-72. McKendree WL, Naim CJ, Bausher MG: Differential Display from Plant Leaves Using Oligo(dT) Magnetic Bead MRNA Isolation end Hot Air PCR. Biotechniques 1995, 19:715. Metzker ML, Lu J, Gibbs RA: Electrophoretically Uniform Fluorescent Dyes for Automated DNA Sequencing. Science 1996, 271:1420-1422. Millard D, Decouat HG: Preparation of Glass Plates with Cerium Oxide for DNA Sequencing. Biotechniques 1995, 19:576. Minami M, Poussin K, Brechot C, Patedini P: Novel PCR Technique Using Alu-apecific Primers to Identity U~known Flanking Sequences from the Human Genome. Genomics 1995, 29:403-408. Naeve CW, Buck GA, Niece RL, Pon RT, Robertson M, • Smith/U: Accuracy of Automated DNA Sequencing: a multi-laboratory Comparison of Sequencing Results. Biotechniques 1995, 19:448-453. [441]. Nicoletti A, Sassyprigent C: An Alternative Quantitative Polymerase Chain Reaction Method. Anal Biochem 1996, 236:229-241, Noble D: Forensic PCR - Primed, Amplified, end Ready for Court. Anal Chem 1995, 67:A613-A615. Olson MV: A Time to Sequence. Science 1995, • 270:394-396. [52"P]. Ossewaerde JM, Dewies A, Beatebroer T, Angulo AF: Application of a Mycoplasma Group-specific PCR for Monitoring Decontamination of Mycoplasma-infected Chlamydla Sp Strains. Appl Environ Microbio/1996, 62:328-331. Ozoline ON, Tsyganov MA: Structure of Open Promoter • Complexes with EscheHchia Col/RNA Polymerase as Revealed by the DNase I Footpdnting Technique: Compilation Analysis. Nucleic Acids Res 1995, 22:4533-4541. [38], Parks ME, Baird EE, Dervan PB: Recognition of • . 5"-(A,T)GG(A,T)2-3'SequencesIn the Minor Groove of DNA by Hairpin Polyamides` J Am Chem Soc 1996, 118:6153-6159. [36]. Patten TE, Xia J, Abernathy T, Matyjaszewski K: Polymers • . with Very Low Polydispersittes from Atom Transfer Radical Polymerization. Science 1996, 272:866-868. [241]. Peacock A, Verhoeve P, Rando N. Van Dordrecht A, Taylor • • BG, Erd C, Pemjman MAC, Venn R, Howlatt J, Goldie DJ et el.: Single Optical Photon Detection with a super-conducting Tunnel Junction. Nature 1996, 381 : 135-137. [341]. Perini LT, Doherty F_A,Wemer E, Senear DF: Multiple -. Spadfic CytR Binding Sites at the E. Coil DeoP2 promoter Mediate Both Cooperative and Competitive Interactions Between CytR and CRP. Biochemistry 1996, in press, [29]. Patti V, Hsieh M, Brenowitz M: Thermodynamic and +• Kinetic Characterization of the Binding of the TATA Binding Protein to the Adenovirus 54 Promoter. Biochemistry 1995, 34:9977-9984. [32]. Pohl TM, Maier E: Sequencing 500 Kb of Yeast DNA Using a GATC(R) 1500 Direct Blotting Elecfrophoresis System. Biotechniques 1995, 19:482-486. Powers T, Noller HF: Hydroxyl Radical Footpdnting of • Ribosomal Proteins on 18S RRNA. RNA 1995, 1: 194-209. [63]. Purendare SM, Breidenbach HH, ~ Y, Zhu XL, Sawada S, Nell SM, Brothman A, White R, C~wthon R, Viskochil D: Identification of Neurofibromatosis 1 (NF1) Homologous Loci by Direct Sequencing, Ruomscence in Situ Hybridization, and PCR Amplification of Somatic Cell Hybrids` Genomics 1995, 30:476-485. Radovich P, Bortolin S, Christopoulos TK: Time-resolved Ruorometdc Hybddizstion Assays with RNA Probes Synthesized from Polyrnerase Chain Reaction-generated DNA Templates. Anal Chem 1995, 67:2644-2649. Reddy P, McKenney K: Improved Method for the Production of M13 Phage and Single-stranded DNA for DNA Sequencing. Biotechniques 1996, 20:854. Reeve MA, Fuller CW: A Novel Thermostable Polymerase for DNA Sequencing. Nature 1995, 376:796-797. Reynolds KA, Gerba CP, Pepper IL: Detection of Infectious Enteroviruses by an Integrated Cell Culture PCR Procedure. Appl Environ Microbiol 1996, 62:1424-1427.

Analytical biotechnology Fluorescence resonance energy transfer spectroscopy

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Fluorescence resonance energy transfer spectroscopy Related reviews: Fluorescence spectroscopy as a tool to investigate protein interactions (pp 45-49); Energy-transfer fluorescent reagents for DNA analyses (pp 94-102)t Alouani S, Gaertner HF, Mermod JJ, Power CA, Bacon KB, Wells TNC, Proudfoot AEJ: A Ruoressant Intedeuldn-8 Receptor Probe Produced by Targetted Labelling at the Amino Terminus (vol 227, Pg 329, 1996). Eur J Biochem 1996, 237:882. Bailey M, Hagmar P, M;llar DP, Davidson BE, Tong G, • HaralambidisJ, Sawyer WH: Interaction Between The EscheHchie Coli regulatory Protein TyrR and DNA: a Ruorescence Footprinting Study. Biochemistry 1995, 34:15802-15812. [29]. Bambot SB, Rao G: Sensing Oxygen Through Skin Using a Red Diode Laser and Ruoreeceece Ufetimes. Biosans Bioe/ectron 1995, 10:643. Barenholz Y, Cohen T, Haas E, Ottolenghi M: Lateral Organization of Pyrone-labeied Upids in Bilayers as Determined from the Deviation from Equllibdum Between Pyrene Monomers and Excimers. J Biol Chem 1996, 271:3085-3090, Bedand KM, So PTC, Chen Y, Mantulin WVV, Gralton • * E: Scanning Two-photon Ructuetion Correlation Spectroscopy: Particle Counting Measurements for Detection of Molecular Aggregation. Biophys J 1996, 71:410-420. [24]. Bowyer WJ, Xie J, Engstrom RC: Ruoroscence Imaging of the Heterogeneous Reduction of Oxygen. AnN Chem 1996, 68:2005-2009. Broos J, Vissar AJWG, Engbersen JFJ,Verboom W, Vanhoek A, Reinhoudt DN: Rexibillty of Enzymes Suspended in Organic Solvents Probed by Time-resolved Ruorescence Anisotropy. Evidence that Enzyme Activity and Enantioseiectivity are Directly Related to Enzyme Rexibility. J Am Chain Soc 1995, 117:12657-12663. Buku A, Probst WC, Weiss KR, Heierhorst J: Studies of the Calmodulin-binding Site of Twitchin with Synthetic Peptides Using Ruorescencs and CD Spectroscopy. Biochem Biophys Res Commun 1996, 218:854-859. Chang Q, Sipior J, Lakowicz JR, Rao G: A Lifetime-based Ruorescence Resonance Energy Transfer Sensor for Ammonia. Anal Biochem 1995, 232:92-97. Churchich JE: Binding of a Ruorescent Nucieotide Analog to Hsc7O - the Effect of Peptide Protein Interactions on the Luminescence Properties of the Probe. Eur J Biochem 1995, 231:736-741. Crameri A, Whitehorn EA, Tale E, Stemmer WPC: Improved Green Fluorescent Protein by Molecular Evolution Using DNA Shuffling. Nat Biotechno11996, 14:315-319. Dane AD, Timmermans PAM, Vansprang HA, Buydens LMC: A Genetic Algorithm for Model-free X-ray Fluorescence Analysis of Thin Rims. Anal Chem 1996, 68:2419-2425. Doevendans PA, Decker KD, an RH, Kass RS: The Utility of Fluorescent in vivo Reporter Genes in Molecular Cardiology. Biochem Biophys Res Commun 1996, 222:352-358. Draxler S, Lippitsch ME: Lifetime-based Sensing: Influence of the MicroenvimnmenL Anal Chem 1996, 68:753-75?. Fedosova NU, Cornelius F, Klodos I: Ruorescant Styryl Dyes as Probes for Na,K-ATPase Reaction Mechanism: Significance of the Charge of the Hydrophilic Moiety of RH Dyes. Biochemistry 1995, 34:16806-16814. Forssen F_A,Malebrune R, Adlermoore JP, Lee MJA, Schmidt PC, Krasieva TB, Shimizu S, Tromberg BJ: Fluorescence Imaging Studies for the Disposition of Daunorubicin Liposomes (DaunoXome) Within Tumor Tissue. Cancer Res 1996, 56:2066-2075. Gryczynski Z, Lubkowski J, Bucci E: Heine-protein • Interactions in Horse Heart Myoglobin at Neutral PH and Exposed to Acid Investigated by Time-resolved Ruorescence in the Pico- and Nanosecond Time Range. J Biol Chem 1995, 270:19232-19237. [4]. Heim R, Tslen RY: Engineering Green Ruorescent Protein for Improved Brightness, Longer Wavelengths and Ruorescence Resonance Energy Transfer. Curt Biol 1996, 6:178-182.


