Clinical Plasma Medicine 3 (2015) 1–2
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Clinical Plasma Medicine journal homepage: www.elsevier.com/locate/cpme
We are presenting the ﬁrst issue of the third year of “Clinical Plasma Medicine” where topics of the back issues are continued. The ﬁrst two articles by Lehman et al. and Dong et al. are in tie with the Focus Issue “Plasma in dentistry” edited by Stefan Rupf, Homburg, Germany, one year ago (Clinical Plasma Medicine, volume 2, issue 2). The articles are covering plasma treatment of dental implant materials to generate antibacterial surfaces as well as plasma treatment of dentin to improve dentin interface bonding characteristics. These are well application-oriented ﬁelds of plasma medicine. From the beginning, research of plasma application in dentistry has had an important research position in plasma medicine. Therefore, we are very curious and promising to receive the ﬁrst clinical report about cold plasma applications in dentistry in the near future! In volume 1, issue 2 (December 2013), Schlegel et al. published a review about “Plasma in cancer treatment”. Meanwhile, this ﬁeld is one of the internationally most investigated areas of possible cold atmospheric plasma application in medicine next to wound healing and dentistry. A special “International Workshop on Plasma in Cancer Treatment” has already taken place two times, in Washington D.C., USA in 2014 and Nagoya, Japan in 2015. A continuation of this workshop series is scheduled. As we have pointed out in the editorial of the recent issue (volume 2, issue 2), in the ﬁeld of cancer treatment plasma application will have a great clinical relevance. We are very happy to present with the article by Metelmann et al. the ﬁrst report of a human trial in the ﬁeld of cancer treatment by cold atmospheric plasma. Fig. 1 illustrates the main ﬁnding of the trial: application of cold atmospheric plasma is able to clinically reduce both the microbial load and tumor cells at the surface of a patient's cancer ulceration (area a), visible obviously in comparison with an untreated tumor surface (area b). From our point of view this marks a milestone in this ﬁeld. Nevertheless, a lot of basic research is needed now as before to get a sound scientiﬁc background for plasma application in this ﬁeld of huge clinical relevance. The article of Schmidt et al. in this issue is dealing with aspects of inﬂuence on melanoma cells in vitro by plasma treatment. The ﬁnding of a strong plasma impact on melanoma cell migration will help to further estimate aspects of potential anti-metastatic effects of plasma treatment. The ﬁfth article of this issue by Vasilets et al. focusses a special principle of medical use of atmospheric plasma. The generation of gaseous mixtures containing nitric oxide (gNO) by a plasma-
http://dx.doi.org/10.1016/j.cpme.2015.06.001 2212-8166/& 2015 Published by Elsevier GmbH.
Fig. 1. Infected metastatic ulceration of a squamous cell carcinoma of the oral cavity, treated with cold atmospheric plasma (area a), compared to untreated tumor tissue (area b).
based device and its medical use is investigated for several years and was described in the ﬁrst review article about plasma medicine in 2008 already (Fridman et al., Applied plasma medicine, Plasma Process. Polym. 2008, 5, 503–533). The article published here presents new observations on the clinical use of plasma gNO therapy in the treatment of soft tissues with undamaged skin surface. With this issue of “Clinical Plasma Medicine” we are starting in the third year of this new journal. “Clinical Plasma Medicine” addresses both application-oriented plasma physical as well as medical aspects of the new and interdisciplinary ﬁeld of plasma medicine including in vitro studies on microorganisms and mammalian cells which investigate biological effects of cold
Editorial / Clinical Plasma Medicine 3 (2015) 1–2
atmospheric plasmas with regard to speciﬁc aspects of its potential medical application as well as to safety aspects of medical plasma applications. The aim of the journal is to ﬁll the gap between journals mainly dedicated to plasma physics on the one hand and specialized medical journals on the other. With this true interdisciplinary platform we will help to transfer this innovative
physical technique into medical reality. May the present issue be a further step in this direction!
Thomas von Woedtke, Hans-Robert Metelmann