trends in analytical chemistry,
vol. 9, no. 7,199O
book reviews NMR dictionary A Dictionary of Concepts in NMR, 1st edition, by S. W Homans, Clarendon Press, 1989, f 40.00, (vi + 343 pages) ISBN: &19-855274-2
It is certainly not coincidental that two NMR dictionaries appear within a short period of time, after 4 decades in which no such glossary of terms has been available. The extensive and sometimes complex NMR literature of different pulse sequences and applications, which surged with the advance of 2D-NMR, has made it necessary. In addition the book reviewed here, an NMR handbook, written by Ray Freeman, has recently appeared. Both books state the analogous purpose of providing quick access to NMR terminology/basic knowledge to the (bio)chemist with only an introductory NMR background, and are mainly directed towards 2D solution NMR. It therefore seems appropriate to compare them in this review. It is directly apparent from a first glance at the book, that Homans dictionary is not easy to understand for a beginning spectroscopist. The remark that only a basic background in mathematics will suffice to understand the text seems overstated. Freemans book, on the contrary appears more suitable for introductory purposes. However, for the spectroscopist, who wishes to gain a deeper understanding of 2DNMR technology, Homans book provides an excellent guide to most available techniques with a clear and concise description of the principal theoretical background. It provides quick access to original literature, which the interested party may wish to read. In this respect it should be noted that most 2D-techniques are treated and are listed alphabetically, contrary to a more general treatment of 2D principles by Freeman. The large number of entries in Homans book makes it truly a dictionary, that will also be very useful to experienced NMR spectros-
copists, who need quick access to the basic description of certain experiments. For example, for most experiments, the origin of cross-peaks in 2D-spectra, in which most application chemists may be interested, is also explained in detail together with an illustrative example. Summarizing, my impression is that it will be very convenient to have both handbooks within reach at the spectrometer, and that they are more complementary than redundant. While
Capillary electrophoresis: Capillary Electrophoresis: Is it Worththe Gamble?, a recent MarketAnalysis and Perspectives report on Capillary Electrophoresis from Strategic Directions International Inc., Los Angeles, 1990, US$ 2995.00
Strategic Directions International, Inc. has published a comprehensive market research report entitled: “Capillary Electrophoresis: Is it Worth the Gamble?” Who is gambling on capillary electrophoresis (CE)? The manufacturer who spends a lot of money on the development of a new analytical instrument, or the user who invests in a new and rapidly developing technique? CE is obviously a big issue these days. At the last Pittsburgh Conference in New York several companies showed prototype instruments as if they were existing products. What is happening? Is everybody running to catch the bus, but don’t they know that the bus might be running late? To avoid such a situation it makes sense at least to try and get some overview and to know what the main issues are. The CE market is growing very fast and the total volume will be as high as US$ 100 million in 1994. This extensive investigation by SDi gives the potential user or manufacturer a lot of information on the actual trends in CE. Until 1994 the CE-mar-
Freemans book will provide initial reading and some enjoyable pictures, Homans book will be a time saving reference for anybody with a more than qualitative interest in 2D high resolution NMR.
P.C.M. VAN ZIJL DE KM. van Zijl is at the National Institates of Health INational Cancer Institute,Building 10, Room BID-125, Bethesda, MD 20205, U.S.A.
a market perspective ket will be mainly a research market and researchers favor modular designed systems. There will thus be a market for modular CE systems in the next few years as pioneers and early adopters create novel applications for the new technique. As is the case with every new technique, new products with additional possibilities will be developed in a relatively short period of time. Customers are aware of this and they probably don’t want to invest too much in a system that will be oldfashioned within two or three years. Therefore it is remarkable that despite the fact that R&D departments favor modular systems, forecasts for 1990 estimate already a tenfold more sales for integrated systems and this figure will increase to somewhat near 17 by 1994. So in the coming years several laboratories will buy integrated systems, possibly for dedicated applications. The market potential for CE might be even bigger than the HPLC market as will be seen in the near future. The absolute potential of CE depends more or less on whether it will be possible to run some important applications in the clinical field with CE better than can nowadays be done with HPLC. Especially micellar electrokinetic capillary chromatography is a promising technique with high selectivity and a broad range of applications. It is speculated that the average researcher in many future application