Analytical biotechnology Surface plasmon resonancespectroscopy and infrared spectroscopy, biosensorsand flow-injectionanalysis

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S u r f a c e p l a s m o n r e s o n a n c e s p e c t r o s c o p y and infrared s p e c t r o s c o p y , biosensors and flow-injection analysis

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GaD XP, White HS: Rotating Microdisk Voltammetry. Anal Chem 1995, 67:4057-4064. Gardiol AE, Hernandez RJ, Reinhammar B, Harte BR: Development of a Gas-phase Oxygen Biosensor Using a Blue Copper-containing Oxidase. Enzyme Microb Technol 1996, 18:347-352. Gatto*Menking DL, Yu H. Bruno JG, Goode MT, Miller M, Zulich AW: Sensitive Detection of Biotoxoids and Bacterial Spores Using an Immunomagnetic Electrochemiluminescence Sensor, Biosens Bioe/ectron 1995, 10:501-508. Gilbert BA, Rando RR: Modular Design of Biotinylated Photoaffinity Probes: Synthesis and Utilization of a biotinylated Pepstatin Photoprobe. J Am Chem Soc 1995, 117:8061-8066. Gondo S, Kirn C, Morishita M, Kawakami M: Frequency Response of the Glucose Sensor Based on Immobilized Glucose Oxidase Membrane. App/ Biochem Biotechno11996, 57-8:8?7-884. Goodacre R, Kell DB: Correction of Mass Spectral Drift Using Artificial Neural Networks. Anal Chem 1996, 68:271-280. Goodman MS, Jubian V, Linton B, Hamilton AD: A Combinatorial Library Approach to Artificial Receptor Design. J Am Chem Soc 1995, 117:11610-11611. Goodwin DC, Yamazaki I, Aust SD, Grover TA: Determination of Rate Constants for Rapid Peroxidase Reactions. Anal Biochem 1995, 231:333-338. G6pel W: Introduction: 'Interfacing Biology with Electronics'. Biosens Bioelectron 1995, 9:iii. G?pel W: Controlled Signal TransducUon Across Interfaces of 'intelligent' Molecular Systems. Biosens Bioelectron 1995, 10:35-60. G6pel W, Heiduschka P: Interface Analysis in Biosensor Design. Biosens Bioelectron 1995, 10:853-884. Grate JW, McGill RA: Dewetting Effects on Polymer-coeted Surface Acoustic Wave Vapor Sensors. Anal Chem 1995, 67:4015-4019. Grate JW, Patrash SJ, Abraham MH, Du CM: Selective Vapor Sorption by Polymers and Cavitands on Acoustic Wave Sensors: is This Molecular Recognition? [Letter]. Anal Chem 1996, 68:913-917 Groom CA, Luong JHT, Thafipalmala R: Dual Functionalities of 4-aminodlphenylamine in Enzymatic Assay and Mediated Biosensor Construction. Anal Biochern 1995, 231:393-399. Gross GW, Rhoades BK, Azzazy HME, Wu MC: The use of Neuronal Networks on Multielectrode Arrays as Biosensors. Biosens Bioelectron 1995, 10:553-568. Guilbault GG, Palleschi G, Lubrano G: Non-invasive Biosensors in Clinical Analysis. Biosens Bioelectron 1995, 10:379-392. Guthrie GD, Nichotsonguthrie CS, Shuck CS: Bacterial Assay for Quantitative Measurement of Nanomolar Concentrations of a Metabolite. Anal Biochem 1995, 225:283-285. Hagenhoff B: Surface Mass Spectrometry: Application to Biosensor Characterization. Biosens Bioelectron 1995, 10:685-894. Hale ZM, Payne FP, Marks RS, Lowe CR, Levine MM: The Single Mode Tapered Optical Fibre Loop Immunosensor. Biosens Bioelectron 1996, 11:137-148. Hall DR, Cann JR, Winzor DJ: Demonstration of an Upper Umit to the Range of Association Rate Constants Amenable to Study by Biosensor Technology Based on Surface Plasmon Resonance. Anal Biochem 1996, 235:175-184. Hammerle H, Egert U, Mohr A, Nisch W: Extrecellular Recording in Neuronal Networks with Substrate Integrated Microelectrode Arrays. Biosens Bioelectron 1995, 9:691-696. Haromerle M, Halt EAH, Cade N, Hodgins D: Electrochemical Enzyme Sensor for Formaldehyde Operating in the Gas Phase. Biosens Bioe/ectron 1996, 11:239-246. Hart AL, Turner APF, Hopcroft D: On the use of Screen- and Ink-jet Printing to Produce Amperometric Enzyme Electrodes for Lactate. Biosens Bioelectron 1996, 11:263-270. Hartsock CE. Lewis JK, Leslie I, Pope JA, Tsal LB, Sachdev R, Meng SY: Assessing Post-induction Cellular Response in a Recombinant E-coil Lactose-inducible System by Monitoring Beta-galactosidase Levels. Biotechnol Lett 1995, 17:1025-1030. Hastings JW: Chemistries and Colors of Bioluminescent Reactions: a Review. Gene 1996, 173:5-11. Hatazawa T, Terrill RH, Murray RW: Microelectrode VoRammetry and Electron Transport in an Undiluted Room Temperature Melt of an Oligo(ethylene Glycot)-tailed Viologen. Anal Chern 1996, 68:597-603.

Healey BG, Walt DR: Improved Fiber Optic Chemical Sensor for Penicillin. Anal Chem 1995, 67:4471-4476. Heding A, Gill R, Ogawa Y, Demeyts P, Shymko RM: Biosensor Measurement of the Binding of Insulin-like Growth Factors I and II and Their Analogues to the Insulin-like Growth FaVor-binding Protein-3. J Biel Chem 1996, 271:13948-13952. Hintsche R, Paeschke M, Woltenberger U, Schnakenberg U, Wagner B, Lisec T: Microelectrode Arrays and Application to Biosensing Devices. Biosans Bioelectren 9:697-706. Hirst J, Sucheta A. Ackrell BAC, Armstrong FA: Electrocetelytic Voltammetry of Sucoinete Dehydmgenasa: Direct Quantification of the Catalytic Properties of a Complex Electron-trensport Enzyme. J Am Chem Soc 1996, 118:5031-5038. Ho WO, Athey D, McNeil C J: Amperometdc Detection of Nkaline Phosphatase Activity at a Horseradish Peroxidase Enzyme Electrode Based on Activated Carbon: Potential Application to Electrochemical Immunoassay. Biosens Bioelectron 1995, 10:683-692. Holt PJ, Bruce NC, Lowe CR: Bioluminescent Assay for Heroin and Its Metabolites. Anal Chem 1996, 68:1877-1882. Holt PJ, Gray Stephens LD, Bruce NC, Lowe CR: An Amperometric Opiate Assay. Biosens Bieelectron 1995, 10:517-526. Holzbaur IE, English AM, Ismail AA: Infrared Spectra of Carbonyl Horseradish Peroxidase and Its Substrata Complexes: Characterization of PH-dependent Conformers. J Am Chem Soc 1996, 118:3354-3359. Huang HL, Dasgupta PK, Genfa Z, Wang J: A Pulse Amperometric Sensor for the Measurement of Atmosphedc Hydrogen Peroxide. Anal Chern 1996, 08:2062-2066. Huang W, Feltus A. Witkowski A, Daunert S: Homogeneous Bioluminescence Competitive Binding Assay for Folete Based on a Coupled Glucose-6-phosphate Dehydrogeneae-bactedal Luciferese Enzyme System. Anal Chem 1996, 68:1646-1650. Ikede T, Kurosaki 1", Takayama K, Keno K, Miki K: Measurements of oxidoreductase-like Activity of Intact Bacterial Cells by an Amperometric Method Using a Membrane-coated Electrode. Anal Chem 1996, 68:192-198. Irnato T, Ishibashi N: Potentiometric Butyrlcholine Sensor for Organophosphete Pesticides. Biosens Bioe/ectron 1995, 10:435-442. Ito N, Miyamoto S, Kimura J, Karube h The Detection of Lactate Using the Repeated Application of Stepped Potentials to a Micro-planar Gold Electrode. Bioaens Bioelectron 1996, 11:119-126. IvnitskJ D, Rishpon J: A One-step, Separetlon-free Amperometric Enzyme Immunosensor, Biosena Bioe/ectron 1996, 11:409-418. Ivnitskil DM, Rishpon J: A Potantiometric Biosensor for Pesticides Based on the Thiocholine Hexacyanoferrete (111)Reaction. Biosens Bioelectron 1995, 9:569-576. Iwuoha El, Adeyeju O, Dempsey E, Smyth MR, Liu J, Wang J: Investigation of the Effects of Polar Organic Solvents on the Activity of Tyrosinese Entrapped in a poly(ester-sulphonio Acid) Polymer. Biosens Bioelectron 1995, 10:661-668. Jacobs MF, Tynkkynen S, Sibekov M: Highly Bioluminescent Streptococcus Thermophilus Strain for the Detection of Dairy-relevant Antibiotics in Milk. Appl Microblo/ Biotechno/1995, 44:405-412. Jacobsen CS: Microscale Detection of Specific Bacterial DNA in Soil with a Magnetic Capture-hybridization and PCR Amplification Assay. Appl Environ Microbiol 1995, 61:3347-3352. Jepras RI, Carter J, Pearson SC, Paul FE, Wilkinson MJ: Development of a Robust Row Cytometric Assay for Determining Numbers of Viable Bacteria. Appl Environ Microbiol 1995, 61:2696-2701. Jin G, Tengvall P, Lundstrom I, Arwin H: A Biosansor Concept Based on Imaging Ellipsomeby for Visualization of Biomolecular Interactions. Anal Biochem 1995, 232:69-72. Jin W, Bier F, Wellanberger U, Scheller F: Construction and Characterization of a Multi-layer Enzyme Electrode: Covalent Binding of Quinoprotein Glucose Dehydrogenase Onto Gold FJectrodes. Biosens Bioelectron 1995, 10:823-830. Jobst G, Moser I, Urban G: Numerical Simulation of Multi-layered Enzymatic Sensors. Biosens Bioelectron 1996, 11:111-118, Joo H. Yoo YJ, Ryu DDY: A Biosensor Stabilized by Polyethylene Glycol for the Monitoring of Hydrogen Peroxide in Organic Solvent Media. Enzyme Microb Techno/1996, 19:50-56.

Analytical biotechnology Surface plasmon resonance spectroscopy and infrared spectroscopy, biosensors and flow-injection analysis

