Oral Sessions

Oral Sessions

ORAL SESSIONS—SCIENTIFIC SESSIONS F R I D A Y SCIENTIFIC SESSIONS ASGE Hands-on 5:00 PM - 7:30 PM CC11AB Hyatt Regency McCormick MAY 29 Chairs: Ca...

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ORAL SESSIONS—SCIENTIFIC SESSIONS F R I D A Y

SCIENTIFIC SESSIONS ASGE Hands-on 5:00 PM - 7:30 PM

CC11AB Hyatt Regency McCormick

MAY 29

Chairs: Carol E. Semrad, Michael V. Chiorean ASGE MASTERS SERIES COURSE: ENTEROSCOPY IN THE 21ST CENTURY - DAY 1 Participants will be able to: • Discuss the indications, contraindications and complications of double balloon enteroscopy; • Describe the principles and techniques for device assisted enteroscopy and their limitations; • Recognize difficult enteroscopy and altered small bowel anatomy; and • Develop a deep enteroscopy program. 5:00

Course Check-in & Reception

5:30

Opening Remarks

5:35 Sp1

Enteroscopy - Indications and Contraindications Christopher J. Gostout

5:50 Sp2

Instruments, Tools and CO2 Jonathan A. Leighton

6:10 Sp3

Setting Up Your Unit and the Learning Curve Mark E. Stark

6:40 Sp4

An Inconvenient Truth - Billing Drew B. Schembre

7:00

Questions & Answers

P-23

S A T U R D A Y MAY 30

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION POSTGRADUATE COURSE/SPECIAL SESSION AASLD Endpoints Workshop 8:00 AM - 5:30 PM

Wabash Parlor Palmer House Hilton

Chairs: Arun J. Sanyal, Arthur J. McCullough ENDPOINTS CONFERENCE ON NONALCOHOLIC FATTY LIVER DISEASE Participants will be able to: • Define areas of consensus and controversy with respect to the definition of NAFLD; • Define the clinical-pathologic phenotypes of NAFLD and the key outcomes associated with these phenotypes; • Identify the key studies that need to be performed in the various phenotypes of NAFLD; and • Define the nature of the study populations, key study design elements and endpoints to be measured in these studies. 8:00 Sp5

Introductory Remarks and Welcome Arthur J. McCullough

1:20 Sp15

Traditional Primary Endpoints Versus “Gestalt Indices” in Clinical Trials Chris Gennings

1:40 Sp16

How to Address Confounders in Clinical Trials for NASH Naga P. Chalasani

2:10

Panel Discussion and Open Forum

2:30

Coffee Break

3:00

Breakout Working Groups

4:30

Reports from Working Groups

AASLD Endpoints Workshop Breakout Sessions 3:00 PM - 4:30 PM

Sp17

Moderator: Matthew Yeh

Breakout Group A: Defining Steatohepatitis and Clinical-Histologic Subsets of Patients Indiana Elizabeth M. Brunt

Palmer House Hilton

SESSION 1: DEFINITIONS AND HISTOLOGY 8:10 Sp6

What Is Steatohepatitis? David Kleiner

8:30 Sp7

Grading and Staging of NASH Elizabeth M. Brunt

8:50 Sp8

Noninvasive Methods for Grading and Staging of NASH Detlef Schuppan

9:10 Sp9

What Makes Steatohepatitis “Non-Alcoholic” Kris V. Kowdley

9:30

Panel Discussion and Open Forum

9:50

Break

Sp18

Palmer House Hilton Sp19

Sp20

Defining Populations for Clinical Trials and Studies of Pathogenesis Stephen H. Caldwell

10:50 Sp12

“What Is the Question”: Implications for Study Design and Endpoints Arun J. Sanyal

11:10 Sp13

Safety Related Endpoints Vlad Ratziu

11:30

Panel Discussion and Open Forum

12:00

Lunch

Breakout Group E: Analytic Issues in Clinical Trials of NAFLD Kris V. Kowdley Millennium

Palmer House Hilton Sp22

The Varying Clinical-Histologic Phenotypes of NAFLD: Do They Have Different Outcomes? Arthur J. McCullough

10:30 Sp11

Breakout Group D: Types of Studies Needed in Specific Populations Nathan M. Bass Medinah

Palmer House Hilton Sp21

10:10 Sp10

Breakout Group C: Endpoints Based On Non-Invasive Markers in Clinical Trials The Dearborn Wing (D1) Joel E. Lavine

Palmer House Hilton

Moderator: Joel E. Lavine SESSION 2: CLINICAL PHENOTYPES AND CLINICAL TRIALS FOR NAFLD

Breakout Group B: Defining Histologic Endpoints and Criteria for Clinical Trials David Kleiner Kimball

Breakout Group F: Safety Related Endpoints in Clinical Trials for NAFLD Naga P. Chalasani The Spire Room

Palmer House Hilton AGA Institute Practice Managers/Administrators Course ‡ 7:30 AM - 5:05 PM Seville Ballroom -First Level Intercontinental Chicago AGA INSTITUTE PRACTICE MANAGERS/ADMINISTRATORS COURSE 7:30

Continental Breakfast

8:00 Sp23

Creating a Culture That Supports Quality Mary Igo

Moderator: Nathan M. Bass

8:40 Sp24

Contracting with Payers and Purchasers Joni Brown

SESSION 3: ENDPOINTS, THEIR ANALYSIS AND INTERPRETATION

9:20 Sp25

Benchmarking for Profitability and Quality Frank J. Chapman

10:00

Panel Discussion and Q&A

10:15

Break

1:00 Sp14

P-24

Analytic Issues Related to Endpoints in Clinical Trials for NASH Aynur Unalp-Arida

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION 10:30 Sp26

Physician and Employee Recruitment for Exceptional Results Robert Kwech

11:10 Sp27

Compensation Arrangements for Physicians Jeffrey Milburn

11:50

Panel Discussion and Q&A

12:05

Lunch

1:00 Sp28

How the Stark Laws Impact Your Practice Daniel Gottlieb

1:40 Sp29

Adding Pathology and Other Business Lines to Your Practice Kirk A. Brandon

2:20 Sp30

Clinical Trials As a Revenue Stream Kathy J. Sammis

3:00

Panel Discussion and Q&A

3:15

Break

3:30 Sp31

ASCs and Gastroenterology - What to Do Now? Scott Becker

4:10 Sp32

Imaging and the GI Practice Vicki King

4:50

Panel Discussion and Q&A

11:00 Sp42

Pathogenesis and Therapy of NERD Ronnie Fass

11:20 Sp43

Esophageal Dysmotility: Achalasia and Beyond Peter J. Kahrilas

11:40 Sp44

Diagnosing and Treating Oropharyngeal Dysphagia Reza Shaker

12:00 Sp45

The Endoscopists’ Corner: Managing Recurrent Esophageal Strictures Todd H. Baron

12:20 Sp46

Moderator’s Summary David C. Metz

Sp47

Sp48

Sp50

Esophageal pH and Motility Testing (L105) Kenneth R. DeVault

E451A McCormick Place

SESSION I: PREVENTING DEATH FROM GASTROINTESTINAL MALIGNANCY

Fecal Incontinence: Diagnosis and Management (L106) S104 Satish S. Rao

McCormick Place Sp51

8:15 Sp33

Welcome from the AGA Institute President Robert S. Sandler

8:20 Sp34

Introduction Nicholas J. Shaheen

8:30 Sp35

CT Colonography: Who Should Get It, Who Should Do It? Brooks D. Cash

8:50 Sp36

Doing Better Than Random Biopsies: Real-Time Imaging of Barrett’s Esophagus Prateek Sharma

9:10 Sp37

CRC Screening and Polyp Surveillance Douglas K. Rex

Sp54

9:30 Sp38

Recognizing and Treating Inherited Colorectal Cancer Syndromes Sapna Syngal

Sp55

9:50 Sp39

The Endoscopist’s Corner: Ablative Therapy in Barrett’s Esophagus: Which Methods and Which Patients? Nicholas J. Shaheen

10:10 Sp40

Moderator’s Summary Douglas K. Rex

Diagnosing Obscure Gastrointestinal Hemorrhage: Do Capsule Endoscopy and Balloon Enteroscopy Improve Outcomes? (L104) Glenn M. Eisen S402

McCormick Place Sp52

Hepatitis B: Who and How to Treat? (L107) Mitchell L. Shiffman

S405 McCormick Place

Sp53

Hereditary Hemochromatosis: Diagnosis and Treatment of a Common Genetic Disorder (L108) Bruce R. Bacon S101

McCormick Place IBD and the Pregnant Patient (L109) Sunanda V. Kane

E350 McCormick Place

Managing Extra-Esophageal Reflux: Why Don’t the PPIs Work? (L110) Michael F. Vaezi E351

McCormick Place Sp56

Standardizing Diagnosis and Defining Therapy in Eosinophilic Esophagitis Glenn T. Furuta

Complementary and Alternative Medicine: What’s the Evidence, and What Interventions Are of Value? (L103) S501D Ronald L. Koretz

McCormick Place

Chair: Douglas K. Rex

10:40 Sp41

Chronic Diarrhea: Etiology, Work-Up and Management (L102) Christina M. Surawicz S504

McCormick Place

Sp49

SESSION II: ESOPHAGEAL DISEASES

MAY 30

AGA Institute Postgraduate Course Luncheon Breakout Sessions 12:30 PM - 1:30 PM

AGA Institute Postgraduate Course General Session 8:15 AM - 10:15 AM B1 McCormick Place

Chair: David C. Metz

S A T U R D A Y

Non-Variceal Upper Gastrointestinal Bleeding (L111) Loren A. Laine S501A

McCormick Place Sp57

NOTES: Is There Opportunity for the Gastroenterologist? (L112) Anthony N. Kalloo

S501BC McCormick Place

P-25

S A T U R D A Y MAY 30

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION Sp58

NSAIDs and the Upper GI Tract: Minimizing Risk, Tailoring Therapy (L113) Neena S. Abraham S502

Sp73

Case Studies in Dysphagia (C104) John E. Pandolfino

S505 McCormick Place

McCormick Place Sp74 Sp59

Nutritional Support and the Gastroenterologist: Of Tubes, Lines and IV Access (L114) Mark H. DeLegge S401A

Completing the Difficult Colonoscopy and the Difficult Polypectomy (C105) S101 Douglas K. Rex

McCormick Place

McCormick Place Sp75 Sp61

Putting Them to Sleep, Waking Them Up: Sedation and Monitoring for GI Procedures (L115) John J. Vargo S503

Fistulizing Crohn’s Disease: What Is the Best Management Algorithm? (C106) William J. Tremaine

S501A McCormick Place

McCormick Place Sp76 Sp62

Recognizing and Managing Celiac Sprue (L116) Sheila E. Crowe

S505 McCormick Place

Managing Chronic Pancreatitis: Enzyme Supplementation, Pain Control and Endoscopic/Surgical Intervention (C107) Peter A. Banks E352

McCormick Place Sp63

Screening for Hepatocellular Carcinoma: How to Do It and Who Deserves It? (L117) Hashem B. El-Serag S401D

Sp77

McCormick Place

McCormick Place

AGA Institute Postgraduate Course General Session 1:45 PM - 3:30 PM B1 McCormick Place

Sp78

Chair: Scott E. Plevy

Sp79

SESSION III: INFLAMMATORY BOWEL DISEASE 1:45 Sp64

Immunomodulators: Initiating, Titrating and Monitoring Stephen B. Hanauer

2:05 Sp65

When to Switch or Stop Biologics William J. Sandborn

2:25 Sp66

Bones, Eyes, and Side-Effects of Therapy: Complications and Chronic Management of IBD Maria T. Abreu

2:45 Sp67

Pouchitis: from Differential Diagnosis to Management Bo Shen

3:05 Sp68

The Endoscopists’ Corner: Who’s At Risk and What Should We Do? Preventing IBD-Associated Colorectal Cancer Bret Lashner

3:25 Sp69

Moderator’s Summary Scott E. Plevy

Sp70

Barrett’s Esophagus: Managing the Patient with HighGrade Dysplasia (C101) Kenneth K. Wang E351

McCormick Place Sp71

C. difficile Colitis: Handling Refractory and Recurrent Cases (C102) Christina M. Surawicz E350

McCormick Place Sp72

Cancer Imaging and the Gastroenterologist: The Role of EUS in Staging Pancreatic, Esophageal, and Rectal Neoplasia (C103) Michael B. Wallace S402

McCormick Place P-26

Stenting and Enteral Access (C110) Todd H. Baron

S403 McCormick Place

The Complicated Functional Bowel Disease Patient: Centrally-Acting Agents and Other Treatment Modalities (C111) S503 William D. Chey

McCormick Place Sp80

AGA Institute Postgraduate Course Clinical Challenge Sessions 4:00 PM - 5:30 PM

Managing the Post-Bariatric Surgery Patient: Recognizing Complications and Improving Outcomes (C109) S501BC Christopher C. Thompson

Treatment of Viral Hepatitis: When First-Line Therapy Fails (C112) Paul Y. Kwo S401D

McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS SCIENTIFIC SESSIONS ASGE Hands-on 7:00 AM - 4:30 PM

S103D McCormick Place

Chairs: Carol E. Semrad, Michael V. Chiorean ASGE MASTERS SERIES COURSE: ENTEROSCOPY IN THE 21ST CENTURY - DAY 2 Participants will be able to: • Discuss the indications, contraindications and complications of double balloon enteroscopy; • Describe the principles and techniques for device assisted enteroscopy and their limitations; • Recognize difficult enteroscopy and altered small bowel anatomy; and • Develop a deep enteroscopy program. 7:00

Breakfast

7:55 Sp81

Introductions to the Core Curriculum Michael V. Chiorean

8:00 Sp82

Balloon Assisted Enteroscopy - Oral Approach Carol E. Semrad

8:20 Sp83

Balloon Assisted Enteroscopy - Anal Approach Charles E. Dye

8:40 Sp84

Spiral Enteroscopy Paul A. Akerman

8:55 Sp85

Panel Discussion: DBE vs. SBE vs. Spiral Enteroscopy Paul A. Akerman, Michael V. Chiorean, Charles E. Dye, Carol E. Semrad

9:10 Sp86

Small Bowel Radiology: Not So Black and White Dean D. Maglinte

9:30

Questions & Answers

9:45

Break

10:15 Sp87

Who’s On First: Video Capsule Endoscopy? Tube Enteroscopy? Radiology? Jonathan A. Leighton

10:30 Sp88

The Difficult Enteroscopy and Altered Anatomy Patrick I. Okolo III

10:50 Sp89

The Impact of DBE: Yield, Outcomes and Complications Lauren B. Gerson

11:10

Questions & Answers

11:30

Box Lunch

GROUP A (HANDS-ON) 12:15 PM - 2:30 PM

Hands-On Stations: Double Balloon Enteroscopy, Single Balloon Enteroscopy, and Spiral Enteroscopy

2:15

Break

12:15

Case Studies

2:15

Break

2:30

Case Studies

4:30

Adjourn

GROUP B (HANDS-ON) 2:30 PM - 4:30 PM

S103D McCormick Place

MAY 30 N228 McCormick Place

2:30

Hands-On Stations: Double Balloon Enteroscopy, Single Balloon Enteroscopy, and Spiral Enteroscopy

4:30

Adjourn

N228 McCormick Place

12:15

GROUP B (CASE STUDIES) 12:15 PM - 2:30 PM

GROUP A (CASE STUDIES) 2:30 PM - 4:30 PM

S A T U R D A Y

S103D McCormick Place

P-27

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION POSTGRADUATE COURSE/SPECIAL SESSION SSAT Postgraduate Course 8:00 AM - 5:15 PM

1:20

S406B McCormick Place

Chairs: Jeffrey H. Peters, Selwyn M. Vickers, Robin S. McLeod, Charles J. Yeo, Kevin E. Behrns ACUTE CARE GASTROINTESTINAL SURGERY: THINKING ON YOUR FEET—A CASE-BASED COURSE

S U N D A Y MAY 31

Participants will be able to: • Clearly understand the current evaluation of—and surgical options to treat—urgent surgical conditions of the esophagus and stomach, acute surgical problems of the midgut viscera, colorectal and perianal emergencies, and hepaticopancreaticobiliary emergencies; and • Know how to deal with special late-night vexing surgical quandaries. 8:00 Sp90

Welcome & Introduction David W. McFadden

SESSION I: ESOPHAGEAL/STOMACH 8:10 Sp91

Free Air from the Foregut Thadeus Trus

8:25 Sp92

Acute Paraesophageal Hernia/Boerhaave Brant K. Oelschlager

8:40 Sp93

Upper GI Bleeding—Surgical Rx Brian J. Dunkin

8:55 Sp94

Calling in Your Colleagues: Upper GI Bleeding, NonSurgical Loren A. Laine

9:10

Panel Discussion

9:30

Break

SESSION II: MIDGUT EMERGENCIES 9:55 Sp95

Peritonitis: Current Radiologic Techniques Patricia L. Abbitt

10:10 Sp96

Small Bowel Obstruction Joseph Cullen

10:25 Sp97

Incarcerated Ventral Hernia Mary T. Hawn

10:40 Sp98

Incarcerated Inguinal Hernia George A. Sarosi Jr.

10:55 Sp99

Post-Bariatric Surgery Emergencies Patrick M. Forgione

11:10

Panel Discussion

11:35

Lunch

SESSION III: HPB EMERGENCIES 12:20 Sp100

The Difficult Gallbladder: How I Do It and Why Ernest L. Rosato

12:35 Sp101

How the Gastroenterologist Manages Biliary Emergencies Richard Zubarik

12:50 Sp102

Acute Pancreatitis: When to Operate Carlos Fernandez-del Castillo

1:05 Sp103

Pancreatic Sepsis: Radiological and Interventional Treatment Eric vanSonnenberg

P-28

Panel Discussion

SESSION IV: HINDGUT EMERGENCIES 1:45 Sp104

Appendicitis: Open vs. LAP vs. Conservative Management Robert Kozol

2:00 Sp105

Perianal Sepsis Scott A. Strong

2:15 Sp106

The Emergency Anastomosis and Stoma Neil H. Hyman

2:30 Sp107

Lower GI Bleeding Anthony M. Vernava

2:45 Sp108

C. Diff in the ICU Nancy N. Baxter

3:00

Panel Discussion

3:25

Break

SESSION V: THE 2 A.M. DREADED CONSULT OR TRANSFER 3:45 Sp109

Is This Malignant Small Bowel Obstruction? Eric H. Jensen

4:00 Sp110

Acidosis and Belly Pain: Is This Dead Gut? Mark A. Newell

4:15 Sp111

The Septic Postoperative Enterocutaneous Fistula Patient Jeffrey G. Chipman

4:30 Sp112

The Patient Is a DNR: Should You Say No to the Request for Operation? Henry J. Schiller

4:45

Panel Discussion

AGA Institute Practice Managers/Administrators Course ‡ 7:30 AM - 12:00 PM Seville Ballroom -First Level Intercontinental Chicago AGA INSTITUTE PRACTICE MANAGERS/ADMINISTRATORS COURSE II 7:30

Continental Breakfast

8:00 Sp113

Implementing An EMR Craig J. Bakken

8:40 Sp114

Preventing Embezzlement and Medical Identity Theft Peter S. Donaldson

9:20 Sp115

What to Do When the RAC Auditor Calls Kevin Ryan

10:00

Panel Discussion Q&A

10:15

Break

10:30 Sp116

The Most Frequent GI Coding Errors Kathleen A. Mueller

11:10 Sp117

Integrating Mid-Levels Into Your Practice Mary Igo, Craig J. Bakken, Frank J. Chapman

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION AGA Institute Postgraduate Course General Session 8:30 AM - 10:15 AM B1 McCormick Place

Sp133

Diagnosing Obscure Gastrointestinal Hemorrhage: Do Capsule Endoscopy and Balloon Enteroscopy Improve Outcomes? (L204) S402 Glenn M. Eisen

McCormick Place Chair: Douglas A. Drossman

Sp134

E451A McCormick Place

SESSION IV: FUNCTIONAL BOWEL DISEASE 8:30 Sp118

Tailoring Treatment in IBS Lin Chang

8:50 Sp119

Evolving Diagnosis and Therapy in Functional Dyspepsia Nicholas J. Talley

Sp136

9:10 Sp120

Approach to Functional Constipation and Lookalikes: IBS-C, Colonic Inertia and Pelvic Dysfunction Charlene M. Prather

Sp137

Sp135

9:50 Sp122

The Endoscopists’ Corner: Is There a Role for Capsule Endoscopy or “SmartPill” in Functional Bowel Disease? Glenn M. Eisen

Sp138

10:10 Sp123

Moderator’s Summary Douglas A. Drossman

Sp139

Sp140

10:40 Sp124

Hepatitis C: Tailoring Therapy to Improve Outcomes Anna S.F. Lok

11:00 Sp125

Management of Hepatocellular Carcinoma: Resect, Ablate, Transplant? Hashem B. El-Serag

11:20 Sp126

Understanding NAFLD: Causes, Consequences and Progress in Therapy Anna Mae Diehl

11:40 Sp127

Drug-Induced Hepatotoxicity Paul B. Watkins

12:00 Sp128

The Endoscopists’ Corner: Prevention and Management of Variceal Bleeding Guadalupe Garcia-Tsao

E350 McCormick Place

Managing Extra-Esophageal Reflux: Why Don’t the PPIs Work? (L210) Michael F. Vaezi E351 Non-Variceal Upper Gastrointestinal Bleeding (L211) S501A Loren A. Laine

McCormick Place Sp141

Sp142

NOTES: Is There Opportunity for the Gastroenterologist? (L212) Anthony N. Kalloo

S501BC McCormick Place

NSAIDs and the Upper GI Tract: Minimizing Risk, Tailoring Therapy (L213) Neena S. Abraham S502

McCormick Place Sp143

Moderator’s Summary Michael W. Fried

Sp146

Complementary and Alternative Medicine: What’s the Evidence, and What Interventions Are of Value? (L203) Ronald L. Koretz S501D

McCormick Place

Recognizing and Managing Celiac Sprue (L216) Sheila E. Crowe

S505 McCormick Place

S401BC McCormick Place

McCormick Place

Putting Them to Sleep, Waking Them Up: Sedation and Monitoring for GI Procedures (L215) John J. Vargo S503

McCormick Place

Sp147

Chronic Diarrhea: Etiology, Work-Up and Management (L202) Christina M. Surawicz S504

Nutritional Support and the Gastroenterologist: Of Tubes, Lines and IV Access (L214) S401A Mark H. DeLegge

McCormick Place Sp145

AGA Institute Postgraduate Course Luncheon Breakout Sessions 12:30 PM - 1:30 PM

Sp132

IBD and the Pregnant Patient (L209) Sunanda V. Kane

McCormick Place

SESSION V: LIVER DISEASE

Sp131

Hereditary Hemochromatosis: Diagnosis and Treatment of a Common Genetic Disorder (L208) S101 Bruce R. Bacon

McCormick Place

Chair: Michael W. Fried

Autoimmune Hepatitis (L201) E. Jenny Heathcote

Hepatitis B: How and Who to Treat? (L207) Mitchell L. Shiffman

S405 McCormick Place

Refractory Nausea, Vomiting and Gastroparesis Pankaj J. Pasricha

Sp130

Fecal Incontinence: Diagnosis and Management (L206) S104 Satish S. Rao

McCormick Place

9:30 Sp121

12:20 Sp129

Esophageal pH and Motility Testing (L205) Kenneth R. DeVault

Screening for Hepatocellular Carcinoma: How to Do It and Who Deserves It? (L217) Hashem B. El-Serag S401D

McCormick Place AGA Institute Postgraduate Course General Session 1:45 PM - 3:30 PM B1 McCormick Place Chair: William R. Brugge SESSION VI: PANCREATICOBILIARY DISEASES 1:45 Sp148

Pancreatic Cysts: When to Worry and What to Do? Stuart Sherman

P-29

S U N D A Y MAY 31

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION

S U N D A Y MAY 31

2:05 Sp149

Managing Acute Pancreatitis Scott M. Tenner

2:25 Sp150

Endoscopic and Surgical Interventions in Chronic Pancreatitis: Timing and Outcomes David L. Carr-Locke

2:45 Sp151

Managing Biliary Strictures John Baillie

3:05 Sp152

The Endoscopists’ Corner: When to Choose EUS vs ERCP vs MRCP Glen A. Lehman

3:25 Sp153

Moderator’s Summary William R. Brugge

Sp164

Sp154

Barrett’s Esophagus: Managing the Patient with HighGrade Dysplasia (C201) Kenneth K. Wang E351

McCormick Place Sp155

C. difficile Colitis: Handling Refractory and Recurrent Cases (C202) Christina M. Surawicz E350

McCormick Place Sp156

Cancer Imaging and the Gastroenterologist: The Role of EUS in Staging Pancreatic, Esophageal, and Rectal Neoplasia (C203) S402 Michael B. Wallace

McCormick Place Sp157

Sp158

Case Studies in Dysphagia (C204) John E. Pandolfino

S505 McCormick Place

Completing the Difficult Colonoscopy and the Difficult Polypectomy (C205) S101 Douglas K. Rex

McCormick Place Sp159

Fistulizing Crohn’s Disease: What Is the Best Management Algorithm? (C206) William J. Tremaine

S501A McCormick Place

Sp160

Managing Chronic Pancreatitis: Enzyme Supplementation, Pain Control and Endoscopic/Surgical Intervention (C207) Peter A. Banks E352

McCormick Place Sp161

Managing Complications of Cirrhosis (C208) Michael R. Lucey

S501D McCormick Place

Sp162

Managing the Post-Bariatric Surgery Patient-Recognizing Complications and Improving Outcomes (C209) Christopher C. Thompson S501BC

McCormick Place Sp163

P-30

Stenting and Enteral Access (C210) Todd H. Baron

McCormick Place Sp165

AGA Institute Postgraduate Course Clinical Challenge Sessions 4:00 PM - 5:30 PM

S403 McCormick Place

The Complicated Functional Bowel Disease Patient: Centrally-Acting Agents and Other Treatment Modalities (C211) S503 William D. Chey Treatment of Viral Hepatitis: When First-Line Therapy Fails (C212) Paul Kwo S401D

McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS SCIENTIFIC SESSIONS AGA Institute Focused Clinical Update Discussions 6:45 AM - 8:00 AM

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM

S406A McCormick Place

Chairs: Thomas F. Imperiale, Robert E. Schoen Sp166

Constipation, Pelvic Floor Dysfunction and Anorectal Motility Disorders (FC07) William E. Whitehead CC12A

Hyatt Regency McCormick Sp167

Emerging Therapies in IBD (FC03) Subrata Ghosh

CC12D Hyatt Regency McCormick

Sp168

Eosinophilic Esophagitis (FC01) Ikuo Hirano

CC10D Hyatt Regency McCormick

Sp169

H. pylori Diagnosis and Treatment in 2009 (FC02) Steven F. Moss CC12B

Hyatt Regency McCormick Sp170

Hepatocellular Carcinoma (FC04) James R. Spivey

CC22AB Hyatt Regency McCormick

Sp171

New Treatments of Functional GI and Motility Disorders (FC06) Adil E. Bharucha CC23AB

Hyatt Regency McCormick Sp172

Update in Treatment Options for Dyspepsia (FC05) Jan F. Tack CC12C

Hyatt Regency McCormick AGA Institute Focused Research Roundtable Discussions 6:45 AM - 8:00 AM

Participants will be able to: • Review emerging research based on abstracts submitted to DDW 2009 focused on digestive disease, disorders and conditions. Sp173

Clinical and Molecular Determinants in Barrett’s (FR01) Yvonne Romero, Rebecca C. Fitzgerald CC10B

Hyatt Regency McCormick Sp175

Highlights of Mucosal Immunology (FR02) Maria T. Abreu

CC10C Hyatt Regency McCormick

ASGE Hands-on 8:00 AM - 12:00 PM

N228 McCormick Place

Sponsored by: Clinical Practice; Gastrointestinal Oncology

COLONOSCOPIC CANCER SCREENING IN 2009 Participants will be able to: • Describe recent advances in CRC screening methods; and • Explain the advantages and disadvantages of CRC screening tests. 8:30 Sp177

FOBT and Fecal Immunochemical Testing: Is FOBT Passé? James E. Allison

8:53 Sp178

Is There Still a Role for Flexible Sigmoidoscopy? Wendy Atkin

9:16 Sp179

Should Colonoscopy Be the Standard of Care? Jason A. Dominitz

9:38 Sp180

Is CTC the Screening Test of Choice? Don C. Rockey

Chairs: Marcia R. Cruz-Correa, Christian D. Stone Sponsored by: Education & Training Committee; Underrepresented Minorities Committee

THE GREAT DEBATE: CHOOSING A CAREER PATH IN GI Participants will be able to: • Discuss the pros and cons of different career pathways within GI; • Examine what personal and professional characteristics befit a particular GI career path; and • Describe the resources available within AGA career advisory program. 8:30 Sp181

Basic Science/Research Maria T. Abreu

8:53 Sp182

Clinical Academics Neena S. Abraham

9:16 Sp183

Private Practice Partha S. Nandi

9:38 Sp184

Private Practice with Clinical Academic Appointment Linda A. Lee

ADVANCED ENDOSCOPY TECHNIQUES 8:00 Sp176

10:00

Didactic Presentations S106B Jennifer S. Chennat, Jonathan Cohen, Massimo Conio, Raquel E. Davila, Jeffrey M. Marks, Dean J. Mikami, Elizabeth Rajan, Shinji Tanaka, Naohisa Yahagi Hands-On Stations

N228

MAY 31

AGA Institute Committee Sponsored Symposium 8:30 AM - 10:00 AM S501D McCormick Place

AASLD Plenary Session 8:30 AM - 10:00 AM

Chairs: Christopher J. Gostout, Irving Waxman

S106A McCormick Place

Chairs: Scott L. Friedman, Jacquelyn J. Maher AASLD PLENARY BASIC 8:30 #1

S U N D A Y

Specific Inhibition of Ikkβ in Hepatocytes Induces Proliferation of Liver Progenitors in Injured Livers Youngmi Jung*, Rafal P. Witek, Wing-Kin Syn, Steve S. Choi, Alessia Omenetti, Anna Mae Diehl

P-31

ORAL SESSIONS—SCIENTIFIC SESSIONS

S U N D A Y MAY 31

8:45 #2

NIM811 Inhibits Mitochondrial Dysfunction, Prevents Liver Injury and Stimulates Liver Regeneration After Massive Hepatectomy Zhi Zhong*, Junjiang Sun, Robert Currin, John J. Lemasters

9:00 #3

The MicroRNA miR-181b Is Involved in Extracellular Matrix Remodeling During Hepatic Regeneration Following Partial Hepatectomy Lyudmyla I. Khrapenko, Nianyuan Huang, Erica Swenson, Chiara Braconi, Tushar Patel*

9:15 #4

The Interferon Stimulated Gene 15 Promotes Hepatitis C Virus Replication, Attenuates the IFN Response in Hepatocytes and Predicts Outcome of Antiviral Therapy Ruth Broering, Martin Trippler, Min Jiang, Mengji Lu, Guido Gerken, Joerg F. Schlaak*

9:30 #5

Rab7 Dependent DR5 Trafficking to Lysosomes Is Required for the Lysosomal Pathway of TRAIL Mediated Apoptosis Yuko Akazawa*, Justin L. Mott, Steven F. Bronk, Nathan W. Werneburg, M. Eugenia Guicciardi, Xue Meng, Mark A. McNiven, Gregory J. Gores

9:45 #6

Identification and Functional Characterization of Intermediate Conductance CA2+-Activated K+ Channels (IKCa2+) in Biliary Epithelium Amal K. Dutta*, Al-Karim S. Khimji, Meghana Sathe, Kangmee Woo, Charles K. Kresge, Vinay K. Parameswara, Victoria Esser, Don C. Rockey, Andrew P. Feranchak

AASLD Topic Forum 8:30 AM - 10:00 AM

S105 McCormick Place

9:30 #12

Pegylated Interferon and Ribavirin Therapy for 24 Weeks Versus Shorter Duration for Patients with Hepatitis C Virus Genotype 2 and 3 Infection and Rapid Virologic Response: A Meta-Analysis Murtaza Arif*, Manish Thapar, Michelle L. Matteson, Abhishek Choudhary, Nicholas M. Szary, Srinivas R. Puli, Matthew L. Bechtold

9:45 #13

Impact of Diet and Exercise Intervention On Insulin Resistance and Early Virological Response to Pegylated Interferon Plus Ribavirin in Patients with Chronic Hepatitis C Yasunori Kawaguchi*, Toshihiko Mizuta, Takuya Kuwashiro, Noriko Oza, Hirokazu Takahashi, Yuichiro Eguchi, Iwata Ozaki, Kazuma Fujimoto

AGA Institute Research Forum 8:30 AM - 10:00 AM Chairs: David Q. Wang, Karel J. Van Erpecum Sponsored by: Liver & Biliary

BILIARY TRACT DISORDERS, STONE DISEASE AND STONE PATHOGENESIS Participants will be able to: • Examine the pathogenesis of gallstones better manage patients with benign biliary disorders learn about new potential therapies for gallstone. 8:30 #14

Body Mass Index and the Risk of Symptomatic Gallstones - A Prospective Cohort Study in a UK Population Heerajnarain Bulluck*, Paul R. Banim, Stephen J. Sharp, Kay-Tee Khaw, Andrew Hart

8:45 #15

Alcohol Intake and Development of Symptomatic Gallstones: An Inverse Association - A UK Prospective Cohort Study Paul R. Banim*, Robert Luben, Heerajnarain Bulluck, Nick Wareham, Stephen J. Sharp, Kay-Tee Khaw, Andrew Hart

