Molecular Biology Biochemistry and Biophysics. 32. Chemical recognition in Biology

Molecular Biology Biochemistry and Biophysics. 32. Chemical recognition in Biology

178 Book Reviews 3 Kinetics and BiotransformatIon of Adrenerglc Inhibltors p 417 4 Toxic Effects of Adrenerglc Nerve-End Inhlbitors, Neural Transmit...

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Book Reviews

3 Kinetics and BiotransformatIon of Adrenerglc Inhibltors p 417 4 Toxic Effects of Adrenerglc Nerve-End Inhlbitors, Neural Transmitter Depleting Agents and False Transmitter P Juul p 505 5 Clinical Features of Adrenergic Agonists and Antagonists B N C Prlchard, C W 1 Owens and J T u c k m a n p 559 Index p 699 Most readers are familiar with this series and they will not be disappointed by the present two volumes The excellent high standard is maintained and the editor is to be congratulated on having such a fine group of contributors

Transport Across Biological M e m b r a n e s - - b y M (Translated by J G Hoggett) 184 pp 1981 Advanced Publishing Program, London £15

Hofer Pitman

The elucidation of the pathways that lead to the production of these antibiotics is a fascinating and important story that still has many new twists to it This volume gives an excellent s u m m a r y of the skdl of Nature as a synthetic organic chemist

Indole and Biogenetically Related Alkaloids---Edited by J D Phllhpson and M H Zenk 379 pp 1980 Academic Press, London US$7500 The plant alkaloids have provided m a n y Important drugs such as the ergot alkaloids, reserpine, vinblastine, vincristlne, strychnine and physotlgmlne These and other alkaloids are discussed in this book In relation to their chemistry, synthesis, isolation and purification At present pharmacologists use only a small fraction of the available alkaloids as research tools The book may suggest to the reader some new and interesting c o m p o u n d s that might well have new and important properties Over 200 alkaloids have so far been isolated from the plants of the Genus

Strychnos This English translation of the G e r m a n e&tlon has been brought up to date and new developments in m e m b r a n e structure and biochemistry and the reconstltUtlOn of membrane bound processes in artlficml phosphohpids vesicles given more coverage The chapter headings are Structure and functmn of biological m e m b r a n e s Transport function of biological membranes Kinetics of catalyzed transport Active transport Molecular basis of carrier transport Appendix Analysis of experimental results Derivation of kinetic equation Some properties of aqueous solutions Mathematical appendix The level Is first or second year U K undergraduate, with the accent on ideas, examples and kinetics The text is not swamped with references so the reader can see the wood from the trees

Structure and Activity of Natural Peptides---Edited by W Voelter and G Weltzel 263 pp 1981 Walter de Gruyter, Berlin D M 150

Molecular Biology Biochemistry and Biophysics. 32. Chemical Recognition in Biology--Edited by F Chapevllle and

The volume starts with a survey of selected topics, gastrotntestlnal h o r m o n e s , amatoxlns & phallatoxlns, insulin, thymlc peptides, AlamethlCln and Trtchotoxm A40, Neuropeptldes, Ohgopeptide hormones, Crystal structure of polypeptides The following main sections are, Isolation of new peptide, Methods of purification, Isolation and characterlsatlon of peptldes, Peptlde synthesis and Biological activity of peptldes There has been a tremendous explosmn of interest and availability of peptides for biological research and this volume will help the reader keep abreast of the present day thinking and developments

A - L Haenni 430 US$57 90 D M 98

Sulfur in Proteins---by Yu M Torchlnsky 294 pp 1981




Berhn Pergamon Press, Oxford £40 US$96

This is a collection of papers presented at a Symposium organized in Grtgnon (France), July 1979, on the occasion of the 80th Anniversary of Fritz L i p m a n n The topics include recognition of hgands, enzyme catalysts, enzyme regulation nucleic acid-protein interactions, mutagenesis protein biosynthesis There are intriguing chapters such as "Why is phosphate so useful 'v" " p p G p p a signal molecule"", "Structure and evolution of Ribosomes" The final section is philosophical with a chapter by R Monro on "Molecular Biology Culture and Society", and a chapter by G D Novell on "Personal recollections of Fritz Llpmann during the early years of Coenzyme A Research"

Antibiotics IV. Biosynthesis---Edited by J W Corcoran 380 pp 1981 Sprtnger-Verlag, Berlin US$116 90 D M 198 This volume brings up to date our present knowledge concerning the biosynthesis of antibiotics The topics chosen and authors are as follows Tetracycline & Anthracycllne C R Hutchinson Ansamyclns G Lanclnl and M Grandl Ammocychtols C J Pearce & K L Rinehart, Jr fl Lactams J O'Sullivan and E P A b r a h a m Methylenomycm U H o r n e m a n n & D A Hopwood Erythmycins J W Corcoran 16 Memberend Macrohde S O m u r a & A Nakagawa U n u s u a l macrohdes H G Floss and Chlbg-Jer C h a n g lsochromanequinone H G Floss Aromatic antibiotics H G Floss Anthramycln, T o m a m y c i n & Siblromycin L H Hurley & M K Speedle Mltomycins U H o r n e m a n n Nitrogen-nitrogen bond containing antibiotics U H o r n e m a n n Peptlde antibiotics K Kurahashl Nucleotlde antibiotics R J Suhadolmk

This m o n o g r a p h has been translated from the Russian edition of 1977, but has been brought up to date with 18 new figures added The chapter headings are Chemical properties of SH groups Sulfhydryl reagents Chemical properties of S-S groups and methods for their cleavage Chemical properties of thloether group of methlonlne Methods for the quantitative determination of SH and S-S groups in proteins Differential reactivity of SH groups of proteins Essential SH groups of enzymes and methods of identification The role of SH groups in enzymes Thlol cofactor The role of S-S groups in proteins The role of the thlother group of methlonlne in proteins Acid labile sulfur in electron-carrier proteins Chemical methods for introduction of SH and S-S groups into proteins There is a good bibliography with over 1800 references The volume is readable and there are useful summaries at the end of each chapter

The "Low T3 Syndrome'--Edlted by R - D Hesch Proceedlngs of the Serono Symposia Volume 40, 263 pp Academic Press, London £16 40 US$39 50


Since the early observations of Pitt-Rivers concerning the greater potency of trnodothyronlne (T3) compared with that of thyroxine (T4) and the subsequent demonstration that a considerable proportion of plasma T3 is derived from T4 by peripheral delodination it has gradually become clear that the Interactions and regulation of thyroid h o r m o n e s are considerably more comphcated than they were first thought to be T4 is now known to be converted to T3 and reverse T3 in the tissues This pen-