Jung SK, Wilson GS: Polymeric Mercaptosilane-modified Platinum Electrodes for Elimination of Interferants in Glucose Biosensors. Anal Chem 1996, 68:591-596. Kxjitx Y, Kobatake E, Ishikawa F, Aizawx M: 81oluminescent Detection of RNA with Seduencs-specificity Using RNA Binding Protein-luciferase Fusion Protein. J Biotechno/1995, 43:63-70. KalluPj KMR, BrennanJD, Krull UJ: Depth Profiling of Functionalized Silene Films on Quartz and Silicon Substrates and of Ureese Immobilised on Such Films by Angle-resolved X-ray Photoelectron Spectroscopy. Anal Chem 1995, 67:2625-2634. Kaprelyxnts AS, MukamolovaGV, Davey HM, Kell DB: Quantitative Analysis of the Physiological Heterogeneity Within Starved Cultures of Micrococcus Luteus by Flow Cytometry and Cell Sorting, App/Environ Microbiol 1996, 62:1311-1316. Kadsson R, Fall A: Expedmentsl Design for Improved G. Kinetic Analysis of Protein Protein Interactions with Surface Plasmon Resonance Biosensors. J immune/ Methods 1996, in press. [23]. Karlsson R, Stahlbxrg R: Surface Plasmon Resonance Detection and Muitispot Sensing for Direct Monitoring of Interactions Involving Low-molecular-weight Analytes and for Determination of Low Affinities. Anal Biochem 1995, 228:274-280. Kaye B, Herren WJ, Macrae PV, Robinson S, Stopher DA, Venn RF, Wild W: Rapid, Solid Phase Extraction Technique for the High-throughput Assay of Darifenacin in Human Plasma. Anal Chem 1996, 68:1658-1660. KaT~nskayaN, Kukhtin A, ManenkovaM, Reshetilov N, YaryshxvaI~ ArzhakovaO, Volynskii A, Bakeyev N: FET-baced Sensors with Robust Photosensitive Polymer Membranes for Detection of Ammonium Ions and Urea. Biosens Bioelectron 1996, 11:253-262. Kikuchi A, Suzuki K, Okabayashi 0, Hoshino H, Kxtaoka K, Sakural Y, Okano T: Glucose-sensing Electrode Coated with Polymer Complex Gel Containing Phenylboronic Acid. Anal Chem 1996, 68:823-828, Kim MJ, Kim HJ, Kim JM, Kim B, Han SH, Cha GS: Homogeneous Assays for Riboflavin Mediated by the Interaction Between Enzyme-bioSn and Avidtn-dboflavin Conjugates. Anal Biochem 1995, 231:400-406. Kobatake E, Niimi 1", HaruyamaT, IkariyamaY, Aizawa M: Biosensing of Benzene Dedvatlves in the Environment by Luminescent Eschedchia Coll. Biosens Bioelectron 1995, 10:601-808. Koncki R, Mohr GJ, Wolfbeis OS: Enzyme Biosensor for Urea Based on a Novel PH Bulk Optode Membrane. Biosens Bioelectron 1995. 10:653-660. Kovacs GTA, Petersen K, AJbin M: Silicon Micromachinlng •- Sensors to Systems. Anal Chem 1998, 68:A-'07-A412, Kriz CB, Rxdevik K, Kriz D: Magnetic Permeability Measurements in Bioanalysis and Biosensors [Letter]. Anal Chem 1996, 68:1966-1970. Krock KA, Wilkins CL: Qualitative Analysis of Contaminated Environmental Extracts by Multidimensional Gas Chromatography with Infrared and Mass Spectral Detection (MDGC-IR-MS). J Chromatogr A 1996, 726:167-178, Kuhn H: Reflections on Biosystems Motivating Supramoleculer Engineering. Biosens Bioelxctron 1995, 9:707-718. Kunz RE, Dr,bendorfer J, Morf RH: Finite Grafting Depth Effects for Integrated Optical Sensors with High Sensitivity. Biosens Bioelectron 1995, 11:653-668. Kurods Y, Kate Y, Higashioji 1", HasegawxJ, KawanamiS, Takxhashi M, Shiraishi N, Tanabe K, Ogoshi H: Chiral Amino Acid Recognition by a Porphydn-bssed Artificial Receptor. J Am Chem Soct 995, 117:10950-10958. Kuziemko GM, Stroh M, Stevens RC: Cholera Toxin • BindingAffinity and Specificity for Gangliosides Determined by Surface Plasmon Resonance. Biochemistry 1996, 35:6375-6384. [18]. Labrou NE, Clonis YD: Biomimetic Dye-ligands for Oxelate-racognizing Enzymes. Studies with Oxalate Oxidase and Oxalate Decarboxylase. J Biotechnol 1995, 40:59-70. Labrou NE, Karagouni A, Clonis YD: Biomimetic-dye Affinity Adsorbents for Enzyme Pudfication: Application to the One-step Purification of Candida Boidinii Formate Dehydrogenase` Biotechnol Bioeng 1995, 48:278-288. Lackmann M, Bucci T, Mann RJ, Kravets I_A,Viney E, • SmithF, Moritz RL, Carter W, Simpson RJ, Nicola NA et AI.: Pudfication of a Ligand for the EPH-like Receptor HEK Using a Biosensor-based Affinity Detection approach. Proc Nat/Acad Sci USA 1996~ 93:2523-2527. [12].

Larsen LH, Revsbech NP, Binnerup SJ: A Micmsensor for Nitrate Based on Immobilized Denifritying Bacteria` Appl Environ Microbio11996, 62:1248-1251. Laurell 1", Droll J, RosengrenL: Silicon Wafer Integrated Enzyme Reactors. Biosens Bioelectron 1995, 10:289-300. Lawrence CR, Geddes NJ, Furlong DN: Surface Plesmon Resonance Studies of Immunoreactions Utilizing Disposable Diffraction Gratings. Biosens Bioelectron 1996, t 1:389-400. LevchenkoA, Mehta BM, Spengler BA, Narkar ~ Fonti R, Biedler JL, Tsuruo1", Larson SM: Measurement of P-glycoprotein Expression in Multidrug-resistsnt Human Neuroblastoma Cell Lines Using Self-competitive Binding Assay. Anal Biochem 1996, 235:338-343. Li JR, Wang JP, Jixng L: Biphasic Photocurrent of a Photocell Containing Retinal Langmuir-Blodgett Film. Biosens Bioe/ectron 1995, 9:147-150. Li L, Walt DR: Dual-analyte Fiber-optic Sensor for the Simultaneous and Continuous Measurement of Glucose and Oxygen. Anal Chem 1995, 67:3746-3752. Li PCH, Thompson M: Mass Sensitivity of the Thin-rod Acoustic Wave Sensor Operated in Flexurel and Extensional Modes. Anal Chem 1996, 68:2590-2597. Liang P, SanchezRI, Martin MT: Elactrochemiluminescence-based Detection of Bets-lactsm Antibiotics and Beta-lactsmases. Anal Chem 1996, 68:2426-2431. Licht S, Myung N, Sun Y: AUght Addressable Photoelectrochemical Cyanide Sensor. Anal Chem 1996, 68:954-959, Lin ZX, Ward MD: Determination of Contact Angles and Surface Tensions with the Quartz Crystal Microbalance` Anal Chem 1996, 68:1285-1291. Linke B, Kerner W, Kiw~t M, Pishko M, Hailer A: Amperometric Biosensor for in Vivo Glucose Sensing Based on Glucose Oxidase Immobilized in a Redox Hydrogel. Biosens Bioelectron 1995, 9:151-158. Lins AM, Sprecher CJ, Puers C, Schumm JW: Multiplex Sets for the Amplification of Polymorphic Short Tandem Repeat Loci - Silver Stain and Ruorescence Detection. Biotechniquex 1996, 20:882-889. Liu D, Chen K, Ge K, Nie L, Yao S: A New Urea Sensor Based on Combining the Surface Acoustic Wave Device with Uresse Extracted from Green Soye Bean and Its Application: Determination of Urea in Human Urine. Biosens Bioelectron 1996, 11:436-442, Liu DZ, Yin AF, Ge K, Chen K, Nie LH, Yao SZ: Enzymatic Analysis of Arginine with the SAW Conductance Sensor System. EnzymeMicrob Techno/1995, 17:856-863, Liu H, Dang .1: An Amperomefric Glucose Sensor Based on Esstmen-AQ-tetrathiafuivalene Modified Bectrode. Biosens Bioelectron 1996, 11:103-110. Liu HH, Dasgupta PK: A Renewable Liquid Droplet as a Sampler and a Windowless Optical Cell. Automated Sensor for Gaseous Chlorine. Anal Chem 1995, 67:4221-4228, Liu ZM, Li JH, Dong SJ, Wang EK: Improvements in the Selectivity of Electrochemical Detectors for Liquid Chromatography and Row Injection Analysis Using the Self-assembled N-alkanethiol Monolayer-modified Au Electrode` Anal Chem 1996, 68:2432-2436. Loessner MJ, Rees CED, Stewart GSAB, Scherer S: Construction of Luciterase Reporter Bacteriophage A511:duxABfor Rapid and Sensitive Detection of Viable Listeria Cells. Appl Environ Microbiol 1996, 62:1133-1140. L6fbs S, JohnssonB, EstrOm A, Hansson A, Lindquist G, M~illerHillgren RM, Stigh L: Methods for Site Controlled Coupling to carboxymethyldextran Surfaces in Surface Plasmon Resonance Sensors. Biosens Bioelectron 1995, t 0:813-822. Loughran MG, Hall JM, TurnerAPF, Davidson VL: Amperometric Detection of Histamine at a Ouinoprotein Dehydrogenase Enzyme Electrode. Biosens Bioelectron 1995, 10:569-576. Lubenova V: On-line Estimation of Biomass Concentration and Non Stationary Parameters for Aerobic Bioprocesses. J Biotechnol 1996, 48:197-207. Lundstrom I: Real-time Biospeciflc Interaction Analysis. Biosens Bioelectron 1995, 9:725-736. Luong JHT, MessonC, Brown RS, MaJeKB, Nguyen AL: Monitoring the Activity of Glucose Oxidase During the Cultivation of Aspergitius Niger Using Novel Amperometric Sensor With 1.1"-dimethylferricinium as a Mediator. Biosens Bioelectron 1995, 9:577-584.