9:00 #16

A Dark Side of FXR Activation in Cholestasis. FXR Is a Negative Regulator of MRP4 Barbara Renga, Marco Migliorati, Andrea Mencarelli, Eleonora Distrutti, Stefano Fiorucci*

9:15 #17

Inhibitory Effects of Myriocin, Sphingolipid Biosynthesis Inhibitor, On Gallstone Formation in C57BL/6J Mice in C57BL/6J Mice Beom Jae Lee*, Jae Seon Kim, Sung Joo Jung, Moon Kyung Joo, Seung Goun Hong, Benjamin Kim, Ji Hoon Kim, Jong Eun Yeon, Jong-Jae Park, Kwan Soo Byun, Young-Tae Bak, Seikwan Oh, Hwan-Soo Yoo

9:30 #18

Effect of Gallbladder Hypomotility On Cholesterol Crystallization and Growth Habit in Cholecystokinin (CCK) Deficient Mice Helen H. Wang, Piero Portincasa, Patrick Tso, Linda C. Samuelson, David Q. Wang*

9:45 #19

A Previous Cholecystectomy Increases the Risk of Developing Advanced Adenomas of the Colon Ramalinga Kedika, Amar Mahgoub, Mahir Patel, Vijay Bapat, Ali Siddiqui*

Chairs: Paul Kwo, Marc G. Ghany HEPATITIS C THERAPY 8:30 #7

The Long Term Effects of Interferon Based (IFNTx) Therapy On Hepatic Histology in Patients with Chronic Hepatitis C Virus. Results of a Five Year Prospective Evaluation On Fibrosis Progression and Fibrosis Regression Mitchell L. Shiffman*, Sarah B. Hubbard, April Long, Melissa J. Contos, A. S. Mills, Richard K. Sterling, Velimir A. Luketic, R. Todd Stravitz, Michael Fuchs, Arun J. Sanyal

8:45 #8

Histologic Outcomes in Non-SVR Patients with Varying Durations of HCV Undetectability After Interferon-Based Treatments Paul Pockros*, Fayez M. Hamzeh, Paul Martin, Ellen Lentz, Anna S. Lok

9:00 #10

Decline in Hemoglobin Is Associated with Sustained Virologic Response (SVR) Among HCV Genotype 1Infected Persons Treated with Peginterferon (PEG)/ Ribavirin (RBV): Analysis from the Ideal Study Mark Sulkowski*, Mitchell L. Shiffman, Nezam H. Afdhal, K. Rajender Reddy, Jonathan McCone, William M. Lee, Steven K. Herrine, Stephen A. Harrison, Weiping Deng, Clifford A. Brass, Kenneth J. Koury, Stephanie Noviello, Janice Albrecht, John McHutchison

9:15 #11

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Treatment Response and Tolerability to Pegylated Interferon (PEG Inf) and Ribavirin (RBV) in TreatmentNaïve Asian American Patients with Chronic Hepatitis C and Genotype 1, 2/3 and 6 Nghia H. Nguyen*, Philip Vutien, Huy N. Trinh, Ruel T. Garcia, Kenton Wan, Huy A. Nguyen, Khanh K. Nguyen, Brian S. Levitt, Mindie H. Nguyen

S502 McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 8:30 AM - 10:00 AM

S501BC McCormick Place

8:45 #27

Novel Purinergic P1, P2X and P2Y Receptor Signaling Targets in the Human Enteric Nervous System and Glia Jacqueline E. Wunderlich*, Tianhua Ren, Bradley Needleman, Dean J. Mikami, Iveta Grants, Fievos L. Christofi

9:00 #28

Cannabinoids Are Retrograde Transmitters in the Myenteric Plexus Ian M. Hons*, Beat Lutz, Keith A. Sharkey

9:15 #29

Nitrosative Stress Followed By Apoptosis via Mitochondrion-Dependent Intrinsic Pathways Mediate Selective Nitrergic Cell Death in Diabetes Shi-Yi Zhou*, Yanping Liu, Il Song, Dabo Xu, Phattrawan Pisuchpen, Chung Owyang

9:30 #30

Effect of Proinflammatory Stimuli On Cellular Activation and Nitric Oxide Production in Primary Cultures of Human Enteric Glia Carla Cirillo*, Giovanni Sarnelli, Annamaria Mango, Ida Esposito, Rosario Cuomo

9:45 #31

The Role of Gastrointestinal Mechanical Forces in the Regulation of Gut Enterochromaffin Cell Secretion and the Implications for Irritable Bowel Disease Mark Kidd*, Alexander Chin, Bjorn I. Gustafsson, ZakiyaLuna Siddique, Ignat Drozdov, Bauer Sumpio, Roswitha Pfragner, Irvin M. Modlin

Chairs: Niall P. Hyland, Million Mulugeta Sponsored by: Neurogastroenterology and Motility

BRAIN GUT INTERACTIONS IN RODENTS Participants will be able to: • Learn about the central effects of neuropeptides on visceral sensitivity and motility; • Learn about the functional role of specific neurons in the nts; and • Learn about the possible role of central stress mediators in gastric motility. 8:30 #20

Pharmacological and Genetic Identification of Neurons of the Nucleus Tractus Solitarius Pars Centralis ShuXia Wan, R. Alberto Travagli*

8:45 #21

Visceral Stimulation Enhances Cortical Registration of Somatic Afferent Signals in Rats Venelin Kounev*, Ranjit S. Makar, Rupeng Li, James S. Hyde, Reza Shaker

9:00 #22

Differential Expression of CRFR1 and CRFR2 mRNA in the Amygdala of Two Animal Models of Irritable Bowel Syndrome (IBS): Relevance to Visceral Pain Processing Javier A. Bravo*, Timothy G. Dinan, John F. Cryan

9:15 #23

9:30 #24

9:45 #25

A Central Serotonin 2C Receptor Pathway Regulates Gastrointestinal Motor Activity via GhrelinNeuropeptide Y Signaling, But Does Not Require Downstream Activation of Melanocortin 3/4 Receptors in Rats Akihiro Asakawa*, Naoki Fujitsuka, Mizuki Hayashi, Marie Sameshima, Haruka Amitani, Shinya Kojima, Mineko Fujimiya, Akio Inui Interdigestive Gastric Motility and Gastric Emptying Are No More Impaired Following Repeated Restraint Stress in Rats; the Possible Involvement of Central CRF, Gastric Ghrelin and HPA Axis in the Adaptation Process to Chronic Stress Jun Zheng*, Reji Babygirija, Anthony Dobner, Ludwig Kirk, Toku Takahashi Supraspinal Activation Associated with Stress-Induced Visceral Hypersensitivity: A Neuroimaging Study in the Awake Rat Pamela E. Paulson, Thomas J. Morrow, John W. Wiley, Shuangsong Hong*

AGA Institute Research Forum 8:30 AM - 10:00 AM

S401D McCormick Place

AGA Institute Research Forum 8:30 AM - 10:00 AM

Chairs: Jonathan D. Kaunitz, Peter Malfertheiner Sponsored by: Esophageal, Gastric & Duodenal Disorders

GERD PATHOGENESIS Participants will be able to: • Learn about advances related to GERD pathogenesis. 8:30 #32

Weight Gain After Resolution of Corpus Gastritis As Risk Factor for Development of Reflux Esophagitis After Eradication of Helicobacter pylori (HP) Justin Wu*, Jessica Ching, Joseph J. Sung, Francis K. L. Chan

8:45 #33

Experimental Induction of Esophageal Mucosa Dilated Intercellular Spaces (DIS) in Healthy Subjects. Perfusion of Different Solutions Can Provoke DIS in the Distal “Exposed” and the Proximal “Non-Exposed” Esophagus Ricard Farré*, Kathleen Blondeau, Fernando Fornari, Rita de Vos, Raf Bisschops, Michael Vieth, Pieter Vanden Berghe, Inge Depoortere, Jan F. Tack, Daniel Sifrim

9:00 #34

Reflux Esophagitis May Result Primarily from An Immune-Mediated Injury Rather Than from a Caustic, Chemical Injury Rhonda F. Souza*, Christopher M. Schuler, Vivek Mittal, Xiaofang Huo, Robert M. Genta, Stuart J. Spechler

9:15 #35

Gastroesophageal Reflux Disease Prevalence and Associated Factors: The Systematic Investigation of Gastrointestinal Diseases in China (SILC) Epidemiological Study Jia He*, Xiuqiang Ma, Yanfang Zhao, Rui Wang, Xiaoyan Yan, Hong Yan, Ping Yin, Xiaoping Kang, Jiqian Fang, Yuantao Hao, Qiang Li, Saga Johansson, Mari-Ann A. Wallander, Wenbin Liu, Zhaoshen Li

9:30 #36

The Position of the Acid Pocket As Risk Factor to Have Acid Reflux During a TLESR Hanneke Beaumont*, Roelof J. Bennink, Jan de Jong, Guy E. Boeckxstaens

Chairs: Tor Savidge, David R. Linden Sponsored by: Neurogastroenterology and Motility

ENTERIC NERVOUS SYSTEM, GLIA & ENTEROCHROMAFFIN CELLS Participants will be able to: • Examine the role of enteric nervous system and glia in neurogastroenterology; and • Review the role of enterochromaffin cells in neurogastroenterology. 8:30 #26

Accurate CA2+ Buffering and Neurotransmitter Release Requires Functional Mitochondria At Enteric Varicosities and Release Sites Pieter Vanden Berghe*, Werend Boesmans, Valentine Van den Abbeel, Jan F. Tack

S101 McCormick Place

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S U N D A Y MAY 31

ORAL SESSIONS—SCIENTIFIC SESSIONS 9:45 #37

Role of the Duodenum in Symptom Generation in GERD Ofke S. van Boxel*, Jose J. ter Linde, Durk Vries, de, André Smout, Peter D. Siersema

AGA Institute Research Forum 8:30 AM - 10:00 AM

8:45 #46

Capsaicin - A Potent Stimulator of Gastric Acid Secretion via Parietal Cell Activation Sascha Kopic*, Michael K. Murek, Elizabeth Arena, Nina Buchinger, Barbara Grotz, John P. Geibel

9:00 #47

Gastric Acid Secretion Suppression Enhanced Aquaporin-4 and KCNQ1 Expressions in the Fundic Parietal Cells Juntaro Matsuzaki*, Hidekazu Suzuki, Yoshimasa Saito, Hitoshi Tsugawa, Sachiko Suzuki, Eisuke Iwasaki, Kenro Hirata, Toshifumi Hibi

9:15 #48

Paradoxical Effects of PACAP and VIP On Mouse Gastric Acid Secretion Yuxin Lu*, Alex Cantrell, Catherine Le, David Oh, Gordon V. Ohning, Patrizia M. Germano, James Waschek, Joseph R. Pisegna

9:30 #49

Novel Roles of Membrane K+ Channels in Mediating Duodenal Epithelial Ion Transport and Bicarbonate Secretion Ho Dong Kim*, Vivian Lin, Chase Wong, Hui Dong

S103D McCormick Place

Chairs: Barbara H. Jung, Lopa Mishra Sponsored by: Gastrointestinal Oncology

MECHANISMS OF TUMOR FORMATION AND METASTASIS IN GI CANCERS

S U N D A Y MAY 31

Participants will be able to: • Understand the mechanisms of tumor formation and metastasis in GI cancers. 8:30 #38

Cited 1 Knockout Mice Have Reduced Growth of Intestinal Tumours Fei Song, Toby J. Phesse, Alan R. Clarke, Alastair J. Watson*

8:45 #39

Generation of a Novel Colon-Specific Cre-Expressing Transgenic Mouse for Colon Cancer Research Yingben Xue*, Paul W. Snyder, James C. Fleet

9:00 #40

The Role of Tyrosine 654 Phosphorylated β-Catenin in Intestinal Tumor Formation Wendy van Veelen*, Hang Le, Lau Blonden, Myrte Theeuwes, Werner Helvensteijn, Ernst J. Kuipers, Riccardo Fodde, Ron Smits

9:15 #41

9:30 #43

9:45 #44

Claudin-2 Expression Induces Epithelial Differentiation and Inhbits Metastasis in Colon Cancer Punita Dhawan, Mukul K. Mittal, Moorthy Krishnan, Nada Bulus, Roy Zent, Kay Washington, Raymond C. Harris, Robert D. Beauchamp, Amar B. Singh* Different Candidate Genes and Their Role During Tumor Progression, Invasion and Metastasis Heike Kunert*, Sarah Hauss, Claus W. Franzke, Nina Hirt, Angela Queisser, Falk Mancke, Thomas Reinheckel, Leena Bruckner-Tudermann, Thomas Brabletz, Christoph Peters, Oliver G. Opitz High Efficacy of Gene Expression Profiling and Regularized Discriminant Analysis in the Prediction of Neuroendocrine Tumor Subtypes and Their Metastases Ignat Drozdov*, Mark Kidd, Robert L. Camp, Shrikant M. Mane, Bjorn I. Gustafsson, Boaz Nadler, Irvin M. Modlin

AGA Institute Research Forum 8:30 AM - 10:00 AM

S401A McCormick Place

9:45 Sp185

AGA Institute Research Forum 8:30 AM - 10:00 AM

NOVEL MECHANISMS OF GASTROINTESTINAL TRANSPORT

Sponsored by: Gastrointestinal Oncology

PREVENTION AND MECHANISMS OF COLITIS-INDUCED CANCERS Participants will be able to: • Learn approaches to prevention and mechanisms associated with colitis-induced cancers. 8:30 #50

5-Aminosalicylic Acid Suppresses Colitis-Associated But Not Sporadic Colorectal Cancer Pim J. Koelink*, Els C. Robanus-Maandag, Daniel Hommes, Hein W. Verspaget

8:45 #51

Omeprazole Treatment As Newer Potential Chemopreventive Therapeutics for Colitic Cancer Ki-Baik Hahm

9:00 #52

Smad7 Expression in T Cells Protects from ColitisAssociated Colorectal Cancer Massimo C. Fantini*, Angelamaria Rizzo, Daniele Fina, Roberta Caruso, Massimiliano Sarra, Carmine Stolfi, Christoph Becker, Thomas T. MacDonald, Francesco Pallone, Markus F. Neurath, Giovanni Monteleone

9:15 #53

TNF-α Knockout Mice Are Not Protected Against Colitis-Associated Cancer Violeta Zaric*, Brian Craven, Celine Inderhaug, Laurence J. Egan

9:30 #54

Chemopreventive Effects of Coltect, a Novel Dietary Supplement and 5-Aminosalicylic Acid, in 1, 2Dimethylhydrazine-Induced Colon Carcinogenesis in Rats Ilan Aroch, Ehud Ron, Aharon Hallak, Sarah Kraus, Diana Kazanov, Shahar Lev-Ari, Baruch Shpitz, Iris Dotan, Nadir Arber*

9:45 #55

Resistance to Colitis-Associated Cancer in Mice Lacking Guanylate Cyclase C Kris A. Steinbrecher*, Monica P. Garin-Laflam, Eleana Harmel-Laws, Lucas D. Bezerra, Elizabeth A. Mann, Mitchell B. Cohen

Participants will be able to: • Identify new mechanisms that regulate ion transport in the upper GI tract. 8:30 #45

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Dual Actions of Estrogen Receptor Subtypes On Murine Intestinal Epithelial Bicarbonate Secretion Hui Dong*, Ho Dong Kim, Vivian Lin, Chase Wong, Christine L. Estrema, Xiao Dong

S503 McCormick Place

Chairs: Christoph Gasche, Fernando S. Velayos

Chairs: Tomasz Brzozowski, Jian-Ying Wang Sponsored by: Esophageal, Gastric & Duodenal Disorders

Summary and Overview Talk Duan Chen

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 8:30 AM - 10:00 AM

S505 McCormick Place

8:45 #63

Proton Pump Inhibitor (PPI) Use Is Independently Associated with Spontaneous Bacterial Peritonitis (SBP) in Cirrhotics with Ascites William J. Bulsiewicz*, John R. Scherer, Joseph M. Feinglass, Colin W. Howden, Steven L. Flamm

9:00 #64

A Systematic Review of the Risk of Colorectal Cancer (CRC) in Liver Transplant Patients Jerome Sint Nicolaas*, Vincent de Jonge, Ernst J. Kuipers, M. E. Leerdam van, Sander Veldhuyzen van Zanten

9:15 #65

Increased Risk of Esophageal Varices, Liver Cancer and Death in Patients with Alcoholic Liver Disease Knut Stokkeland*, Anders Ekbom

9:30 #66

Rifaximin Reduces the Risk of Hospitalizations in Patients with Previous Episodes of Hepatic Encephalopathy: Results from a Phase 3 PlaceboControlled Trial Guy Neff*, Carroll B. Leevy, Todd Frederick, Kunal Merchant, Shirley Huang, Audrey L. Shaw, William P. Forbes

Chairs: Shrikant Anant, Jean Marie Houghton Sponsored by: Gastrointestinal Oncology

STEM CELL BIOLOGY IN GI CANCERS Participants will be able to: • Understand the role of stem cells in the development of GI cancers. 8:30 #56

8:45 #57

9:00 #58

9:15 #59

9:30 #60

9:45 #61

Comparison of CD133-Positive and CD133-Negative Colon Cancer Cells Celia Chao*, Kirk L. Ives, Courtney M. Townsend Jr., Mark R. Hellmich Bone Marrow Derived Cells Contribute to the Tumor Microenvironment and Increase the Aggressiveness of Colon Cancer Cells Jan Cerny*, Hanchen Li, Calin Stoicov, Xueli Fan, Jian Hua Liu, Glennice Bowen, Anna Cerny, Evelyn A. Kurt-Jones, Susan Erdman, Jean Marie Houghton Bone Marrow Derived Lin-Cd44hisca1-Ckit+CD34- Can Give Rise to Mesenchymal Stem Cells and Delay Progression to Dysplasia in a Murine Helicobacter Model of Gastric Cancer Sheng-Wen Wang, Samuel Asfaha*, Tomoyuki Okumura, Kelly S. Betz, Sureshkumar Muthupalani, Shuiping Tu, Shigeo Takaishi, Guangchun Jin, Xiangdong Yang, DengChyang Wu, James G. Fox, Timothy C. Wang Deficiency of Bone Marrow Derived TNF α Impairs Stem Cell Activation and Promotes Apoptosis in Murine Small Intestine Following T Cell Activation Ajaypal Singh*, Mutazz Darweesh, Goo Lee, Ramanarao Dirisina, Rebecca B. Katzman, Terrence A. Barrett Identification of a Novel Pancreatic Stem Cell Marker DCAMKL-1 in Mouse Pancreas and in Pancreatic Cancer Randal May*, Sripathi M. Sureban, Stan A. Lightfoot, Daniel J. Brackett, Russell G. Postier, Rama P. Ramanujam, James H. Wyche, Zhiyong Han, Chinthalapally V. Rao, Shrikant Anant, Courtney W. Houchen

9:45 Sp186

MICROBIAL INDUCED INTESTINAL INFLAMMATION Participants will be able to: • Review the key factors most relevant to microbial induced intestinal inflammation. 8:30 #67

Activation of Host Proteolytic Pathways By Nematode Generated Serine Proteases Is a Stereotypic Mechanism of Molecular Mimicry Jennifer A. Stiltz*, Sarah Netzel-Arnett, Luigi Notari, Toni Antalis, Joseph F. Urban Jr., Terez Shea-Donohue, Aiping Zhao

8:45 #68

Bacterial Type Three Secretion Protein AvrA Increases p53 Acetylation in Intestinal Inflammation Yun Zhao, Zhongde Ye, Shaoping Wu, Yinglin Xia, Andrew Steiner, Elaine O. Petrof, Erika C. Claud, Jun Sun*

9:00 #69

Acute Intestinal Inflammation Decreases Microbial Diversity and Triggers the Proliferation of Adherent and Invasive E. coli Melanie Craven*, Charlotte E. Egan, Belgin Dogan, Eric Denkers, Sean McDonough, Ellen J. Scherl, Kenneth W. Simpson

9:15 #70

CD-Associated Adherent-Invasive Escherichia coli LF82 Colonize and Induce Severe Intestinal Inflammation in Transgenic Mice Expressing the Human CEACAM6 Receptor Nicolas Barnich*, Frédéric A. Carvalho, Carlos H. Chan, Clifford P. Stanners, Arlette Darfeuille-Michaud

9:30 #71

Clonal Invasive Escherichia coli Isolates from Inflammatory Bowel Disease (IBD) Resections Erin K. Okeefe, Edgar C. Boedeker*

9:45 #72

Experimental Colitis Induces Cecal Escherichia coli to Upregulate the Small Heat Shock Protein, Ibpb, In Vivo Jonathan J. Hansen*, Sandra C. Kim, Bo Liu, R. Balfour Sartor

CARE OF THE PATIENT WITH CHRONIC LIVER DISEASE

8:30 #62

Measuring Quality of Care in Patients with Cirrhosis: Development of An Explicit Quality Indicator Set Fasiha Kanwal*, Steven M. Asch, Jennifer R. Kramer, Steven A. Edmundowicz, Arun J. Sanyal, Hashem B. El-Serag, Jason A. Dominitz, Kenneth R. McQuaid, Paul Martin, Emmet B. Keeffe, Lawrence S. Friedman, Samuel B. Ho, Francisco A. Durazo, Bruce R. Bacon

S404 McCormick Place

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases; Hormones, Transmitters, Growth Factors & Their Receptors

Sponsored by: Clinical Practice; Gastrointestinal Oncology; Liver & Biliary

Participants will be able to: • Review the metrics for assessing quality of care in cirrhosis; and • Become familiar with measures to treat hepatic encephalopathy in cirrhosis.

MAY 31

Chairs: Charles O. Elson, Edgar C. Boedeker

S405 McCormick Place

Chairs: Robert S. Brown, F. Fred Poordad

Maintenance Care of the Cirrhotic Patient Nancy Reau

AGA Institute Topic Forum 8:30 AM - 10:00 AM

Curcumin Targets Colon Cancer Stem-Like Cells Adhip N. Majumdar*, Yingjie Yu, Bhaumik B. Patel

AGA Institute Topic Forum 8:30 AM - 10:00 AM

S U N D A Y

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ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 8:30 AM - 10:00 AM

S U N D A Y

S401BC McCormick Place

AGA Institute Topic Forum 8:30 AM - 10:00 AM

S103ABC McCormick Place

Chairs: Francisco Sylvester, Wallace Crandall

Chairs: Gil Y. Melmed, Iris Dotan

Sponsored by: Growth, Development & Aging; Immunology, Microbiology & Inflammatory Bowel Diseases

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases; Intestinal Disorders

PEDIATRIC INFLAMMATORY BOWEL DISEASE: CLINICAL AND TRANSLATIONAL RESEARCH

TOPICS IN INTESTINAL INFLAMMATION AND IBD

Participants will be able to: • Learn about emerging therapies for growth failure in Crohn disease; • Appreciate the potential of new biologic therapies for IBD; and • Understand the importance of C. difficile infections in IBD. 8:30 #73

Innate Dysfunction and Linear Growth Failure in Pediatric Crohn Disease Sharon D’Mello, Anna Trauernicht, Erin L. Bonkowski, Tara Willson, Subra Kugathasan, Lee Denson*

8:45 #74

A Randomized Controlled Trial of Growth Hormone in Active Pediatric Crohn Disease Lee Denson*, Ramona Bezold, Erin L. Bonkowski, Mi-Ok Kim, David J. Klein

9:00 #75

STAT6 Activation in Ulcerative Colitis: A Target for Prevention of IL-13-Induced Colonic Epithelial Cell Dysfunction Michael J. Rosen*, Mary Kay Washington, D. Brent Polk

9:15 #76

Genome Wide Association (GWA) Predictors of AntiTNFα Therapeutic Responsiveness in Pediatric Inflammatory Bowel Disease (IBD) Marla Dubinsky*, Ling Mei, Madison Friedman, Hakon Hakonarson, Talin Haritunians, Cecilia Kim, Joseph Glessner, Stephan R. Targan, Dermot P. McGovern, Kent D. Taylor, Jerome I. Rotter

MAY 31

9:30 #77

9:45 #78

Human Alpha Defensin 5 mRNA Levels Are Decreased in Children with Untreated, Newly Diagnosed Crohn Disease Kyle Kusek*, Jaya Punati, Charles L. Bevins, John A. Barnard, Robert J. Kays, Hiutung Chu, Laura Mackner, Wallace Crandall

Participants will be able to: • Be familiar with the association of chronic intestinal inflammation with bacterial gastroenteritis and with anti-CTLA4 antibody (ipilimumab); • Be familiar with the efficacy of budesonide and mesalamine in active ulcerative colitis; and • Be familiar with long term trends in surgery for ulcerative colitis, and effects of maternal IBD on the health of offspring. 8:30 #79

Ipilimumab-Related Colitis in Patients with Advanced Melanoma Receiving Ipilimumab Therapy: Histopathologic and Serologic Characterization Hanlin L. Wang*, Zenta Tsuchihashi, Stephan R. Targan, Susan M. Parker, Jonathan Siegel, David Berman

8:45 #80

Increased Risk of Inflammatory Bowel Disease After Salmonella or Campylobacter Gastroenteritis: A Population-Based Cohort Study Henrik Nielsen*, Kim Gradel, Hans L. Nielsen, Henrik C. Schønheyder, Brian Kristensen, Tove Ejlertsen

9:00 #81

Stool Coliform Testing Can Predict Effective Treatment Regimes for Patients with Antibiotic Resistant Pouchitis Simon D. McLaughlin*, Susan K. Clark, Paris P. Tekkis, liljana petrovska, Paul J. Ciclitira, Ralph. J. Nicholls

9:15 #82

Surgical Rates in Ulcerative Colitis: Have We Made a Difference? Eoin Slattery*, Denise Keegan, Hugh Mulcahy, Diarmuid P. O’Donoghue

9:30 #83

Efficacy and Tolerability of a Once Daily Treatment with Budesonide Capsules Versus Mesalamine Granules for the Treatment of Active Ulcerative Colitis: A Randomized, Double-Blind, Double-Dummy, Multicenter Study Volker Gross*, Ivan Bunganic, Tatyana L. Mikhailova, Limas Kupcinskas, Gediminas Kiudelis, Zsolt Tulassay, Libor Gabalec, Andrey Dorofeyev, Jelena Derova, Roland Greinwald, Ralph Mueller

9:45 #84

The Effect of Inflammatory Bowel Disease (IBD) During Pregnancy On Long-Term Health and Illness in Children of IBD Patients-a Multicenter Israeli Study Iris Dotan*, Arik Alper, Daniel Rachmilewitz, Selwyn Odes, Irit Chermesh, Gerald Fraser, Vardit Peles, Shimon Reif

Rate of Recurrence of Clostridium difficile in Pediatric Patients with Inflammatory Bowel Disease Judith R. Kelsen*, Daniel R. Latta, Theoklis Zaoutis, Karin L. McGowan, Petar Mamula, Robert Baldassano

AASLD State-of-the-Art Lecture 10:30 AM - 11:30 AM

S105 McCormick Place

Chair: Mitchell L. Shiffman HCV THERAPY ADVANCES: TODAY AND TOMORROW Participants will be able to: • Review the advances in HCV therapy since the AASLD practice guidelines of 2004; • Address the continuing areas of uncertainty and knowledge gaps; and • Assess the developmental progress of newer HCV therapies and their potential role in the future. 10:30 Sp187

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HCV Therapy Advances: Today and Tomorrow Donald M. Jensen

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute State-of-the-Art Lecture 10:30 AM - 11:30 AM

S405 McCormick Place

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM

S406A McCormick Place

Chair: Enrique Rozengurt

Chairs: Braden Kuo, Jeffrey L. Conklin

Sponsored by: Hormones, Transmitters, Growth Factors & Their Receptors; Growth, Development & Aging; Neurogastroenterology and Motility; Pancreatic Disorders

Sponsored by: Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Imaging & Advanced Technology; Neurogastroenterology and Motility

BASIC MECHANISMS REGULATING CALCIUM SIGNALING AND HOMEOSTASIS

MOTILITY CONTROVERSIES IN FUNCTIONAL GI DISORDERS

Participants will be able to: • Examine polarized Ca2+ signaling and intracellular Ca2+ homeostasis in polarized cells with emphasis on pancreatic acinar cells; • Review the special nature of the CCK - CCK receptor - intracellular naadp Ca2+ signal generating system, with emphasis on human pancreatic acinar cells; and • Describe pathological Ca2+ signaling in relationship to acute pancreatitis and possible therapeutic approaches.

Participants will be able to: • Review data regarding gastric emptying studies in functional dyspepsia and gastroparesis; and explore the role of measuring colonic transit time in constipation; • Define when and how to screen for pelvic dyssynergia; and • Review the potential role of capsule-assisted motility measurements in GI practice.

10:30 Sp188

Basic Mechanisms Regulating Calcium Signaling and Homeostasis Ole H. Petersen

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM

S402 McCormick Place

Chairs: Michelle Pietzak, Joel R. Rosh Sponsored by: Growth, Development & Aging; In collaboration with NASPGHAN; Hormones, Transmitters, Growth Factors & Their Receptors; Immunology, Microbiology & Inflammatory Bowel Diseases; Intestinal Disorders; Nutrition & Obesity

GROWTH HORMONE AND OTHER TROPHIC FACTORS IN SHORT-BOWEL SYNDROME AND CROHN DISEASE Participants will be able to: • Review potential applications of trophic factors in treating shortbowel syndrome; • Examine the effects of trophic factors on the intestine; and • Discuss the role of trophic factors in treating children with Crohn’s disease. 10:30 Sp189

Human Growth Hormone in Short-Bowel Syndrome Ezra Steiger

10:45 Sp190

Glucagon-Like Peptide 2 in Intestinal Adaptation David L. Sigalet

11:00 Sp191

Growth Hormone Therapy in Crohn Disease Richard J. Grand

10:30 Sp192

Measuring Gastric Emptying for Foregut Symptoms: When, How, and Why? Edy E. Soffer

10:52 Sp193

Is There a Role for Measuring Colonic Transit Time in Chronic Constipation? William D. Chey

11:14 Sp194

Screening for Pelvic Dyssynergia in Chronic Constipation: When, How, and Why? Satish S. Rao

11:36 Sp195

SmartPill: Changing Our Practice, or a Technology Looking for An Application? Kenneth L. Koch

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM

S103ABC McCormick Place

Chair: Massimo Raimondo Sponsored by: Pancreatic Disorders; Clinical Practice; Gastrointestinal Oncology; Imaging & Advanced Technology

PANCREATIC CYSTS: MANAGEMENT OF BRANCH DUCT IPMN Participants will be able to: • Describe the natural history of branch duct IPMN; • Examine the surveillance strategy for branch duct IPMN; and • Illustrate an evidence based clinical algorithm for branch duct IPMN management. 10:30 Sp196

Management Consensus Guidelines: Are They Effective? Massimo Raimondo

10:52 Sp197

IPMN: An Update On Molecular Pathogenesis Sushovan Guha

11:14 Sp198

IPMN: A Surgeons Perspective Carlos Fernandez del-Castillo

11:37 Sp199

Endoscopic Cyst Ablation John M. DeWitt

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S U N D A Y MAY 31

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Committee Sponsored Symposium 10:30 AM - 12:00 PM S501A McCormick Place

AGA Institute Research Symposium 10:30 AM - 12:00 PM

Chair: James M. Anderson

Chairs: Christian Jobin, Mark R. Frey

Sponsored by: Research Policy Committee; Underrepresented Minorities Committee

Sponsored by: Intestinal Disorders; Esophageal, Gastric & Duodenal Disorders; Growth, Development & Aging; Gastrointestinal Oncology; Hormones, Transmitters, Growth Factors & Their Receptors; Immunology, Microbiology & Inflammatory Bowel Diseases; Liver & Biliary; Neurogastroenterology and Motility

HOW TO TAKE ADVANTAGE OF THE NIH ROADMAP: DEVELOPING AND BUILDING A COLLABORATIVE RESEARCH GROUP

S U N D A Y MAY 31

Participants will be able to: • Discuss the fundamentals of developing a translational research program, using complex genetic diseases, as an example; • Explain how to develop and build a successful clinical research team; and • State the fundamentals of working with biotechnology in an effort to establish fundable research ventures. 10:30 Sp200

How to Develop a Fundable Translational Research Program in Complex Genetic Diseases Judy H. Cho

10:53 Sp201

Developing and Building Clinical Research Teams Ronald J. Sokol

11:16 Sp202

How to Work with Biotechnology to Develop Fundable Ventures Samuel Wickline

11:38 Sp203

Overview of the National Commission On Digestive Disease’s Report, Opportunities and Challenges in Digestive Diseases Research and the Burden of Digestive Diseases in the United States Stephen P. James

S503 McCormick Place

NF-KB: FRIEND OR FOE? Participants will be able to: • Describe the biological function of NF-kB in the intestine; • Review the differential role of NF-kB subunits in regulating intestinal homeostasis; and • Appreciate the function of NF-kB signaling in terminating inflammation, and contrast the protective and deleterious function of NF-kB in the liver. 10:30 Sp207

Impact of IKKg On the Maintenance of Intestinal Homeostasis Manolis Pasparakis

10:52 Sp208

NF-kB Signaling Mediates Resolution of Inflammation Toby Lawrence

11:14 Sp209

The Protective and Deleterious Role of NF-kB Subunits in Colitis Bruce Horwitz

11:36 Sp210

The Contradictory Function of NF-kB in Liver Physiology Yinon Ben-Neriah

AGA Institute Committee Sponsored Symposium 10:30 AM - 12:00 PM S501BC McCormick Place

AGA Institute Research Symposium 10:30 AM - 12:00 PM

Chair: Darrell S. Pardi

Chairs: Wael M. El-Rifai, Ajay Goel

Sponsored by: Education & Training Committee

Sponsored by: Gastrointestinal Oncology; Growth, Development & Aging; Esophageal, Gastric & Duodenal Disorders

