Mass Spectrometry. Clinical and Biomedical applications

Mass Spectrometry. Clinical and Biomedical applications

Book Reviews /And. 294 instrumentation the main text deals with five separation/concentration areas namely: liquidliquid extraction, sorption, gas-l...

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Book Reviews /And.


instrumentation the main text deals with five separation/concentration areas namely: liquidliquid extraction, sorption, gas-liquid separation, dialysis and precipitation. The principles and practical aspects of these areas are illustrated within two applications chapters on “Environmental and Agricultural Analysis” and “Clinical and Pharmaceutical Analysis”. Both of these chapters most usefully contain working details for selected procedures for the analysis of difficult samples. It is the reviewer’s opinion that the author has met his declared aim in what is a beautifully produced volume, well illustrated and in excellent format and English. This monograph provides a useful introduction to FIA per se and to the field of FIA separations/concentrations in particular. D. Thorbum Bums

Karl Blau and John M. Halket, Handbook of Derivativ& for Chromatography, Wiley, Chichester, 1993 (ISBN O-471-92699-X). ix + 369 pp. Price US$95.00. This handbook presents a variety of derivatization reagents for gas chromatography (GC) and liquid chromatography (LC), including the details of their chemistry, guidance of their use, examples of their applications to real samples and plenty of references. Non-volatile analytes would be easily derivatized and analyzed by GC with various detection methods wluding mass spectrometry referring to the suggestions described in the text. The less detectable analytes would also be converted to the derivatives separable by LC and sensitively detected with UV-visible or fluorescence detection. Thus, this book deserves to be an appropriate textbook, guidebook or handbook for graduate students and researchers in the fields of pharmaceutical chemistry, analytical biochemistry, clinical chemistry, food chemistry and environmental analytical chemistry. K. Imai

Chim. Acta 287 (1994) 293-296

Dominic M. Desiderio, Mass Spectrometry. Ciinical and Biomedical Applications, Vol. 1, Plenum Press, London, 1993 (ISBN O-306-44261-2). xiii + 353 pp. Price US$83.40. This volume, part of the Modern Analytical Chemistry series, is a collection of self-contained articles describing recent developments in the use of mass spectrometry in clinical and medical research. A large proportion of the mass spectrometry content is devoted to the electrospray ionisation technique which is considered in some detail and merits a complete chapter detaihng theoretical and practical considerations. Other mass spectral methods sare dealt with in a less rigorous manner and are considered only as methods of analysis of the biomolecules under examination. The analytical procedures discussed involve the use of gas and liquid chromatography-mass spectrometry (GC-MS and LC-MS) metastable ion analysis, tandem mass spectrometry (MS-MS), chemical ionisation (CD, electron bombardment ionisation (EB) and fast atom bombardment (FAB). Several broad areas of biomedical and clinical research are described in the fields of metabolism and physiology. Specifically the employment of mass spectrometry in the analysis of amino acids, proteins, platelet-activating factor, muscle relaxants, acylcarnitines, neurotransmitters, neuropeptides, cannabinoids and glycoproteins is presented. Alternative methods of analysis are also considered and their relative merits in comparison with mass spectrometry assessed. Each chapter is concluded with an extensive collection of literature references, review articles and suggestions for further reading. This work will appeal most to clinicians and biochemists engaged in, or contemplating, mass spectral analysis of biochemical systems. There is no doubt that workers in the broad areas described will find a wealth of chemical and analytical information and practical direction within the text. Mass spectroscopists will find less to appeal, however. The coverage of electrospray ionisation is wide ranging but other techniques are described in considerably less detail and the analyst already possessing a basic knowledge of mass

Book Reviews/Ad

Chim. Acta 287 (1994) 293-296

spectral methods will probably only gain in biochemical understanding from a reading of this text. A.D. Roberts

J.R. Chapman, Practical Organic Mass S’ctrometry (2nd edn.) - A Guide for Chemical and Biochemical Analysis, Wiley, Chichester, 1993 (ISBN O-471-92753-8). xiii + 330 pp. Price f34.00. This volume extends the coverage of mass spectrometry to include techniques which have become readily available in the eight years since the first edition was published. Two new chapters are presented on the ionisation of labile materials including fast atom bombardment, secondary ion mass spectrometry, desorption chemical ionisation, electrospray, thermospray, plasma desorption, laser desorption and field desorption. The sections dealing with liquid chromatography-MS, tandem mass spectrometry and collision induced dissociation have been expanded and updated and time of flight and Fourier transform-MS introduced. The overall layout is retained, each technique being considered in respect of theory, instrumentation and practical details and applications. Extensive updating of the reference sections which follow each chapter has been conducted. The main appeal of this work will once again be to readers with some initial understanding of mass spectrometry who wish to expand their breadth of knowledge of practical techniques and require direction to more specific reading. Students at both undergraduate and postgraduate level will also find this to be an excellent text book at, what is’ by present standards, a very modest cost. A.D. Roberts

Vladimir Betina, Chromatography of Mycotoxins (Journal of Chromatography Library, Vol. 541, Elsevier, Amsterdam, 1993 (ISBN O-444-81521-X). xiii + 436 pp. Price US$180.OO/Dfl.350.00.


Mycotoxins (aflatoxins, tricothecenes, etc.) present a particular challenge to analytical scientists. The variety of compounds and matrices, their toxicity and the very low levels at which they often are found make their accurate analysis difficult. This book brings together many aspects of mycotoxins analysis, mainly covering chromatographic techniques, but also dealing with sample preparation, and with ELISA procedures. There are nine chapters, each written by experts, and grouped into Techniques (sampling, sample preparation, extraction and clean up, and TLC, LC, GC, immunoaffmity chromatography and ELISA) and Applications (the applications of TLC, LC and GC). The material is clearly presented, in camera ready copy, and, in addition to a considerable amount of descriptive and instructional material, includes a great deal of data. There is an extensive subject index.

Phyllis R. Brown and Eli Grushka (Eds.), Advances in Chromatography, Vol. 33, Marcel Dekker, New York, 1993 (ISBN O-8247-9064-2). xviii + 283 pp. Price US$135.00. This volume contains six articles on topical themes, viz. planar chips technology of separation systems (Harrison, Widmer et al.), liquid chromatographic determination of ligand-biopolymer interactions (Wainer and Noctor), expert systems in chromatography (Hamoir and Massart), information potential of chromatographic data for pharmacological classification and drug design (Kaliszan), fusion reaction chromatography (for polymers) (Haken), and enantioselective liquid chromatography using chiral stationary phases in pharmaceutical analysis (Levin and Abu-Lafi). All are well written, with a considerable amount of information, and supported by a good subject index.

M. Parkany, Quality Assurance for Analytical Laboratories, Royal Society of Chemistry, Cambridge, 1993 (ISBN o-85186-705-7). xiii + 193 pp. Price f 39.50.