Me CO, Li KA, Tong SY: MicrodetenninaUon of Proteins by Resonance Ught Scattenng Spectroscopy with Bmmophenol Blue. Anal Biochem 1998, 239:56-91. Ma Y, Galal A, Lunsford K, Zimmer H, Mark HB Jr, Huxng Z, Bishop PB: Pely(binaphthyl-20-crown-6) as Receptor Based Molecular Selective Potentiometric ElectTodss for Catacholamines and Other 1,2-dihydmxybenzene Derivatives. Biosens Bioelectron 1995, 10:705-716. Mabrouk PA: Direct Electrochemistry for the Imidazole Complex of Microperoxidase-11 in Dimethyl Sulfoxide Solution at Naked ElectTode Substrates Including Glassy Carbon, Gold, and Platinum. Anal Chem 1996, 68:189-191, Mackenzie CR, Hirama T, Deng SJ, Bundle DR, Narang SA, Young NM: Analysis by Surface Placmon Resonance of the Influence of Valence on the Ligand Binding Affinity and Kinetics of an Anti-carbohydrate Antibody. JBiol Chem 1996, 271:1527-1533. Maclaurin P, Crabb NC, Wells I, Worsfold PJ, Coombs D: Quantitative in Situ Monitoring of an Elevated Temperature Reaction Using a Water-cooled Mid-infrared Fiber-optic Probe. Anxl Chem 1996, 68:1116-I 123. MacNab AJ, Gagnon RE: Potential Sources of Discrepandes Between Uving Tissue Near Infrared Spectroscopy Algorithms. Anal Biochem 1996, 236:375-377. Male KB, Luong JHT: Improvement of the Selectivity of an FIA Amperomefric Biosensor System for Glucose. Biosens Bioelectron 1995, 8:239-248. Manowitz P, Stoecker PW, YacynychAM: Galectose Biosensors Using Composite Polymers to Prevent interferences. Biosens Bioe/ectron 1995, 10:369-370. Martens N, Hindle A, Hall EAH: An Assessment of Mediators as Oxidants for Glucose Oxidase in the Presence of Oxygen. Biosens Bioelectron 1996, 10:393. Matsunaga 1".Okochl M, NakasonoS: Direct Count of Bacteria Using Fluorescent Dyes: Application to Assessment of Electrochemical Disinfection. Anal Chem 1995, 67:4487-4490. Maule CH, Molloy J, Goddard NJ: The Resonant Mirror:. s Nov~ Optical Biesensor for Direct Sensing of Blomolaculer Interactions. Part h Principle of Operation and Associated Instrumentation. R Cush, JM Cronin, WJ Stewart. Biosens Bioelectron 1995, 8:34?-364. Mauro JM, Cxo LK, Kondracki LM, Walz SE, Campbell JR: Fiber-optic Ruoromeld¢ Sensing of Polymerase Chain Reactionoamplified DNA Using an Immobilized DNA Capture Protein. Anal Biochem 1996, 235:81-72. McAdams ET, LackermeierA, McLaughlinJA, Mxcken D, Jossinet J: The Unesr and Non-linear Electrical Properties of the Electrode-electrolyte Interface. Biosens Bioe/ectron 1995, 10:67-74. McGrath MJ, Iwuoha El, Diamond D, Smyth MR: The use of Differential Measurements with a Glucose Biosensor for Interference Compensation Dudn9 Glucose Detanntnations by Flow Injection Analysis. Biosens Bioe/ectron 1995, 10:937-944. McGuire JM, Lynch CC: Characterization of Nonmicrobiological Paper Mill Deposits by Simultaneous TG-IR-MS.Anal Chem 1996, 68:2459-2463. McKelvy ML, Britt,TR, Davis BL, Gillie JK, Lentz LA, Leugers A, Nyquist RA, Putzig CL: Infrared Spectroscopy. Anal Chem 1996, 68:R93-R160. McNeil CJ, Athey D, BaH M, He WO, Krause S, Armstrong RD, Wright JD, Rawson K: Electrochemical Sensors Based on Impedance Measurement of Enzyme-catalyzed Polymer Dissolution: Theory and Applications. Anal Chem 1995, 67:3928-3935. McNeil CJ. Athey D. He WO: Direct Electron Transfer Bioelectronic Interfaces: Application to Clinical Analysis. Bicsens Bioelectron 1995, 10:75-64, Meruva RK, MeyerhoffME: Mixed Potential Response Mechanism of Cobalt Electrodes Toward Inorganic Phosphate. Anal Chem 1996, 68:2022-2026. Messia MC, Compagnone D, Esti M, Pallsschi G: A Bienzyme Electrode Probe for Malats. Anal Chem 1996, 68:360-365. Meusel M, Renneberg R, Spener F, Schmitz G: Development of a Heterogeneous Amperomefric Immunosensor for the Determination of Apolipoprotein E in Serum. Biosens Bioelectron 1995, 10:577-586. Meyerhoff ME, Fu B, Bxkker E, Yun JH, Yang VC: PolYion-sensitive Membrane Electrodes for Biomedical Analysis, Anal Chem 1996, 68:A168-A175. Millington RB. MayasAG, Blyth J, Lowe CR: A Holographic Sensor for Proteases. Anal Chem 1995, 67:4229-4233.


Analytical biotechnology

S u r f a c e p l a s m o n r e s o n a n c e s p e c t r o s c o p y and infrared s p e c t r o s c o p y , b i o s e n s o r s and f l o w - i n j e c t i o n analysis

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Nikolelis DP, Siontorou CG, Krull UJ, Katrivanos PL: Ammonium Ion Minisensors from Self-assembled Bilayer Lipid Membranes Using Gremicidin as an Ionophore. Modulation of Ammonium Selectivity by Platelet-activating Factor. Anal Chem 1996, 68:1735-1741. Nisch W, Bock J, Egert U, Hammerle H, Mohr A: A Thin Film Mlcroelectrode Array for Monitoring Extracellular Neuronal Activity in Vitro. Biosens Bioelectron 1995, 9:737-742. Niwa O, Morita M: Carbon Film-based Interdigitated Ring Array Electrodes as Detectors in Radial Flow Cells. Anal Chem 1996, 68:355-359. Niwa O, Torimitsu K, Morita M, Osborne P, Yamamoto K: Concentration of Extrecellular L-glutamata Released from Cultured Nerve Cells Measured with a Small Volume Online Sensor. Anal Chem 1996, 68:1865-1870. Ohashi E, Karube h Development of a thin Membrane Glucose Sensor Using Beta-type Crystalline Chitin for Implantable Biosensor. J Biotechnol 1995, 40:13-19. Olson MW, Dallmann HG, McHenry CS: DnaX Complex of • Escherichia Coil DNA Polymerese III Holoenzyme. J Bio/Chem 1995, 270:29570-29577. [11]. Olthuis W, Luo J, Bergveld P: Characterization of Proteins by Means of Their Buffer Capacity, Measured with an ISFET-besed Coulometdc Sensor-actuator System. Biosens Bioe/ectron 1995, 9:743-752. Onnedjord P, Emnbus J, Marko-Varga G, Gorton L, Ortega F, Dominguez E: Tyrosinese Graphite-epoxy Based Composite Electrodes for Detection of Phenols. Biosens Bioelectron 1995, 10:607-620. Orr JT, Wikial K, Osteryoung J: Anodization of Copper Mlcroelectrodes in a Complexing Medium: Determination of Stability Constants of Products. Anal Chem 1995, 67:2714-2722. O'Shannessy DJ, Odonnell KC, Martin J, Brighamburke M: Detection and Quantitation of Hexa-histidine-tagged Recombinant Proteins on Western Blots and by a surface Plasmon Resonance Biosensor Technique. Anal Biochem 1995, 229:119-124. O'Shannessy DJ, Winzor DJ: interpretation of Deviations from Pseudo-first-order Kinetic Behavior in the Characterization of Ligand Binding by Biosensor Technology. Anal Biochem 1996, 236:275-283. Palmisano F, Centonze D, Ouinto M, Zambonin PG: A Microdialysis Fibre Based Sampler for Row Injection Analysis: Determination of L-lactate in Biofluids by an Electrochemically Synthesised Biiayer Membrane Based Biosensor. Biosens Bioe/ectron 1996, 11:419-426. Palmqvist E, Kriz CB, Khayyami M, Danielsson B, Larsson PO, Mosbach K, Kriz D: Development of a Simple Detector for Microbial Metabolism, Based on a Polypyrrole Dc Resistometdc Device. Biosens Bioelectron 1995, 9:551-556. Palmqvist E, Kriz CB, Svanberg K, Khayyami M, Kriz D: DC-resistometric Urea Sensitive Device Utilizing a conducting Polymer Film for the Gas-phase Detection of Ammonia. Biosens Bioelectron 1995, 10:283-288. Pan ST, Chung H, Arnold MA, Small GW: Near-infrared Spectroscopic Measurement of Physiological Glucose Levels in Variable Matrices of Protein and Tdglyceridas. Anal Chem 1996, 68:1124-1135. P~ndey PC, Aston RW, Weetall HH: Tetracyanoquinodimethsne Mediated Glucose Sensor Based on a self-assembling Alkanethiol/phospholipid Bilayer. Biosens Bioelectron 1995, 10:669-674. Pantano P, Walt DR: Analytical Applications of Optical Imaging Fibers. Anal Chem 1995, 67:A481-A487` Papkovsky DB, Ponomarev GV, Trettnak W, Oleary P: Phosphorescent Complexes of Porphydn Ketones: Optical Properties and Application to Oxygen Sensing. Anal Chem 1995, 67:4112-4117, Pariente F, Lorenzo E, Tobalina F, Abruna HD: Aldehyde Biosensor Based on the Determination of NADH Enzymatically Generated by Aldehyde Dehydrogenase. Anal Chem 1995, 67:3936-3944. Park JK, Ye I-U, K3m ST: Amperometric Biosensor for Determination of Ethanol Vapor. Biosens Bioelectron 1995, 10:587-594. Paulson SC, Okedund ND, White HS: Diffusion Currents in Concentrated Redox Solutions. Anal Chem 1996, 68:581-584. Perham RN: Structural Aspects of Biomolecular Recognition and Self-assembly. Biosens Bioelectron 1995, 9:753-760. Petty MC: Gas Sensing Using Thin Organic Films. Biosens Bioelectron 1995, 10: t 29-134. Pfeiffer D, Scheller P-~V,McNeil CJ, Schulmeister T: Cascade-like Exponential Substrata Amplification in Enzyme Sensors. Biosens Bioe/ectron 1995, 10:169-180.

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S u r f a c e p l a s m o n r e s o n a n c e s p e c t r o s c o p y and infrared s p e c t r o s c o p y , b i o s e n s o r s and flow-injection analysis