ISSUES FACING GI FELLOWSHIP PROGRAMS: A PRIMER FOR PROGRAM DIRECTORS Participants will be able to: • Identify how to implement the ACGME six core competencies; • Review the “institutional rules” regarding salary and remuneration; and • Examine various opportunities to fund fellowship positions; review the status of the hepatology CAQ and other 4th year fellowships. 10:30 Sp204

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Panel Discussion Deborah D. Proctor, Ellen M. Zimmermann, M. Michael Wolfe

S403 McCormick Place

ONCOGENOMICS AND EPIGENOMICS IN HUMAN CANCERS Participants will be able to: • Review the mechanisms of genomic instability in gastrointestinal cancers; • Examine the role of chromosomal alterations and epigenetics in GI cancers; and • Review the role of CpG island hypermethylation as a predictive tool in GI cancers. 10:30 Sp211

The Genetics and Epigenetics of Esophageal Carcinogenesis Stephen J. Meltzer

11:00 Sp212

CpG Island Hypermethylation As a Potential Biomarker for Cancer Prediction Ajay Goel

11:30 Sp213

Chromosomal Aberrations in the Human Cancer Genome Thomas Ried

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Translational Symposium 10:30 AM - 12:00 PM

S504 McCormick Place

11:30 #89

Sustained Activation of RAC1 Enhances HedgehogMediated Epithelial-Mesenchymal Transition in Mice with Chronic Liver Injury Steve S. Choi*, Rafal P. Witek, Alessia Omenetti, Liu Yang, Wing-Kin Syn, Youngmi Jung, Jason K. Sicklick, Anna Mae Diehl

11:45 #90

Proliferative Advantage of Transplanted Wildtype Hepatocytes Results in Spontaneous Repopulation of the Liver of a Mouse Model of Human Alpha-1-Antitrypsin Disease Jianqiang Ding*, Govardhana R. Yannam, Tunda Hidvegi, Xia Wang, Chandan Guha, Namita Roy-Chowdhury, David H. Perlmutter, Ira J. Fox, Jayanta Roy-Chowdhury

Chairs: Kevin W. Olden, Thomas L. Abell Sponsored by: Neurogastroenterology and Motility; Esophageal, Gastric & Duodenal Disorders; Growth, Development & Aging; Hormones, Transmitters, Growth Factors & Their Receptors; Clinical Practice

CYCLICAL VOMITING SYNDROME (CVS) DURING THE LIFESPAN: ADVANCES IN BASIC UNDERSTANDING AND CLINICAL MANAGEMENT Participants will be able to: • Review the epidemiology and clinical presentation of CVS in children and adults; • Analyze the genetic basis of CVS and its relationship to other clinical syndromes; and • Describe the evolving understanding of neurobiological mechanisms and treatment targets for CVS. 10:30 Sp214

The Clinical Spectrum of CVS in Adults - New Insights Into Understanding the Disorder David R. Fleisher

10:52 Sp215

CVS in Children - Diagnosis and Therapeutic Options B. U. Li

11:14 Sp216

Genetic Aspects of CVS - Links Between Early CVS, Adult Migraine and Other Symptom-Based Disorders Richard G. Boles

11:36 Sp217

Neurobiological Basis of Vomiting in CVS and Therapeutic Implications Yvette Tache

AASLD Research Forum 10:30 AM - 12:00 PM

S106A McCormick Place

Chairs: Natalie Torok, Lopa Mishra

AGA Institute Research Forum 10:30 AM - 12:00 PM Chairs: Roy C. Orlando, David I. Soybel

Sponsored by: Esophageal, Gastric & Duodenal Disorders

ADVANCES IN GERD PATHOGENESIS II

Cultured Mouse Menchymal Stem Cells Form Hepatocytes By FUSION with Host Hepatocytes and Directly Contribute to Sinusoidal Cells By Transdifferentiation Jean Marie Houghton, Hanchen Li*, Xueli Fan, Jian Hua Liu

10:45 #86

Dysfunction of Hepatocyte Nuclear Factor-4α Contributes to Alcohol-Induced Intestinal Barrier Disruption Hai Zhong*, Yantao Zhao, Craig J. McClain, Y. James Kang, Zhanxiang Zhou

11:00 #87

Nucleoplasmic Calcium Regulates Proliferation of Hepatocytes Through Legumain and Reticulon4 Viviane A. Andrade*, Camila A. Jardim, Flávia M. Melo, Wilson A. Silva Jr, Michael H. Nathanson, J Miguel Ortega, Maria F. Leite

11:15 #88

TGF-β Signaling Modulates Hepatocyte Phenotype in Liver Regeneration Following Partial Hepatectomy Arun Thenappan*, Majed El Zouhairi, Kirti Shetty, Lynt Johnson, Lopa Mishra

S U N D A Y MAY 31

Participants will be able to: • Learn new advances in GERD pathogenesis. 10:30 #91

Esophageal Mucosal Damage Induced By Weakly Acidic Solutions Containing Unconjugated Bile Acids, Similar to Reflux in GERD Patients “On” PPI, Can Be Prevented with Anti-Oxidants Ricard Farré*, Lucia Cardozo, Kathleen Blondeau, Rita de Vos, Pieter Vanden Berghe, Inge Depoortere, Jan F. Tack, Daniel Sifrim

10:45 #92

Increased Esophagogastric Junction Distensibility in GERD Patients Assessed with the Endoscopically Placed Functional Luminal Imaging Probe (Endoflip®) Monika A. Kwiatek*, Ikuo Hirano, Peter J. Kahrilas, Barry P. McMahon, John E. Pandolfino

11:00 #93

Enhanced Esophageal NADPH Oxidase 3 Expression and Free Radical Production in Response to Acid Eisuke Iwasaki*, Hidekazu Suzuki, Yoshimasa Saito, Tatsuhiro Masaoka, Toshihiro Nishizawa, Hitoshi Tsugawa, Sachiko Suzuki, Juntaro Matsuzaki, Kenro Hirata, Toshifumi Hibi

11:15 #94

Adaptive Responses of the Esophagogastric Junction High Pressure Zone: High Resolution Manometry Analysis in Normal Subjects and Patients with Hiatal Hernia Javier Gomez*, Annapurna Korimilli, Zeeshan Ramzan, Michael S. Smith, Joel Richter, Robert S. Fisher, Henry P. Parkman

11:30 #95

Luminal Nitric Oxide Provoked Dilated Intercellular Spaces in Esophageal Epithelium of Rats Hirotaka Ito*, Katsunori Iijima, Nobuyuki Ara, Shuichi Ohara, Tooru Shimosegawa

11:45 #96

The Structure and Function of the Gastro-Esophageal Junction in Health and Reflux Disease Assessed By Magnetic Resonance Imaging and High Resolution Manometry Elad Kaufman*, Jelena Curcic, Anupam Pal, Zsofia ForrasKaufman, Reto Treier, Werner Schwizer, Michael Fried, Peter Boesiger, Mark Fox

STEM CELL BIOLOGY, SIGNALING AND GENE EXPRESSION 10:30 #85

S104 McCormick Place

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ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 10:30 AM - 12:00 PM

S401BC McCormick Place

10:45 #104

Expression of Mucosal Cytokine and SERT in Rats of Chronic Visceral Hypersensitivity Induced By Colon Irritation During Postnatal Development Yan Chi*, Chengcheng Sun, Yixuan Li, Huahong Wang, Xinguang Liu

11:00 #106

Fecal Supernatants from Ulcerative Colitis Patients Display Antinociceptive Effects On Colorectal Sensitivity When Infused Intracolonically in Mice: Role of Cathepsin-G Anita Annahazi*, Krisztina Gecse, Marta Dabek, Afifa AitBelgnaoui, Andras I. Rosztoczy, Richárd Róka, Tamas Molnar, Vassilia Theodorou, Tibor Wittmann, Lionel Bueno, Helene Eutamene

11:15 #107

Stimulation of Spinal Afferents Evokes Slowly-Activating Excitatory Responses in Enteric Neurons in Parallel with Release of Mast Cell Proteases in Guinea Pig Ileum and Colon Guo-Du Wang, Xiyu Wang, Yun Xia, Sumei Liu, Mei-Hua Qu, Wei Ren, Jackie D. Wood*

Chairs: Jennifer S. Labus, Qasim Aziz Sponsored by: Neurogastroenterology and Motility

BRAIN RESPONSES TO ESOPHAGEAL AND RECTAL STIMULI

S U N D A Y

Participants will be able to: • Review brain responses to rectal and esophageal stimulation; • Examine attentional modulation of brain responses to visceral stimuli; and • Examine human swallowing motor cortex. 10:30 #97

Effect of Perception On Cerebral Cortical Functional Connectivity Networks Associated with Rectal Sensation Mark Kern*, Jonathan Huang, Reza Shaker

10:45 #98

Effect of Subliminal Esophageal Acid Stimulation On Cerebral Cortical Activity Associated with Volitional Gastrointestinal and Somatic Motor Tasks Jonathan Huang*, Mark Kern, Stephen J. Antonik, Rachel Mepani, Syed Q. Hussaini, Matthew D. Verber, Safwan Jaradeh, Reza Shaker

11:30 #108

Involvement of the Transient Receptor Potential Vanilloid 1 (TRPV1) in the Development of Acute Visceral Hyperalgesia During Colorectal Distension in Rats Anna Ravnefjord, Mikael Brusberg, Daiwu Kang, Udo Bauer, Håkan Larsson, Erik Lindström, Vicente Martinez*

11:00 #99

Increased Allocation of Cognitive Resources for Selective Attention in IBS Patients Eduardo Vianna*, Jennifer S. Labus, Steven M. Berman, Brandall Y. Suyenobu, Johanna Jarcho, Kirsten Tillisch, Bruce D. Naliboff, Emeran A. Mayer

11:45 #109

Role of the Sympathetic Nervous System in Chronic Visceral Hypersensitivity in Rats Jing Wang, Krishnapraveen Yadlapalli, John E. Donello, Daniel W. Gil, Elie D. Al-Chaer*

11:15 #100

Reversibility in Human Swallowing Motor Cortex By Paired Cortical and Peripheral Stimulation to a Unilateral Virtual Lesion: Evidence for Targetting the Contralesional Cortex Emilia Michou, Satish Mistry, Samantha Jefferson, Shaheen Hamdy*

MAY 31

11:30 #101

11:45 #102

Functional Network Activation During Pelvic Visceral Distension in Healthy Controls and Patients with Irritable Bowel Syndrome: A Quantitative Meta-Analysis Jennifer S. Labus*, Kirsten Tillisch, Emeran A. Mayer Both Visceral and Somatic Endogenous Pain Modulation Is Abnormal in IBS Patients: A Meta-Analysis Across Different Races Clive H. Wilder-Smith

AGA Institute Research Forum 10:30 AM - 12:00 PM

S101 McCormick Place

Chairs: Keith A. Sharkey, Michael Beyak

AGA Institute Research Forum 10:30 AM - 12:00 PM Chairs: Marla Dubinsky, Peter L. Lakatos

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

IBD EPIDEMIOLOGY AND NATURAL HISTORY Participants will be able to: • Be familiar with new epidemiologic associations with IBD, including arachidonic acid and sunlight exposure, and changing patterns of disease incidence; • Be familiar with colonic neoplasia risks in IBD and in microscopic colitis; and • Understand the relationship between genetic and environmental risks for intestinal inflammation as indicated by fecal calprotectin. 10:30 #110

Arachidonic Acid Increases the Risk of Ulcerative Colitis - A Prospective Cohort Study in EPIC-Denmark Using Biomarker Data Punyanganie S. de Silva*, Anja Olsen, Anne Tjonneland, Kim Overvad, Erik Berg Schmidt, Andrew Hart

10:45 #111

Low Frequency of IBD-Related Colorectal Carcinoma in Non-Tertiary Centers: Final Results of a Nation Wide Long-Term Survey Judith E. Baars*, Ernst J. Kuipers, Ruud Beukers, Adriaan C. Tan, Bas L. Weusten, M. K. Casparie, Christien J. van der Woude

11:00 #112

Concomitant Adenoma Rates in Patients with Microscopic Colitis Eugene F. Yen*, Bhupesh Pokhrel, Laura K. Bianchi, Hemant K. Roy, Curtis R. Hall, Benjamin Witt

Sponsored by: Neurogastroenterology and Motility

COLONIC VISCEROSENSITIVITY MECHANISMS Participants will be able to: • Examine central viscerosensory mechanisms in colorectal hypersensitivity; and • Examine peripheral mechanisms in colorectal hypersensitivity. 10:30 #103

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Up-Regulation of Phosphorylated NR2B Subunit of the NMDA Receptors (NMDAR) in the Postsynaptic Density Contributes to Anterior Cingulate Cortex Synaptic Plasticity and Visceral Hypersensitivity Jing Fan, Xiaoyin Wu, Haiyan Liu, Chung Owyang, Ying Li*

S502 McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS 11:15 #113

11:30 #114

11:45 #115

Subclinical Inflammation Due to Environmental Exposure in Healthy Co-Twins to Twins with Inflammatory Bowel Disease Yaroslava Zhulina*, Marie Carlson, Christer G. Peterson, Curt Tysk, Anders Gustavsson, Johan Bohr, Lennart Bodin, Jonas Halfvarson

AGA Institute Research Forum 10:30 AM - 12:00 PM

The Changing Pattern of Crohn’s Disease Incidence According to Age in Northern France: A Constant Increase in the 0-19 Year’s Age Group (1988-2005) Vincent Chouraki, Luc Dauchet, Gwenola VernierMassouille, Veronique Merle, Jean-Louis Dupas, Eric Lerebours, Jean-Eric Laberenne, jean-Louis Salomez, Guillaume Savoye, Antoine Cortot, Corinne GowerRousseau, Jean-Frederic Colombel*

Sponsored by: Esophageal, Gastric & Duodenal Disorders

Geographic Distribution of Inflammatory Bowel Disease (IBD) in France and Sunlight Exposure Virginie Nerich, Elisabeth Monnet, Marie-Christine BoutronRuault, Hubert Allemand, Alain Weill, Franck Carbonnel*

AGA Institute Research Forum 10:30 AM - 12:00 PM

Chairs: Andrzej S. Tarnawski, Jonathan D. Kaunitz

NEW DEVELOPMENTS IN MUCOSAL DEFENSE, INJURY AND CYTOPROTECTION Participants will be able to: • Understand molecular mechanisms that regulate wound healing; and • Understand in more detail mechanisms that regulate mucosal defense. 10:30 Sp218

State-of-the-Art Overview Sandor Szabo

10:45 #122

Acid and Bile Acids Modulate the Esophageal Squamous Barrier Function By Modulating the Localization of Claudins Tadayuki Oshima*, Junichi Koseki, Karin Gedda, Stefan E. Pierrou, Hiroto Miwa

11:00 #123

Trefoil Factor-2 and Sodium-Hydrogen Exchanger Share Common Pathways in Stimulating Gastric Epithelial Repair of Microlesions In Vivo Lin Xue*, Eitaro Aihara, Marshall H. Montrose

11:15 #124

Down-Regulation of 15-Hydroxyprostaglandin Dehydrogenase During Gastric Ulcer Healing Tetsuya Tanigawa*, Toshio Watanabe, Hiroshi Tatsuwaki, Hirohisa Machida, Hirotoshi Okazaki, Hirokazu Yamagami, Kenji Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara, Nobuhide Oshitani, Tetsuo Arakawa

11:30 #125

M-Numb Expression Induced Gastric Mucosal Regeneration After Injury By Stimulating the Expression of Morphogenic Genes Tetsufumi Takahashi*, Hidekazu Suzuki, Yoshimasa Saito, Hiroshi Nagata, Hideyuki Okano, Toshifumi Hibi

11:45 #126

STAT3 Tyrosine Phosphorylation and Its Nuclear Import Are Novel Molecular Mechanisms in Experiment Duodenal Ulceration in Rats and Egr-1 Knockout Mice Tetyana Khomenko*, Longchuan Chen, Xiaoming Deng, Amrita Ahluwalia, Andrzej S. Tarnawski, Sandor Szabo

E350 McCormick Place

Chairs: Kim E. Barrett, Dirk Haller Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

INTERACTIONS BETWEEN THE INTESTINAL MICROBIOTA AND INTESTINAL INFLAMMATION Participants will be able to: • Review the key factors most relevant to interactions between the intestinal microbiota and intestinal inflammation. 10:30 #116

Phylogenetic Fingerprinting of the Faecal Microbiota in IBD-Patients Using the Human Intestinal Tract (HIT) Chip Approach: A Twin Study Daisy Jonkers*, Erwin G. Zoetendal, Marielle Romberg, Martine Hesselink, Willem de Vos, Ad Masclee, Marie J. Pierik

10:45 #117

Prebiotics Maintain Biodiversity of the Intestinal Microbiota and Reduce Colitis in HLA-B27 Transgenic Rats Rosica Valcheva, Bibi Slingerland, Amanda Farrant, Michael G. Gänzle, Levinus A. Dieleman*

11:00 #118

Enteropathogenic E. coli Non-Lee Encoded Effectors NleH1 and NleH2 Inhibit NF-κB Activation Sandhya V. Royan*, Rheinallt Jones, Jennifer L. Roxas, Athanasia Koutsouris, Amy Bellmeyer, V.K. Viswanathan, Andrew S. Neish, Jerrold R. Turner, Gail A. Hecht

11:15 #119

Bacterial Proteases Contribute to the Development of Chronic Intestinal Inflammation By Impairing Epithelial Barrier Function Natalie Steck, Micha Hoffmann, Carrie M. Hew Ferstl, Sandra C. Kim, Bo Liu, Rudi F. Vogel, R. Balfour Sartor, Dirk Haller*

11:30 #120

Epithelial PI3K Signaling Is Critical to Epithelial and Innate Immune Responses to Citrobacter rodentium Infection Jeffrey Brown*, Paul Cheresh, Terrence A. Barrett

11:45 #121

Cholesterol-α-Glucosyltransferase Is Important for Establishing Colonization By Helicobacter Hepaticus in Male A/JCr Mice Zhongming Ge*, Yan Feng, Sureshkumar Muthupalani, Mark T. Whary, James G. Fox

S501D McCormick Place

AGA Institute Research Forum 10:30 AM - 12:00 PM

S505 McCormick Place

Chairs: Lori A. Fischbach, Ernst J. Kuipers Sponsored by: Esophageal, Gastric & Duodenal Disorders

NOVEL TREATMENT STRATEGIES FOR HELICOBACTER PYLORI Participants will be able to: • Understand the most effective diagnostic and treatment regimens for H. pylori; and • Review research about antimicrobial resistance patterns of Helicobacter pylori. 10:30 #127

Difluoromethylornithine, A Novel Treatment for Helicobacter pylori? David A. Leiman*, Daniel P. Barry, Kathleen Fletcher, M. Blanca Piazuelo, Rupesh Chaturvedi, Keith T. Wilson

10:45 #128

Substitutions in Penicillin-Binding Protein 1 in Amoxicillin-Resistant Helicobacter pylori Strains Isolated from Korean Patients Jae G. Kim*, Ki S. Kim, Won S. Cheon, Jeong Wook Kim

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S U N D A Y MAY 31

ORAL SESSIONS—SCIENTIFIC SESSIONS 11:00 #129

11:15 #130

11:30 #131

S U N D A Y MAY 31

11:45 Sp219

Ferric Uptake Regulator (FUR) Mutation in Helicobacter pylori Associated with the Development of Resistance to Metronidazole: Implication of the Structural-Functional Relationships of Mutant-Type Fur Hitoshi Tsugawa*, Hidekazu Suzuki, Izumi Nakagawa, Kenro Hirata, Toshihiro Nishizawa, Yoshimasa Saito, Juntaro Matsuzaki, Eisuke Iwasaki, Toshifumi Hibi Trend of First-Line and Second-Line Eradication Therapy for Helicobacter pylori Infection in Korea Jun-Won Chung*, Hwoon-Yong Jung, Kee Don Choi, Ho June Song, Kwi-Sook Choi, Kee Wook Jung, Gin Hyug Lee, Do Hoon Kim, Jin-Ho Kim A Randomized Open-Label Clinical Trial with Levofloxacin, Omeprazole, Alinia (Nitazoxanide), and Doxycycline (LOAD) Versus Lansoprazole, Amoxicillin and Clarithromycin (LAC) in the Treatment Naive Helicobacter pylori Population P Patrick Basu*, Krishna Rayapudi, Tommy Pacana II, Sindhu Ramamurthy State-of-the-Art Overview Dino Vaira

AGA Institute Research Forum 10:30 AM - 12:00 PM

S401A McCormick Place

AGA Institute Research Forum 10:30 AM - 12:00 PM Chairs: Maria T. Abreu, Sunanda V. Kane

Sponsored by: Clinical Practice; Immunology, Microbiology & Inflammatory Bowel Diseases

PATIENT-CENTERED OUTCOMES IN INFLAMMATORY BOWEL DISEASE Participants will be able to: • Understand the impact of IBD on quality of life; and • Know the available measures for quanitfying quality of life in the IBD patient. 10:30 #138

Distorted Perceptions of the Utility of Ulcerative Colitis: Is Colectomy a Mind-Altering Experience? Akbar K. Waljee*, Jennifer F. Waljee, Arden M. Morris, Shannan R. Tujios, Peter D. Higgins

10:45 #139

Development and Validation of the Crohn’s Disease Perceived Disability Questionnaire (CPDQ) Mercedes Vergara*, Francesc Casellas, David Suarez, Mireia Miquel, Meritxell Casas Rodrigo, Xavier Calvet

11:00 #140

Direct and Indirect Economic Burdens and Impact On Salary Growth of Moderate to Severe Crohn’s Disease Edward V. Loftus* Jr., Annie Guérin, Magda Tsaneva, Andrew P. Yu, Jingdong Chao, Parvez Mulani

11:15 #141

Pregnancy Outcome in Inflammatory Bowel Disease for Women Treated with Thiopurine: Cohort from the CESAME Study Jessica Coelho*, Laurent Beaugerie, Jean-Frederic Colombel, Xavier Hebuterne, Eric Lerebours, Marc Lemann, Philippe Baumer, Jacques Cosnes, Arnaud Bourreille, Jean-Pierre Gendre, Philippe Seksik, Fabrice Carrat, Philippe Marteau

11:30 #142

Pregnancy Outcomes in Women Exposed to Adalimumab: The OTIS Autoimmune Diseases in Pregnancy Project Diana L. Johnson, Kenneth L. Jones, Christina D. Chambers, Elizabeth Salas*

11:45 #143

Welcome: A Randomized, Double-Blind, Controlled Trial Comparing Certolizumab Pegol 400 Mg Every 2 Weeks with Every 4 Weeks for Maintenance of Response and Remission in Patients with Moderate to Severe Crohn’s Disease with Secondary Failure to Infliximab William J. Sandborn*, Severine Vermeire, Geert R. D’Haens, Jean-Frederic Colombel, Richard N. Fedorak, Martina E. Spehlmann, Douglas C. Wolf, Maria T. Abreu, Krassimir Mitchev, Corinne Jamoul, Paul J. Rutgeerts

Chairs: Gyorgy Baffy, George H. Greeley, Jr. Sponsored by: Nutrition & Obesity

OBESITY: REGULATION OF FOOD INTAKE AND SATIETY Participants will be able to: • Review and examine basic mechanisms regulating food intake and satiety. 10:30 #132

Electrophysiological and Molecular Signatures of Glucose Inhibited Neurons in the Nodose Ganglia (NG) Projecting to the Portal Vein: Mediation of Feeding Behavior in Response to Changing Glucose Levels in the Portal Vein Gintautas Grabauskas*, Ying Li, Il Song, Chung Owyang

10:45 #133

Bombesin Receptor Subtype-3 Signaling Targets Glut4 Translocation in Human Adipocytes Jessica Lam, Anita Ratnasari, Dongmei Xiao, David H. Coy, Horst C. Weber*

11:00 #134

Physiological Regulators of Melanin-Concentrating Hormone (MCH) Receptor 1 Expression in Fat Efi Kokkotou*, Chris Mantzoros, Mary Ziotopoulou

11:15 #135

Appetite Suppression in Rats Post Ileal Transposition (IT) Surgery Is Independent of Peptide-Y Y3-36 (PYY) Levels Rohit Kohli*, Michelle Kirby, Benedikt Aulinger, Stephen C. Woods, David D’Alessio, Randy J. Seeley

11:30 #136

Release of Satiety Hormones Induced By the Five Basic Tastants Is Controlled By the Influx of Calcium Maartje Geraedts*, Freddy Troost, Wim Saris

11:45 #137

The Particle Size of Intraduodenal (ID) Fat Emulsions Modifies Antropyloroduodenal (APD) Motility, Hormone Release and Appetite in Healthy Males Radhika V. Seimon*, Tim J. Wooster, Baerbel Otto, Matt Golding, Li Day, Tanya J. Little, Michael Horowitz, Peter Clifton, Christine Feinle-Bisset

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S102 McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 10:30 AM - 12:00 PM

E351 McCormick Place

AGA Institute Topic Forum 10:30 AM - 12:00 PM

E352 McCormick Place

Chairs: F. Fred Poordad, Bernd Schnabl

Chairs: Brennan M. Spiegel, Joel H. Rubenstein

Sponsored by: Liver & Biliary; Gastrointestinal Oncology

Sponsored by: Clinical Practice; Immunology, Microbiology & Inflammatory Bowel Diseases

COMPLICATIONS OF LIVER DISEASE/LIVER AND BILIARY CARCINOMA Participants will be able to: • Examine the complications of end-stage liver diseases better manage patients with cirrhosis and liver cancers learn about new potential therapies for hepatic malignancies. 10:30 #144

The Effect of Prognostic Factors On the Maintenance of Remission in Hepatic Encephalopathy Patients Treated with Rifaximin Samuel Sigal*, F. Fred Poordad, Kimberly L. Beavers, Kunal Merchant, Shirley Huang, Audrey L. Shaw, Enoch Bortey, William P. Forbes

10:45 #145

Enhanced TLR Signaling Breaks Endotoxin Tolerance in Human Biliary Epithelial Cells in END-Stage Chronic Inflammatory Liver Disease Tobias Mueller*, Andreas Pascher, Peter Neuhaus, Bertram Wiedenmann, Thomas Berg

11:00 #146

The Impact of Cirrhosis or Prior Liver Transplant On Obstetrical Outcomes: A National Study Sanjay K. Murthy*, Jenny Heathcote, Geoffrey C. Nguyen

11:15 #147

Intraductal Ultrasonography Combined with Percutaneous Transhepatic Cholangioscopy for the Preoperative Evaluation of Longitudinal Tumor Extent in Advanced Hilar Cholangiocarcinoma Hee Man Kim*, Jeong Youp Park, Kyung Sik Kim, Mi-Suk Park, Myeong-Jin Kim, Young Nyun Park, Seungmin Bang, Si Young Song, Jae Bock Chung, Seung Woo Park

11:30 #148

11:45 #149

Serum TNF-α, IL-10 and IL-18 Levels and the Cytokine Releasing Activity of Cd4cd57αβTCR-Positive T Cells in HCV-Related Hepatocellular Carcinoma Patients During Tumor Progression Tatsuya Shiraki*, Eiji Takayama, Hirohito Magari, Yoshiyuki Mori, Kosaku Moribata, Naoki Shingaki, Hisanobu Deguchi, Izumi Inoue, Takao Maekita, Mikitaka Iguchi, Kimihiko Yanaoka, Hideyuki Tamai, Kenji Arii, Masashi Oka, Masao Ichinose Tissue Inhibitor of Metalloproteinases 3 (TIMP3) Regulation in Cholangiocarcinoma By MicroRNA-21 and Promoter Hypermethylation Florin M. Selaru*, Bogdan C. Paun, James P. Hamilton, Alexandru Olaru, Yulan Cheng, Takatsugu Kan, John M. Abraham, Rachana Agarwal, Jian Yang, Stefan David, Yuriko Mori, Zhe Jin, Gregory J. Gores, John H. Kwon, Stephen J. Meltzer

HEALTH SERVICES RESEARCH Participants will be able to: • Understand the techniques used to perform health services research in gastroenterology; and • Know the impact of hospital and surgeon volume on colectomy outcomes in ulcerative colitis. 10:30 #150

Complex Antithrombotic Therapy (CAT) and the Risk of Upper Gastrointestinal Events (UGIE) Among Vulnerable Elders Neena S. Abraham*, Aanand D. Naik, Peter Richardson, Christine M. Hartman

10:45 #151

The Effect of Direct to Consumer Advertisement and Physician Promotion of Tegaserod (Zelnorm) On Physician Visits, Diagnoses, and Prescriptions for Irritable Bowel Syndrome and Constipation Spencer D. Dorn*, Joel F. Farley, Richard A. Hansen, Nilay Shah, Robert S. Sandler

11:00 #152

Early Fecal Occult Blood Test (FOBT) After a Normal Colonoscopy: Too Much, Too Soon? Douglas J. Robertson*, Heiko Pohl, Dawn Provenzale

11:15 #153

Colonoscopy Yields Fewer Polyps As the Day Progresses Despite Use of Social Influence to Reverse the Trend Michael Y. Chan, Hartley Cohen, Jennifer Talley, Brennan M. Spiegel*

11:30 #154

Inter-Center Variation in the Clinical Outcomes of Pediatric Crohn’s Disease Michael D. Kappelman*, James Markowitz, Athos Bousvaros, Ryan S. Carvalho, Wallace Crandall, Jonathan Evans, Joseph A. Galanko, Anne M. Griffiths, David J. Keljo, Subra Kugathasan, Christine R. Langton, Neal S. Leleiko, David R. Mack, Anthony R. Otley, Marian D. Pfefferkorn, Joel R. Rosh, Gitit Tomer, Jeffrey S. Hyams

11:45 #155

Impact of Hospital Volume, Surgeon Volume, and Missed Quality Measures On Post-Operative Mortality Following Colectomy for Ulcerative Colitis Fernando S. Velayos*, Judy Maselli, Peter K. Lindenauer, Andrew D. Auerbach

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S U N D A Y MAY 31

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 10:30 AM - 12:00 PM

S103D McCormick Place

10:45 #162

Mass Internalization and Downregulation of the EGF Receptor in Pancreatic Tumor Cells By Circular Dorsal Ruffles Requires Dynamin and Its Associated Adaptor Grb2 Robbin Eppinga, Eugene Krueger, Barbara Schroeder, James Orth, Mark A. McNiven*

11:00 #163

Ribonulceotide Reductase M2 (RRM2): Predictive Marker of Response to Gemcitabine in Pancreatic Cancer James J. Farrell*, Miguel Garcia Jr., Xiyong Liu, Ali Ammar, William F. Regine, Ross A. Abrams, Hany Elsaleh

11:15 #164

NF-κB Mediates TGFβ-Induced PTEN Suppression in Human Pancreatic Cancer Cells via SMAD-Independent Signaling Jimmy Chow*, Makiko Ban, Helen L. Wu, Heekyung Chung, John M. Carethers

11:30 #165

Hedgehog Signaling Regulates Angiogenesis in Pancreatic Cancer Yoshiaki Sugiyama*, Yusuke Mizukami, Kazumasa Nakamura, Junpei Sasajima, Tomoya Nishikawa, Kazuya Koizumi, Mikihiro Fujiya, Satoshi Tanno, Toshikatsu Okumura, Toru Kono, Daniel C. Chung, Yutaka Kohgo

11:45 #166

N-MYC Downstream Regulated Gene-1 Expression Correlates with Reduced Pancreatic Cancer Growth In Vitro and In Vivo Eliane Angst*, Melvie Kim, Jenny L. Park, Beat Gloor, Howard A. Reber, Oscar J. Hines, Guido Eibl

Chairs: Yehuda Ringel, Lesley A. Houghton Sponsored by: Neurogastroenterology and Motility; Intestinal Disorders

IBS THERAPIES Participants will be able to: • Examine candidate drugs for IBS treatment; • Review the placebo response in IBS trials; and • Examine novel treatments for chronic constipation.

S U N D A Y

10:30 #156

MAY 31

10:45 #157

Effect of Linaclotide On IBS-C Symptoms in the First Week of Treatment: Results from a Phase 2B Study Anthony J. Lembo, Jeffrey M. Johnston*, Bernard J. Lavins, James E. MacDougall, Harvey Schneier, Steven J. Shiff, Caroline B. Kurtz, Mark G. Currie

11:00 #158

Efficacy of ATI-7505, a Novel Highly Selective 5-HT4 Receptor Agonist, in a Rodent Model of Colonic Hypersensitivity. Anthony C. Johnson, Karl R. Tyler*, Monica Palme, Beverley Greenwood-Van Meerveld

11:15 #159

11:30 #160

11:45 Sp220

Clinical Benefit in IBS After Disodium Cromoglycate Involves Mast Cell-Mediated Recovery of Healthy-Like Innate Immunity Genes Expression Profile in the Jejunal Mucosa Beatriz Lobo*, Maria Vicario, Cristina Martinez, Laura Ramos, Carmen Alonso, Mar Guilarte, Ines de Torres, Esteban Saperas, Javier Santos

The Placebo Response in IBS Trials: Asimadoline in the Treatment of D-IBS Patients with At Least Moderate Pain or Discomfort Jeffrey Bornstein*, Allen W. Mangel, Lynne Hamm, Jeff Buda, David M. Urso Long-Term Follow-Up of Safety and Satisfaction with Bowel Function in Response to Oral Prucalopride in Patients with Chronic Constipation Michael Camilleri*, Greet Beyens, Rene Kerstens, Lieve Vandeplassche Is There Progress in the Development of Novel Therapies for IBS and Chronic Constipation? Robin C. Spiller

AGA Institute Topic Forum 10:30 AM - 12:00 PM

S401D McCormick Place

Chairs: Jimmy Y.C. Chow, Roland M. Schmid

AGA Institute GRG Spring Symposium 1:00 PM - 3:30 PM

S403 McCormick Place

Chair: Nicholas O. Davidson AUTOPHAGY Participants will be able to: • Define the three recognized forms of autophagy (macroautophagy, microautophagy, and chaperone-mediated autophagy), and identify the critical mechanisms autophagy plays in human health and disease, especially as related to the digestive tract. 1:00

Welcome and Introduction

1:15 Sp221

Autophagy: A Tightly Regulated Pathway of Subcellular Degradation That You Rely On More Than You Realize Daniel J. Klionsky

2:00 Sp222

The Role of Autophagy and the Autophagy Gene ATG16L1 in the Intestine Thaddeus S. Stappenbeck

2:45 Sp223

Autophagy in Liver Injury and in the Stress Response of Hepatocytes Xiao-Ming Yin

Sponsored by: Gastrointestinal Oncology; Pancreatic Disorders

PANCREATIC CANCER: BIOLOGY, DIAGNOSIS & TREATMENT Participants will be able to: • Become familiar with the biology, diagnosis, and treatment of pancreatic cancers. 10:30 #161

P-44

A Novel Mouse Model, K19CreERT2; Rosa26R, for the Selective and Specific Marking of Pancreatic Ductal Epithelial Cells Johannes von Burstin*, Sherri-Gae Scott, Maximilian Reichert, Melanie P. Wescott, Steven D. Leach, Anil K. Rustgi

ASGE Business Meeting ‡ 1:30 PM - 2:15 PM ASGE BUSINESS MEETING

Mayfair Sheraton Chicago

ORAL SESSIONS—SCIENTIFIC SESSIONS AASLD Clinical Symposium 2:15 PM - 3:45 PM

S105 McCormick Place

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM

S402 McCormick Place

Chairs: Marc G. Ghany, George K. Lau

Chairs: Ikuo Hirano, David A. Katzka

AVOIDING HBV DRUG RESISTANCE: HOW MANY DRUGS?

