Heparin therapy in intracranial sinus venous thrombosis

Heparin therapy in intracranial sinus venous thrombosis

S132 ABSTRACTS OF 12TH NATIONAL CONGRESS Vol. 70, Suppl. 1 P 047 UPPER-EXTREMITY DEEP VENOUS THROMBOSIS: STUDY OF AN OUTPATIENT POPULATION. G.Casta...

94KB Sizes 1 Downloads 32 Views

S132

ABSTRACTS OF 12TH NATIONAL CONGRESS

Vol. 70, Suppl. 1

P 047 UPPER-EXTREMITY DEEP VENOUS THROMBOSIS: STUDY OF AN OUTPATIENT POPULATION. G.Castaman, M.Ruggeri, F. Rodeghiero. Department of Hematology and Hemophilia and Thrombosis Center, San Bortolo Hospital, Vicenxa. From 1985 to 1991, 271 patients (206 males, 165 females) with thrombotic episodes were referred to our Center for laboratory and clinical investigation. 13 (6 males, 7 females) suffered from thrombosis of superior venous district (DVTs). Their mean age was 39.7 (range 17-66), 10 (75%) with age below 45. The diagnosis of DVTs was made by flebography (lo), CT (2), Ecodoppler (1). Thrombosis involved jugular vein (l), basilica (l), axillary (3), omeral (3), subclavian (5); 7 involved the left district, 6 the right. Laboratory investigation (Antithrombin III, Plasminogen, Protein C and S, lupus anticoagulant and antiphospholipid antibodies) failed to detect any abnormality. The personal and familial history was negative. In one case an anatomical abnormality (cervical rib) was evident; 5/13 referred a strong physical exercise; l/13 had a trauma; 3113 referred risk jobs (smith, canoeist, painter); in 3113 the thrombosis occurred spontaneously. Oral anticoagulant treatment was stopped after 6 months in 10 patiens, with a follow-up off therapy of 27 months (median, range 3-108): no recurrence was observed. Analysis of our series of patients suggests that DVTs in not a rare event in outpatients without venous catheter and without anatomical abnormality. No abnormality of clotting inhibitors or fibrinolytic system associated to thrombotic diathesis was present. Oral anticoagulant for 6 months seems sufficient to prevent recurrence of thrombosis.

P 048 SIlWSllliNXS

HEPARIN’IHEWIPYINm-

L. Steidl, G. Crippa,

‘RwoMBosE.

M.Bossi,A.Vemo.Clinica&dica-UniversityofFkvia-

&x-km of Varese -

kpedaleI%ltizmalediVzese. nxmpyof~~al.simlsv~

-is

(ISvr) is ozrlttuversial.

bIytYheqmlticalagentshavebeenproposed:in-anedoctal-~ Maqy investiggtirshave strmgly opposed

hepsrinwesusedwithsuccess.

use because of the possibility of intracmnial hmmmges.

its

We have treated

3casesofISVT,atonset,witfi~usted~~~~maintaining the sFTl'ratio be-

1,5 and 2,5. The diagmsis of ISVl'wasposed by means of

~~ic~~,~scanardMRI.~oftfiethreefemalepatientswere uxkrestmprqestativetreatmmt. beenclassifiedaccording ptqmedby

Agerangzdfkrm23to4ELAll

to the sins

patients have

venous thrurkxis severity scale

Einbkpletal. (1991).'Ihescoreataxsetsmlaf'bzr 3X-942

was tfiefollaklg: pt. 1: -5-3-2; patients2ard3havereached

acmplete

days

pt. 2: 3-2-l-l-O; pt. 3: 5-!xx%O. remission (score 0) while patient 1

has reached only score 2 (mild left paresis). By Rleansofencephalicseriate ~scam,nointmcmnialhmxqgeshavebeendisanm-ed,

tiingtieperiodof

heparinacki.nistraticn.Warfarti was achrinistralxdfor 642 hemri.ndismntimarxx.mlackingm~-cases, torecentli~~,~theparinisnot~~~cate~t,cnthe~~, is effectivein ISVT.

mths

aft9

we ccnclukd, acxonkg