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Sch0tz S, Weissbecker B, Hummel HE: Biosensor for Voletiles Released by Damaged Plants. Biosens Bioelectron 1996, 11:427-434. Severs AH, Schasfoort RBM: Enhanced Surface Plasmon Resonance Inhibition Test (ESPRIT) Using Latex Particles. Biosens Bioelectron 1995, 8:365-370. Shaffer RE, Small GW, Amold MA: Genetic Algorithm-based Protocol for Coupling Digital Filtering and Partial Laast-squeres Regression: Application to the Near Infrared Analysis of Glucose in Biological Matrices. Anal Chem 1996, 68:2663-2675. Sharptess KS, Duewer DL: Population Distributions and Intralaborstory Reproducibility for Fat-soluble Vitamin Related Compounds in Human Serum. Anal Chem 1995, 67:4416-4422. Shepherd KM, Wynjones AP: An Evaluation of Methods for the Simultaneous Detection of Cryptosporidium Oocysts and Giardia Cysts from Water. Appl Environ Microbial 1996, 62:1317-1322. Shin MC, Kim HS: Electrochemical Characterization of Polypyrrole/glucose Oxidase Biosensor. Part 1. Influence of Enzyme Concentration on the Growth and Properties of the Film. Biosens Bioalectron 1996, 11:161-170. Shin MC, Kim HS: Electrochemical Characterization of Polypyrrole/glucose Oxidase Biosensor: Part II. Optimal Preparation Conditions for the Biosensor. Biosens Bioelectron 1996, 11:171. Shoham B, Migron Y, Riklin A, Willner I, Tartakovsky B: A Bilirubin Biosensor Based on a Multilayer Network Enzyme Electrode. Biosens Bioelectron 1995, 10:341-352. Shoham NG, Arad T, Rosinabersfeld R, Mashiah P, Gazit A, Yaniv A: Differential Display Assay end Analysis. Biotechniques 1996, 20:182. Shortreed M, Kopelman R, Kuhn M, Hcyland B: Fluorescent Fiber Optic Calcium Sensor for Physiological Measurements. Anal Chem 1996, 68:1414-1418. Siegel G, Walter A, Kauschmann A, Malmsten M, Buddecke E: Anionic Biopolymers as Blood Row Sensors. Biosens Bioelectron 1996, 11:281-294. Sigal GB, Bamdad C, Barberis A, Strominger J, Whitesides GM: A Self-assembled Monolaysr for the Binding end Study of Histidine Tagged Proteins by Surface Plasmon Resonance. Anal Chern 1996, 68:490-497. Silber A, Hampp N, Schuhmann W: Poly(mathylene Blue)-modified Thick-film Gold Electrodes for the Electrocataiytic Oxidation of NADH and Their Application in Glucose Biosensors. Biosens Bioelectron 1996, 11:215-224. Somsen GW, Hooijschuur EWJ, Gooijer C, Brinkman UAT, Velthorst NH, Visser T: Coupling of Reversed-phase Liquid Column Chromatography and Fourier Transform Infrared Spectrometry Using Postcolumn On-line Extraction and Solvent Elimination. Anal Chem 1996, 68:746-752. Sorochinskii W, Kurganov Bh Amperomatdc Biosensors with a Laminated Distribution of Enzymes in Their Coating. Steady-state Kinetics. Biosens Bioelectron 1996, 11:45-52. Sorochinsk~i W, Kurganov Bh Steady-state Kinetics of Cyclic Conversions of Substrata in Amperometdc Bienzyme Sensors. Biosens Bioelectron 1996, 11:225-238. Souse MDB, Bertazzoli R: Praconcentratlon and Voitammetdc Determination of Mercury(ti) at a chemically Modified Glassy Carbon Electrode. Anal Chem 1996, 68:1258-1261. Sreenivas G, Ang SS, Fritsch I, Brown WD, Gerhardt GA, Woodward DJ: Fabrication and Characterization of Sputtered-carbon Microelectrode Arrays. Anal Chem 1996, 68:1858-1864. Srikantha T, Klapach A, Lorenz WW, Tsai LK, Laughlin LA, Gorman JA, Soil DR: The Sea Pansy Renilla Reniformis Luciferase Serves as a Sensitive Bioluminescent Reporter for Differential Gene Expression in Candida Albicans. J Bacteriol 1996, 178:121-129. Stein 1", Gerisch G: Oriented Binding of a Lipid-anchored Cell Adhesion Protein Onto a Biosensor Surface Using Hydrophobic Immobilization and Photoactive CrosslinJ(in9. Anal Biochem 1996, 237:252-259. Stigter ECA, Dejong GAH, Jongejan JA, Duine JA, Vandedugt JP, Somers WAC: Electron Transfer Between a quinohemopretein Alcohol Dehydrogenase and an Electrode Via a Redox Polymer Network. Enzyme MJcrob Techno/1996, 18:489-494. Strehlitz B, Grundig B, Schumacher W, Kroneck PMH, Vorlop KD, Kotte H: A Nitrite Sensor Based on a Highly Sensitive Nitrite Reductasa Mediator-coupled Amperometric Detection. Anal Chem 1996, 68:807-816. Striebel C. Brecht A, Gauglitz G: Characterization of Biomembrenes by Spectral Ellipsometry, Surface


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Analytical biotechnology Microscopy

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Genome mapping, hybridization techniques and immobilization Related reviews: Optical mapping approaches to molecular genomics (pp 70-74); RecA-mediated Achilles' heel cleavage (pp 75-81)t Akopian AN, Wood JN: Pedpherel Nervous System-specific Genes Identified by Subtractive CDNA Cloning. J Biol Chem 1995, 270:21264-21270. Albertin G, Rossi GP, Majone F, Tiso N, Matters A, Danieli GA, PessinaAC, Palu G: Rne Mapping of the Human Endothelin-converting Enzyme Gene by Ruoreacent in Situ Hybridization and Rediation Hybdds. Biochem Biophys Res Commun 1996, 221:682-687, Alkorta I, Garbisu C, Llama MJ, Serfs JL: Immobilization of Pectin Lyesefrom Penictlllum Itslicum by Covalent Binding to Nylon. Enzyme Microb Technol 1996, 10:141-146. Alters DL: Critical Issues in Applications of Self-assembled Monelayers.Biosens Bioelectron 1995, 10:771-784. Asselbergs FAM, Widmer R: Use of the Eecherichia Coil Chromosomal DHFR Gone as Selection Marker in Mammalian Cells. J Biotechnol 1995, 43:133-138. Baldocchi RA, Tartaglia KE, Bryda EC, RahertyL: Recovery of Probes Unked to the Jcpk Locus on Mouse Chromosome 10 by the use of an Improved Representstionel Difference Analysis Technique.. Genomics 1996, 33:193-198. Bevedoo HB, LeconiatM, Wljsman J, Lillington DM, Bernard O, Deklein A, Vsnwering E, Welborn J, Young BD; Hagemeijer A, Berger R: Breakpoint Heterogeneity in T(10;11) Transloca6on in AML-M4/M5 Resulting in Fusion of AFrO and MLL is Resolved by Ruorescent in Situ Hybridization Analysis. Cancer Res 1995, 58:4220-4224. Bier FF, ScheUerFW: Label-free Observation of DNA-hybddisation and Endonuclease Activity on a Wave Guide Surface Using a GraUng Coupler. Biosens Bioelectran 1996, 11:669-674. Bloch CA, Rode CK, Obreque VH, Mahillon J: Purification of Eechadchls Coil Chromosomal Segments Without Cloning• Biochem Biophys Res Commun 1996, 223:104-111. Bonnington LS, Henderson W, Petach HH: P(CH2OH)3-polyetheramine-dedved Polymedc Rims for Enzyme Immobilization. Enzyme Microb Techno/1g95, 17:746-750. Borodovsky M, Mclninch ]D, Koonin EV, Rudd KE, Medigue C, Danchin A: Detection of New Genes in a Bacterial Genome Using Markov Models for Three Gone Classes. Nucleic Acids Res 1995, 23:3554-3562. Brayward P, Menninger.I, LiamanJ, Desai 1", MokadyN, Banks A, Ward DC: Integration of the Cytogeneti¢, Genetic, and Physical Maps of the Human Genome by FISH Mapping of CEPH YAC Clones. Genomics 1996, 32:1-14. Brunk CF, Avanissaghajani E, Brunk CA: A Computer Analysis of Primer and Probe Hybridization


Analytical biotechnology G e n o m e

mapping, hybridization t e c h n i q u e s a n d immobilization

Potential with Bacterial Small-subunit RRNA Sequences. Appl Environ Microbiol 1996, 62:872-879. Buchanan AC, Britt PF, Thomas KB, Biggs CA: Evidence for a Radical Relay Mechanism Dunng Reaction of Surface-immobilized Molecules. J Am Chem Soc 1996, 118:2182-2189. Burset M, Guigo R: Evaluation of Gene Structure Prediction Programs. Ganomics 1996, 34:353-367. Caetanoanolles G, Gresshoff PM: Generation of Sequence Signatures from DNA Amplification Rngerpdnts with Mini-hairpin and Microsetellite Primers. Biotechniques 1996, 20:1044. Cai L, Taylor JF, Wing RA, Gallagher DS, Woo SS, Davis SK: Construction and Charectadzation of a Bovine Bacterial Artificial Chromosome Library. Genomics 1995, 29:413-425. Cai W, Aburatani H, Housman D, Wang Y, Schwartz • . DC: Ordered Restriction Endonuclsase Maps of Yeast Artificial Chromosomes Created by Optical Mapping on Surfaces. Proc Natl Acad Sci USA 1995, 92:5164-5168. [12]. Cao SG, Yang H, Me L, Guo SQ: Enhancing Enzymatic Properties by the Immobilization Method. Appl Biochem Biotechnol 1996, 50:7-14. Carlsson C, Jonsson M, Norden B, Dulay MT, Zare RN, Noolandi J, Nielsen PE, Tsui LC, Zielenski J: Screening for Genetic Mutations [Letter]. Nature 1996, 380:207. Cascon A, Anguita J, Hemanz C, Sanchez M, Fernandez M, Nsharro G: Identification of Aeromones Hydrophila Hybridization Group 1 by PCR Assays. Appl Environ Microbiol 1996, 62:1167-1170. Chariot A, Cestronovo V: DateclJon of HOXA1 Expression in Human Breast Cancer. Biochem Biophys Res Commun 1996, 222:292-297. Chatelier RC, Gengenbach TR, Griesser HI, BrJghamburke M, O'Shannessy DJ: A General Method to Recondition and Reuse BIAcoro Sensor Chips Fouled with CovalenUy Immobilized Proteln/peptide" Anal Biochem 1995, 229:112-11B. Chaudhury MK: Self-assembled Monolayers on Polymer Surfaces. Biosens Bioelectron 1995, 10:785-788. Chang CHK, Hui STY: Immobilized Glucose-6-phosphate Dehydrogenase as a Substrata for Solubilizad Epidermal Growth Factor Receptor Tyrosina Kinese - a Convenient Microtiter Plats Assay System. Appl Biochem Biotechnol 1996, 56:155-16?. Chenliu LW, Huang BC, Scald JM, Hall BK, Sims KR, Davis LM, Siebert PD, Hoder JC: Selection of Hybdds by Affinity capture (SHAC): • Method for the Generation of CDNAs Enriched in Sequences from a Specific Chromosome Region. Genomics 1995, 30:388-392. Char ML, Boys GS, Moore DH, Small F_J,Carroll PR, Pin SS, Epstein JI, Isaacs WB, Jansen RH: Genetic .~lteratlons in Untreated Metastases and Androgen-independent Prostate cancer Detected by Comparative Genomlc Hybridization and Allelotyping. Cancer Res 1996. 56:3091-3102. Cifarelli RA, Gallitelli M, Cellini F: Random Amplified Hybridization Microsatellitss (RAHM): Isolation of a New Class of Microsatelllte-containing DNA Clones. Nucleic Acids Res 1995, 23:3802-3803. Clark P: Cell Behaviour on Micropatterned Surfaces. Biosens Bioelectron 1995, 9:657-662. Cochrane FC, Petach HH, Henderson W: Application of Tds(hydroxymethyl)phosphine as s Coupling Agent for Alcohol Dehydrogenase Immobilization. Enzyme Microb Technol 1996, 18:373-378. Couto MMB, Eijsma B, Hofstra H, Huisintveld JHJ, Vandervossen JMBM: Evaluation of Molecular Typing Techniques to Assign Genetic Diversity Among Seccharomyces Cerevisiae Strains. App/EnvJrot3 Microbic/1996, 62:41-46. Denizli A, Rad A'(, Piskin E: Protein a immobilized Polyhydroxyathylmathacrylate Beads for Affinity Sorption of Human Immunoglobulin G. J Chromatogr B Biomed App11995, 668:13-19. Devlin B, Risch N: A Comparison of Linkage Disequilibrium Measures for Fine-scale Mapping. Genomics 1995, 29:311-322. Diatchenko L, Lau YFC, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED, Siebert PD: Suppression Subtractive Hybridization: a Method for Generating Differentially Regulated or Tisaue-specific CDNA Probes and Libraries. Proc Natl Acad Sci USA 1996, 93:6025-6030. Dietrich C, Boscheinen O, Schad KD, Schmitt L, Tampa R: Functional Immobilization of a DNA-binding Protein at a Membrane Interface Via Histidine Tag and Synthetic Chelator Lipids. Biochemistry 1996, 35:1100-1105. Doretti L, Ferrara D, Gattolin P, Lora S: Covatantiy Immobilized Enzymes on Biocompatible Polymers for Amperometdc Sensor Applications. Biosens Bioelectron 1996, 11:365-374.