Sponsored by: Esophageal, Gastric & Duodenal Disorders; Clinical Practice; Growth, Development & Aging; Neurogastroenterology and Motility

Participants will be able to: • Understand the definitions of and how to monitor for antiviral resistance during therapy for chronic Hepatitis B; • Review the role of combination therapy and identify special populations where it may be appropriate; and • Management and prevention of antiviral resistance. 2:15 2:20 Sp224

Welcome and Introduction Why Does Resistance Develop, Nomenclature and Monitoring for Antiviral Resistance Anna S. Lok

2:40 Sp225

Rates of Resistance to Approved Therapies and Clinical Outcomes of Resistance Daryl Lau

3:00 Sp226

Are Two Better Than One?: The Role of Combination Therapy to Prevent Antiviral Resistance George K. Lau

3:20 Sp227

Management and Strategies to Prevent Antiviral Resistance Marc G. Ghany

3:40

Panel Discussion

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM

NEW FRONTIERS IN EOSINOPHILIC ESOPHAGITIS Participants will be able to: • Examine the pathogenesis of eosinophilic esophagitis; and • Describe novel diagnostic techniques for eosinophilic esophagitis. 2:15 Sp231

Molecular Epidemiology of Eosinophilic Esophagitis Simon P. Hogan

2:37 Sp232

Eosinophilia Beyond the Esophagus: Eosinophilic Gastroenteritis Nicholas J. Talley

2:59 Sp233

Advanced Diagnostic Modalities: Beyond Endoscopy Ikuo Hirano

3:21 Sp234

Treatment Options: Beyond Steroids and Acid Suppression Glenn T. Furuta

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM

S103D McCormick Place

Chairs: Jorge A. Marrero, Claudia O. Zein S404 McCormick Place

Chairs: Robert S. Fisher, Atif Zaman Sponsored by: Clinical Practice; Liver & Biliary

HEPATITIS C FOR THE NON-HEPATOLOGIST Participants will be able to: • Identify candidates for HCV treatment; • Define current treatment guidelines for HCV; and • Describe HCV treatment side-effect management strategies.

Sponsored by: Liver & Biliary; Clinical Practice; Gastrointestinal Oncology

THE MILAN CRITERIA REVISITED: HEPATOCELLULAR CANCER DIAGNOSIS AND TREATMENT Participants will be able to: • Discuss the increased prevalence of HCC related to HCV cirrhosis; • Describe fundamentals in science, imaging and non-surgical treatment options; and • Recognize MELD exceptions for HCC when listing patients for liver transplantation are timely; and that therapy may be expanding.

2:15 Sp228

When Should HCV Treatment Be Recommended? Eugene R. Schiff

2:15 Sp235

Screening and Diagnosis Jorge A. Marrero

2:45 Sp229

What HCV Treatment Is Best? Michael W. Fried

2:45 Sp236

Therapy of HCC Riad Salem

3:15 Sp230

Managing Side Effects of HCV Treatment Norah Terrault

3:15 Sp237

Liver Transplantation for HCC James R. Spivey

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S U N D A Y MAY 31

ORAL SESSIONS—SCIENTIFIC SESSIONS

S U N D A Y MAY 31

AGA Institute Committee Sponsored Symposium 2:15 PM - 3:45 PM S501BC McCormick Place

AGA Institute Translational Symposium 2:15 PM - 3:45 PM

Chair: James B. McGee

Chairs: Estella M. Alonso, Philip Rosenthal

Sponsored by: Education & Training Committee

Sponsored by: Growth, Development & Aging; Liver & Biliary

MANAGING DIGITAL KNOWLEDGE: LESS TIME, BETTER ANSWERS

HEPATOCYTE TRANSPLANTATION: WHERE WE ARE AND WHERE WE NEED TO GO

Participants will be able to: • Describe new technologies, devices, and strategies to acquire knowledge more efficiently; • Discuss ways that gastroenterologists can benefit from technology and lifelong learning; and • Apply internet search techniques to improve research and clinical performance.

Participants will be able to: • Discuss the current experience with hepatocyte transplantation in humans; • Define the importance of the proper environment for the transplanted hepatocytes; and • Appreciate the options for obtaining hepatocytes for transplantation.

2:15 Sp238

Maintenance of Certification and CME Opportunities from GI LEARN John F. Kuemmerle

2:45 Sp239

Using the Internet As Your Primary Information Resource: Pros and Cons Geoffrey L. Braden

3:15 Sp240

Managing Digital Knowledge: So Much Data, So Little Time James B. McGee Jr.

AGA Institute Research Symposium 2:15 PM - 3:45 PM

S504 McCormick Place

Chairs: Craig D. Logsdon, David C. Whitcomb Sponsored by: Pancreatic Disorders; Growth, Development & Aging; Gastrointestinal Oncology; Hormones, Transmitters, Growth Factors & Their Receptors

S503 McCormick Place

2:15 Sp244

The Experience with Hepatocyte Transplantation in Humans Anil Dhawan

2:45 Sp245

The Factors Affecting the Competitive Repopulation of the Liver with Transplanted Hepatocytes Jayanta Roy-Chowdhury

3:15 Sp246

Sources of Hepatocytes for Transplantation Ira J. Fox

AGA Institute Translational Symposium 2:15 PM - 3:45 PM

S101 McCormick Place

Chairs: Raj K. Goyal, Sacha Malin Sponsored by: Neurogastroenterology and Motility; Hormones, Transmitters, Growth Factors & Their Receptors; Immunology, Microbiology & Inflammatory Bowel Diseases; Esophageal, Gastric & Duodenal Disorders; Intestinal Disorders; Pancreatic Disorders

ALTERING GENE EXPRESSION IN THE PANCREAS

RECEPTOR AND ION CHANNEL ALTERATIONS IN GASTROINTESTINAL INFLAMMATION

Participants will be able to: • Review the latest experimental approaches for modifying gene expression in the exocrine pancreas; • Examine the effects of disease processes on pancreatic gene expression; and • Evaluate effects of gene expression on pancreatic growth and regeneration.

Participants will be able to: • Discuss the role of inflammation induced changes in ion channel and receptor function and inflammatory and functional GI disorders; • Analyze ion channel changes on GI smooth muscle; and • State the ion channel changes underlying hyperexcitability of sensory neurons. 2:15 Sp247

The Effect of Inflammation On Visceral Sensory Processing David Grundy

Altering Gene Expression in Pancreatitis Roland M. Schmid

2:37 Sp248

Gene Expression in Response to Intracellular Active Trypsin Craig D. Logsdon

Voltage-Gated Channels in Inflammation Induced Hyperexcitability of Sensory Neurons Stephen J. Vanner

2:59 Sp249

Altered Smooth Muscle Ion Channels in Inflammation Hamid I. Akbarali

3:21 Sp250

Clinical Manifestations of Altered Neuromuscular Function in Functional and Inflammatory Bowel Disease David R. Linden

2:15 Sp241

Altering Gene Expression in Pancreatic Regeneration B. M. Evers

2:45 Sp242 3:15 Sp243

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ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Translational Symposium 2:15 PM - 3:45 PM

S104 McCormick Place

AASLD Research Forum 2:15 PM - 3:45 PM

S106A McCormick Place

Chair: Gerard E. Mullin

Chairs: Florence Wong, Lewis R. Roberts

Sponsored by: Nutrition & Obesity; Gastrointestinal Oncology; Immunology, Microbiology & Inflammatory Bowel Diseases; Intestinal Disorders

COMPLICATIONS OF CIRRHOSIS: EXPERIMENTAL 2:15 #167

Single Agent Activity of Obatoclax (Gx15-070) in a Rat Cholangiocarcinoma Model Rory Smoot*, Boris Blechacz, Alphonse E. Sirica, Gregory J. Gores

2:30 #168

SULF2 Promotes Tumorigenesis of Hepatocellular Carcinoma By Activating the Wnt/β-Catenin Pathway Jinping Lai*, Chunrong Yu, Catherine D. Moser, Hajime Isomoto, Ju-Seog Lee, Alex A. Adjei, Snorri Thorgeirsson, Schuyler Sanderson, Lewis R. Roberts

VITAMIN D AND GASTROINTESTINAL DISEASE Participants will be able to: • Describe the role of vitamin D in complications of IBD; • Review the role of vitamin D in the development of colon cancer; and • Review the role of vitamin D in disease pathogenesis. 2:15 Sp251

Vitamin D in IBD: Beyond the Bones? Margherita T. Cantorna

2:45 Sp252

Colon Cancer: Does Vitamin D Provide Protection? Cindy D. Davis

3:15 Sp253

Life or No Life Without Vitamin D: Effects On Morbidity and Mortality Hector Deluca

ASGE Clinical Symposium 2:15 PM - 3:45 PM

S102 McCormick Place

Chairs: Daniel J. Pambianco, Jenifer R. Lightdale ENDOSCOPIC SEDATION AND MONITORING ISSUES IN 2009 2:15 Sp254

Advances in Endoscopic Sedation Daniel J. Pambianco

2:40 Sp255

Role of Anesthesia Care in Endoscopy Thomas W. Cutter

3:05 Sp256

Unmet Needs of Endoscopic Sedation Jenifer R. Lightdale

3:30

2:45 #169

Neutral Endopeptidase (EC 3.4.24.11) Inhibition Blunts Endothelin-1 Production in Cirrhotic Rat Livers: Physiopathological Implications Giovanni G. Sansoe*, Manuela Aragno, Floriano Rosina, Antonina Smedile, Maurizio Parola

3:00 #170

Hemodynamic Effects of Propofol Sedation During Hepatic Venous Pressure Gradient Measurement Mona Y. Hellstern*, Ludwig T. Heuss, Markus H. Heim

3:15 #171

Outcomes of Digital Image Analysis (DIA) and Fluorescence in situ Hybridization (FISH) Test in Primary Sclerosing Cholangitis (PSC) Sanjay Bangarulingam*, Einar Bjornsson, Keith D. Lindor

3:30 #172

In Experimental Preascitic Liver Cirrhosis CalciumDependent Diuretic Systems Are Downregulated, But May Be Normalized By Specific Metabolic and Pharmacologic Stimuli Giovanni G. Sansoe*, Manuela Aragno, Floriano Rosina, Antonina Smedile, Maurizio Parola

AASLD Topic Forum 2:15 PM - 3:45 PM

S106B McCormick Place

Chairs: Helen S. Te, Josh Levitsky

Questions & Answers

LIVER TRANSPLANTATION & SURGERY ASGE Clinical Symposium 2:15 PM - 3:45 PM

S103ABC McCormick Place

Chairs: Thomas A. Ullman, Colleen M. Schmitt

2:15 #173

Risk of De-Novo Hepatitis from Hepatitis B Core Antibody Positive Grafts - A Systematic Analysis Catherine Skagen*, Adnan Said

2:30 #174

Plant Polyphenols Prevent Suppression of Mitochondrial Biogenesis in Small-for-Size Liver Grafts Hasibur Rehman, John J. Lemasters, Zhi Zhong*

2:45 #175

Text Messaging Reduces Rejection in Pediatric Liver Transplant Recipients Tamir Miloh*, Rachel Annunziato, Ronen Arnon, Jill K. Warshaw, Frederick J. Suchy, Kishore Iyer, Nanda Kerkar

3:00 #176

Prospective Randomized Controlled Study of Short-Term Perioperative Enteral Nutrition Support with Branched Chain Amino Acids in Liver Surgery Yoshinori Ishikawa*, Hiroshi Yoshida, Joshua Weiner, Takashi Tajiri

3:15 #177

The Effect of Donor Race On Survival of Hepatitis CPositive African American Liver Transplant Patients Phillip S. Pang, Ahmad Kamal*, Jeffrey Glenn

ENDOSCOPY ISSUES IN THE PATIENT WITH IBD 2:15 Sp257

Assessment of IBD Activity By Colonoscopy: State-ofthe-Art Paul J. Rutgeerts

2:35 Sp258

Chromoendoscopy and Detection of IBD-Related Dysplasia James F. Marion

2:55 Sp259

Endoscopic Management of IBD-Related Strictures John F. Valentine

3:15

Questions & Answers

P-47

S U N D A Y MAY 31

ORAL SESSIONS—SCIENTIFIC SESSIONS 3:30 #178

Total Tumor Volume (TTV) Predicts Recurrence of Hepatocellular Carcinoma (HCC) Post Liver Transplantation (LT) in Patients Beyond Milan or UCSF Criteria and May Optimize Selection of LT Candidates Carole Macaron*, Ibrahim Hanouneh, Rocio Lopez, Federico N. Aucejo, Nizar N. Zein

AGA Institute Research Forum 2:15 PM - 3:45 PM

S501A McCormick Place

2:30 #185

An Exploratory Investigation of the Utility of the Immunknow™ Assay in Inflammatory Bowel Disease Louis Cohen*, Rui Wang, Hang Lee, Joshua R. Korzenik

2:45 #186

Ulcerative Colitis: Fecal Calprotectin Correlates Closely with the Endoscopically Assessed Disease Activity Alain Schoepfer*, Christoph Beglinger, Alex Straumann, Pietro Renzulli, Frank Seibold

3:00 #187

Comparative Evaluation of a New Semi-Quantitative, Rapid, Office-Based Strip Test with An ELISA-Based Assay for Measuring Fecal Calprotectin to Assess Intestinal Inflammation: Prospective Multicenter Clinical Study Yogesh Shastri*, Oliver Schröder, Jurgen Stein

3:15 #188

Accuracy of Preoperative Serologic Testing in Patients Undergoing Intestinal Resection for Inflammatory Bowel Disease Nicolas M. Intagliata*, Brian R. Swenson, Charles M. Friel, Eugene F. Foley, Brian W. Behm

3:30 #189

Analysis of Volatile Organic Compounds in Exhaled Air As a Non Invasive Biomarker for Inflammatory Bowel Disease (IBD) Alexander Bodelier*, Marie J. Pierik, Jan W. Dallinga, Joep Van Berkel, Edwin Moonen, Wim Hameeteman, Daisy Jonkers, Ad Masclee, Frederik J. Van Schooten

Chairs: Sandor Szabo, Gordon V. Ohning Sponsored by: Esophageal, Gastric & Duodenal Disorders

S U N D A Y MAY 31

BIOLOGY AND PATHOBIOLOGY OF EPITHELIAL RESTITUTION Participants will be able to: • Understand regulatory mechanisms that mediate tissue repair. 2:15 #179

Functional Characterization of Toll-Like Receptor 3 Signaling in Human Esophageal Keratinocytes Diana M. Lim, LeighAnn Lombardi, Carmen Z. Michaylira, Anil K. Rustgi, Mei-Lun Wang*

2:30 #180

Involvement of Asymmetric Dimetylarginine (ADMA), An Endogenous Inhibitor of Nitric Oxide (NO) Synthase, in the Pathogenesis of Acute Gastric Lesions Slawomir Kwiecien, Tomasz Brzozowski*, Peter C. Konturek, Robert Pajdo, Agata Ptak-Belowska, Wladyslaw Bielanski, Stanislaw Konturek, Wieslaw W. Pawlik

2:45 #181

HO-1 Induction Through Nrf-2 Transcription A Key Anti-Inflammatory Action of Pantoprazole; PPI Beyond Acid Suppression Ki-Baik Hahm

3:00 #182

L-Tryptophan Rich Diet Accelerates Gastric Ulcer Healing via Increase in Endogenous Melatonin, Prostaglandin Generation and Downregulation of Hypoxia Inducible Factor-1alpha Tomasz Brzozowski*, Peter C. Konturek, Danuta Drozdowicz, Jacek S. Zagajewski, Iwona Brzozowska, Piotr M. Laidler, Stanislaw Konturek, Wieslaw W. Pawlik

3:15 #183

Altered Expression of a Stem Cell Marker DCAMKL1 in the Gastric Epithelium with Regeneration, Metaplasia and Dysplasia Miho Kikuchi*, Hiroshi Nagata, Toshifumi Hibi

3:30 Sp260

Summary and Overview Talk Jonathan D. Kaunitz

AGA Institute Research Forum 2:15 PM - 3:45 PM

AGA Institute Research Forum 2:15 PM - 3:45 PM Chairs: Peter H. Green, Joseph A. Murray Sponsored by: Intestinal Disorders

CELIAC DISEASE: CLINICAL Participants will be able to: • Examine how psychological and psychiatric factors are associated with celiac disease; • Review the clinical characteristics and natural history of celiac disease; and • Examine new therapeutic and diagnostic approaches that may have utility in celiac disease. 2:15 #190

Retrospective Study of the Natural Long-Term History of Untreated Celiac Disease Debby Kryszak*, Bushra N. Bhatti, Craig Sturgeon, Sandra Clipp, Kathy Helzlsouer, Alessio Fasano

2:30 #191

ALV003, a Combination Oral Protease, Is Active, Safe and Tolerable in Healthy Volunteers and Subjects with Celiac Disease in Phase 1 Trials Mitchell Garber, Matthew Siegel, Vijaya Pratha*, Andrew Spencer, Pawan Kumar, Wendy A. Botwick, Revati Shreeniwas

2:45 #192

Prevalence of Celiac Disease and Gluten-Sensitivity in Subjects with Schizophrenia Debby Kryszak*, Bushra N. Bhatti, Craig Sturgeon, William W. Eaton, Nicola G. Cascella, Patricia Gregory, Alessio Fasano

3:00 #193

Enhanced I-FABP Levels in Children with Celiac Disease Rapidly Recover After Gluten Free Diet; Potential Marker for Diagnosis and Follow-Up of Celiac Disease Anita Vreugdenhil*, Victorien M. Wolters, Anita Van den Neucker, Joep Derikx, Roderick Houwen, Wim Buurman

3:15 #194

Psychological Factors Are More Important Than Disease Activity in Determining Health Status in Celiac Disease Spencer D. Dorn*, Lincoln Hernandez, Maria T. Minaya, Carolyn B. Morris, Yuming J. Hu, Jane Leserman, Suzanne K. Lewis, Shrikant I. Bangdiwala, Peter H. Green, Douglas A. Drossman

E350 McCormick Place

Chairs: Joshua R. Korzenik, Richard N. Fedorak Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

BIOMARKERS IN IBD Participants will be able to: • Become familiar with novel fecal, blood, and exhaled biomarkers of disease activity. 2:15 #184

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MicroRNAs Are Differentially Expressed in Crohn’s Disease Feng Wu, Simin Zhang, Yuriko Mori, Theodore M. Bayless, Stephen J. Meltzer, John H. Kwon*

E451B McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS 3:30 #195

Clinical Characteristics of Patients with Concurrent Celiac Disease and Microscopic Colitis David A. Neumann* II, Brian Lahr, Darrell S. Pardi, Joseph A. Murray

AGA Institute Research Forum 2:15 PM - 3:45 PM

S501D McCormick Place

Chairs: Judy H. Cho, Severine Vermeire AGA Institute Research Forum 2:15 PM - 3:45 PM

S401D McCormick Place

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

Chairs: Ajay Goel, William M. Grady

IBD GENETICS

Sponsored by: Gastrointestinal Oncology

Participants will be able to: • Be familiar with novel IBD susceptibility loci harboring galant2, JAK2, MST1 and IL2/IL21; • Be familiar with genetic loci associated with crohn’s disease in individuals with african american ancestry; and • Understand the implications of NOD2 risk alleles for intestinal microbial community imbalances.

EPIGENETICS OF GI CANCERS Participants will be able to: • Understand the role of epigenetics in gastrointestinal cancers. 2:15 #196

A Sensitive Methylation Marker Panel That Discriminates Normal Mucosa from Colorectal Cancer Tissue with High Specificity Patric Urfer, Stefan Weis, Faiza Noreen, Mirco Menigatti, Corina Kim-Fuchs, Oliver Tschaler, Rolf Schlumpf, Primo Schaer, Kaspar Truninger*

2:30 #197

A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett’s Esophagus Zhe Jin*, Yulan Cheng, Jessie Gu, Yingye Zheng, Yuriko Mori, Alexandru Olaru, Bogdan C. Paun, Takatsugu Kan, James P. Hamilton, Florin M. Selaru, Stefan David, Herbert C. Wolfsen, Michael B. Wallace, Nicholas J. Shaheen, Mary Kay Washington, Jean S. Wang, Marcia I. Canto, Achyut K. Bhattacharyya, Mark A. Nelson, Paul D. Wagner, Yvonne Romero, Kenneth K. Wang, Ziding Feng, Richard E. Sampliner, Stephen J. Meltzer

2:45 #198

CpG-Island Methylator Phenotype (CIMP) and Alterations in RAS-Raf Signaling in Hereditary NonPolyposis Colorectal Cancers Without Mismatch Repair Deficiency (MSS HNPCC) Rosa M. Xicola*, Thuy-Phuong T. Nguyen, Brian J. Doyle, Prathap Bandipalliam, Sapna Syngal, Jose Reyes, Carmen Cordero, Jessica Grzybowski, Vanessa R. Sapoznik, Michael N. Grzybowski, Antoni Castells, Rodrigo Jover, Montserrat Andreu, C. R. Boland, Xavier Llor, Ajay Goel

3:00 #199

DNA Methylation Throughout the Normal Human Colorectum: Evidence of An Epigenetic Field Effect Daniel L. Worthley*, Vicki L. Whitehall, Ron Buttenshaw, Kylie-Ann Mallitt, Richard K. Le Leu, Graeme P. Young, Barbara A. Leggett

3:15 #200

Aberrant Gene Promoter Methylation Is Associated with Colorectal Cancer Multiplicity Victoria Gonzalo*, Juan José Lozano, Jenifer Muñoz, Francesc Balaguer, Maria Dolores Giraldez, Oriol Sendino, Sergi Castellvi-Bel, Antoni Castells

3:30 #201

Gene Expression Profiling Identifies Loss of Fhit Expression Due to Epigenetic Silencing As a Frequent Event in African American (AA) Patients with Colorectal Cancer (CRC) Ajay Goel, Thuy-Phuong T. Nguyen*, Alexander Link, Takeshi Nagasaka, Minoru Koi, Wen Sui, Xiang Jun Shen, Norman E. Sharpless, Joseph A. Galanko, Robert S. Sandler, Temitope O. Keku, C. R. Boland

2:15 #202

In African Americans, NOD2, SLC22A5 and ATG16L1 But Not Il23R or IRGM Are Genetic Risk Factors for Crohn’s Disease Ming-Hsi Wang*, Toshihiko Okazaki, Kim L. Isaacs, James D. Lewis, Duane T. Smoot, John F. Valentine, Themistocles Dassopoulos, Maria Oliva-Hemker, Mary L. Harris, Yuqiong Wu, Lisa W. Datta, Steven R. Brant

2:30 #203

Genetic Variants in the Region Harbouring IL2/IL21 Associated to Ulcerative Colitis Eleonora A. Festen*, Philippe Goyette, Regan Scott, Vito Annese, Alexandra Zhernakova, Steven R. Brant, Judy H. Cho, Mark S. Silverberg, Kent D. Taylor, Dirk J. De Jong, Pieter Stokkers, Dermot P. McGovern, Orazio Palmieri, Jean-Paul Achkar, Ramnik J. Xavier, Richard H. Duerr, Mark J. Daly, Cisca Wijmenga, Rinse K. Weersma, John D. Rioux

2:45 #204

Genetic and Mucosal Expression Analysis Shows Important Roles for JAK2 and MST1 in the Pathogenesis of Ulcerative Colitis and Identifies More Susceptibility Loci Eleonora A. Festen*, Pieter Stokkers, Martin C. Wapenaar, Cleo C. van Diemen, Ad A. van Bodegraven, Marcel Bruinenberg, Hendrika M. Boezen, Bart Crusius, Daniel Hommes, Christien J. van der Woude, Tobias C. Balschun, Hein W. Verspaget, Stefan Schreiber, Dirk J. De Jong, Andre Franke, Klaas Nico Faber, Gerard Dijkstra, Cisca Wijmenga, Rinse K. Weersma

3:00 #205

Novel Genetic Risk Markers for Ulcerative Colitis in the IL2/IL21 Region Are in Epistasis with Il23R and Suggest a Common Genetic Background for Ulcerative Colitis and Celiac Disease Johannes Stallhofer*, Jürgen Glas, Sibylle Koletzko, Matthias Folwaczny, Burkhard Göke, Thomas Ochsenkühn, Bertram Müller-Myhsok, Stephan Brand

3:15 #206

NOD2 Risk Alleles Are Associated with Microbial Community Imbalances in Human Inflammatory Bowel Diseases Zegbeh Z. Kpadeh*, Daniel Frank, Edgar C. Boedeker, Noam Harpaz, Norman R. Pace, R. Balfour Sartor, Ellen Li

3:30 #207

Developing Genetic Models for Predicting Crohn’s Disease Risk Adam S. Kim*, Hui Shen, Ji Young Lee, Jia Kang, Hongyu Zhao, Judy H. Cho

P-49

S U N D A Y MAY 31

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 2:15 PM - 3:45 PM

S406A McCormick Place

2:45 #216

MyD88/NF-κB Dependent Campylobacter Jejuni-Induced IL-12p40 Gene Expression Is Negatively Regulated By the AKT/GSK-3β Signaling Pathway in Murine Bone Marrow-Derived Dendritic Cells Xiaolun Sun*, Brigitte Allard, Christian Jobin

3:00 #217

Decreased Development of Experimental Necrotizing Enterocolitis in Apical Sodium-Dependent Bile Acid Transporter Knockout Mice Mitchell A. Thomas, Crystal Johnson, Ludmila Khailova, Kelly M. Arganbright, Bohuslav Dvorak, Melissa Halpern*

3:15 #218

The Regulation of the Intestinal Mucin MUC2 Expression By Short Chain Fatty Acids: Implications for Epithelial Protection Nanda Burger-van Paassen, Audrey Vincent, Patrycja Puiman, Maria van der Sluis, Janneke Bouma, Guenther Boehm, Hans van Goudoever, Isabelle VAN SEUNINGEN, Ingrid B Renes*

3:30 #219

Prohibitin (PHB) Is a Novel Antioxidant That Attenuates Colonic Inflammation in Mice Arianne L. Theiss*, Matam Vijay-Kumar, Tracy S. Obertone, Dean Jones, Jason Hansen, Andrew T. Gewirtz, Didier Merlin, Shanthi V. Sitaraman

Chairs: John J. Vargo, David H. Balaban Sponsored by: Clinical Practice

IMPROVING COLONOSCOPY: OF PREPS AND PERFS Participants will be able to: • Understand the factors impacting the quality of preparation in colonoscopy; and • Know the incidence of adverse events in colonoscopy.

S U N D A Y

2:15 #208

Experienced Endoscopists Display a Lack of Consensus When Encountering Suboptimal Bowel Preparation During Colonoscopy Rajiv Sharma*, Snorri Olafsson, David S. Condon

2:30 #209

A Randomized Endoscopist-Blinded Clinical Trial Comparing the Bowel Cleansing Effect of Same Day Polyethylene Glycol (PEG) Bowel Preparation Regimen vs. Regimen Given On the Day Before Colonoscopy Shibu Varughese*, Anand Raman Kumar, Amy George, Fernando J. Castro-Pavia, Manuel O. Gonzalez, Tolga Erim, Roger J. Charles

MAY 31 2:45 #210

Risk of Perforation During Colonoscopy: A Systematic Review and Meta-Analysis Syed M Abbas Fehmi, Neel Choksi*, Sameer D. Saini, Grace H. Elta, Philip S. Schoenfeld

3:00 #211

Incomplete Colonoscopy: Significant Findings in a Mixed Referral Population During Follow Up Maarten Neerincx*, Jochim S. Terhaar sive Droste, Mirre Räkers, Ruud J. Loffeld, Chris J. Mulder, René W. van der Hulst

3:15 #212

Impact of a Novel Patient Educational Booklet On the Quality of Colonoscopy Preparation in Colorectal Cancer Screening Brennan M. Spiegel*, Michael Y. Chan, Jennifer Talley, Hartley Cohen

3:30 #213

Ethnicity Is a Critical Factor Predicting Non-Attendance to Scheduled Colonoscopy: Hispanics and Native Americans Have Alarmingly High Non-Attendance Rates Nitesh B. Vachhani*, Wen-Huan S. Ho, Mohamed O. Othman, Thomas Y. Ma

AGA Institute Research Forum 2:15 PM - 3:45 PM

S505 McCormick Place

Chairs: Mark W. Musch, Mitchell B. Cohen

AGA Institute Research Forum 2:15 PM - 3:45 PM Chairs: Steven J. Czinn, Keith T. Wilson

Sponsored by: Esophageal, Gastric & Duodenal Disorders

MANIPULATION OF THE HOST IMMUNE RESPONSE BY H. PYLORI Participants will be able to: • Recognize how H. pylori induces an aberrant host immune response that leads to pathogenesis; and • Understand recent basic research of immune responses and vaccines targeting Helicobacter pylori. 2:15 #220

Arginase II Restricts Host Defense to Helicobacter pylori By Limiting the Pro-Inflammatory Immune Response Nuruddeen D. Lewis*, Mohammad Asim, Daniel P. Barry, Thibaut de Sablet, M. Blanca Piazuelo, Rupesh Chaturvedi, Keith T. Wilson

2:30 #221

Helicobacter pylori Immune Escape Mechanism Mediated By Regulation of TH17:Treg Balance John Y. Kao*, Min Zhang, Kathryn A. Eaton, Bradford E. Berndt

2:45 #222

T-Bet Deficient Mice Are Protected from Helicobacter Induced Mucosal Injury: Role of T-Bet in the Induction of Inflammatory Cytokines Calin Stoicov*, Jian Hua Liu, Anna Cerny, Glennice Bowen, Evelyn A. Kurt-Jones, Jean Marie Houghton

3:00 #223

Toll-Like Receptor 2-Dependent Chemokine Induction in Epithelial Cells By Lipopolysaccharide Contained in Helicobacter pylori Outer Membrane Vesicles Sinead M. Smith*, Anthony P. Moran, Erica Mullaney, Shane P. Duggan, Henry J. Windle, Luke A. O’Neill, Dermot P. Kelleher

3:15 #224

Delineation of a Pathogenic Helicobacter pylori Proteome Identifies a Locus That Modifies cag Secretion System Substrates Toni Nagy*, Aime Franco, David Friedman, Uma S. Krishna, Amy Kendall, Dawn Israel, Steffen Backert, Richard M. Peek

3:30 Sp261

State-of-the-Art Overview Richard L. Ferrero

Sponsored by: Intestinal Disorders

INTESTINAL INJURY AND INFLAMMATION Participants will be able to: • Examine novel mechanisms by which intestinal injury can be modulated in rodent models; • Review how cytokine and growth factor signaling play a role in the intestinal inflammatory response; and • Examine how intestinal transporters are relevant to intestinal inflammation. 2:15 #214

Expression of hPepT1 Aggravates Intestinal Inflammation Guillaume Dalmasso*, Hang Thi Thu Nguyen, Yutao Yan, Mauricio Rojas, Shanthi V. Sitaraman, Didier Merlin

2:30 #215

Protective Role of EGFR in IL-10-Mediated Colitis Philip E. Dubé*, Kay Washington, D. Brent Polk

P-50

E351 McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 2:15 PM - 3:45 PM

S405 McCormick Place

2:30 #231

Usefulness of Endoscopic Ultrasound (EUS) Elastography for the Detection of Malignant Infiltration of Mediastinal and Abdominal Lymph Nodes Jose Larino, Julio Iglesias-Garcia*, Ana Alvarez-Castro, Jose Mera, Marta Iglesias-Rivas, Ihab Abdulkader, Jeronimo Forteza, Enrique Dominguez-Munoz

2:45 #232

High-Resolution Magnetic Resonance Colonography and Contrast-Enhanced Magnetic Resonance Imaging Can Distinguish Early Murine Colorectal Tumors from Colitis In Vivo Devkumar Mustafi*, Urszula Dougherty, Xiaobing Fan, Gregory S. Karczmar, Erica Markiewicz, Marta Zamora, Marc Bissonnette