Drach J, Schuster J, Nowotny H, Angeder J, Rosenthal F, F~egl M, Rothermundt C, Gsur A, Jager U, Heinz R, Lechner K, Ludwig H, Huber H: Multiple Myetoms: High Incidence of Chromosomal Aneuploidy as Detected by Interphese Ruorescence in Situ Hybridization. Cancer Res 1995, 55:3654-3859. Elender G, Kuhner M, Sackmann E: Functionalisetion of Si/SiO2 and Glass Surfaces with Uifzathln Dextran Films and Deposition of Lipid Bilayers. Biosena Bioelectron 1996, 11:565-576. EIkahloun AG, Meltzer PS, Guan XY, McNinch JS, Trent JM, Dejong PJ: Isolation of a Cosmid Sublibrary for a region of Chromosome 12 Frequently Amplified in Human Cancers Using a complex Chromosome Microdissestioo Probe, Genomics 1996, 31:343-347. Ermacora MR, Ledman DW, Fox RO: Mapping the Structure of a Non-native State of Staphylococcal Nuclease" Nature 1996, 3:59-66. Faranda S, Frattini A, Zucchi I, Patrosso C, Milanesi L, Montagna C, Vezzoni P: Characterization and Roe Localization of Two New Genes in Xq28 Using the Genomic Sequence F.ST Database Screening Approach. Genomics 1996, 34:323-327. Farmsc ML, Leong SA: Genetic and Physical Mapping of • Telomeros in the Rice Blast Fungus, Msgnaporthe Grisee" Genetics 1995, 140:479-492. [431]. Ferreira MASV, Tooley PVV,Hatziloukea E, Castro C, Schaad NW: Isolation of a Species-specific Mitochonddsl DNA Sequence for Identification of Tillatie Indica, the Kernel Bunt of Wheat Fungus. Appl Environ Microbiol 1996, 62:87-93. Ferrin LJ: Manipulating and Mapping DNA with • RecA-assisted Restriction Endonuclease (RARE) Cleavage. In Genetic Engineering, Principles end Methods, Vo117. Edited by Setlow JK. New York: Plenum Press; 1995:21-30. [451]Fliss I, Stlaurent M, Emond E, Simard RE, Lemieux R, Ettriki A, Pandian S: Anti-DNA.RNA Antibodies: an Efficient Tool for Non-isotopic Detection of Listeria Species Through a Liquid Phase Hybridization Assay. Appl Microbiol Biotechnol 1995, 43:717-724. Florijn R, Bonden L, Vrolljk H, Wiegant J, Vaandrager JW, • Baas F, Dunnen J, Tanke H, Van Ommen GJ, Rasp AK: High Resolution DNA Fiber-FiSH for Genomic DNA Mapping and Colour Bar-coding of Large Genes. Hum Mol Genet 1995, 4:831-836. [23]Franse D, Lange U, Hartrneier W: Immobilization of Candida Rugosa Lipese in Lyotropic Liquid Crystals and Some Properties of the Immobilized Enzyme. Biotechnol Lett 1996, 18:293-298. Fray BL, Jordan CE, Komguth S, Corn RM: Control of the Specific Adsorption of Proteins Onto Cold Surfaces with Poly(L-lysine) Monolayers. Anal Chem 1995, 67:4452-4457. Gajardo R, Bouchriti N, Pinto RM, Bosch A: Genotyping of Rotaviruses Isolated from Sewage. Appl Environ Microbiol 1995, 61:3460-3462. Gastier JM, Brody T, Pulido JC, Businga T, Sunden S, Hu XT, Maitra S, Buetow KH, Murray JC, Sheffield VC, Boguski M, Duyk GM, Hudson TJ: Development of a Screening Set for New (CAG/CTG)(n) Dynamic Mutations. Genomics 1996, 32:75-85. Gattoni M, Boffi A, Sarti P, Chiancone E: Stability of the Heme-globin Linkage in Alpha Beta Dimors and Isolated Chains of Human Hemoglobin - a Study of the Heme Transfer Reaction from the Immobilized Proteins to Albumin. J Biol Chem 1996, 271:10130-10136. Ge SJ, Zhang LX: The Immobilized Porcine Pancreatic Exopeptideses and Its Application in Casein Hydrolysates Debittering. Appl Biochem Biotechnol 1996, 59:159-165. Gi{bert BA, Rando RR: Modular Design of Biotlnytatad Photoafflnity Probes: Synthesis and Utilization of a biotinyleted Pepststin Photoprobe" J Am Chem Soc 1995, 117:8061-8066. Gingnch JC, Boehrer DM, Games JA, Johnson W, Won9 BS, Bergrnann A, Eveleth GG, Langlois RG, Carrano AV: Construction and Characterization of Human Chromosome 2-specific Cosmid, Fosmid, and PAC Clone Libraries. Genomics 1996, 32:65-74. Grabski AC, Coleman PL, Dr6na GJ, Burgess RR: Immobilization of Manganese Peroxidase from Lantinula Edodes on Azlactone-functional Polymers and Generation of Mn3+ by the Enzyme-polymer Complex. Appl Biochem Biotechnol 1995, 55:55-73. Gusc XY, Xu J, Andck SL, Zhang HE, Trent JM, Meltzer PS: Hybrid Selection of Tronscdbed Sequences from Microdissected DNA: Isolation of Genes Within an Amplified Region At 20ql 1-ql 3.2 in Breast Cancer. Cancer Res 1996, 56:3446-3450. Guardiola J, Iborra JL, Rodenas L, Canovas M: Biotransformation from Geraniol to Nerol by Immobilized Grapevine Cells (V-vinitera). Appl B~ochemBiotechnol 1996, 58:169-180. Gussoni E, Wang YM, Fraefel C, Miller RG, Blau HM, Geller AI, Kunkel LM: A Method to Codetect

Introduced Genes end Their Products in Gene Therapy Protocols. Nat Biotechnol 1996, 14:1012-1016. Hale JE: Irreversible, Odented Immobilization of Antibodies to Cobalt-iminodiacatate Resin for use as Immunoaffinlty Media. Anal Biochem 1995, 231:46-49. Heurguehamard V, More L, Buckingham RH: Rapid and Precise Chromosomal Mapping of Genomic Probes in Escherichia Coil Using the Digital Physical Map. Nucleic Acids Res 1995, 23:2801-2602. Hobson NS, Tothill I, Turner APF: Microbial Detection [review]. Biosans Bioelectron 1996, 11:455-478. ladonato SP, Gnirke A: RARE-desvage Analysis of YACs. • in YAC Protocols. Methods in Molecular Biology, Vol 54. Edited by Merkie A. Totowe, NJ: Humans Press; 1996:75-85. [371]Janolino VG, Fontecha J, Swaisgood HE: A Spectrophotometdc Assay for Biotin-binding Sites of Immobilized Avidin. Appl Biochem Biotechnol 1996, 56:1-7. Janssen P, Coopman R, Huys G, Swings J, Bleeker . M, Vos P, Zabeau M, Kersters K: Evaluation of the DNA Fingerprinting Method AFLP as a New Tool in Bacterial Taxonomy. Microbiology 1996, 142:1881-1893. Joulin V, Richardfoy H: A New Approach to Isolate Genomic Control Regions - Application to the GATA Transcription Factor Family. Eur J Biochem t995, 232:620-626. Ju YH, Huang FC: Lipase Immobilized on Hydrophobic Microporous Polypropylene for the Hydrolysis of Palm Kernel Olein. Appl Biochem Biotechnol 1995, 55:17-26. Kainu T, Kononen J, Johansson O, Olsson H, Borg A, Isola J: Detection of Germline BRCA1 Mutations in Breast Cancer Patients by Quantitative Messenger RNA in Situ Hybddlsatton. Cancer Res 1996, 56:2912-2915. Kalkner KM, Janson ET, Nilsson S, Carlsson S, Oberg K, Westlin JE: Somatostetin Receptor Scintigraphy in Patients with Carcinoid Tumors: Comparison Between Radioligand Uptake and Tumor Markers. Cancer Res 1995, 55 (suppl):S5801-$5804. Kallury KMR, Brennan JD, Krull UJ: Depth Profiling of Functionalized Silane Films on Quartz and Silicon Substrates and of Urease Immobilised on Such Films by Angle-resolved X-ray Photoelectron Spectroscopy. Anal Chem 1995, 67:2625-2534. Kim JH. Puder M, Soberman RJ: Joining of DNA Fragments by Repasted Cycles of Denaturation, Annealing end Extension. Biotechnlquea1996, 20:954-955. Klockars T, Savukoski M, Isosomppi J, Lean M, Jarvela I, Petrukhin K, Pslotie A, Peltonen L: Efficient Construction of a Physical Map by Rber-fish of the CLN5 Region: Refined Assignment and Long-range Contig Covering the Cdtical Region on 13¢122. Genomics 1996, 35:71-78. Konishi H, Steinbach G, Terry NHA, Lee JJ, Dubin JA, Glober GA, Fujita K, Spaulding D, Cass L, Hittelman WN: Hietone H3 Messenger RNA in Situ Hybridization Correlates with in Vlvo Bromodeoxyuddine Labeling of S-phase Cells in Rat Colonic Epithelium. Cancer Res 1996, 56:434-437. Kumar S, Kimberling WJ, Lanyi A, Sumegi J, Pinnt J, Ing P, Tinley S, Marres HAM, Cramers CWRJ: Narrowing the Genetic Interval and Yeast Artificial Chromosome Map in the Branchio-oto-renal Region on Chromosome 8¢1.Genomics 1996, 31:71-79. Kumke MU, Li G, McGown LB, Walker GT, Linn CP: Hybridization of Fluorescein-labeled DNA Oligomers Detected by Ruorescence Anisotropy with Protein Binding EnhancemenL Anal Chem 1995, 67:3945-3951. Kuo WS, Chak KF: Identification of Novel Cry-type Genes from Bacillus Thudngiensis Strains on the Basis of Restriction Fragment Length Polymorphism of the PCR-amplified DNA. Appl Enwron Microbio/ 1996, 62:1369-137?. Kwok PY, Dang Q, Zakeri H, Taylor SL, Nickerson DA: Increasing the Information Content of STS-based Genome Maps: Identifying Polymorphisms in Mapped STSs. Genomics 1996, 31:123-126. Labanca F, Krishnan BR, Chaplin DD, Berg DE, Berg CM: Restriction Map of a 35-kb HLA Fragment Constructed by Nested Deletion 'drop-out' Mapping. Gene 1995, 164:335-339. Lee JW, Lee ], Greenbaum E: Pletinization: a Novel Technique to Anchor Photosystem I Reaction Centres Onto a Metal Surface at Biological Temperature and PH. Biosens Bioelectron 1996, 11:375-388. Lets SS, Kulkarni AG, Kulkarni PR: Immobilization of Fungal Spores on Synthetic Polymers. Biotechnol Lett 1996, 18:515-5~)0.