3:00 #233

Optical Coherence Tomography (OCT) Imaging Can Detect Fine Morphologic Features of Pancreatic Cystic Neoplasms and Differentiate Between Mucinous and Non-Mucinous Cysts Sevdenur Cizginer*, Vikram Deshpande, Nicusor Iftimia, Cetin Karaca, William R. Brugge

3:15 #234

Elastic Scattering Spectroscopy-Guided Forceps for RealTime Detection of Dysplasia in Barrett’s Esophagus Theresa M. Lee*, Ashish Sharma, Qin Huang, Ahchean Chen, Huihong Xu, Eladio Rodriguez-Diaz, Irving J. Bigio, Satish K. Singh

Chairs: Grigorios I. Leontiadis, Uri Ladabaum Sponsored by: Esophageal, Gastric & Duodenal Disorders

NON-VARICEAL UGI BLEEDING: NEW DEVELOPMENTS & NEW ISSUES Participants will be able to: • Examine developments and issues in non-variceal UGI bleeding. 2:15 #225

Intravenous Esomeprazole for Prevention of Peptic Ulcer Re-Bleeding in a Predominantly Caucasian Population: Results On Clinical Benefits and Hospital Resource Use Alan N. Barkun*, Joseph J. Sung, Ernst J. Kuipers, Joachim Mössner, Dennis M. Jensen, Robert Stuart, James Y. Lau, Henrik Ahlbom, Jan Kilhamn, Peter Wahlqvist, Bengt Liljas, Tore Lind

2:30 #226

Scheduled 2nd Endoscopy or High Dose Omeprazole Infusion in Preventing Peptic Ulcer Rebleeding - A Prospective Randomized Trial Philip W. Chiu*, Henry Joeng, Catherine Choi, Kelvin K. Tsoi, Kwok hung Kwong, Siu Ho Lam

2:45 #227

3:00 #228

3:15 #229

3:30 Sp262

Prolonged Low-Dose Omeprazole Infusion for 7 Days Can Reduce Peptic Ulcer Re-Bleeding for High-Risk CoMorbid Patients Hsiu-Chi Cheng*, Hsiao-Bai Yang, Wei-Lun Chang, BorShyang Sheu Clinical Judgement Versus Risk Scores for Predicting Outcome in Patients Bleeding from High Risk Peptic Ulcer. Preliminary Results of a Prospective Multicenter Study Enric Brullet*, Xavier Calvet, Rafel Campo, Michel Papo, Montserrat Planella, Félix Junquera, Pilar Garcia-Iglesias, Silvia Montoliu, Albert Pardo, Raquel Ballester-Clau, Mireia Miquel, Valentí Puig Diví, Eva Martinez-Bauer, Albert Villoria, Marta Gallach, Meritxell Casas Rodrigo, Mercedes Vergara Does Proton Pump Inhibitor (PPI) Treatment Initiated Before Endoscopy Work in Unselected Upper Gastrointestinal Bleeding? A Cochrane Systematic Review Update Aravamuthan Sreedharan*, Janet Martin, Grigorios I. Leontiadis, David Forman, Colin W. Howden, Paul Moayyedi State-of-the-Art Overview Grigorios I. Leontiadis

AGA Institute Research Forum 2:15 PM - 3:45 PM

S502 McCormick Place

Chairs: Sarah Rodriguez, Mohamad A. Eloubeidi

3:30 Sp263

AGA Institute Research Forum 2:15 PM - 3:45 PM

Participants will be able to: • Identify new information and recent advances in imaging for clinical applications; and • Review new imaging methods that may have clinical applications in the near future. 2:15 #230

Active Gastrointestinal Bleeding: Detection and Localization with Contrast-Enhanced Ultrasonography Noriaki Manabe*, Jiro Hata, Ken Haruma, Hiroshi Imamura, Tomoari Kamada, Hiroaki Kusunoki

E352 McCormick Place

Chairs: Kirsten Tillisch, Anthony Lembo Sponsored by: Neurogastroenterology and Motility

PHARMACOTHERAPEUTICS OF FUNCTIONAL AND MOTILITY DISORDERS Participants will be able to: • Learn about emerging new therapies for IBS and constipation; • Learn about new prokinetic drugs in IBS; and • Learn about possible new treatments for functional dyspepsia. 2:15 #235

PF-04548043, a Novel Motilin Receptor Agonist, Increases Gastric Emptying in Healthy Volunteers and Does Not Undergo Tachyphylaxis Jeremy D. Gale*, Peter J. Colman, Constantino Kantaridis, Catherine Claes, Radu Tutuian

2:30 #236

Global Endpoints in IBS Clinical Trials: Results from a Phase 2B Study of Linaclotide Jeffrey M. Johnston*, James E. MacDougall, Bernard J. Lavins, Anthony J. Lembo, Harvey Schneier, Steven J. Shiff, Caroline B. Kurtz, Mark G. Currie

2:45 #237

LX1031: A New Approach for Managing Irritable Bowel Syndrome (IBS) Philip Brown, Jessica Jackson, Zhi-Cai Shi, Kenneth Frazier, Qi M. Yang, Qingyun Liu, Stephen C. Pappas*

3:00 #238

Effects of Rimonabant On Gastric and Small Intestinal Motility in Dogs Yan Sun*, Geng-Qing Song, Jiande Chen

3:15 #239

A Double-Blind, Randomized, Placebo-Controlled Study of Mirtazapine in Functional Dyspepsia with Weight Loss. Lukas Van Oudenhove*, Lieselot Holvoet, Raf Bisschops, Philip Caenepeel, Joris Arts, Dominiek De Wulf, Rita Vos, Daniel Sifrim, Jan F. Tack

Sponsored by: Imaging & Advanced Technology

NOVEL IMAGING FOR CLINICAL APPLICATIONS

State-of-the-Art Overview Brian C. Jacobson

P-51

S U N D A Y MAY 31

ORAL SESSIONS—SCIENTIFIC SESSIONS 3:30 #240

A Double-Blind, Placebo-Controlled Trial to Evaluate the Safety and Tolerability of Prucalopride Oral Solution in Constipated Elderly Patients Living in a Nursing Facility Michael Camilleri*, Rene Kerstens, Greet Beyens, Patricia Robinson, Lieve Vandeplassche

AGA Institute Research Forum 2:15 PM - 3:45 PM

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

MAY 31

PRECLINICAL TREATMENT OF EXPERIMENTAL INTESTINAL INFLAMMATION Participants will be able to: • Review the key factors most relevant to preclinical treatment of experimental intestinal inflammation. 2:15 #241

Interleukin (IL)-25 Inhibits IL-12 Production and TH1 Cell- Driven Inflammation in the Gut Roberta Caruso*, Massimiliano Sarra, Carmine Stolfi, Angelamaria Rizzo, Massimo C. Fantini, Francesco Pallone, Thomas T. MacDonald, Giovanni Monteleone

2:30 #242

Melatonin Prevents Colitis-Induced Dysplasia Through Inhibition of PI3K-Mediated β-Catenin Signaling Goo Lee*, Tatiana Goretsky, Ajaypal Singh, Jae Wook Dong, Dong Hoon Kim, James B. Young, Terrence A. Barrett

2:45 #243

Use of Enterally-Delivered Angiotensin II Type IA Receptor Antagonists to Reduce the Severity of Colitis Manabu Okawada*, Hiroyuki Koga, Scott D. Larsen, Hollis D. Showalter, Peter C. Lucas, Daniel H. Teitelbaum

3:00 #244

Anti-Interleukin (IL)-21 Monoclonal Antibody Reduces Disease Severity and Inflammatory Cytokines in Murine Colitis Katherine E. Lewis*, Janine Bilsborough, Mark F. Maurer, Kristen Bontadelli, Kim Waggie, Cecile M. Krejsa, Stacey R. Dillon

3:15 #245

3:30 #246

S401A McCormick Place

Chairs: Rebecca C. Fitzgerald, Rhonda F. Souza Sponsored by: Esophageal, Gastric & Duodenal Disorders

E451A McCormick Place

Chairs: David E. Elliott, Pawel R. Kiela

S U N D A Y

AGA Institute Research Forum 2:15 PM - 3:45 PM

Mechanisms Underlying the Anti-Inflammatory Effects of Adenosine Deaminase Inhibitors in Experimental Colitis Matteo Fornai*, Luca Antonioli, Rocchina Colucci, Narcisa Ghisu, Federico Da Settimo, Concettina La Motta, Gianfranco Natale, Olga Kastsiuchenka, Emiliano Duranti, Agostino Virdis, Mario Del Tacca, Corrado Blandizzi Is the Murine Dextran Sodium Sulfate-Induced Colitis Model Valid for Predicting Drug Efficacy in IBD? Yvette M. Petersen*, Birgitte Bjôrkenberg, Kennet N. Christjansen, Martin Stalhut, Henrik D. Pedersen, Christian Thorkildsen

UPDATE IN BARRETT’S ESOPHAGUS PATHOGENESIS Participants will be able to: • Learn new developments related to pathogenesis of Barrett’s Esophagus. 2:15 #247

Ectopic Expression of the Intestine-Specific Transcription Factor CDx2 in the Mouse Esophagus Alters Cell Proliferation and Morphology Jianping Kong*, Mary Ann S. Crissey, John P. Lynch

2:30 #248

Differences in CDX-2 Expression After Exposure to Acid and Bile Salts in Esophageal Squamous Cell Lines Derived from GERD Patients with and Without Barrett’s Esophagus Xiaofang Huo*, Hui Ying Zhang, Xi Zhang, Kathy HormiCarver, John P. Lynch, Stuart J. Spechler, Rhonda F. Souza

2:45 #249

DNA Ploidy As a Prognostic Biomarker After Ala Photodynamic Therapy for High Grade Dysplasia in Barrett’s Oesophagus Jason M. Dunn*, Gary D. Mackenzie, Dahmane Oukrif, Sarah J. Green, Yishyene Chew, Charles A. Mosse, Sally Thorpe, Marco Novelli, Stephen G. Bown, Laurence Lovat

3:00 #250

Characterisation of Squamous Oesophageal Epithelium and Location of Epithelial Stem Cells Mariagnese Barbera*, David P. Doupe, Allon M. Klein, Benjamin D. Simons, Philip H. Jones, Rebecca C. Fitzgerald

3:15 #251

Does CDx2 Provoke Expression of Intestinal Genes in Oesophageal Cells? Benjamin J. Colleypriest*, John M. Farrant, Jonathan M. Slack, David Tosh

3:30 #252

Diminished Salivary Epidermal Growth Factor Secretion in Patients with Barrett’s Esophagus Could Be a Potential Link to Its Development in Patients with Reflux Esophagitis Marek Majewski, Richard McCallum, Grzegorz Wallner, Jerzy Sarosiek*

AGA Institute Research Forum 2:15 PM - 3:45 PM

S401BC McCormick Place

Chairs: David W. Adelson, Andrea Todisco Sponsored by: Hormones, Transmitters, Growth Factors & Their Receptors

NOVEL SIGNALING PATHWAYS IN GASTROINTESTINAL CHEMOSENSING Participants will be able to: • Examine endocrine and neuronal pathways that initiate and regulate gastrointestinal response to luminal contents.

P-52

2:15 #253

Glucose Modulates the Response of Vagal Sensory Neurons and Their Central Terminals to GLP-1 Kirsteen N. Browning

2:30 #254

Novel Role of Intestinal Glucose in the Regulation of Gastrin Secretion Jianying Feng*, Stephen A. Wank

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:45 #255

Enteric Nematodes Secrete a Thrombin-Like Serine Protease Which Interacts with Host PAR1 and Barrier Function Luigi Notari*, Jennifer A. Stiltz, Prasad Rallabhandi, Jaladanki N. Rao, Sarah Netzel-Arnett, Toni Antalis, Joseph F. Urban Jr., Terez Shea-Donohue

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM

3:00 #256

The Cold and Menthol Receptor TRPM8 Is Expressed in Epithelial Cells of the Human and Murine Gastric Antrum Werend Boesmans*, Valentine Van den Abbeel, Grzegorz Owsianik, Thomas Voets, Jan F. Tack, Pieter Vanden Berghe

Sponsored by: Neurogastroenterology and Motility; Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Imaging & Advanced Technology; Intestinal Disorders

3:15 #257

Activation of the Glucagon-Like Peptide-2 Receptor Inhibits Neurally-Evoked Mucosal Chloride Secretion in the Guinea Pig Ileum In Vitro Sara Baldassano, Sumei Liu, Mei-Hua Qu, Wei Ren, Xiyu Wang, Guo-Du Wang, Yun Xia, Jackie D. Wood*

3:30 #258

Evolutionary Conservation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Gene Regulation and the Enteroinsular Axis Michelle Musson, Torfay Sharifnia*, Lisa I. Jepeal, M. Michael Wolfe

AASLD State-of-the-Art Lecture 4:00 PM - 5:00 PM

S105 McCormick Place

Chair: Scott L. Friedman DONORS AFTER CARDIAC DEATH FOR LIVER TRANSPLANTATION - WILL IT ADDRESS THE DONOR SHORTAGE? Participants will be able to: • Have a greater understanding of the technical aspects of DCD liver donation; • Understand the ethical issues surrounding DCD donation; and • Understand outcomes of DCD donor transplantation. 4:00 Sp264

Donors After Cardiac Death (DCD) for Liver Transplantation - Will It Address the Donor Shortage? Douglas W. Hanto

AASLD Clinical Symposium 4:00 PM - 5:30 PM

S104 McCormick Place

Chair: Michael R. Narkewicz CYSTIC FIBROSIS LIVER DISEASE IN THE 21ST CENTURY Participants will be able to: • Know the common hepatic complications in cystic fibrosis; • Discuss the role of CFTR dysfunction in the development of liver disease in CF; and • Compare the outcomes from various management options for advanced CF liver disease. 4:00 Sp265

Welcome and Introduction Michael R. Narkewicz

4:05 Sp266

Cystic Fibrosis Liver Disease: Definitions and Clinical Correlates Michael R. Narkewicz

4:30 Sp267

Pathophysiology and Risk Factors for Advanced CF Liver Disease Andrew P. Feranchak

4:55 Sp268

Management of Complications of CF Liver Disease: To Transplant the Liver or Not Saul J. Karpen

5:20

S404 McCormick Place

Chairs: André Smout, Satish S. Rao

ADVANCES IN THE DIAGNOSIS OF GASTROINTESTINAL DYSMOTILITY: WHAT’S NEW AND USEFUL IN THE CLINIC Participants will be able to: • Discuss evolving technologies to assess gastrointestinal motility; • Review new ways of diagnosing intestinal motility disorders; and • Explain which of the new technologies are likely to translate into clinically useful tools. 4:00 Sp269

High Resolution Esophageal Manometry Peter J. Kahrilas

4:22 Sp270

Current Gold Standards: Motility and Scintigraphy Michael Camilleri

4:44 Sp271

Emerging Technologies - Capsules, Pills and Magnets Who Needs Them Henry P. Parkman

5:06 Sp272

Non-Invasive, Automated Diagnosis By Endoluminal Image Analysis Fernando Azpiroz

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM

S103D McCormick Place

Chairs: Bruce A. Luxon, Albert J. Czaja Sponsored by: Liver & Biliary; Clinical Practice

AUTOIMMUNE HEPATITIS Participants will be able to: • Review treatment strategies in the ANA negative patient; • Discuss complications in autoimmune hepatitis; and • Review revenue of disease in the liver transplant recipient. 4:00 Sp273

AI Disease Review Samir Parekh

4:30 Sp274

Treatment of AIH Jenny Heathcote

5:00 Sp275

Overlap Syndrome Keith D. Lindor

Discussion

P-53

S U N D A Y MAY 31

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Clinical Symposium 4:00 PM - 5:30 PM

PATIENT WITH BARRETT’S ESOPHAGUS AND DYSPLASIA: S406A McCormick Place

4:35 Sp282

Patient with Barrett’s Esophagus and Dysplasia: Endoscopic and Clinical Assessment of Barrett’s Esophagus Jacques Bergman

4:40 Sp283

Patient with Barrett’s Esophagus and Dysplasia: Histologic Diagnosis of Dysplasia in Biopsy Samples Lisa M. Yerian

4:50 Sp284

Patient with Barrett’s Esophagus and Dysplasia: Endoscopic Mucosal Resection Liebwin Gossner

4:55 Sp285

Patient with Barrett’s Esophagus and Dysplasia: Histologic Assessment of Endoscopic Mucosal Resection Specimens in Barrett’s Esophagus Gregory Y. Lauwers

5:05 Sp286

Patient with Barrett’s Esophagus and Dysplasia: Impact of Histologic Diagnosis On Patient Management Prateek Sharma

Chairs: Stephen B. Hanauer, Peter D. Higgins Sponsored by: Clinical Practice; Intestinal Disorders; Immunology, Microbiology & Inflammatory Bowel Diseases

CROHN’S DISEASE: SHOULD WE USE BIOLOGIC THERAPY EARLIER IN DISEASE COURSE TO CHANGE OUTCOMES?

S U N D A Y MAY 31

Participants will be able to: • Incorporate existing knowledge about prognostic markers for response to biologic therapy in crohn’s disease; • Integrate an approach to earlier treatment of crohn’s disease with biologic therapy; and • Identify patients who will most benefit by earlier use of biologic therapy. 4:00 Sp276

What Are the Most Useful Markers to Predict Response to Biologic Therapy? Severine Vermeire

4:30 Sp277

Should We Combine Immunosuppressants to Achieve Better Short or Long Term Outcomes? Brian G. Feagan

5:00 Sp278

When Is the Best Time to Use Biologic Therapy in Crohn’s Disease? William J. Sandborn

5:15

Questions and Discussion

5:25

Summary

AGA Institute Committee Sponsored Symposium 4:00 PM - 5:30 PM S401BC McCormick Place Chairs: Benjamin C.Y. Wong, Robert S. Bresalier

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM

E451A McCormick Place

Chairs: Alyssa M. Krasinskas, Prateek Sharma Sponsored by: Rodger C. Haggitt Gastrointestinal Pathology Society

RODGER C. HAGGITT GASTROINTESTINAL PATHOLOGY SOCIETY SESSION: “A CLINICOPATHOLOGIC DISCUSSION OF REFLUX ESOPHAGITIS, BARRETT’S ESOPHAGUS, AND DYSPLASIA” Participants will be able to: • Relate the histopathologic features of non-erosive reflux disease to the clinical diagnosis and patient management; • Review the morphologic features of Barrett’s Esophagus and dysplasia; and • Assess and report the histopathologic findings in esophageal endoscopic mucosal resection (EMR) specimens. 4:00

Introduction to the Program

PATIENT WITH NON-EROSIVE REFLUX DISEASE: 4:05 Sp279

Patient with Non-Erosive Reflux Disease: Endoscopic and Clinical Assessment Ralf Kiesslich

4:10 Sp280

Patient with Non-Erosive Reflux Disease: Presentation and Discussion of Histologic Findings Michael Vieth

4:20 Sp281

Patient with Non-Erosive Reflux Disease: Impact of Histologic Diagnosis On Patient Management David Armstrong

4:25

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Questions and Discussion

Sponsored by: International Committee

THE CHANGING FACE OF GASTROINTESTINAL CANCER: A WORLDWIDE PERSPECTIVE Participants will be able to: • Explain how epidemiologic data indicates major variations in GI cancers worldwide; • Summarize how GI cancer incidence is changing in the nonwestern world with westernization of the life style; and • State the histologic, molecular, and therapeutic consequences of these differences and what the ongoing changes are. 4:00 Sp287

The International Face of Colorectal Cancer: One Disease or Many C. R. Boland

4:30 Sp288

Changes in Hepatocellular Carcinoma: The Impact of Vaccination Programs Anna S. Lok

5:00 Sp289

Gastroesophageal Cancer in Asia: Endogenous and Environmental Factors Benjamin C.Y. Wong

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Symposium 4:00 PM - 5:30 PM

S502 McCormick Place

AGA Institute Translational Symposium 4:00 PM - 5:30 PM

S405 McCormick Place

Chairs: Linda C. Samuelson, James R. Goldenring

Chairs: Alan L. Buchman, Pauline K. Lund

Sponsored by: Hormones, Transmitters, Growth Factors & Their Receptors; Gastrointestinal Oncology; Growth, Development & Aging; Neurogastroenterology and Motility

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases; Nutrition & Obesity; Clinical Practice; Growth, Development & Aging; Intestinal Disorders

MICRORNA REGULATION OF CELL SIGNALING AND PROLIFERATION

THERAPEUTIC AND ETIOLOGIC CONSIDERATIONS OF NUTRITION IN IBD

Participants will be able to: • Discuss stimuli and processes regulating miRNA biogenesis; • Explore the potential value of MicroRNAs as prognostic and predictive biomarkers for cancer; and • Describe how MicroRNAs regulate gene expression at the transcription and translational levels.

Participants will be able to: • Explain how nutrition can be used as primary or secondary therapy of IBD; • Name mechanisms of weight gain induced by corticosteroids and anti-TNF therapy; and • Define how sugar and iron affects intestinal inflammation and gut microbial composition and function.

4:00 Sp290

MicroRNAs and BMP Signaling Akiko Hata

4:30 Sp291

Role of MicroRNAs in GI Malignancies Carlo M. Croce

5:00 Sp292

Non-Coding RNAs in Gastroenterology - From the Scientist Benchside to the Patient Bedside George Calin

AGA Institute Research Symposium 4:00 PM - 5:30 PM

S401A McCormick Place

4:00 Sp296

Nutritional Treatment of IBD: Enteral and Parenteral Nutrition and Exclusion Diets Ernest G. Seidman

4:30 Sp297

Obesity and IBD Samuel Klein

5:00 Sp298

Dietary and Bacterial Interactions in Experimental Colitis: Clinical Implications for IBD R. Balfour Sartor

ASGE Clinical Symposium 4:00 PM - 5:30 PM

Chairs: Mark Donowitz, Ernest M. Wright Sponsored by: Intestinal Disorders; Esophageal, Gastric & Duodenal Disorders; Growth, Development & Aging; Hormones, Transmitters, Growth Factors & Their Receptors; Nutrition & Obesity

STRUCTURAL, MOLECULAR AND CELL BIOLOGIC ADVANCES IN GLUCOSE TRANSPORT Participants will be able to: • Describe the tertiary structure of sugar transporters and how it impacts on transport function; and • Review regulation and membrane trafficking of sugar transporters. 4:00 Sp293

Cell Biologic Insights On Trafficking Mechanisms of Glut 4 Tim McGraw

4:30 Sp294

Structure of SGLT1: Functional Implications of Structure Ernest M. Wright

5:00 Sp295

Functional Consequences On Sugar Absorption of Mutant Neurogenin-3 Martin G. Martin

S102 McCormick Place

Chairs: Jacques Van Dam, Douglas O. Faigel HOT TOPICS IN EUS 4:00 Sp299

EUS-Guided Fiducial Marker Insertion for Image-Guided Stereotactic Radiation Therapy Brian M. Yan

4:20 Sp300

EUS-Guided Biliary Access Michel Kahaleh

4:40 Sp301

Management of Mucinous Neoplasms of the Pancreas Operate or Observe John M. DeWitt

4:50 Sp302

Management of Mucinous Neoplasms of the Pancreas Operate or Observe Brendan C. Visser

5:00

Questions & Answers

ASGE Clinical Symposium 4:00 PM - 5:30 PM

S103ABC McCormick Place

Chairs: Charles E. Dye, Lauren B. Gerson MANAGING SMALL BOWEL DISEASE IN 2009: DEEP ENTEROSCOPY AND THERAPY 4:00

Introduction

4:05 Sp303

Deep Enteroscopy for Bleeding Jeffrey L. Tokar

4:25 Sp304

Enteroscopy for Inflammatory Disorders Daniel S. Mishkin

4:45 Sp305

ERCP and Other Therapeutic Interventions Andrew S. Ross

P-55

S U N D A Y MAY 31

ORAL SESSIONS—SCIENTIFIC SESSIONS 5:05 Sp306 5:20

Outcomes, Cost, and Complications Lauren B. Gerson

4:30 #267

No-Induced Proteasomal Degradation of Mypt1 Enhances Giant Migrating Contractions and Tone in Colonic Inflammation Qingjie Li*, Sushil K. Sarna

4:45 #268

Proliferation of Interstitial Cells of Cajal Occurs in Adult Mice and Is Dependent On 5HT2B Receptors and Protein Kinase C γ Vivek S. Tharayil*, Mira M. Wouters, Jennifer E. Stanich, Michael D. Gershon, Luc Maroteaux, Simon J. Gibbons, Gianrico Farrugia

5:00 #269

Expression of AMP-Activated Kinase (AMP Kinase) and Inactivation of Myosin Light Chain (MLC) Kinase By AMP Kinase Determines the Magnitude of Smooth Muscle Contraction in Different Regions of the Stomach Othman Al-Shboul*, Sunila Mahavadi, Carissa Strane, Karnam S. Murthy

5:15 #270

Irreversible Dedifferentiation of Interstitial Cells of Cajal (ICC) in the Absence of Adequate Kit Signaling Andrea Lorincz, Michael R. Bardsley, Jüri J. Rumessen, Peter R. Strege, Viktor J. Horvath, Doug Redelman, Gianrico Farrugia, Tamas Ordog*

Questions & Answers

AASLD Topic Forum 4:00 PM - 5:30 PM

S106A McCormick Place

Chairs: Vijay Shah, Jasmohan S. Bajaj COMPLICATIONS OF CIRRHOSIS: CLINICAL 4:00 #259

S U N D A Y MAY 31

The Effects of Long Term PEG-Interferon Therapy On the Development of Esophageal Varices and Variceal Bleeding Jn Patients with Hepatitis C and Advanced Fibrosis: Final Results from the Copilot Trial Andres Cardenas*, Sean Pritchett, Robert S. Brown Jr., Robert A. Levine, Michael P. Curry, Nezam H. Afdhal

4:15 #260

The Use of Thromboelastography, Platelets, and INR in a Clinical Model for Bleeding Risk in Cirrhotic Patients Neeral L. Shah*, Edward Xavier, Patrick G. Northup, Gavin Slitt, Curtis K. Argo, Abdullah M. Al-Osaimi, Stephen H. Caldwell

4:30 #261

Cirrhotic Cardiomyopathy: An Overall Assessment and Role of NT-PROBNP Vanesa Bernal*, Isaac Pascual, Paula Esquivias, Agustin Garcia Gil, César Fernández, José María Mateo Agudo, Trinidad Serrano, Miguel Angel Simón

4:45 #262

Terlipressin Therapy for Reversal of Hepatorenal Syndrome: A Metaanalysis Sashidhar V. Sagi*, Sahil Mittal, Krishna S. Kasturi, Gagan Sood

5:00 #263

Coronary Artery Disease in Liver Cirrhosis: A Comparison Between NASH-Related Cirrhosis, Alcoholic Cirrhosis and Cirrhosis Due to Other Etiologies Evangelos Kalaitzakis*, Einar Bjornsson

5:15 #264

Cystatin C Concentration As a Predictor of Death and Cardiovascular Events After Liver Transplantation Vanesa Bernal*, Isaac Pascual, Agustin Garcia Gil, Paula Esquivias, César Fernández, Miguel Angel Simón

AGA Institute Research Forum 4:00 PM - 5:30 PM

E451B McCormick Place

Chairs: Paul J. Limburg, Chin Hur Sponsored by: Gastrointestinal Oncology

SCREENING, SURVEILLANCE AND DIAGNOSIS OF GI CANCERS I Participants will be able to: • Understand the role of imaging and other tests for colorectal cancer screening. 4:00 #271

Natural History of Intermediate-Sized Colon Polyps On CTC: Growth Rates Predict Histology Brooks D. Cash*, Patrick E. Young, James W. Kikendall, Andrew Gentry, Scott L. Itzkowitz, Lawrence Goldkind, Mylena Truesdale, Cathy Dykes, Donald W. Jensen, Duncan S. Barlow

4:15 #272

Cost-Effectiveness of CT Colonography to Screen for Colorectal Cancer: Report to Center for Medicare and Medicaid Services from Cancer Intervention and Surveillance Modeling Network (CISNET) Ann G. Zauber*, Amy B. Knudsen, Carolyn M. Rutter, Iris Lansdorp-Vogelaar, James E. Savarino, Marjolein van Ballegooijen, Karen M. Kuntz

INTERSTITIAL CELLS OF CAJAL & SMOOTH MUSCLE

4:30 #273

Participants will be able to: • Examine the role of interstitial cells of cajal in gastrointestinal motility; and • Examine the role of smooth muscle in gastrointestinal motility.

Patient and Physician Preferences for Management of Small Polyps On Screening CT Colonography Jessica Shah*, Linda S. Hynan, Don C. Rockey

4:45 #274

Prevalence of Advanced Histology in Diminutive Colonic Polyps in An Average Risk Population: Implications for Colorectal Cancer Screening Andrea Buda*, Eva Zabeo, Manuela De Bona, Renzo Barbazza, Pierluca Piselli, Angelo Bellumat, Flavio Valiante, Massimo Pignatelli, Giacomo C. Sturniolo, Michele De Boni

5:00 #275

Comparing Diagnostic Yield and Interval Cancer Rates of Different Strategies of Colorectal Cancer Screening Carlo Senore*, Nereo Segnan, Alessandra Santarelli, Adriano Giacomin, Orietta Giuliani, Marco Zappa, Paola Piccini, Fabio Falcini, Luigi Bisanti

AGA Institute Research Forum 4:00 PM - 5:30 PM

S504 McCormick Place

Chairs: Hamid I. Akbarali, Ravinder K. Mittal Sponsored by: Neurogastroenterology and Motility

4:00 #265

4:15 #266

P-56

Immunoreactivity for Ano1 Detects Depletion of Interstitial Cells of Cajal in Patients with Slow Transit Constipation Purna C. Kashyap*, Pedro J. Gomez-pinilla, Matthew S. Lurken, Robert R. Cima, Eric J. Dozois, David W. Larson, Tamas Ordog, Simon J. Gibbons, Gianrico Farrugia Accelerated Turnover of Interstitial Cells of Cajal (ICC) from Local Progenitors in a Mouse Model of Gastrointestinal Stromal Tumors (GIST) Michael R. Bardsley*, Laura Popko, David L. Young, Gianrico Farrugia, Brian P. Rubin, Tamas Ordog

ORAL SESSIONS—SCIENTIFIC SESSIONS 5:15 #276

Wireless Capsule Colonoscopy Compared to Conventional Colonoscopy in Patients At Moderate or Increased Risk for Colorectal Cancer. Interim Analysis of a Prospective Multicenter Study Sylvie Sacher-Huvelin, Marc Le Rhun, Véronique Sébille, Marianne Gaudric, Stanislas Chaussade, Jeanne Boitard, Bernard Filoche, Elise Chanteloup, Christophe Cellier, JeanChristophe Saurin, Thierry Ponchon, Philippe R. Ducrotté, Denis Heresbach, Dimitri Coumaros, Muriel Frederic, Robert Benamouzig, Jean-Paul Galmiche*

S U N D A Y MAY 31

P-57

ORAL SESSIONS—SCIENTIFIC SESSIONS SCIENTIFIC SESSIONS Sp323

ASGE Breakfast with Champions 6:30 AM - 8:00 AM

Updates in Pancreatitis Research: TRPV1 and Beyond (FR06) CC12D Rodger A. Liddle

Hyatt Regency McCormick Sp307

Endoscopic Sedation: Painless Endoscopy (BC01) CC10A John J. Vargo

SSAT Special Session 7:45 AM - 8:15 AM

Hyatt Regency McCormick Sp308

Sp309

ERCP Case Studies (BC02) Glen A. Lehman

Chair: David W. McFadden CC20AB Hyatt Regency McCormick

EUS: Master Level Cases (BC03) Robert H. Hawes

CC21AB Hyatt Regency McCormick

Sp310

S504 McCormick Place

Polypectomy: The Only Waye (BC04) Jerome D. Waye

Pullman Room Hyatt Regency McCormick

SSAT OPENING SESSION AGA Institute Plenary Session 8:00 AM - 10:00 AM

S406A McCormick Place

Chair: Ian L. Taylor Sponsored by: AGA Institute

AGA Institute Focused Clinical Update Discussions 6:45 AM - 8:00 AM

BASIC SCIENCE PLENARY Participants will be able to: • Examine the role of intestinal development and the relationship of the host with the microflora in promoting digestive health.