Analytical biotechnology Genome mapping, hybridization techniques and immobilization

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Analytical biotechnology Chromatography and electrophoresis

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C h r o m a t o g r a p h y a n d electrophoresis

1 39

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Analytical biotechnology Oligonucleotides,antisenseand ribozymes • Peptide librariesand phage display

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Comprehensive Two-dimensional Gas Chromatography. Anal Chem 1996, 68:1486-1492. Vonheeren F, Verpoorte E, Manz A, Thormann W: Micellar Electmkinetic Chromatography Separations and Analyses of Biological Samples on a Cyclic Planar Micrestructure. Anal Chem 1996, 68:2044-2053. Walker KL, Chiu RW, Monnig CA, Wilkins CL: Off-line Coupling of Capillary Bectrophoresis and Metdx-asslated Laser Desorption Ionization Time-of-fllght Mass Spectrometry. Anal Chem 1995, E7:4197-4204. Walker PA, Kowalchyk WK, Morris MD: On-line Ramen Spectroscopy of Ribonucleotides Preconcentrated by Capillary Isotechophoresis. Anal Chem 1995, 67:4255-4260. Wang J, Warner IM: Combined Polymerized Chirel Micelle and Gamma-cyclodextdn for Chirel Separation in Capillary Bectrophoresis. J ChromatogrA 1995, 711:297-304. Watts HJ, Yeung D, Perkes H: Real-time Detection and Quantification of DNA Hybddization by an Optical Biosensor. Anal Chem 1995, 67:4283-4289. Williams DC, Soper SA: URrasensitive Neer-IR Ruorescence Detection for Capillary Gel Electmphoresis and DNA Sequencing Applications. Anal Chem 1995, 67:3427-3432. Williams SJ, Schwer C, K~shnarao ASM, Heid C, Karger BL, Williams PM: Quantitative Competitive Polymersse Chain Reaction: Analysis of Amplified Products of the HIV-1 Gag Gene by Capillary EleCtrophoresis with Laser-induced Fluorescence Detestion. Anal Biochem 1996, 236:146-152. Woolley AT, Mathies RA: Ultra-high Speed DNA Sequencing Using Capillary Bectrophoresis Chips. Anal Chem 1995, 67:3676-3680. Wu C, Quesada MA, Schneider DK, Fadnato R, Studier • FW, Chu B: Polyacrylamide Solutions for DNA Sequendng by Capillary Electrophoresis: Mesh Sizes, Separation and Dispersion. Electrophoresis 1996, 17:1103-1109. [39]. Wu N. Webb L, Peck TL, Sweedler JV: On-line NMR Detection of Amino Acids end Peptides in Micmbore LC. Anal Chem 1995, 67:3101-3107. Yamaki S, Isobe T, Okuyama 1", Shinoda T: High-performance Liquid Chromatography of Peptides on a microspherical Carbon Column. J Chromatogr A 1996, 729:143-153. Ying Q, Wu G, Chu B, Farinato R, Jackson L: Laser Upht • Scattering of Poly(acrylamide) in 1 M NaCI Aqueous Solution. Macromolecules 1996, 29:4646-4654. [43]. Young KD: A Simple Gel Eleetrophoretic Method for Analyzing the Muropeptide Composition of Bacterial Peptidoglycan. J Bacterio/1996, 178:3962-3966. Zschadou M, Hearn MTW: Application of Immobilized Metal Ion Chelate Complexes as Pseudocation Exchange Adsorbents for Protein Separation. Biochemistry 1996, 35:202-211. Zhang J, Fang Y, Hou JY, Ren HJ, Jiang R, Roos P, • DovichiNJ: Use of Non-cross-linked Polyscrylamide for Four-color DNA Sequencing by Capillary Electrophoresla Separation of Fragments Up to 640 Bases in Length in Two Hours. Anal Chem 1995, 87:4589-4593. [9]. Zhong M, Lunte SM: Integrated On-capillary Bectrnchemical Detector for Capillary Electrephoresis. Anal Chem 1996, 68:2468-2493. Zhong M, Zhou JX, Lunte SM, Zhao G, Giolando DM, Kirchhoff JR: Dual-electrode Detection for Capillary Electrophoresis Electrochemistry. Anal Chem 1996, 68:203-207.

Oligonucleotides, antisense and ribozymes Delumleywoodyear 1", Campbell CN, Heller A: Direct Enzyme-amplified Electrical RecogniUon of a 30-bese Model Oligonuclentide. J Am Chem Soc 1996, t 18:5504-5505. Drolet DW, Moonmcdermott L, Romig TS: An Enzyme-linked Oligonucleotide Assay. Nat Biotechno11996, 14:1021-1025. Frank P, Albert S, Cazenave C, Touline JJ: Pudtication and Charectedzat~on of Human Ribonucleese HIL Nucleic Acids Res 1994, 22:5247-5254. Haynes CA, Sherwood CS, Turner RFB: Charactedzetion of an Oligonucleotide-blnding Ruorescent Ligand for Application in Affinity Purification of DsDNA. Biotechnol Bioeng 1995, 48:25-35. Hung WC, Huang JS, Chuang LY: Antisense Oligodeoxynucleotides Targeted Against Different Regions of CyclinD1 MRNA May Exert Different Inhibitory Effects on Cell Growth and Gene E~pression. Biochem BJophysRes Commun 1996, 720 71 rJ-?23.

Ivanov IG, Abouhaldar MG: Thermal Stability of Oligodeoxynudeotide Duplexes Bound to Nitrocellulose Filters. Anal Biochem 1995, 232:249-251. Manz W, Amann R, Ludwig W, Vancanneyt M, Schleifer KH: Application of a Suite of 15S RRNA-spesific Oligonucleotide Probes Designed to Investigate Bacteria of the Phylum Cytophaga-flavobacter-bactaroides in the Natural EnvironmenL Microbiology 1996, 142:1097-1106. Maruyama IN, Rakow TL, Maruyams HI: cRACI=' a Simple Method for Identification of the 5" End of MRNAs. NucJeic Acids Res 1995, 23:3796-3797. Pierrou S, Enerback S, Cadseon P: Selection of High-affinity Binding Sites for Sequence-spedfic. DNA Binding Proteins from Random Sequence Oligonudeotides. AnN Biochem 1995, 229:99-105. Yershov G, Barsky V, Belgovskiy A, KirUlov E, Kreindlin E, Ivanov I, ParinovS, Guschin D, Drobishev A, Dubiley S, MirzabekovA: DNA Analysis and Diagnostics on OIIgonucleotide Microchips. Proc Nat/Acad Sci USA 1996, 93:4913-4918.

Peptide libraries and phage display Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA: A "double Adaptor" Method for Improved Shotgun Library Construction. Anal Binchem 1996, 236:107-113. Averboukh L, Dougies SA. Zhao S, Lowe K, Maher ,l, Pardee AB: Better Gel Resolution and Longer CDNAs Increase the Precision of DifferenUal Display. Biotechniques1996, 20:918-921. Boutin JA, Hennig P, Lambert PH, Bertin S, Petit L, Mahieu JP, Serkiz B, Volland JP, Fauchere JL: Comblcatodel Peptide Ubredes: Robotic Synthesis and Analysis by Nuclear Magnetic Resonance, Mass Spectrometry, Tandem Mass Spectrometry, and Nigh-performance Capillary Electrophorasls Techniques. Anal Biochem 1996, 234:126-141. Brummei CL, Vickerman,lC, Can" SA, Hemling ME, Robells GD, Johnson W, :Weinstock ,l, Gaitanopoulos D, Benkovic S,l, Winograd N: Evaluation of Mass Spectrometric Methods Applicable to the Direct Analysis of Non-baptide Bead-bound Combinatorial Ubrades. Anal Chem 1996, 68:237-242. Burritt JB, Bond CW, Doss KW, Jesahis A~I: Rlamentous Phage Display of Oligopeptide Libraries. Anal Biochem 1996, 238:1-13. Chen DH, Johnson AF, Severin ,lM, Rank DR, Smith LM, G uiffoyle RA: M13-102: a Vector for Facilitating Construction and Improving Quality of M13 Shotgun Ubraries. Gene 1996, 172:53-57. Chen JJW, Peck K: Non-radioisotopic Differential Display Method to Directly Visualize and Amplify Differential Bands on Nylon Membrane. Nucleic Acids Res 1996, 24:793-794. Cheng X, Kay BK, ,luliano RL: Identification of a Biologically Significant DNA-binding Peptide Motif by use of a Random Phage Display Library. Gene 1996, 171:1-8. Colas P, Cohen B, .lessen T, Grishina I, Mccoy ,l. Brent R: Genetic Selection of Peptlde Aptemera that Recognize and Inhibit Cyclin-dependent Kinase 2. Nature 1996, 380:548-550. Dekruif J, Logtenber9 T: Leucine Zipper Dimedzed Bivalent and Bispecific ScFv Antibodies from a semi-synthetic Antibody Phage Display Library. J Bio/Chem 1996, 271 :?630-7634. Dennis MS, Herz~a A, Lazarus RA: Potent and Selective Kunitz Domain Inhibltora of Plasma Kanikrein Designed by Phage Display. J Biol Chem 1995, 270:25411-25417. Diatchenko L, Lau YFC, Campbell AP, C~enchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurekaya N, Sverdlov ED, Siebert PO: Suppression Subtractive Hybridization: a Method for Generating Differentially Regulated or Tissue-specific CDNA Probes and Ubrades. Proc Nat/Acad Sci USA 1996, 93:6025-6030. Edwards KJ, Barker JHA, DaJy A, Jones C, Karp A: Microsetellito Ubrades Endched for Several Microsetellito Sequences in Plants. Biotechniques 1996. 20:758. Evans DM, Williams KP, McGuinness B, Tart G, Regnier F, Afeyan N, Jindsl S: Affinity-baaed Screening of Combinatorial Ubrades Using Automated, Sedel-column Chromatography. Nat Biotechnol 1996, 14:504-507. Fang R, Qi ,l, Lu ZB, Zhou H, Li W, Shen JC: Selection of Trypsin Inhibitors in Phage Peptide Library. Biochem Biophys Res Commun 1996, 220:53-66. Giebel LB, Cass RT, Milligan DL, Young DC, Arze R, Johnson CR: Screening of Cyclic Peptide Phage Libraries Identifies Ligands that Bind