Sp311

M O N D A Y

Sp312

Celiac Disease (FC09) Detlef Schuppan

CC22AB Hyatt Regency McCormick

Sp313

Sp314

Distinguished Mentor Award to Jerry S. Trier Robert S. Sandler

8:05 #277

Adam10 Is Required for Cell Lineage Specification of the Intestinal Epithelium Kelli L. VanDussen*, Alex Stoeck, Li Shang, Howard C. Crawford, Linda C. Samuelson, Peter J. Dempsey

8:22 #278

Genetic Ablation of the Notch Signaling Promotes TGFβ-Induced Epithelial-Mesenchymal Transition Involving Posttranscriptional Regulation of ZEB1 and ZEB2 By MicroRNA-200 Family Members Shinya Ohashi, Ross A. Kalman*, Mitsuteru Natsuizaka, Katharine D. Grugan, Douglas B. Stairs, Jiri Kalabis, Claudia Andl, Yizeng Yang, Ben Rhoades, Warren S. Pear, Jonathan P. Katz, Hiroshi Nakagawa

8:39 Sp325

Overview Lecture: Microbial-Innate Immune Interactions At the Epithelial Cell Interface D. Brent Polk

9:04 #279

Changes in Mucosal Homeostasis Leading to Hypersensitivity to Mucosal Injury in NHE3 Knockout Mice Daniel Laubitz*, Claire B. Larmonier, Monica T. MiduraKiela, Robert D. Thurston Jr., Pawel R. Kiela, Fayez K. Ghishan

Microbial-Host Interactions (FR03) Christian Jobin

9:21 #280

Colitis-Associated Variant of TLR2 Causes Impaired Mucosal Repair Due to TFF3 Deficiency Annette Eyking, Daniel K. Podolsky, Elke Cario*

Molecular Biology of GI Cancer (FR05) John P. Lynch

9:38 Sp326

Closing Remarks/Adjournment Ian L. Taylor

Nutritional Support (FC10) Douglas L. Seidner

CC10D Hyatt Regency McCormick

Pancreatic Cysts: Update On Management (FC11) Paul S. Jowell, Darren A. Pavey CC12B

Hyatt Regency McCormick Sp316

Pediatric Issues in UGI Diseases (FC13) Nicola L. Jones

CC24AB Hyatt Regency McCormick

Sp317

Peptic Ulcer Disease (FC12) Mitchell L. Schubert, Juan D. Baltodano

CC23AB Hyatt Regency McCormick

AGA Institute Focused Research Roundtable Discussions 6:45 AM - 8:00 AM

Sp319

CC10B Hyatt Regency McCormick

Sp320

CC12A Hyatt Regency McCormick

Sp321

New Models to Study GI Motility Disorders (FR04) Michael A. Pack, Adam J. Rich CC10C

Hyatt Regency McCormick

P-58

Opening Remarks Ian L. Taylor

8:02

Colorectal Cancer Screening (FC08) Paul J. Limburg

CC12C Hyatt Regency McCormick

JUNE 1

8:00 Sp324

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Plenary Session 8:00 AM - 10:00 AM

B1 McCormick Place

Chair: Gail A. Hecht

CLINICAL SCIENCE PLENARY Participants will be able to: • Become familiar with new information about colorectal cancer screening and medications that impact development and outcomes of colorectal neoplasia. 8:00 Sp327

Opening Remarks Gail A. Hecht

8:05 #281

Thiopurine Therapy Is Associated with a Three-Fold Decrease in the Incidence of Advanced Colorectal Neoplasia in IBD Patients with Longstanding Extensive Colitis: Results from the CESAME Cohort Laurent Beaugerie, Philippe Seksik*, Anne-Marie Bouvier, Franck Carbonnel, Jean-Frederic Colombel, Jean Faivre, Jean-Francois Flejou, Jean-Louis Dupas, Jean-Pierre Gendre, Philippe Godeberge, Jean-Pierre Hugot, Marc Lemann, Stephane Nahon, Jean-Marc Sabaté, Gilbert Tucat, Fabrice Carrat, Study Group for the CESAME

8:20 #282

Aspirin Use and Survival After Diagnosis of Colorectal Cancer Andrew T. Chan*, Charles S. Fuchs, Shuji Ogino

8:35 #283

First Randomised Trial On the Risk of Colorectal Cancer After Flexible Sigmoidoscopy Screening Geir Hoff*, Tom Grotmol, Skovlund Eva, Michael Bretthauer

9:05 Sp328 9:30

Colorectal Cancer Despite Colonoscopy: Critical Is the Endoscopist, Not the Withdrawal Time Rohit Gupta*, Michael Steinbach, Karla V. Ballman, Vipin Kumar, Petrus C. de Groen Quality and Effectiveness of Endoscopic Colorectal Cancer Screening Linda Rabeneck Distinguished Clinician Awards to Lin Chang, Stephen E. Goldfinger, Damian H. Augustyn, and Robert M. Craig Robert S. Sandler Distinguished Educator Award to William F. Balister Robert S. Sandler

9:40 Sp329

Closing Remarks Gail A. Hecht

DDW Nurses Program ‡ 8:00 AM - 12:00 PM

9:05

Questions and Answers

9:20

Break

9:35 Sp333

Assessing and Improving Quality in Endoscopy Douglas O. Faigel

9:55 Sp334

Quality: From Concept to Implementation David Hambrick

10:15 Sp335

Recognizing and Managing Complications of Endoscopy David A. Greenwald

10:35

Questions and Answers

10:50

Break

SESSION 3: THERAPEUTIC ENDOSCOPY 11:05 Sp336

Advances in Therapeutic Endoscopy Thomas J. Savides

11:25 Sp337

New Therapies and New Challenges James Slattery

11:45

Questions and Answers

ASGE Video Forum 8:00 AM - 12:00 PM

S402 McCormick Place

NURSES PROGRAM (PART I)

S100 McCormick Place

2009 ASGE ENDOSCOPIC VIDEO FORUM 8:00 Sp338

Introduction Neena S. Abraham

Chairs: John A. Dumot, Grace H. Elta, Thierry Ponchon

8:05 Sp339

8:12 8:15 Sp340

8:24 Sp341

8:30 8:33 Sp342

EUS-Guided Biliary Drainage with One-Step Placement of Newly Designed Fully Covered Metal Stent for Malignant Biliary Obstruction: A Prospective Feasibility Study Do Hyun Park Q&A Therapeutic EUS for the Treatment of a Pancreaticopleural Fistula Scott T. Cooper Q&A Direct Pancreatoscopy with Narrow Band Imaging in Patient with Pancreas Divisum and Intraductal Papillary Mucinous Neoplasm Daniel A. Ringold Q&A Digital Cholangioscopy with Narrow Band Imaging and Confocal Microscopy Ram Chuttani

Welcome and Introduction

SESSION 1: ENDOSCOPY ESSENTIALS: WHAT’S NEW? 8:05 Sp330

Options for Sedation Julia J. Liu

8:25 Sp331

Issues in Sedation: The Nurses’ Perspective Sue Nuccio

8:41 8:44 Sp343 8:49

M O N D A Y JUNE 1

SESSION I

8:21

Chair: John R. Saltzman and David Hambrick

8:00

Electrocautery David L. Carr-Locke

SESSION 2: IMPROVING QUALITY, PREVENTING COMPLICATIONS

Sponsored by: AGA Institute

8:50 #284

8:45 Sp332

Q&A Peroral Cholangioscopy: Removal of Foreign Body from Biliary Tree Shahzad Iqbal Q&A

P-59

ORAL SESSIONS—SCIENTIFIC SESSIONS 8:52 Sp344 8:58 9:01 Sp345 9:05 9:08 Sp346 9:16 9:19 Sp347 9:24 9:27 Sp348 9:32 9:35 Sp349

M O N D A Y

Direct Peroral Cholangioscopy in the Management of Refractory Stone Disease Gregory A. Cote

Endoscopic Resection of Distal Bile Duct Mass Shyam S. Varadarajulu Q&A Advanced Endoscopic Pancreaticobiliary Therapy in Surgically-Altered Enteral Anatomy Marvin K. Ryou Q&A Endoscopic Anastomosis Between the Cystic Duct Stump and a Severed Aberrant Right Hepatic Duct Guido Costamagna Q&A Pancreatic Balloon Sphincteroplasty for Removal of Large Radiolucent Pancreatic Stones Amit P. Maydeo

10:54 Sp355

Endoscopic Submucosal Dissection for Esophageal Cancer On the Varix Tsuneo Oyama

10:59

Q&A

11:02 Sp356

Endoscopic Repair of a Type II Paraesophageal Hernia with Mesenteroaxial Volvulus Keith L. Obstein

11:09

Q&A

11:12 Sp357

EUS-Guided Coil Embolization of Gastric Varices After Unsuccessful Endoscopic Glue Injection Andres Sanchez Yague

11:18

Q&A

11:21 Sp358

Loop-and-Let-Go for Gastric GISTs Kenneth F. Binmoeller

11:28

Q&A

11:31 Sp359

Endoscopic Mangement of a Tubular Esophageal Duplication Diagnosed in a 14 Year Old Male Dimitri Coumaros

11:37

Q&A

11:40 Sp360

Endoscopic Mediastinal Abscess Drainage Arnab Biswas

11:46

Q&A

11:49 Sp361

Endoscopic Submucosal Dissection with a Water-Jet Hybrid Knife (ESDH) of Mucosal and Submucosal Lesion in the Upper GI Tract Horst Neuhaus

11:57

Q&A

12:00

Conclude

Q&A Endoscopic Treatment of Gallstone Illeus of the Colon Todd H. Baron Q&A

9:45

Presentation of ASGE Audiovisual Award, Presented by John L. Petrini, MD, FASGE, ASGE President Award Winner: Endoscopic Management of Variceal Hemorrhage in Cirrhosis Soung Won Jeong Award Recipient: Infectious Colitides Michael J. Krier Award Recipient: The Non-Polypoid (Flat and Depressed) Cobrectal Neoplasms Tonya R. Kaltenbach

9:53

Q&A

Q&A

9:42

JUNE 1

10:51

SSAT Plenary Session 8:15 AM - 9:15 AM

Break

S504 McCormick Place

Chairs: Charles E. Dye, Joseph J.Y. Sung, Marcia I. Canto

Chair: Michael J. Zinner

SESSION II

PRESIDENTIAL PLENARY A (PLENARY SESSION I)

10:13 Sp350

Lower Gastrointestinal Bleeding in a Post Kidney Pancreas Transplant Patient Srikrishna Vemana

10:18

Q&A

10:21 Sp351

Enteral Stent Placement Using Spiral Enteroscopy for Malignant Mid-Jejunal Obstruction Eun Ji Shin

10:26

Q&A

10:29 Sp352

NOTES® Transgastric Hernia Repair in a Porcine Model David J. Desilets

10:35

Q&A

10:38 Sp353

Feasibility of Small Bowel Resection By NOTES® Transgastric and Transvaginal Approach Elena Dubcenco

10:43

Q&A

10:46 Sp354

Endoluminal Treatment of Obesity: First Case Report of Transoral Gastroplasty in the US Gregory A. Cote

P-60

Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 8:15 #285

Effect of Multiple Pre-Operative Endoscopic Interventions On Outcomes After Laparoscopic Heller Myotomy for Achalasia Christopher W. Snyder*, Ryan C. Burton, Lindsay E. Brown, Manasi S. Kakade, Mary T. Hawn

8:30 #286

The Extent of Resection and Insulin-Dependent Diabetes But Neither Preoperative Chemotherapy Nor (Chemotherapy-Induced) Liver Injury Influence Morbidity After Surgery for Hepatic Colorectal Metastases Frank Makowiec*, Simone Moehrle, Hannes P. Neeff, Oliver G. Opitz, Ulrich T. Hopt, Axel zur Hausen

ORAL SESSIONS—SCIENTIFIC SESSIONS 8:45 #287

9:00 #288

Improvement in Peripheral Glucose Uptake After Gastric Bypass Is Only Observed After Massive Weight Loss and Is Associated with Altered Patterns of Gut and Pancreatic Hormone Secretion Guilherme M. Campos*, Charlotte Rabl, Ruxandra Ciovica, Sofia Peeva, Madhu Rao, Morris Schambelan, Jean-Marc Schwarz, Kathleen Mulligan Transoral Endoscopic Esophagectomy Bart P. Witteman*, Andres Gelrud, George M. Eid, Alejandro Nieponice, Stephen F. Badylak, Blair A. Jobe

AASLD Clinical Symposium 8:30 AM - 10:00 AM

S106A McCormick Place

Chairs: Robert J. Fontana, R. Todd Stravitz THERAPEUTIC ADVANCES IN ACUTE LIVER FAILURE Participants will be able to: • Increase awareness of the epidemiology and outcomes in adult acute liver failure including recommended disease specific interventions and treatments; • Improve working knowledge of the ICU management of patients with acute liver failure with an emphasis on the pathophysiology, diagnosis, and treatment of cerebral edema; • Identify current and future medical treatments for hyperammonemia in acute liver failure and other disease states; and • Gain further understanding of the current and future role for extra corporeal therapies in acute liver failure including bioartificial devices. 8:30 Sp362

Epidemiology of ALF and Etiology-Specific Medical Treatments Robert J. Fontana

8:50 Sp363

ICU Management of the ALF Patient Including Cerebral Edema R. Todd Stravitz

9:10 Sp364

Current and Future Use of Medical Therapies for Hyperammonemia Rajiv Jalan

9:30 Sp365

Bioartificial Liver Devices: Past, Present and Future Norman L. Sussman

9:50

Panel Discussion

ASGE Clinical Symposium 8:30 AM - 10:00 AM

ASGE Clinical Symposium 8:30 AM - 10:00 AM Chairs: Douglas K. Rex, Philip S. Schoenfeld

POLYPECTOMY: NEW TECHNIQUES FOR AN OLD PROCEDURE 8:30

Piecemeal Polypectomy - Pearls and Pitfalls Douglas K. Rex

9:00 Sp370

Preventing Polypectomy Complications - Minimizing Post-Polypectomy Bleeds and Perforations Douglas B. Nelson

9:20 Sp371

Managing Polypectomy Complications - New Endoscopic Approaches to Management of Post-Polypectomy Bleeding & Perforation Michael B. Wallace

9:40

Introduction

8:40 Sp366

In Stent Karma Todd H. Baron

9:00 Sp367

Arts and Craft: Clips and Glue Gottumukkala S. Raju

9:20 Sp368

A Stitch in Time Saves Nine Robert H. Hawes

9:40

Questions & Answers

Questions & Answers

AASLD Plenary Session 8:30 AM - 10:00 AM

S105 McCormick Place

Chairs: Arun J. Sanyal, T Jake Liang AASLD PLENARY CLINICAL 8:30 #289

Pesticide and Heavy Metal Exposures Are Associated with ALT Elevation in American Adults: NHANES 20032004 Mihir Patel*, Keith C. Falkner, Craig J. McClain, Matthew C. Cave

8:45 #290

Cumulative Incidence and Risk Factors of Hepatocellular Carcinoma (HCC) in Patients with ENDStage Liver Disease Secondary to Nonalcoholic Steatohepatitis (NASH) Mustafa S. Ascha*, Ibrahim Hanouneh, Rocio Lopez, Tarek I. Abu-Rajab Tamimi, Mazen Albeldawi, Ariel E. Feldstein, Arthur J. McCullough, Nizar N. Zein

9:00 #291

Monitoring Peripheral Blood CD4+ Adenosine Triphosphate (ATP) Activity in Orthotopic Liver Transplantation (OLT) Recipients with Hepatitis C Virus (HCV) Infection and Its Correlation to Fibrosis Progression Naim Alkhouri*, Ibrahim Hanouneh, Rocio Lopez, Nizar N. Zein

9:15 #292

Does the Model for END-Stage Liver Disease (MELD) Underestimate the Severity of Liver Disease in Women with Kidney Dysfunction? Ayse L. Mindikoglu*, Laurence S. Magder, Warren L. Kupin, Arie Regev

9:30 #293

Outcomes of Pediatric Living Related Versus Deceased Donor Transplantation: A Case-Control Study of a Single-Center Experience Bella Zeisler*, John Bucuvalas, Maria Alonso, Frederick Ryckman, Greg Tiao, Kathleen M. Campbell

9:45 #295

Final Results of the EPIC3 Cirrhosis Maintenance Trial: Pegintron Maintenance Therapy in Cirrhotic (METAVIR F4) HCV Patients, Who Failed to Respond to Interferon/ Ribavirn (IR) Therapy: Jordi Bruix*, Thierry Poynard, Massimo Colombo, Eugene R. Schiff, Jurg Reichen, Kelly W. Burak, Jenny Heathcote, Thomas Berg, Jorge L. Poo, Carlos E. Brandao-Mello, Rainer Günther, Claus Niederau, Ruben Terg, Navdeep Boparai, Joann Harvey, Louis H. Griffel, Margaret Burroughs, Clifford A. Brass, Janice Albrecht

CLOSING LEAKS AND HOLES: WHAT CAN WE ACCOMPLISH WITH THE ENDOSCOPE? 8:30

Introduction

8:40 Sp369

S101 McCormick Place

Chairs: Gregory G. Ginsberg, Mark D. Topazian

S102 McCormick Place

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M O N D A Y JUNE 1

ORAL SESSIONS—SCIENTIFIC SESSIONS ASGE Topic Forum 8:30 AM - 10:00 AM

9:06 #305

Safety and Efficacy of Double Balloon Enteroscopy in Pediatrics Nishimura Naoyuki*, Tomonori Yano, Yoshikazu Hayashi, Masayuki Arashiro, Tomohiko Miyata, Keijiro Sunada, Hironori Yamamoto, Kentaro Sugano

9:18 #306

Esophageal Stenting with Removable Tracheobronchial Stents in Children Chad Best*, Khalid Khan

9:30 #307

The Utility of Endoscopic Ultrasound for Evaluating Gastrointestinal Disorders in Pediatric Patients Abdullah Rashdan*, John M. DeWitt, Stuart Sherman, Julia K. LeBlanc, Lee McHenry Jr., Mohammad A. Al-Haddad

9:42 Sp373

State-of-the-Art Lecture: Endoluminal Interventions in Pediatric Gastroenterology Patrick I. Okolo III

S104 McCormick Place

Chairs: Virender K. Sharma, Lauren B. Gerson ADVANCES IN CAPSULE ENDOSCOPY 8:30 #296

Does Capsule Endoscopy Improve Outcomes in Obscure GI Bleeding: Randomized Controlled Trial of Capsule Endoscopy vs. Dedicated Small Bowel Radiography Loren A. Laine*, Amandeep Sahota, Abbid Shah

8:42 #297

In Vivo Trial of Driving System for Capsule Endoscopy Using a Magnetic Field Eijiro Morita*, Naotake Ohtsuka, Mitsuyuki Murano, Sadaharu Nouda, Takanori Kuramoto, Kazuki Kakimoto, Ken Kawakami, Kumi Ishida, Yosuke Abe, Takuya Inoue, Naoko Murano, Yasunori Shindo, Eiji Umegaki, Kazuhide Higuchi

8:54 #298

M O N D A Y JUNE 1

A New Extracorporeal Magnetic Navigation Tool for Capsule Endoscopy Hidetoshi Ohta*, Yasuhiro Sato, Shingo Tanaka, Toshinori Okuda, Tadashi Doi, Akihito Fujimi, Yuji Kanisawa

9:06 #299

Capsule Endoscopy (CE) Appears to Be Underutilized in Evaluating Obscure Gastrointestinal Bleeding (OGIB) Ian M. Gralnek*, Denise Malvehy

9:18 #300

Negative Capsule Endoscopy Does Not Predict Lower Rebleeding Rate in the Long Term: A Study to Evaluate the Long-Term Clinical Outcomes of Patients with Obscure Gastrointestinal Bleeding After Capsule Endoscopy Guided Therapy Jae Jun Park*, Jae Hee Cheon, Duk Hwan Kim, Chang Mo Moon, Song Yi Han, Eun Soo Kim, TAE IL KIM, Won Ho Kim

9:30 #301

Distribution of Small Intestinal Mucosal Injuries with Short-Term Administration of Non-Steroidal AntiInflammatory Drugs Shunji Fujimori*, Katya Gudis, Yoko Takahashi, Tsuguhiko Seo, Akihito Ehara, Tsuyoshi Kobayashi, Keigo Mitsui, Shu Tanaka, Atsushi Tatsuguchi, Choitsu Sakamoto

9:42 Sp372

State-of-the-Art Lecture: Capsule Endoscopy: Can We Improve Diagnostic Accuracy and Outcomes? Lauren B. Gerson

ASGE Topic Forum 8:30 AM - 10:00 AM

S103ABC McCormick Place

ASGE Topic Forum 8:30 AM - 10:00 AM Chairs: Uri Ladabaum, Jason A. Dominitz COLON CANCER SCREENING 8:30 #308

The FOBT-Pos-Finger Followed By FOBT-6-Pack May Be a Viable Screening Policy for Colo-Rectal Cancer Shivani Jain*, Stephen J. Sontag, Thomas G. Schnell, Jack Leya, Harish Bhatia

8:42 #309

Is American College of Radiology Recommendations for CT Colonography Reporting Suitable for Asia? Joseph J. Sung*, Kelvin K. Tsoi, Yee Yu Pau, Bing-yee Suen, Derek Luo, Simon S. Ng

8:54 #310

Colonoscopy Versus Virtual Colonoscopy: A Systematic Review and Meta-Analysis of Patient Preference, Acceptance, and Satisfaction Otto S. Lin*, Richard A. Kozarek

9:06 #311

Randomized, Controlled Trial of the Use of Magnesium Citrate with Polyethylene Glycol Electrolyte Lavage Solution for Morning Colonoscopy Preparation Sin Sil Park, Sing Dong Hyun, Lee Chang Hoon, Bae Sun Youn

9:18 #312

Influence of Endoscopy Unit Procedure Volumes On Polyp Detection Rates Charles Filipiak, Usman Ahmad*, Thanigaiarsu Thiyagarajan

9:30 #313

Improved Adenoma Detection Rates Using High Definition Colonoscopes Versus Standard Definition Colonoscopes Aliya G. Hasan*, Stevany L. Peters, Nicole Jacobson, Gregory L. Austin

9:42 Sp374

State-of-the-Art Lecture: Disparities in Utilization: If You Build It Will They Come? John M. Inadomi

Chairs: Chris A. Liacouras, Jenifer R. Lightdale ADVANCES IN PEDIATRIC ENDOSCOPY 8:30 #302

8:42 #303

8:54 #304

P-62

Incidence of Perforation in Pediatric Gastrointestinal Endoscopy: 11-Year Experience in a Series of 30,177 Procedures Performed At a Tertiary Care Center Petar Mamula*, Jonathan E. Markowitz, David A. Piccoli, Chris A. Liacouras Barrett’s Esophagus in Children and Adolescents Without Neurodevelopmental or Tracheoesophageal Abnormalities Hashem B. El-Serag*, Kenneth Fairly, Mitchell D. Shub, Mark Integlia, Mark A. Gilger, Louise Henderson The Role of the Bulb Biopsies in Children with Celiac Disease Benedetto Mangiavillano*, Barbara Parma, Luca Albarello, Paolo Viaggi, Elisabetta Morandi, Graziano Barera, Alberto Mariani, Pier A. Testoni, Enzo Masci

S103D McCormick Place

SSAT Address/Oration/Lecture 9:15 AM - 10:00 AM PRESIDENTIAL ADDRESS 9:15 Sp375

Introduction Michael J. Zinner

9:20 Sp376

“Above Average” David W. McFadden

S504 McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Plenary Session 10:00 AM - 12:00 PM

B1 McCormick Place

SSAT Plenary Session 10:30 AM - 11:15 AM

S504 McCormick Place

Chair: Robert S. Sandler

Chair: David W. McFadden

2009 PRESIDENTIAL PLENARY: CRUCIAL QUESTIONS FOR GASTROENTEROLOGY IN 2009

PRESIDENTIAL PLENARY B (PLENARY SESSION II) Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract.

10:00 Sp377

Introduction: Crucial Questions for Gastroenterology in 2009 Robert S. Sandler

10:05 Sp378

Which Basic Science Breakthroughs of Today Will Impact Patient Care of the Future? David A. Brenner

10:15 Sp379

Can We Do a Better Job Preventing Colon Cancer? Douglas K. Rex

10:25 Sp380

Quality Assessment and Pay-for Performance: Will Gastroenterologists Take Home a “Report Card? John I. Allen

10:35 Sp381

Endoscopic Ablation in Barrett’s: Who Needs It, and What Weapon? Nicholas J. Shaheen

10:45 Sp382

What Is the Role of the Gastroenterologist in Treating Liver Cancer? Norah Terrault

10:55 Sp383

How Will We Train the Gastroenterologist of the Future? Lawrence S. Friedman

11:05 Sp384

How Do We Balance the Risks, Benefits and Costs of Various Treatment Strategies for IBD? William J. Sandborn

AASLD State-of-the-Art Lecture 10:30 AM - 11:30 AM

11:15 Sp385

NOTES: Is the Future of Endoscopy in the Lumen or the Peritoneum? Anthony N. Kalloo

Chair: Stephen H. Caldwell

11:25 Sp386

Presidential Address: How Will We Address the Crucial Questions Facing Our Field? Robert S. Sandler

11:45 Sp387

Presentation of Friedenwald Medal to Daniel K. Podolsky Robert S. Sandler

11:50 Sp388

Presentation of the William Beaumont Prize in Gastroenterology to Warren Strober Robert S. Sandler

11:55 Sp389

Adjourn Robert S. Sandler

10:30 #314

Single-Port Access (SPA™) Surgery of the Alimentray Tract: 18 Months Experience with a Single Umbilical Incision Approach to Laparoscopy Erica R. Podolsky*, Paul G. Curcillo II

10:45 #315

The Hindgut Improves Glucose Homeostasis After Metabolic Surgery Independent of Weight Loss and Insulin Secretion in the Goto-Kakizaki Rat Tammy L. Kindel*, Stephanie M. Yoder, David D’Alessio, Patrick Tso

11:00 #316

Margin Positive Pancreaticoduodenectomy Is Superior to Palliative Bypass in Advanced Stage Pancreatic Adenocarcinoma Harish Lavu*, Andres A. Mascaro, Dane Grenda, Patricia K. Sauter, Ernest L. Rosato, Eugene P. Kennedy, Charles J. Yeo

S104 McCormick Place

HEMATOLOGIC COMPLICATIONS OF CHRONIC LIVER DISEASE AND TRANSPLANTATION Participants will be able to: • Review normal coagulation processes; • Review changes in coagulation system in liver disease; • Review methods to evaluate changes in coagulation system; • Review clinical implications of changes in coagulation in liver disease; and • Review methods to manage coagulopathy of liver disease. 10:30 Sp390

Hematologic Complications of Chronic Liver Disease and Transplantation Arun J. Sanyal

ASGE Clinical Symposium 10:30 AM - 12:00 PM

S101 McCormick Place

Chairs: Gary W. Falk, Ganapathy A. Prasad ENDOSCOPIC MANAGEMENT OF BARRETT’S ESOPHAGUS: WHAT’S CHANGED 10:30 Sp391

What Are Current Issues in the Endoscopic Management of Barrett’s Esophagus? Ganapathy A. Prasad

10:35 Sp392

Patient Selection: Variables to Consider Jacques Bergman

P-63

M O N D A Y JUNE 1

ORAL SESSIONS—SCIENTIFIC SESSIONS 10:55 Sp393

Endoscopic Mucosal Resection: Which Technique and What Should I Do with the Remainder of the Barrett’s Segment? Christian Ell

ASGE Topic Forum 10:30 AM - 12:00 PM

11:15 Sp394

Endoscopic Thermal Ablation: What Technique and Which Patient? Prateek Sharma

Chairs: Subbaramiah Sridhar, V. Raman Muthusamy

11:35 Sp395

Endoscopic Ablation 2009: What Should I Do Now? Gary W. Falk

11:40

Questions & Answers

AASLD Topic Forum 10:30 AM - 12:00 PM

S105 McCormick Place

ADVANCES IN ENDOSCOPIC PRACTICE: IMPROVING QUALITY AND REDUCING COMPLICATIONS 10:30 #323

Balanced Propofol Sedation Versus Fentanyl and Midazolam Titrated to Moderate Sedation for EGD - A Prospective, Randomized Clinical Trial Benjamin Levitzky*, Rocio Lopez, John A. Dumot, John J. Vargo

10:42 #324

Do Proton Pump Inhibitors Prevent Bleeding from Ulcers After Endoscopic Submucosal Dissection or Endoscopic Mucosal Resection? Janet Martin*, Myoungok Kim, Daniel Bainbridge, Davy Cheng

10:54 #325

The Clinical Value of the Duodenal Biopsy: A NationWide Clinicopathologic Analysis of 20,000 Patients Susanne W. Carmack*, Robert M. Genta

11:06 #326

A Randomized, Double-Blinded, Placebo-Controlled Trial of Promethazine and Diphenhydramine As Adjunct Sedatives for Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP): Interim Analysis Results Swapna B. Reddy*, Kenneth J. Chang, John G. Lee, Thomas T. Nguyen, Christopher E. Lee, Charles Whang, Makoto Nishimura, Susumu Shinoura, Reiko Ashida, Raman Muthusamy

11:18 #327

A Comparison of Split Dose Polyethylene GlycolElectrolyte Solution + Simethicone Versus Standard Overnight Fast for Small Bowel Cleansing Prior to Capsule Endoscopy (CE) Bridget J. Seymour*, Rebecca Matro, Constantine Daskalakis, Neilanjan Nandi, David M. Kastenberg

11:30 #328

Risk of Immediate and Delayed Complications with Percutaneous Gastrostomy and Jejunostomy Tubes in Patients Receiving Bevacizumab Anjani Jammula*, Mark A. Schattner, Moshe Shike

11:42 Sp396

State-of-the-Art Lecture: Improving Quality and Outcomes in Gastrointestinal Endoscopy Glenn M. Eisen

Chairs: Chinweike Ukomadu, Mindie H. Nguyen HBV: DISEASE PROGRESSION AND THERAPY 10:30 #317

M O N D A Y

Risk and Predictors of HCC in People Less Than 40 Years of Age: Update from the Reveal HBV Study Chien-Jen Chen*, Hwai-I Yang, Jun Su, Chin-Lan Jen, SanLin You, Uchenna H. Iloeje

10:45 #318

Hepatitis B Virus (HBV) Drugs in Pregnancy: Findings from the Antiretroviral Pregnancy Registry Robert S. Brown* Jr., Maria Buti, Diane Goodwin, Sherry Zhang, Elizabeth A. Fagan

11:00 #319

Response to Entecavir (ETV) in Patients with Chronic Hepatitis B (CHB) and Prior Suboptimal Response to Adefovir (ADV): Interim Report of a Multicenter Study Mindie H. Nguyen*, Huy N. Trinh, Son T. Do, Thuan T. Nguyen, Phuong L. Tran, Ruel T. Garcia, Nghia H. Nguyen, Huy A. Nguyen, Khanh K. Nguyen

11:15 #320

JUNE 1

11:30 #321

11:45 #322

P-64

Long-Term Histologic Improvement with Entecavir (ETV) Therapy in Patients with Chronic Hepatitis B (CHB) from Japanese and Worldwide Development Programs Yun-Fan Liaw*, Ting-Tsung Chang, Shun-Sheng Wu, Eugene R. Schiff, Kwang-Hyub Han, Ching-Lung Lai, Rifaat Safadi, Samuel S. Lee, Waldemar Halota, Zachary D. Goodman, Hui Zhang, Uchenna H. Iloeje, Suzanne Beebe, Bruce Kreter, Hiroki Ishikawa, Yoshiaki Katano, Koichi Takaguchi, Masao Omata Safety and Efficacy of 96 Weeks of Tenofovir Disoproxil Fumarate Therapy in Lamivudine Experienced Patients Michael P. Manns*, Lennox Jeffers, Georgios N. Dalekos, Thomas Berg, Christian Trepo, Stuart K. Roberts, Martin Prieto, Mario Rizzetto, Patrick Marcellin, Jenny Heathcote, Jeff Sorbel, Jane Anderson, Elsa Mondou, Franck Rousseau Tenofovir Disoproxil Fumarate (TDF) Versus Emtricitabine Plus TDF (FTC/TDF) for Treatment of Chronic Hepatitis B (CHB) in Patients with Persistent Viral Replication Receiving Adefovir Dipivoxil Thomas Berg*, Bernd Moeller, Huy N. Trinh, Sing Chan, Patrick Marcellin, Emilio Suarez, Andrea Snow-Lampart, David W. Oldach, Jeff Sorbel, Katyna Borroto-Esoda, David Frederick, Franck Rousseau

S103D McCormick Place

ASGE Topic Forum 10:30 AM - 12:00 PM

S102 McCormick Place

Chairs: Patrick I. Okolo, III, Marcia R. Cruz-Correa ETHNIC, RACIAL, AND GENDER DISPARITIES IN ENDOSCOPY: YES WE CAN DO BETTER 10:30 #329

Disparities in Surveillance Colonoscopy Participation: Determining Gender and Race Specific Targets for Future Quality Improvement Interventions D. Eli Penn*, Joseph Romagnuolo

10:42 #330

Prevalence of Colon Polyps >9mm Detected By Colonoscopy Screening in Asymptomatic Hispanic and Asian/Pacific Islander Patients: Results from the National Endoscopic Database Brent Lee*, David A. Lieberman, Jennifer L. Holub

10:54 #331

The Effect of Acculturation On Colorectal Polyp Prevalence Among Hispanics Neal Joseph*, Nora Muakkassa, Sergio Quijano, Martin J. Wolff, Fritz Francois

ORAL SESSIONS—SCIENTIFIC SESSIONS 11:06 #332

Time Trends and Racial Disparities in the Stage of Diagnosis of Esophageal Adenocarcinoma (EAC) in the United States Sachin B. Wani*, Amit Rastogi, Mandeep Singh, Vikas Singh, John D. Keighley, Ajay Bansal, Prateek Sharma

11:18 #333

Physician and Gender Differences Among the PatientPhysician Discussion Prior to Open Access Colonoscopy Dana Freeman*, James Paulson, David A. Johnson, Michael J. Ryan, F Taylor Wootton, Jeff R. Willis, Kelvin Hornbuckle, Whitney D. Brooks, Stacy B. Menees

11:30 #334

Colorectal Cancer Screening Above Age 75: Outcomes of Colonoscopies in Symptomatic African American and Hispanic Adults Shashideep Singhal*, Rinky Walia, Gokulakrishnan Balasubramanian, Arun Verma, Kris Anand

11:42 Sp397

State-of-the-Art Lecture: We Are All the Same Robynne K. Chutkan

ASGE Topic Forum 10:30 AM - 12:00 PM

S103ABC McCormick Place

SSAT Address/Oration/Lecture 11:15 AM - 12:15 PM

S504 McCormick Place

DORIS AND JOHN L. CAMERON GUEST ORATION 11:15 Sp399

Communication As a Quality Maker: A Cut to the Chase Stephen C. Beeson

ASGE Hands-on 12:00 PM - 2:00 PM

CC11AB Hyatt Regency McCormick

Chairs: Jonathan A. Leighton, John Losurdo INTRODUCTION TO CAPSULE ENDOSCOPY 12:00 Sp400

Introduction to Capsule Endoscopy Jonathan A. Leighton, John Losurdo

ASGE Hands-on Workshop 12:00 PM - 2:00 PM

N228 McCormick Place

Chairs: Richard C.K. Wong, Bhavani Moparty NOVEL TECHNOLOGIES FOR THE DIAGNOSIS OF GI DISORDERS: FROM THE BENCH TO THE ENDOSCOPY UNIT 10:30 #335

A Swallowable Tethered Capsule Endoscope for Diagnosing Barrett’s Esophagus Paul Glass*, Metin Sitti, Arjun Pennathur, Ragunath Appasamy

10:42 #336

Ingestible Event Marker System — A Novel, Physiologically-Sized Device Platform for Frequent, Repeated Use Michael Epstein

10:54 #337

Suction Parameters for the Development of a Robotic Endoscope for Traversing the Small Intestine Roberto Montane* Jr., Lukasz M. Kowalczyk, Anand Gupte, Carl D. Crane III, Mihir S. Wagh

11:06 #338

The Clinical Utility of Tandem Auto-Flourescence (AFI) and Narrow Band Imaging (NBI) in Patients with Barrett’s Esophagus (BE) Ajay Bansal*, Vikas Singh, Amit Rastogi, Sachin B. Wani, Mandeep Singh, April D. Higbee, Prateek Sharma

Chair: Vanessa M. Shami ENDOSCOPIC MUCOSAL RESECTION 12:00 Sp401

ASGE Poster Grand Rounds 12:15 PM - 1:00 PM Sp402

Sp403

11:18 #339

11:30 #340

11:42 Sp398

Detection of Pre-Neoplastic Gastric Lesions in a High Risk Chinese Cohort Using Endoscopic Autofluorescence Imaging Followed By Narrow Band Imaging Versus Standard White Light Endoscopy Prospective Randomized Double Blind Crossover Study Andrea Rajnakova*, Manuel Salto-Tellez, Ming Teh, Huak Y. Chan, Jimmy B. So Guided Esophageal Surveillance Biopsy with a Laser Marking Optical Frequency Domain Imaging System Melissa J. Suter*, Priyanka A. Jillella, Benjamin J. Vakoc, Brett E. Bouma, Norman S. Nishioka, Guillermo J. Tearney State-of-the-Art Lecture: It’s Not Your Father’s Endoscope: Advances in Endoscopic Imaging Kenneth K. Wang

Endoscopic Mucosal Resection Brenna C. Bounds, Samer S. El-Dika, Michel Kahaleh, John A. Martin, Andrew S. Ross, Jeffrey L. Tokar, Shyam S. Varadarajulu, Kenneth K. Wang, Paul Yeaton

Colonoscopy Tonya R. Kaltenbach

S102 McCormick Place

Small Bowel Imaging Lauren B. Gerson

S103ABC McCormick Place

DDW Meet-the-Investigator Luncheons 12:30 PM - 1:45 PM

Participants will be able to: • Identify new scientific and clinical information relevant to digestive diseases; • Engage in scholarly and dynamic discussions of specific clinical topics; and • Engage in scholarly and dynamic discussions of specific investigative topics. Sp404

Advances in Celiac Pathogenesis (M1) Martine Heyman

CC10D Hyatt Regency McCormick

Sp405

Intestinal Adaptation in Short Bowel Syndrome (M2) CC12B Kelly A. Tappenden

Hyatt Regency McCormick Sp406

Regulatory T Cell Function in the Intestine (M3) CC10C Tim Dennig

Hyatt Regency McCormick

P-65

M O N D A Y JUNE 1

ORAL SESSIONS—SCIENTIFIC SESSIONS Sp407

Use of Health Related Quality of Life Instruments (M4) Brennan M. Spiegel, Fasiha Kanwal CC12A

Sp421

CC22A Hyatt Regency McCormick

Hyatt Regency McCormick Sp422

DDW Meet-the-Professor Luncheons 12:30 PM - 1:45 PM

Sp423

Sp424

Capsule: Endoscopy of the Small Bowel and Beyond (M6) Sponsored by the ASGE CE/SBE SIG S401BC Robynne K. Chutkan

McCormick Place Sp410

Coding: The Right and the Wrong Way (M7) Glenn D. Littenberg, Thomas M. Deas Jr.

CC23A Hyatt Regency McCormick

Sp411

M O N D A Y JUNE 1

Critical Assessment of Emerging IBS Therapies (M8) CC21B Jan F. Tack

Hyatt Regency McCormick Sp412

Endoscopic Mucosal Ablation: Techniques and Technology (M9) Sponsored by the ASGE ETED SIG Amitabh Chak, Ananya Das S401D Endoscopic Prevention of Esophageal Adenocarcinoma (M10) Nicholas J. Shaheen, Julian A. Abrams S402

Sp426

Sp427

Eosinophilic Esophagitis (M11) Chris A. Liacouras, Jonathan Markowitz

CC21C Hyatt Regency McCormick

Sp415

Sp416

HCV Treatment Prospects (M12) Donald M. Jensen, Nancy Reau

S403 McCormick Place

Liver Fibrosis Non-Invasive Diagnostics (M13) Don C. Rockey

CC10A Hyatt Regency McCormick

Sp417

Sp418

Sp419

Lunch At the Movies: ERCP (M14) Stuart Sherman Lunch At the Movies: EUS (M15) Sponsored by the ASGE EUS SIG Brenna C. Bounds

S401A McCormick Place

Sp428

Preventing Complications of Parenteral Nutrition (M24) CC22C James S. Scolapio Probiotics in Functional GI Disorders (M25) Lesley A. Houghton

CC20C Hyatt Regency McCormick

Sp429

Techniques to Increase Resectability of Liver Tumors (M26) S502 Jean-Nicolas Vauthey, Elijah Dixon

McCormick Place Sp430

The Biliary Atresia Research Consortium: What Are We Learning? (M27) CC10B Tbd Tbd

Hyatt Regency McCormick Sp431

Tips and Tubes in Enteral Nutrition (M28) Stephen A. McClave

S503 McCormick Place

AGA Institute Problem-Based Learning Luncheons 12:30 PM - 1:45 PM

Participants will be able to: • Interact in a small group setting to define facts, develop hypotheses, and determine learning agenda; • Increase participant’s current knowledge of interesting gastrointestinal issues; and • Evaluate this method of teaching with respect to achieving objectives. Sp432

Sp433

32-Year-Old Woman with Fever and Jaundice and An Unusual Diagnosis (LL01) Meeting Suite #4 Sanjiv Chopra

Management of Patients Following Liver Transplant: Do’s and Don’ts (M17) S501BC Josh Levitsky, Kymberly D. Watt

Clinical Trials in Private Practice 101 (LL03) Colleen M. Schmitt Meeting Suite #3

Hyatt Regency McCormick

Management of Functional Dyspepsia (M16) William D. Chey

McCormick Place

P-66

S501D McCormick Place

Hyatt Regency McCormick S501A McCormick Place

CC12C Hyatt Regency McCormick

Sp420

Polypectomy: How I Do It (M23) Jerome D. Waye

Hyatt Regency McCormick

McCormick Place Sp414

Pediatric Inflammatory Bowel Disease (M22) Jeffrey S. Hyams, Francisco Sylvester

CC21A Hyatt Regency McCormick

McCormick Place Sp413

Outcomes Measures in IBD (M21) Peter D. Higgins, Akbar K. Waljee

CC20B Hyatt Regency McCormick

Sp425

Autoimmune Liver Disease (M5) Jenny Heathcote

Multidisciplinary Treatment of Inflammatory Bowel Disease (M20) Fabrizio Michelassi, Ellen J. Scherl CC12D

Hyatt Regency McCormick

CC20A Hyatt Regency McCormick

Sp409

Minimally Invasive Esophagectomy (M19) John G. Hunter

CC22B Hyatt Regency McCormick

Participants will be able to: • Identify new scientific and clinical information relevant to digestive diseases; • Engage in scholarly and dynamic discussions of specific clinical topics; and • Engage in scholarly and dynamic discussions of specific investigative topics. Sp408

Medical Therapy of Microscopic Colitis (M18) Darrell S. Pardi, Corey A. Siegel

Sp434

Cystic Neoplasms of the Pancreas: Diagnosis and Management (LL04) David R. Lichtenstein CC24A

Hyatt Regency McCormick

ORAL SESSIONS—SCIENTIFIC SESSIONS Sp435

Management of Crohn’s Disease: Merging Evidence with Experience, An Interactive Session (LL02) David T. Rubin CC24C

DDW Combined Clinical Symposium 2:15 PM - 3:45 PM

Hyatt Regency McCormick Sp436

When “the Going” Gets Tough: What’s New in the Management of Chronic Constipation? A 33-Year-Old Woman with Constipation, Straining, and Incomplete Evacuation (LL05) Suzanne Rose CC24B

Hyatt Regency McCormick AGA Institute Curbside Consultant 12:30 PM - 2:00 PM

S103D McCormick Place

CURBSIDE CONSULTANT, DIFFICULT ERCP CASES Participants will be able to: • Provide participants with a chance to answer specific questions and/ or seek clinical guidance in the management of a variety of complex gastrointestinal disorders; • Exchange educational and research information informally among gastroenterologists; and • Encourage camaraderie and academic and potential research ties between senior AGA consultants and AGA members and provide faculty with thought-provoking ideas for continued study and research; and inspire new gastroenterologists to the highest levels of professionalism. 12:30 Sp437

Curbside Consultant, Difficult ERCP Cases John Baillie

AASLD State-of-the-Art Lecture 2:15 PM - 3:15 PM

Chairs: Stuart J. Spechler, Kenneth K. Wang Sponsored by: AGA Institute; ASGE; SSAT

MULTIMODALITY DETECTION AND MANAGEMENT OF BARRETT’S AND DYSPLASIA Participants will be able to: • Determine how to better evaluate and treat Barrett’s Esophagus and Dysplasia. 2:15

Introduction

2:20 Sp440

Seeing Is Believing: Multimodal Imaging of Barrett’s Esophagus Jacques Bergman

2:40 Sp441

Removing the Neoplaysia, Endoscopic Surgical (Mucosal) Resection Kenneth K. Wang

3:00 Sp442

Burning Barrett’s Mucosa, What Can Be Achieved Nicholas J. Shaheen

3:20 Sp443

Multimodal Approach to Barrett’s Esophagus Stuart J. Spechler

3:40

Questions

DDW Combined Clinical Symposium 2:15 PM - 3:45 PM S105 McCormick Place

S100 McCormick Place

B1 McCormick Place

Chairs: Richard D. Schulick, Teresa Brentnall

Chair: Frank A. Anania Sponsored by: AGA Institute; SSAT; ASGE

NASH AND CO-MORBIDITIES

2:15 Sp438

NASH and Co-Morbidities Brent A. Tetri

AGA Institute State-of-the-Art Lecture 2:15 PM - 3:15 PM

Participants will be able to: • Screen for pancreatic cancer in high risk patients based on genetic predisposition; and • Identify new pancreatic cancer screening techniques. 2:15 Sp444

Epidemiology, Risk Factors, and Cost Effectiveness for Pancreatic Cancer Screening in the General Population Richard D. Schulick

ADULT DIABETICS AS HIGH RISK PATIENTS

E451B McCormick Place

2:25 Sp445

Prevalence and Temporal Onset of DM in PC Suresh T. Chari

2:40 Sp446

Cost-Effectiveness of Screening for PC in New Onset DM Luke M. Richey

Chairs: Marc S. Levin, Noah F. Shroyer Sponsored by: Growth, Development & Aging; Gastrointestinal Oncology; Intestinal Disorders; Hormones, Transmitters, Growth Factors & Their Receptors

ENDODERMAL ORGAN DEVELOPMENT IN ZEBRAFISH Participants will be able to: • Appreciate the use of zebrafish as a model for human development; • Examine the development of endodermal organs including the gut; and • Discuss Wnt signalling pathways in endodermal organ formation and regeneration. 2:15 Sp439

JUNE 1

PANCREATIC CANCER: ARE WE READY TO SCREEN?

Participants will be able to: • Explain the roles of free fatty acids, metabolic intermediates of free fatty acids and accumulated triglyceride in causing hepatocellular injury; • Explain the roles of exercise and pharmacological approaches to preventing and treating fatty liver disease; and • Provide accurate information to patients regarding the prevention and treatment of fatty liver disease.

SCREENING IN HIGH RISK PATIENTS: GENETIC PREDISPOSITION 2:50 Sp447

Seattle Approach Michael D. Saunders

3:05 Sp448

Johns Hopkins Approach Marcia I. Canto

3:20 Sp449

New and Evolving Screening Techniques for the General Population Teresa Brentnall

3:30

M O N D A Y

Panel Discussion

Endodermal Organ Development in Zebrafish Didier Stainier

P-67

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Clinical Symposium 2:15 PM - 3:45 PM

S404 McCormick Place

Chairs: Richard M. Green, Vijay Shah

Sponsored by: Cochrane Hepato-Biliary Group

Sponsored by: Liver & Biliary; Gastrointestinal Oncology; Growth, Development & Aging

Participants will be able to: • Review the principles and importance of evidence-based medicine, especially systematic reviews; and • Discuss the evidence that is currently available regarding the management of the complications of end-stage liver disease. 2:15 Sp450

JUNE 1

S103D McCormick Place

Chairs: Ronald L. Koretz, Christian Gluud

EVIDENCE-BASED MANAGEMENT OF END-STAGE LIVER DISEASE

M O N D A Y

AGA Institute Research Symposium 2:15 PM - 3:45 PM

Glucocorticosteroids or Pentoxiphylline for Alcoholic Hepatitis - Are We There Yet? Christian Gluud

2:37 Sp451

Transarterial Embolisation or Transarterial Chemoembolization for Hepatocellular Carcinoma - Are We There Yet? Roberto S. Oliveri

2:59 Sp452

Nutrition for end-Stage Liver Disease - Are We There Yet? Ronald L. Koretz

3:21 Sp453

Emergency Sclerotherapy versus Medical Interventions for Bleeding Oesophageal Varices in Cirrhotic Patients Are We There Yet? Gennaro D’Amico

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM

S406B McCormick Place

Chairs: Michelle K. Kim, David Weinberg Sponsored by: Gastrointestinal Oncology; Imaging & Advanced Technology; Clinical Practice; Immunology, Microbiology & Inflammatory Bowel Diseases

NEW INNOVATIONS IN COLORECTAL CANCER SCREENING Participants will be able to: • Review new techniques involved in colonoscopic imaging; • State approaches to improved detection of colorectal neoplasia; and • Discuss imaging modalities that can detect neoplasia in inflammatory bowel diseases. 2:15 Sp454

Spectroscopic and Optical Signatures for Colorectal Cancer Screening Hemant K. Roy

2:45 Sp455

In Vivo Colorectal Neoplasia Detection Using PeptideTargeted Confocal Endoscopy Thomas D. Wang

3:15 Sp456

In Vivo Confocal Laser Scanning ChromoEndomicroscopy of Colorectal Neoplasia Ralf Kiesslich

P-68

RECENT STUDIES IN HEPATOLOGY RESEARCH Participants will be able to: • Grasp current thoughts on contemporary tools and concepts in liver development; • Appreciate the potential of the liver stem cell niche for hepatocyte growth, cancer, and development; and • Gain insights into mechanical stress as a means to perpetuate liver fibrosis and cirrhosis. 2:15 Sp457

Mechanical Factors in the Development of Cirrhosis Rebecca Wells

2:37 Sp458

Liver Regeneration and Hepatocellular Carcinoma: Role of SOCS-3 Jean Campbell

2:59 Sp459

CD133 and Stem Cell Biology C. B. Rountree Jr.

3:21 Sp460

Uhrf1 in Liver Development Kirsten Sadler Edepli

AGA Institute Translational Symposium 2:15 PM - 3:45 PM

S405 McCormick Place

Chairs: Richard M. Peek, Benjamin D. Gold Sponsored by: Esophageal, Gastric & Duodenal Disorders; Growth, Development & Aging; Intestinal Disorders; Immunology, Microbiology & Inflammatory Bowel Diseases; Neurogastroenterology and Motility

EFFECTS OF ALTERING THE GI MICROBIOME Participants will be able to: • Recognize that the gut microbiota influences disease states; • Describe the effects of altering the gut microbiome on human biology; and • Discuss the microbial regulation of host immune response. 2:15 Sp461

Loss of H. pylori and Increases in Allergic Responses Martin J. Blaser

3:00 Sp462

The Hygiene Concept and Implications for Altered Host Responses Joel V. Weinstock

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Translational Symposium 2:15 PM - 3:45 PM

E350 McCormick Place

ASGE Special Session 2:15 PM - 3:45 PM

S103ABC McCormick Place

Chairs: Xavier Llor, Shrikant Anant

Chairs: Pankaj J. Pasricha, Robert A. Ganz

Sponsored by: Nutrition & Obesity; Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Gastrointestinal Oncology; Liver & Biliary

ENDOSCOPY FOR THE FUTURE: HOW TO TEACH OLD DOGS NEW TRICKS

NUTRITION AND GASTROINTESTINAL CANCERS Participants will be able to: • Describe the role of nutrition and nutritional deficiencies in development of gastrointestinal cancer; and • Review the role of obesity in the pathogenesis of GERD, Barrett’s Esophagus, and esophageal cancer. 2:15 Sp463

Gastrointestinal Cancers: Global Epidemiology Bernard W. Stewart

2:45 Sp464

Nutrients, Obesity and Barrett’s Esophagus/Esophageal Cancer Thomas L. Vaughan

3:15 Sp465

Nutrients, Lifestyle and Colorectal Cancer Sharon Ross

ASGE Clinical Symposium 2:15 PM - 3:45 PM

S101 McCormick Place

Chairs: James T. Frakes, Evan L. Fogel

2:15 Sp466

Cholangiopancreatoscopy: Seeing Is Believing Raj J. Shah

2:35 Sp467

Autoimmune Pancreatitis: Papillas, Pancreatograms, and Plasma Cells Lee McHenry Jr. SOD: Beyond I - II - III Martin L. Freeman

3:15

Questions & Answers

ASGE Clinical Symposium 2:15 PM - 3:45 PM

Advances in Optical Imaging - Are We Blind to the Unmet Needs? Marcia I. Canto

2:25 Sp474

The Great Colonoscopy Bubble - Why and When It Will Burst? John I. Allen

2:35 Sp475

The Gastroenterologist As Surgeon: Prodigy or Pariah? Peter B. Cotton

2:45 Sp476

Endoscopy and Unmet Needs in GI: How We Can Expand the Pie Instead of Just Slicing It Into Smaller Pieces? Pankaj J. Pasricha

2:55 Sp477

Who Will Pay and for What in the Future: Irrational Reimbursement and How to Fix It Joel V. Brill

3:05 Sp478

New Business Models for Gastroenterologists - Should We Make the Patients Pay for the Procedures They Want and Will They Do It? Robert A. Ganz

3:15

HOT TOPICS IN ERCP

2:55 Sp468

2:15 Sp473

S102 McCormick Place

Chairs: Gregory G. Ginsberg, Kenneth R. McQuaid MANAGING THE ON-CALL GI BLEEDING CONSULT

Questions & Answers

SSAT Conference/Debate/Panel/Symposium 2:15 PM - 3:45 PM

S505b McCormick Place

Chairs: Michael S. Nussbaum, Steven D. Schwaitzberg

JUNE 1

CONTROVERSIES IN GI SURGERY A Participants will be able to: • Debate 1: understand the historical perspectives on mechanical bowel prep (MBP); understand what levels of evidence support the ongoing use of mbp in lower GI surgery; and understand what levels of evidence show lower GI surgery is safe without MBP; and • Debate 2: understand the differences between NOTES and single port access surgery; detail whether they are competing or cooperating technologies; and understand the near term and long term roles of NOTES and single port technology.

DEBATE 1: IS BOWEL PREP NECESSARY FOR LOWER INTESTINAL SURGERY: YES OR NO?

2:15 Sp469

Risk Stratification and Pre-Procedure Management: Who, Where, When, and What? Lisa L. Strate

2:15 Sp479

Frame the Issue: Is Bowel Prep Necessary for Lower Intestinal Surgery: Yes or No? Michael S. Nussbaum

2:35 Sp470

Treatment of Varices: Esophageal, Gastric and Ectopic Arun J. Sanyal

2:20 Sp480

Yes, Bowel Preparation Is Necessary Gerald M. Larson

2:55 Sp471

Non-Variceal Bleeding: Consensus and Controversy Loren A. Laine

2:30 Sp481

No, Bowel Preparation Is Not Necessary Carmine Volpe

3:15 Sp472

What’s New? Evolving Technologies for Diagnosis and Management Richard C.K. Wong

3:35

Questions & Answers

2:40

Panel and Audience Discussion

DEBATE 2: NOTES VS. SINGLE PORT SURGERY: COMPETING OR COOPERATING TECHNOLOGIES? 3:00 Sp482

M O N D A Y

Frame the Issue: NOTES vs. Single Port Surgery: Competing or Cooperating Technologies? Steven D. Schwaitzberg

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ORAL SESSIONS—SCIENTIFIC SESSIONS 3:05 Sp483

Effective Single Port Surgery Essentially Eliminates the Need to Develop NOTES Procedures Alexander S. Rosemurgy II

AGA Institute Research Forum 2:15 PM - 3:45 PM

3:15 Sp484

NOTES Is Here to Stay Regardless of What Happens with Single Port Surgery Mark A. Talamini

Chairs: Francis M. Giardiello, Frank A. Sinicrope

3:25

BIOMARKERS, PREVENTION AND TREATMENT OF GI CANCERS S106A McCormick Place

Chairs: Andrew P. Feranchak, Jonathan A. Dranoff CHOLANGIOCYTE SIGNALS AND EXPERIMENTAL CHOLESTASIS

JUNE 1

2:15 #341

Suppression of the Hypothalamic-Pituitary-Adrenal Axis Is An Early Event That Results in Cholangiocyte Proliferation After Bile Duct Ligation Monique Coufal, Sharon DeMorrow*

2:30 #342

Novel Evidence for An Autocrine Mechanism By Which Neuropeptide Y Inhibits Cholangiocarcinoma Growth In Vitro and In Vivo Monique Coufal*, Eugenio Gaudio, Guido Carpino, Shelley Kopriva, Julie Venter, Paolo Onori, Antonio Franchitto, Heather Francis, Mellanie White, Giammarco Fava, Gianfranco Alpini, Sharon DeMorrow

2:45 #343

3:00 #344

3:15 #345

3:30 #346

Sponsored by: Gastrointestinal Oncology

Panel and Audience Discussion

AASLD Research Forum 2:15 PM - 3:45 PM

M O N D A Y

S401A McCormick Place

Myofibroblasts Promote the Growth of Biliary Tree During Cholestatic Liver Injury By Suppressing Tryptophan Hydroxylase 2 (TPH2) Expression and Serotonin Secretion in Neighboring Cholangiocytes Alessia Omenetti*, Liu Yang, Raul R. Gainetdinov, Steve S. Choi, Rafal P. Witek, Youngmi Jung, Wing-Kin Syn, Wei Chen, Marc G. Caron, Anna Mae Diehl Novel Evidence for CaMK I-Dependent Differentiation of Small Cholangiocytes Into Functional Large Cholangiocytes Following Gamma-Aminobutyric Acid (GABA) Treatment Romina Mancinelli*, Eugenio Gaudio, Paolo Onori, Heather Francis, Antonio Franchitto, Guido Carpino, Sharon DeMorrow, Shannon Glaser, Domenico Alvaro, Yoshiyuki Ueno, Giammarco Fava, Julie Venter, Marco Marzioni, Shelley Kopriva, Gianfranco Alpini Farnesoid X Receptor-Mediated Regulation and Modulation By Ursodeoxycholic Acid of the Human UDP-Glucuronosyltransferase 1A3 Thomas J. Erichsen*, André Aehlen, Ursula Ehmer, Tim O. Lankisch, Michael P. Manns, Christian P. Strassburg Increased Hepatic Bile Acid (BA) Synthesis Prevents Cholesterol Gallstones in Small Heterodimer Partner (SHP) Knockout Mice Helen H. Wang, Mark J. Evans, Piero Portincasa, David Q. Wang*

Participants will be able to: • Understand the role of biomarkers and the prevention and treatment of GI cancers. 2:15 #347

Highly Sensitive and Specific Detection of Colorectal Cancer and Adenoma in Peripheral Blood By mRNA Expression Array Technology- Relation to Local Expression Patterns and Identification of Migrating Cell Population Béla Molnár*, Orsolya Galamb, Norbert Solymosi, Kinga Tóth, Anna Mária Németh, Tamás Zágoni, Pál Miheller, Márk Juhász, Sándor Spisák, Zsolt Tulassay

2:30 #348

A Simple Blood Test, Evaluating the Level of CD24 Protein, Can Detect Subjects with Adenomas Sarah Kraus, Inna Naumov, Diana Kazanov, Lior Galazan, Shiran Shapira, Aharon Hallak, Moshe Inbar, Itay Shafat, Nadir Arber*

2:45 #349

A New Biomarker Panel to Predict Hepatocellular Carcinoma in Chronic HCV Patients John R. Petersen*, Cornelis Elferink, Hyunsu Ju, Heidi Weiss, Eric T. Fung, Luca Cicalese, Ned Snyder

3:00 #350

Cyclin E and Histone H3 Levels Are Regulated By 5Fluorouracil (5-FU) in a DNA Mismatch Repair (MMR)Dependent Manner Heekyung Chung*, John M. Carethers

3:15 #351

Lovastatin Acts As Demethylating Agent in Colorectal Cancer Cell Lines Liudmila L. Kodach*, Rutger Jacobs, Maikel P. Peppelenbosch, Daniel Hommes, Gijs R. van den Brink, James C. Hardwick

3:30 #352

LX1032: A Potential New Therapy for Chronic Diarrhea in Carcinoid Syndrome (CS) Stephen C. Pappas*, Philip Brown, Anne Turnage, Kenneth Frazier, Qi M. Yang, Zhi-Cai Shi, Qingyun Liu

AGA Institute Research Forum 2:15 PM - 3:45 PM

S402 McCormick Place

Chairs: Bana Jabri, Martin F. Kagnoff Sponsored by: Intestinal Disorders

CELIAC DISEASE: BASIC MECHANISMS Participants will be able to: • Examine new murine models of celiac disease; • Review advances in the characterization T-Cell responses relevant to the pathogenesis of celiac disease; and • Examine new serum markers associated with celiac disease. 2:15 #353

P-70

Localization and Phenotype of the Gliadin-Specific TCell Response After Oral Gliadin Intake in Mice M. Fleur du Pré, Lisette van Berkel, Mariëtte ter Borg, Lise Torp-Jensen, E.Yvonne M. Kooy-Winkelaar, Frits Koning, Ludvig M. Sollid, Edward Nieuwenhuis, Lars Fugger, Janneke N. Samsom*

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:30 #354

Dominance, Hierarchy and Redundancy of T Cell Stimulatory Peptides in Celiac Disease Jessica A. Stewart, James Dromey, Jason A. Tye-Din, Robert P. Anderson*

AGA Institute Research Forum 2:15 PM - 3:45 PM

2:45 #355

Immune Tolerance Induced By Peptide Immunotherapy in An HLA Dq2-Dependent Mouse Model of Gluten Immunity Catherine L. Keech*, James Dromey, Zhenjun Chen, Robert P. Anderson, James McCluskey

Chairs: Hans-Christian Reinecker, Christian Jobin

3:00 #356

Wnt11 and BMP-4 Are Uniquely Upregulated in a Mouse Model of Gluten-Induced Enteropathy Donatella Barisani*, Yvonne Junker, Tobias Freitag, Raffaella Meneveri, Maria Teresa Bardella, Detlef Schuppan

3:15 #357

Serum Immune Responses to Anti-CBIR1 Flagellin (CBIR1) Correlates with HLA DQA1*05-DQB1*0201 (DQ2.5) and DQA1*03-DQB1*0302 (DQ8) in a Large Group of U.S. Patients At-Risk for Celiac Disease (N= 5406) Who Are Ema Positive Michelle M. Pietzak*, Derren M. Barken, Timothy C. Schofield, Matthew J. McGinniss

3:30 #358

Constitutive Inhibition of Hedgehog (HH) Signaling Causes Intestinal Villus Atrophy, Spontaneous Small Intestinal Inflammation, and Dermatitis: A Mouse Phenocopy of Human Celiac Disease? William J. Zacharias*, John Y. Kao, Xing Li, Deborah L. Gumucio

AGA Institute Research Forum 2:15 PM - 3:45 PM

S403 McCormick Place

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

EFFECTOR CYTOKINES IN INTESTINAL INFLAMMATION Participants will be able to: • Review the key factors most relevant to effector cytokines in intestinal inflammation. 2:15 #364

Role of Mast Cell-Derived Interferon Lambda in Intestinal Inflammation Induced By Microbial Antigens Xiao Chen, Shao-Heng He, Bai-Sui Feng, Ping-Chang Yang*

2:30 #365

The Lymphatic System Controls Intestinal Inflammation and Inflammation-Associated Colon Cancer Through the Chemokine Decoy Receptor D6 Stefania Vetrano*, Elena M. Borroni, Raffaella Bonecchi, Carmen Correale, Adelaida Sarukhan, Vincenzo Arena, Massimo C. Fantini, Massimo Roncalli, Alberto Malesci, Annunciata Vecchi, Alberto Mantovani, Massimo Locati, Silvio Danese

2:45 #366

TL1A Enhances the Differentiation of Human TH17 Cells Kathrin S. Michelsen*, Qi T. Yu, Brian Ko, Lisa S. Thomas, Hidetoshi Takedatsu, Carol J. Landers, Stephan R. Targan

3:00 #367

Molecular Regulation of Il23a Gene Expression in Murine Macrophages and Experimental Colitis Shehzad Z. Sheikh*, Katsuyoshi Matsuoka, Jennifer K. Uno, Fengling Li, Scott E. Plevy

3:15 #368

Recombinant Tumor Necrosis Factor Alpha (TNFα) Peptide-Based Vaccine Ameliorates Acute and Chronic Murine Colitis Zhikang Peng*, Qingdong Guan, Yueqin Zhou, Allan Ma, Tingting Zhang, Yanbing Ma, Gefei Qing, Angelo Corti, Richard Warrington

Chairs: Guy E. Boeckxstaens, Roberto Penagini Sponsored by: Esophageal, Gastric & Duodenal Disorders

DYSPEPSIA: ACID, ALLERGY OR POST INFECTIOUS? Participants will be able to: • Increase understanding of etiologies for dyspepsia; and • Understand treatment options for patients with dyspepsia induced by different factors.