Analytical biotechnology Immunotechniques 141

Streptevidin with High Affinities. Biochemistry 1995. 34:15430-15435. Gui J, Moyana T, Malcolm B, Xiang J: Idenl~fication of • Dscapeptide with the Binding Reactivity for Tumor-associated TAG72 Antigen from a Phage Displayed Library. Proteins 1996, 24:352-358. Gui J, Moyana 1", Xiang J: Selncfion of a peptide with Affinity for the Tumor-assodated TAG72 Antigen from a phage-displayed Ubrary. Biochem Biophys Res Commun 1996, 218:414-419. Hodits RA, Nimpf J, Pfistermueller DM, Hiesberger T, Schneider WJ, Vaughan TJ, Johnson KS, Haumer M, Kuechler E, Winter G, Bless D: An Antibody Fragment from a Phage Display Library Competes for Ugend Binding to the Low Density Upoproteln Receptor Family and Inhibits Rhinevims Infection. J Biol Chem 1995, 270:24078-24085. Ikonomov OC, Jacob MH: Differential Display Protocol with Selected Primers that Preferentially Isolates MRNAn of Moderate- to Low-abundance in • Microscopic System. Bioteohniques1996, 20:1030. InDue S, Kiyame R, Oishi M: Construction of Highly Extensive Polymorphic DNA Ubrades by In-gel Competitive Reaesoclation Procedure. Genomics 1996, 31:271-276. Johansen LK, Albrechtsen B, Andersen HW, Engberg J: pFaba0: a New, Efficient Vector for Expression of Antibody Feb Fragments Displayed on Phage. Protein Eng 1995, 8:1063-1067. Johnson SW, I_issy NA, Miller PD, Testa JR, Ozols RF, Hamilton TC: Identification of Zinc Rnger MRNAs Using Domain-specific Differential Display. Anal Biochem 1996, 236:348-352. Katz BA: Binding to Protein Targets of Peptidic Leads Discovered by Phage Display: Crystal Structures of Streptavidin-bound Linear and Cyclic Peptide Ugends Containing the HPG Sequence. Biochemistry 1995, 34:15421 - 15429. Krook M, Lindbladh C, Bimbaum S, Naess H, Edksen JA, Mosbach K: Selection of Peptides with Surface Affinity for Alpha-chymotrypsin Using a Phage Display Ubrary. J ChromatogrA 1995, 711:119-128. Lang IM, Barbss CP, Schleef RR: Recombinant Rabbit Feb with Binding Activity to TyPe-I I~esminogen Activator Inhibitor Derived from a Phage-display Library Against Human Npha-granules. Gone 1996, 172:295-298. Lavargnemazeau I=, Maftah A, Cenatiempo Y, Julien R: Unear Correlation Between Bacterial Overexpression of Recombinant Peptides and Cell Light Scatter. Appl Environ Microbiol 1996, 52:3042-3046. Little M, Breitling F, Dubel S, Fuchs P, Braunagel M: Human Antibody Ubranes in Escherichia Coll. J Biotechno/1995, 41 :I 87-195. McNally AJ, Mattsson L, Jordan F: A Ubrary of Monoclonel Antibodies to Escherichia Coil K-12 Pyruvata Dehydrogenase Complex - Competitive Epitope Mapping Studies. J Biol Chem 1995, 270:19744-1 g751, McNaHy AJ, Mortar K, Jordan F: A Library of Monocionel Antibodies to Esoherichla COIl K-12 Pyruvato Dehydrogenase Complex - a Biochemical Anelysis and Their Ability to Inhibit the Enzyme Complex. J Biol Chem 1995, 270:19736-19743. Muller K, Gombert FO, Manning U, Grossmuller F, Graft P, Zaagel H, Zuber IF, Freular F, Tschopp C, Baumann G: Rapid identification of Phosphopeptide Li9ands for SH2 Domains -Screening of Peptide Libraries by Fluorescence-activated Bead Sorting. J Biol Chem 1996, 271:16500-16505. Perezpaya E, Hou9hlen RA, Blondelle SE: Funcfionelized Protein-like Structures from Contormationelly Defined Synthetic Combinatorial Ubrades. J Biol Chem 1996, 271:4120-4126. Ruizrnartinez MC, Carrilho E, Berka J, Kieleczawa J, Miller AW, Forest F:, Carson S, Karger BL: DNA Sequencing by Capillary Elestrophorasis Using Short Oli9onudeotide Primer Ubraries, Biotechniques 1996, 20:1058. Schumanher TNM, Mayr LM, Minor DL, Milhollan MA, Burgess MW, Kim PS: Identification of D-peptide Ugands Through Mirror-image Phage Display. Science 1996, 271:1854-1857. Shoham NG, Areal T, Rosinabarsfefd R, Mashiah P, Gazit A, Yaniv A: Differential Display Assay and Analysis. Biotechniques 1996, 20:182. Sidhu SS, Borgford TJ: Selection of Streptomyces Griseus Protease B Mutants with Desired Alterations in Primary Specificity Using • Library Screen|ng Sbategy. J Mol Biot 1996, 257:233-245. Sodedind E, Vergeles M, Borrebaeck CAK: Domain Ubraries: Synthetic Diversity for De Novo Design of Antibody V-regions. Gene 1995, 160:269-272. Sompayrac L Jane S, Burn TC, Tenon DG, Danna KJ: Overcoming Limitations of the MRNA Differential

Display Technique. Nucleic Acids Res 1995, 23:4?38-4739. Steinberger P, Kraft D, Valenta R: Construction of a Combinatorial IgE Library ~rom an Allergic Patient - isolation and Characterization of Human IgE labs with Specificity for the Major Timothy Grass Pollen Allergen, Phi P 5. J Biol Chem 1996, 271:10967-10972. Takenaka IM, Leung SM, McAndrew SJ, Brown JP, Hightowar LE: HecYO-bindin9 Pepfides Selected from a Phage Display Peptide Library that Resemble Orgeeellar Targeting Sequences. J Biol Chem 1995, 270:19839-t 9844. Tegge W, Frank R, Hofmann F, Dostmann WRG: Determination of Cyclic Nucleotide-dependent Protein Kinase Substrata Specificity by the use of Peptide Ubredes on Cellulose Paper. Biochemistry 1995, 34:10569-10577. Tsurushita N, Fu H, Warren C: Phage Display Vectors for in Vivo Recombination of Immunoglobulin Heavy and Light Chain Genes to Make Large Combinatorial Ubraries. Gone 1996, 172:59-63, Uebel S, Meyer TH, Kreas W, Kienle S, Jung G, Wiesmuller KH, Tempe R: Requirements for Peptide Binding to the Human Transporter Associated with Antigen Processing Revealed by Pepfide Scans and Complex Peptide Ubraries. J B/o/Chem 1995, 270:18512-16516. Vanmeijer M, Roelofs Y, Neels J, Horrevoets AJG, Van~onneveld AJ, Pannekoek H: Selective Screening of • large Phage Display Library of Plasminogen Activator Inhibitor 1 Mutants to Localize Interaction Sites with Either Thrombin or the Variable Region 1 of Tissue-type Plasminogen Activator. )Biot Chem 1996, 271:7423-7426. Vaughan TJ, Williams AJ, Pritchard K, Osbourn JK, Pope AR, Earnshaw JC, McCefferty J, Hodits RA, Wilton J, Johnson KS: Human Antibodies with Sub-nanomoler Affinities Isolated from a Large Non-immunized Phage Display Library. Nat Biotechno/1996, 14:309-314. Wang BC, Dickinson LA, Koivunen E, Ruoslahtl E, Kohw~shigematsu T: A Novel Matrix Attachment Region DNA Binding Motif Identified Using a Random Phage Peptide Library. J Biol Chem 1995, 270:23239-23242.

Immunotechniques Andreotti PE, Cree IA, Kurbacher CM, Hartmann DM, Lindar D, Harel G, Gleiberman I, Caruso PA, Ricks SH, Untch M, Sartori C, Bruckner HW: Chemosonsltivlty Testing of Human Tumors Using a Microplato Adenosine Triphosphate Luminescence Assay:. Clinical Correlation for Cisplatin Resistance of Ovarian Carcinoma. Cancer Res 1995, 55:5276-5282, Beckar WS, Behr TM, Cumme F, Rossler W, Wendler J, Kern PM, Gramatzki M, Ksiden JR, Goldenberg DM, Wolf FG: Ga-67 Citrate Versus Tc-99m-labeled LL2-Feb" (anti-CD22) Fragments in the Staging of B-cell Non-Hodgkin's Lymphoma. Cancer Res 1995, 55(suppl):SS??1-S5773. Behr TM, Sharkey RM, Juweid MI, Dunn RM, Ying ZL, Zhang CH, Siegel JA, Gold DV, Goldenberg DM: Factors Influencing the Pharmecokinetics, Dosimetry, and Diagnostic Accuracy of Radioimmunodetection and Radioimmunotherapy of Carcinoembryonic Antigen-expressing Tumors. Cancer Res 1996, 56:1805-1816. Bermingham S, Dewey FM, Maltby L: Development of a Monocional Antibody-based Immunoassay for the Datection and Quantification of Anguillospora Longissima Colonizing Leaf Material. Appl Environ Microbiol 1995, 61:2606-2613. Beumer T, Haarbosch P, Carpay W: Convection During Incubation of Microplate Solid Phase Immunoaseay: Effects on Assay Response and Variation. Anal Chem 1996, 68:1375-1380, Bier FF, Schmid RD: Real Time Analysis of Competitive Binding Using Grating Coupler Immunosensors for Pesticide Detection. Biosens Bioelectron 1995, 9:125-130. Blend MJ, Hyun H, KozJoffM. Lev~ H, Mills GG, Gasparini M, Buraggi G, Hughes L Pinsky CM, Goldenber9 DM: Improved Staging of B-cell Non-Hodgkin's Lymphoma Patients with Tc-g9m-labeled LL2 Monoclonel Antibody Fragment. Cancer Res 1995, 55(suppl):S5764-$5770. Bollheimer LC, Schwartzalbiez R, Sauar A, Gross HJ: Enzymatic Analysis of Cell Surface Lactosaminyl Glycans by Row Cytometry. Biochem Biophys Res Commun t995, 215:30-40. Brecht A, Gauglitz G, Polster J: Interferometric Immunoassay in a FIA-system: a Sensitive and

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Analytical biotechnology Molecular imprinting • Miscellaneous

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