3:30 #369

Neutrophil Recruitment Is Deficient in Bacteria-Depleted Mice and Is Necessary for Recovery from DSS-Induced Colitis via TLR4-Dependent MIP2 Expression Di Meng, Weishu Zhu, Kewei Zhang, Rex Pillai, W. Allan Walker, N. Nanda Nanthakumar*

2:15 #359

Risk Factors for Dyspepsia: Systematic Review and Meta-Analysis Avantika Marwaha*, Alexander C. Ford, Allen Lim, Paul Moayyedi

2:30 #360

Augmented Symptomatic Response to Acid in Patients with Functional Dyspepsia Toshihiko Tomita*, Tadayuki Oshima, Jun Sakurai, Chizuko Hayashi, Junji Tanaka, Yongmin Kim, Kazutoshi Hori, Takayuki Matsumoto, Kazuma Fujimoto, Yoshikazu Kinoshita, Ken Haruma, Hiroto Miwa

AGA Institute Research Forum 2:15 PM - 3:45 PM

Evaluation of Gastric and Duodenal Eosinophils in Functional Dyspepsia Mauro Bafutto*, Naylé V. Leite, Jose R. Almeida, Joffre Rezende Filho

Sponsored by: Pancreatic Disorders

2:45 #361

3:00 #362

Non-Ulcer Dyspepsia Not Associated with Gastric or Duodenal Eosinophilia Ganesh R. Veerappan*, Fouad J. Moawad, Timothy J. Duncan, Corinne Maydonovitch, Thomas P. Baker, Joseph L. Perry, Eric M. Osgard, Roy K. Wong

3:15 #363

Post-Infective Dyspepsia Eight Years After the Walkerton Outbreak of Waterborne Gastroenteritis (GE) Alexander C. Ford*, Marroon Thabane, Stephen M. Collins, Paul Moayyedi, Amit X. Garg, William F. Clark, John K. Marshall

3:30 Sp485

State-of-the-Art Overview Paul Moayyedi

E352 McCormick Place

S501D McCormick Place

Chairs: Julia Mayerle, Fred S. Gorelick

EXPERIMENTAL ACUTE AND CHRONIC PANCREATITIS Participants will be able to: • Understand the current concepts underlying the pathogenesis of pancreatitis and pancreatic fibrosis; • Understand the relationship between pancreatic injury and induction of pain; and • Understand the role of enzyme activation in pancreatitis. 2:15 #370

Role of Mitochondrial Permeability Transition Pore in Pancreatitis Olga A. Mareninova*, Irina V. Odinokova, Moses A. Lee, Ilya Gukovsky, Anna S. Gukovskaya

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M O N D A Y JUNE 1

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:30 #371

STAT3 Tyrosine Phosphorylation in Acinar Cells Determines Severity of Acute Pancreatitis As Revealed Genetically and Pharmacologically: A Novel Target in Acute Pancreatitis Hana Algül*, Roland M. Schmid

2:45 #372

Release of Cathepsin B Into Cytosol Induces Apoptosis in Pancreatic Acinar Cells Through Mitochondrial Pathways During Pancreatitis Rajinder Dawra*, Rupjoyti Talukdar, Vikas Dudeja, Rohit Chugh, Yumi Yokoyama, Daniel Borja-Cacho, Selwyn M. Vickers, Ashok K. Saluja

3:00 #373

3:15 #374

3:30 #375

Mechanisms Mediating Acinar Cell Necrosis and Autophagy in Experimental Acute Pancreatitis: The Role of PI3K Gamma Wenzhuo Jia, Lars Fischer, Jae Hyuk Do, Sheyla Perez, Anna S. Gukovskaya, Stephen J. Pandol, Ilya Gukovsky* Transgenic Expression of R122H_hPRSS1 Aggravates Experimental Pancreatitis in BALB/C Mice Lena Selig*, Günter Klöppel, Rolf Gebhardt, Volker Keim, Joachim Mössner, Hans Bodeker Sensitization of Anterior Cingulate Cortex Due to Upregulationof NR2B Subunit of the NMDA Receptors Contribute to Pain Responses in Rats with Chronic Pancreatitis Xiaoyin Wu, Jing Fan, Chung Owyang, Ying Li*

AGA Institute Research Forum 2:15 PM - 3:45 PM

M O N D A Y JUNE 1

3:29 #380

AGA Institute Research Forum 2:15 PM - 3:45 PM

Sponsored by: Esophageal, Gastric & Duodenal Disorders

GERD: DIAGNOSTIC TESTING Participants will be able to: • Learn new insights into GERD diagnostic testing. 2:15 #381

Intercellular Space Distance Is Increased in Refractory Heartburn Patients with GERD But Not Those with Functional Heartburn (FH): A Study Using ImpedancepH and Electron Microscopy Marcelo F. Vela*, Brandon M. Craft, Neeraj Sharma, Janice Freeman, Debra Hazen-Martin

2:30 #382

Salivary Pepsin in Patients with Refractory GERD: Double Blinded Assessment of Test Sensitivity, Specificity, Positive and Negative Predictive Values Shih-Kuang S. Hong*, Peter W. Dettmar, James C. Slaughter, Vicki Strugala, Marion Goutte, Michael F. Vaezi

2:45 #383

Optimization of the Reflux-Symptom Association Statistics in Infants Taher Omari*, Andrea Schwarzer, Michiel P. van Wijk, Stamatiki Kritas, Lisa McCall, Sibylle Koletzko, Geoffrey Davidson

3:00 #384

Predictive Validity and Responsiveness of the Mayo Dysphagia Questionnaire-30 for the Outcome of Dysphagia Dawn L. Francis*, Felicity Enders, Michael D. Crowell, K.Robert Shen, Robert C. Miller, Catherine R. Weiler, Rayna Grothe, Judith L. McElhiney, Gianrico Farrugia, Melissa M. Kuntz, Nancy Diehl, Matthew R. Lohse, Amindra S. Arora, Darlene E. Graner, Nicholas J. Talley, G. Richard Locke III, Joseph A. Murray, Jeffrey A. Alexander, Timothy J. Beebe, Adil A. Abdalla, Joanna M. Peloquin, April Grudell, Ganapathy A. Prasad, Yvonne Romero

3:15 #385

The Relationship Between Nasopharyngeal pH Environment and Gastroesophageal Reflux Daniel Luger*, John E. Pandolfino, Peter J. Kahrilas, Anita Fareeduddin, Monika A. Kwiatek

3:30 #386

Reflux and Dyspeptic Symptom Patterns in Patients with Non Erosive Reflux Disease (NERD) Subclassified Using 24-Hour Ambulatory Intraluminal pH-Impedance Edoardo Savarino*, Daniel Pohl, Patrizia Zentilin, Giorgio Sammito, Elisa Marabotto, Luca M. Sconfienza, Andrea Parodi, Simone Vigneri, Radu Tutuian, Vincenzo Savarino

Sponsored by: Neurogastroenterology and Motility

GASTROPARESIS: PATHOGENESIS & THERAPY Participants will be able to: • Examine the pathophysiology of gastroparesis; and • Examine new therapeutic options for gastroparesis. 2:15 Sp486

An Update On the Gastroparesis Consortium Pankaj J. Pasricha*, Frank A. Hamilton

2:29 #376

Enterra® Gastric Electrical Stimulation for Diabetic Gastroparesis: Results from a Multicenter Randomized Study Richard McCallum*, Fredrick J. Brody, Henry P. Parkman, John M. Wo, Thomas V. Nowak, William J. Snape Jr., Darin R. Lerew, Lisa Ruehlow, Irene Sarosiek

2:44 #377

CD206 Positive M2 Macrophages Expressing Ho1 Protect Against the Development of Delayed GE in a Mouse Model of Diabetic Gastroparesis Kyoung Moo Choi*, Purna C. Kashyap, Nirjhar Dutta, Gary Stoltz, Tamas Ordog, Joseph H. Szurszewski, Simon J. Gibbons, Gianrico Farrugia

2:59 #378

Gastric Muscle Tone During Emptying Analyzed By Finite Element Simulation Using Concurrent Magnetic Resonance Imaging and Fiber Optic Pressure Measurement Tanu Rawal, Mohammed S. Rizvi, Vikram Pagaria, Mark R. Fox, Reto Treier, Peter Boesiger, Michael Fried, Werner Schwizer, Anupam Pal*

3:14 #379

Insulin-Like Growth Factor-I (IGF-I) Reverses Delayed Gastric Emptying in Calorically Restricted Mice and Stimulates Gastric Expression of Stem Cell Factor (SCF) Yujiro Hayashi*, Laura Popko, David L. Young, Michael R. Bardsley, Ferenc Izbeki, Kirsten H. Aarsvold, Gianrico Farrugia, Simon J. Gibbons, Tamas Ordog

P-72

S401BC McCormick Place

Chairs: Timothy T. Nostrant, Jean Paul Galmiche

S502 McCormick Place

Chairs: Jan F. Tack, Tamas Ordog

Simultaneous Assessment of Symptoms During Gastric Emptying Scintigraphy to Correlate Symptoms to Delayed Gastric Emptying Umar Khayyam*, Priyanka Sachdeva, Javier Gomez, Zeeshan Ramzan, Michael S. Smith, Alan H. Maurer, Robert S. Fisher, Henry P. Parkman

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 2:15 PM - 3:45 PM

E450B McCormick Place

AGA Institute Research Forum 2:15 PM - 3:45 PM

Chairs: William J. Sandborn, James D. Lewis

Chairs: Wayne I. Lencer, Fang Yan

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

Sponsored by: Intestinal Disorders

IBD CONTROLLED CLINICAL TRIALS Participants will be able to: • Be familiar with novel therapeutic approaches for Crohn’s disease and ulcerative colitis, including chemokine receptor inhibition, antibodies against CD3 and CD25; and • Be familiar with new findings on existing agents to treat IBD, including probiotics, 5-aminosalicylates and corticosteroids.

S501BC McCormick Place

INTESTINAL EPITHELIUM HOMEOSTASIS Participants will be able to: • Examine how the intestinal inflammatory response can alter the epithelial phenotype; • Review new advances in protein and lipid trafficking in the intestinal epithelium; and • Examine the importance of MicroRNAs in intestinal epithelial function.

2:15 #387

A Placebo-Controlled Trial of Visilizumab in Patients with Intravenous (IV) Steroid Refractory Ulcerative Colitis (UC) William J. Sandborn*, Jean-Frederic Colombel, Matthew Frankel, Daniel Hommes, James Lowder, Lloyd Mayer, Scott E. Plevy, Pieter Stokkers, Simon Travis, Gert A. Van Assche, Stephan R. Targan

2:15 #393

Apical Recycling Endosome-Associated Myosin Vb Is Mutated in Microvillus Inclusion Disease and Is Involved in Intestinal Brush Border Development Magdalena R. Golachowska*, Agata Szperl, Marcel Bruineberg, Rytis Prekeris, Andy-Mark W.H. Thunnissen, Dick Hoekstra, Cisca Wijmenga, Janusz Ksiazyk, Edmond H. Rings, Martin C. Wapenaar, Sven C. IJzendoorn

2:30 #388

Supplementation with the Probiotic VSL#3 in Patients with Mild-to-Moderate Active Ulcerative Colitis: A Double-Blind, Randomized, Placebo-Controlled Study Antonio Tursi*, Giovanni Brandimarte, Alfredo Papa, Andrea Giglio, Walter Elisei, GianMarco Giorgetti, Giacomo Forti, Silvio Danese, Antonio Gasbarrini

2:30 #394

Intestine Specific Deletion of N-WASP Leads to Alteration of Gut Homeostasis in Mice John J. Garber*, Deanna D. Nguyen, Michel H. Maillard, Emiko Mizoguchi, Atul K. Bhan, Scott B. Snapper

2:45 #395

The Role of MicroRNAs in the Intestinal Epithelium Lindsay McKenna*, Klaus H. Kaestner, Jonathan Schug

3:00 #396

The ZO-1 Actin Binding Region (ABR) Is Required for Cytoskeletal Tight Junction Regulation Dan Yu*, Amanda M. Marchiando, Le Shen, Jerrold R. Turner

3:15 #397

Notch1 Activation Promotes Goblet Cell Depletion and Expression of Pla2g2a in the Inflamed Mucosa of Ulcerative Colitis Ryuichi Okamoto*, Kiichiro Tsuchiya, Yasuhiro Nemoto, Junko Akiyama, Tetsuya Nakamura, Takanori Kanai, Mamoru Watanabe

3:30 #398

Lipid Trafficking in Epithelial Cells: Structure-Function Studies On the Cholera Toxin Receptor Ganglioside GM1 Daniel Chinnapen*, Wendy Hamman, Jessica Wagner, M. David Ullman, Wayne I. Lencer

2:45 #389

A Randomized, Double-Blind, Placebo-Controlled Trial of Basiliximab with Concomitant Corticosteroids in Steroid-Refractory Ulcerative Colitis Bruce E. Sands*, William J. Sandborn, Tom J. Creed, Colin M. Dayan, Gert A. Van Assche, Mary Jean Stempien, Daniel Levitt, Christopher S. Probert

3:00 #390

Maintenance Treatment of Ulcerative Colitis with 5Aminosalicylic Acid (5-ASA): Results from the Italian Population of a One Year, Randomized, Multinational Study Comparing MMx® with Asacol® Anna Kohn*, Cosimo Prantera, Renzo Caprilli, Massimo Campieri, Mario Cottone, Francesco Pallone, Vincenzo Savarino, Giacomo C. Sturniolo, Maurizio Vecchi, Alfredo Ardia, Salvatore Bellinvia

3:15 #391

3:30 #392

Both Budesonide (9mg) As Well As High-Dose EudragitL-Coated Mesalamine (4.5g) Lead to High Remission Rates in Moderately Active Crohn’s Disease Patients: A Double-Blind, Double-Dummy, Randomized, Multicenter Study Andreas Tromm*, Ivan Bunganic, Eva Tomsová, Zsolt Tulassay, Milan Lukas, Jan Kykal, Marian Bátovský, Bohumil Fixa, Libor Gabalec, Rifaat Safadi, Heinz-Jochen Kramm, István Altorjay, Hanns Löhr, Ioannis E. Koutroubakis, Simon Bar-Meir, Davor Štimac, Ralf Mohrbacher, Roland Greinwald PROTECT-1 Study Demonstrated Efficacy of the Intestine-Specific Chemokine Receptor Antagonist CCX282-B (Traficet-EN) in Treatment of Patients with Moderate to Severe Crohn’s Disease Satish Keshav*, Daniel Johnson, Pirow Bekker, Thomas J. Schall

AGA Institute Research Forum 2:15 PM - 3:45 PM

S401D McCormick Place

Chairs: Lin Chang, Lesley A. Houghton Sponsored by: Neurogastroenterology and Motility

NOVEL PATHOPHYSIOLOGICAL MECHANISMS IN IBS Participants will be able to: • Learn about new mucosal mechanisms involved in visceral hypersensitivity; • Review and examine stress-related biomarkers in IBS; and • Examine possible genetic risk factors in IBS. 2:15 #399

Peripheral Cellular Mechanisms of Induction of Visceral Hypersensitivity By Chronic Stress John H. Winston*, Guang-Yin Xu, Sushil K. Sarna

2:30 #400

Differential Expression of Toll-Like Receptors (TLRS)in Irritable Bowel Syndrome (IBS) Elizabeth Brint*, John MacSharry, Fergus Shanahan, Eamonn M. Quigley

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M O N D A Y JUNE 1

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:45 #401

Stress-Related Biomarkers and Symptoms Are Predictive of Irritable Bowel Syndrome (IBS) Mopelola A. Adeyemo*, Elizabeth J. Videlock, Collin Bowe, Iordanis Karagiannidis, Charalabos Pothoulakis, Galen Cortina, Arlene Licudine, Melissa Alberto, Emeran A. Mayer, Lin Chang

3:00 #402

Neuropeptide S Receptor 1 Gene Polymorphism Is Associated with Susceptibility to Altered Colonic Transit and Rectal Sensitivity in Patients with Functional Gastrointestinal Disorders Paula Carlson*, Michael Camilleri, Alan R. Zinsmeister, Sanna McKinzie, Irene Busciglio, Duane D. Burton, Mauro D’Amato

3:15 #403

3:30 #404

Decreased Anti-Inflammatory and Cytoprotective Molecules in Colonic Mucosa of Patients with DiarrheaPredominant Irritable Bowel Syndrome Yehuda . Ringel*, Ian M. Carroll, R. Balfour Sartor Validation of Genetic Risk Factors for Post-Infectious Irritable Bowel Syndrome (IBS) in Patients with Sporadic IBS Alexandra-Chloe Villani*, Yuri A. Saito, Mathieu Lemire, Marroon Thabane, Joseph J. Larson, Elizabeth J. Atkinson, Janice Zimmerman, Ann E. Almazar Elder, Stephen M. Collins, Denis Franchimont, John K. Marshall

JUNE 1

Proton Pump Inhibitor Prescription in High-Risk Cardiac Patients: A Missed Opportunity? Liz Guastello, Sameer D. Saini, Angel Lanas, James M. Scheiman*

AGA Institute Research Forum 2:15 PM - 3:45 PM

E451A McCormick Place

Chairs: David C. Metz, Colin W. Howden Sponsored by: Clinical Practice

USE OF PROTON PUMP INHIBITORS: BENEFITS AND CONSEQUENCES Participants will be able to: • Understand the risks of chronic proton pump inhibitor usage; and • Be familiar with the efficacy of proton pump inhibitors in preventing ulcers in the setting of NSAID use. 2:15 #412

Prevention of Low-Dose Acetylsalicylic Acid-Associated Gastric/Duodenal Ulcers with Esomeprazole 20mg and 40mg Once Daily in Patients At Increased Risk of Ulcer Development: A Randomized Controlled Trial (OBERON) James M. Scheiman*, Christoffel J. van Rensburg, Peter Uebel, Ladislav Douda, Krzysztof Niezgoda, Emma Nauclér, Lars-Erik Svedberg

2:30 #413

Chronic Proton Pump Inhibitor Use Is Not Associated with An Increased Risk of Osteoporosis Laura E. Targownik*, Lisa M. Lix, Stella Leung, William D. Leslie

NSAIDS UPDATE

2:45 #414

Proton Pump Inhibitors, H2 Antagonists, and Risk of Hip Fracture: A Large Population-Based Study Douglas A. Corley

Participants will be able to: • Learn new advances relating to NSAIDs and NSAID-related disorders.

3:00 #415

The Use of Proton Pump Inhibitors Is Not Associated with Accelerated Bone Mineral Loss Laura E. Targownik*, Lisa M. Lix, Stella Leung, William D. Leslie

3:15 #416

PPI-Realted SIBO: Clinical Significance and Risk Factors Lombardo Lucio*, Monica Foti, Ruggia Olga

3:30 #417

Effect of Esomeprazole On Sleep Quality in Patients with Gastroesophageal Reflux Disease (GERD)-Related Sleep Disturbances David A. Johnson*, Joseph A. Crawley, Clara Hwang, Kurt A. Brown

AGA Institute Research Forum 2:15 PM - 3:45 PM

M O N D A Y

3:30 #410

E351 McCormick Place

Chairs: Jay L. Goldstein, Byron L. Cryer Sponsored by: Esophageal, Gastric & Duodenal Disorders

2:15 #407

Does High-Dose Famotidine Reduce Gastric and Duodenal Ulcers in NSAID Users? Two Double-Blind Six-Month Trials of Single-Tablet Combination Ibuprofen-Famotidine vs. Ibuprofen Alone (Reduce-1 and 2) Loren A. Laine*, Michael Schiff, Mark Genovese, Alan Kivitz, George Tidmarsh, Michael E. Weinblatt

2:30 #405

What Is the Risk of Recurrent Lower Gastrointestinal Bleeding with Continued Low-Dose Aspirin Therapy? An 8-Year Prospective Cohort Study Francis K. L. Chan*, Jessica Ching, Kim WL Au, Kee Ka Man Carmen, Grace Wong, Dorothy K. Chow, Joseph J. Sung, Justin Wu

2:45 #406

Famotidine for the Prevention of Peptic Ulcers in Users of Low-Dose Aspirin. Placebo-Controlled Prospective Trial [Famous Trial] Ali S. Taha*, Caroline McCloskey, Rakesh Prasad, Vladimir Bezlyak

3:00 #408

Increased Aspirin Use and Upper Gastrointestinal Bleeding Rates in Socially Deprived Patients Yana Vinogradova, Matthew Leighton, Anthony Avery, Richard F. Logan, Denise Kendrick, John C. Atherton, Anthony Shonde, Julia Hippisley-Cox, Chris J. Hawkey*

3:15 #409

Prescription Rates of PPI Therapy Are High in Patients On Dual Antiplatelet Therapy in Spain, Regardless of the Presence of Risk Factors Ruben Casado, Monica Polo-Tomas, Alfonso Del Rio, James M. Scheiman, Angel Lanas*

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ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 2:15 PM - 3:45 PM

S406A McCormick Place

Chair: Yuri A. Saito Sponsored by: Clinical Practice; Neurogastroenterology and Motility

ADVANCES IN CLINICAL CARE OF FUNCTIONAL BOWEL DISEASE

2:30 #425

Gastric Bypass Surgery Suppresses Pancreatic Exocrine Function Tina Rakitt*, Ihab I. El Hajj, Junhai Ou, Anita P. Courcoulas, Stephen J. O’Keefe

2:45 #426

Swedish Nation-Wide Incidence of Post-Gastric Bypass Hypoglycemia Among 5124 Patients Operated for Obesity with Gastric Bypass 1986 - 2006 Erik Naslund*, Richard Marsk, Per M. Hellström, Finn Rasmussen

3:00 #427

A 12-Month Interdisciplinary Lifestyle Intervention Improves Risk Factors for Nonalcoholic Fatty Liver Disease in Morbidly Obese Patients - Comparison of Two Noninvasive Scores Stefan Marcel Loitsch*, Imke Behnken, Astrid Waechtershaeuser, Irina Blumenstein, Michael Brenner, Jurgen Stein

Participants will be able to: • Know the metrics for assessing efficacy in functional bowel disease; and • Understand the relationship between a history of trauma and functional bowel disease. 2:15 #418

Effect of Linaclotide On Quality of Life in Adults with Chronic Constipation: Results from a Phase 2B Study Bernard J. Lavins*, Jeffrey M. Johnston, James E. MacDougall, Anthony J. Lembo, Harvey Schneier, Steven J. Shiff, Robyn T. Carson, Caroline B. Kurtz, Mark G. Currie

3:15 #428

Peripheral Nerve Stimulation of the Occipital Region to Control Appetite and Lose Weight in Morbidly Obese Subjects- 18 Months Observation Irene Sarosiek*, Desiree Rogers, Katherine Roeser, John Grant, Richard McCallum

2:30 #419

Type and Timing of Trauma History and Risk of Irritable Bowel Syndrome in Women Veterans Donna L. White*, Lara S. Savas, Stephanie Fitzgerald, David P. Graham, Gabriel Tan, Shirley L. Smith, Hashem B. El-Serag

3:30 #429

Early Changes in Glucose Homeostasis After Gastric Bypass Surgery for Obesity Ylva Häglund*, Wiveca Ring-Persson, Jens J. Holst, Per M. Hellström, Erik Naslund

2:45 #420

The Effects of Bifidobacterium breve On Gastrointestinal Symptoms, Cytokines, Fecal Microbiota and Organic Acids in Irritable Bowel Syndrome Chie Tana*, Yoshinori Umesaki, Akemi Imaoka, Tomomi Handa, Motoyori Kanazawa, Shin Fukudo

ASGE Topic Forum 2:15 PM - 3:45 PM

Implementation of National Dyspepsia Guidelines to Reduce Prescribing and Return Patients to Self Care: Results from An Educational Intervention and Prospective Clinical Audit in England Mark Connolly*, Aomesh Bhatt

COLONOSCOPY: WHEN, WHAT, AND HOW TO FIND POLYPS

3:00 #421

3:15 #422

3:30 #423

Impact of Baseline Severity On the Performance of IBS Clinical Trial Endpoints: Results of the ROME Foundation Endpoints Working Group Meta-Analysis Brennan M. Spiegel*, Roger E. Bolus, Michael Camilleri Performance of Competing IBS Trial Endpoints Depends On IBS Subtype: Results of the ROME Foundation Endpoints Working Group Meta-Analysis Brennan M. Spiegel*, Roger E. Bolus, Michael Camilleri

AGA Institute Topic Forum 2:15 PM - 3:45 PM

E450A McCormick Place

Chairs: Yutaka Saito, Roy M. Soetikno

2:15 #430

To Continue or to Stop Clopidogrel for Screening Colonoscopy: Clinical Experience and Comparison of the Alternatives Using Decision Models Shai Friedland*, Tonya Kaltenbach, Cynthia W. Leung, Roy M. Soetikno

2:27 #431

Assessing the Efficacy of Cold Biopsy Forceps Polypectomy for Diminutive Polyps Marios Efthymiou*, Robert Chen, Andrew Taylor, Paul Desmond

2:39 #432

Can We Really Expect a Therapeutic Benefit After Two Preventive Colonoscopies?: A Retrospective VA Medical Center Study Jonathan Mellen*, Lydia Aye, Francisco C. Ramirez

2:51 #433

Does the Location of Adenoma At Baseline Predict the Location of Subsequent Recurrence? Evidence from the Polyp Prevention Trial Adeyinka O. Laiyemo*, Chyke Doubeni, Paul Pinsky, Vincent P. Doria-Rose, Pamela Marcus, Amanda J. Cross, Elaine Lanza, Arthur Schatzkin

3:03 #434

Morphologic Reclassification of Large Hyperplastic Polyps Into Serrated Polyps with Malignant Potential Veronika Karasek, Samuel F. Castillo*, Anna M. FeltyDuckworth, Bo Wang, Glenda Amog-Jones, Huijun Dong, Francisco C. Ramirez

3:15 #435

Large Tubular Adenomas, Villous Polyps, and Lesions with High Grade Dysplasia: Can We Really Be Comfortable Waiting 3 Years Before Repeat Colonoscopy?: A Retrospective VA Medical Center Study Jonathan Mellen*, Lydia Aye, Francisco C. Ramirez

3:27 Sp488

State-of-the-Art Lecture: Improving the Quality of Colonoscopy Philip S. Schoenfeld

Chairs: J Christopher Eagon, John A. Martin Sponsored by: Nutrition & Obesity; Hormones, Transmitters, Growth Factors & Their Receptors

MEDICAL, SURGICAL, AND ENDOSCOPIC MANAGEMENT OF OBESITY Participants will be able to: • Describe medical, surgical, and endoscopic management in the treatment of obesity. 2:15 #424

A Prospective, Randomized, Double-Blind, Controlled Trial On Efficacy of Weight Reduction of Endoscopic Intrasgastric Balloon Versus Oral Sibutramine in Patients with Non-Morbid Obesity Enders K. Ng*, Wlifred L. Mui, Bonnie Y. Tsung, Man Yee Yung, Candice C. Lam, Simon K. Wong, Joseph J. Sung

S104 McCormick Place

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M O N D A Y JUNE 1

ORAL SESSIONS—SCIENTIFIC SESSIONS ASGE Topic Forum 2:15 PM - 3:45 PM

S501A McCormick Place

3:32 #446

Completion of Pancreatectomy for IPMN Recurrence After Pylorus-Preserving Pancreatoduodenectomy with a New Pancreaticogastrostomy Technique Laureano Fernández-Cruz*, Raquel Garcia Sanchez, Mario A. Acosta Pimentel jr., Jaume Comas, Miguel Angel LópezBoado

3:52 #447

Laparoscopic Resection of a Gastroesophageal Junction Leiomyoma Timothy E. Oppermann*, Patrick R. Reardon, Fariba Dayhim, Garth Davis, Robert Davis, Brian J. Dunkin

4:11 #448

Laparoscopic Paraesophageal Hernia Repair with Mesh and Collis Gastroplasty with Nissen Fundoplication Preeti Malladi*, Nathaniel J. Soper

Chairs: Andrew W. DuPont, Chin Hur ENDOSCOPIC OUTCOMES 2:15 #436

2:27 #437

The Economics of Complex Endoscopic Procedures in a Tertiary Care Medical Center Atul Bhardwaj*, Charles E. Dye, Nakechand R. Pooran, Abraham Mathew

2:39 #438

Return On Investment Analysis of Double Balloon Enteroscopy: Implications for Financial Reimbursement and Program Establishment Mark E. Benson*, Wendy Horton, Jill Gluth, Vincent A. Sawma Jr., Patrick Pfau, Sigurdur Einarsson, Anurag Soni, Deepak V. Gopal

2:51 #439

M O N D A Y JUNE 1

Surveillance in a Prospectively Followed Cohort of Patients with Barrett Esophagus in the Netherlands: A Cost-Effectiveness Analysis Marjolein Sikkema*, Esther W. de Bekker-Grob, Marjon Kerkhof, Marinus J. Eijkemans, Caspar W. Looman, John B. Wong, Dawn Provenzale, Ernst J. Kuipers, Peter D. Siersema, Ewout W Steyerberg

3:03 #440

The Impact of On-Site Cytopathology On the Clinical Evaluation and Management of Patients Who Undergo EUS-Guided Fine Needle Aspiration for Suspected Pancreatic Cancer Nam Q. Nguyen*, Kenneth F. Binmoeller, Janak N. Shah, Rupert W. Leong, Neil Merrett, Andrew V. Biankin Projected Growth Rate of Anesthesiologist-Delivered Sedation in Colonoscopy and EGD in the United States: 2009- 2011 John M. Inadomi*, Candace L. Gunnarsson, John A. Rizzo, Hai Fang, Xin Ye

3:15 #441

Errors in Endoscopy Lyndon V. Hernandez*, Scott Regenbogen

3:27 Sp489

State-of-the-Art Lecture: Endoscopy 2010: Can We Still Have Both Mission and Margin? John I. Allen

SSAT Video Session 2:15 PM - 4:30 PM

S503 McCormick Place

SSAT Plenary Session 2:15 PM - 5:00 PM Chairs: Elijah Dixon, David Shibata PLENARY SESSION III

Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 2:15 #449

Medical and Surgical Treatment of Chronic Anal Fissure: Prospective Longer-Term Results Pierpaolo Sileri*, Vito M. Stolfi, Marco Venza, Michele Grande, Stefano D’ Ugo, Marco D’Eletto, Alessandra Di Giorgio, Achille Gaspari

2:30 #450

Disparities in Presentation and Treatment of Diverticular Disease: Impact of Socioeconomic Status Nicholas Csikesz*, Anand Singla, Melissa M. Murphy, Jennifer F. Tseng, Shimul A. Shah

2:45 #451

Improved Mortality for Same Hospital Readmission Following Rectal Cancer Resection Hiroko Kunitake*, David S. Zingmond, Clifford Y. Ko

3:00 #452

Activation of Hepatic AMP-Protein Kinase (AMPK) Is Mediated By LKB1 After Roux-en-Y Gastric Bypass in Obese Rats Yanhua Peng, Drew A. Rideout*, Steven S. Rakita, William R. Gower Jr., Min You, Michel M. Murr

3:15 #453

Quality-of-Life After Pancreatic Resection with Islet Cell Autotransplant for the Treatment of Severe Chronic Pancreatitis Joshua L. Argo*, Juan L. Contreras, Shyam S. Varadarajulu, Camille D. Blackledge, John D. Christein

3:30 #454

The Clinical Value of Hepatocyte Growth Factor in Patients with Peri-Ampullary Cancer Before and After Pancreaticoduodenectomy Omar Barakat*, Gabriela C. Rodriguez, Isaac Raijman, Paul M. Allison, Javier Nieto, Claire F. Ozaki, Robert P. Wood

3:45 #455

Impact of Institutional Case Volume On Inpatient Morbidity and Mortality After Paraesophageal Hernia Repair Thai H. Pham*, Kyle A. Perry, Eugene Y. Chang, Brian S. Diggs, James P. Dolan, John G. Hunter, Brett C. Sheppard

4:00 #456

Endoluminal Fundoplication (ELF) for GERD - 12 Month Follow Up Riccardo Rosati, Uberto Fumagalli*, Roberta Barbera, Alberto Malesci, Alessandro Repici

Chairs: Thomas A. Aloia, Margo Shoup VIDEO SESSION I: CLINICAL HPB/UPPER GI Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas. 2:15 #442

Totally Laparoscopic Anatomic Segment 6 Liver Resection Carlos U. Corvera

2:34 #443

Robotic Liver Tumor Resection Awad M. Jarrar*, John J. Fung, Eren Berber

2:53 #444

Management of Anatomic Hilar Variations During Laparoscopic Right Hepatectomy Aziz M. Merchant, Edward Lin, Juan M. Sarmiento*

3:13 #445

Key Images and Technical Considerations for Minimally Invasive Robotics in Pancreaticobiliary Surgery Shawn MacKenzie*, Kambiz Kosari, Timothy D. Sielaff

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S505a McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS 4:15 #457

Gastric Pacing Can Eliminate Dependency On Supplemental Nutrition and Improve Medically Refractory Gastroparesis Jill Zink*, Joseph A. Talarico, Amy Cha, Fady Moustarah, Matthew Kroh, Stacy A. Brethauer, Bipan Chand

4:30 #458

Outcome Based On Management for Duodenal Adenomas: Sporadic Versus Familial Disease Michael D. Johnson*, Richard A. Mackey, Nancy Brown, James M. Church, Carol A. Burke, Matthew Walsh

4:45 #459

Duodenal Switch Provides Superior Resolution of Metabolic Comorbidities Independent of Weight Loss in the Super-Obese (BMI ≥ 50 Kg/M2) Compared with Gastric Bypass Vivek N. Prachand*, Marc Ward, John C. Alverdy

ASGE Nurses Program ‡ 3:00 PM - 5:00 PM

N228 McCormick Place

Chairs: John R. Saltzman, David Hambrick

ASGE Hands-On Nursing Workshop Rosie Parker, Thor L. Sell, James Slattery, Courtney Thomas, Jill Tolentino, Cynthia Webb, Precious Williams

SSAT Conference/Debate/Panel/Symposium 3:00 PM - 5:00 PM

S505b McCormick Place

Chair: Attila Nakeeb CLINICAL WARD ROUNDS: BILIARY DISEASE Participants will be able to: • Understand the different surgical options for the management of complicated choledocholithiasis; • Be familiar with the appropriate therapies for biliary malignancies; and • Describe the management of bile duct injuries and strictures. 4:00 Sp496

Panelists Jeffrey M. Hardacre, W. S. Melvin, Paresh C. Shah

DDW Combined Clinical Symposium 4:00 PM - 5:30 PM

S100 McCormick Place

Chairs: Myron E. Schwartz, David A. Geller

NURSES PROGRAM (PART II): ASGE HANDS-ON NURSING WORKSHOP 3:00 Sp490

SSAT Conference/Debate/Panel/Symposium 4:00 PM - 5:00 PM

S504 McCormick Place

Chair: Anthony Senagore Sponsored by: ASCRS

SSAT/ASCRS JOINT SYMPOSIUM: SURGICAL MANAGEMENT OF COMPLEX COLORECTAL DISORDERS Participants will be able to: • Understand management options for perforated diverticulitis and discuss management strategies for C difficile colitis; • Describe the management options for complicated Crohn’s disease; and • Debate management options for ulcerative colitis in actue flares or after prolonged immunosuppressive therapy.

Sponsored by: AASLD; SSAT; AGA Institute

HEPATIC RESECTION FOR LIVER MASSES Participants will be able to: • Describe several resection techniques for HCC. 4:00 Sp499

Open Resection for HCC in MELD Era Myron E. Schwartz

4:20 Sp500

Laparoscopic Resection of HCC David A. Geller

4:40 Sp501

Liver Resection for HCC with Salvage Liver Transplantation Ronnie T. Poon

5:00

M O N D A Y JUNE 1

Questions and Answers

DDW Combined Clinical Symposium 4:00 PM - 5:30 PM

B1 McCormick Place

Chairs: Donald E. Low, David A. Katzka Sponsored by: SSAT; ASGE; AGA Institute

3:00 Sp491

Introduction Anthony Senagore

WHO OWNS ACHALASIA?

3:05 Sp492

Management Options for Perforated Diverticulitis: Diversion or No Diversion Martin A. Luchtefeld

Participants will be able to: • Describe both the endoscopic and laproscopic Surgical treatments for Achalasia.

3:25 Sp493

Management Strategies for C Difficile Colitis: Operate Too Soon or Too Late? David A. Margolin

3:45 Sp494 4:05 Sp495

4:25

4:00 Sp502

How Do We Measure Success in the Treatment of Achalasia and Why Is the Current Assessment of Treatment Approaches Appropriate? David R. Urbach

Management Options for Complicated Crohns Disease: Resection vs. Stricturoplasty vs. Bypass Eric G. Weiss

4:15 Sp503

The Majority of Patients Are Best Managed with Endoscopic Therapy Joel Richter

Management Options for Ulcerative Colitis in Acute Flares or After Prolonged Immunosuppressive Therapy: Does Too Much Medicine Make a Difference? Eric J. Dozois

4:40 Sp504

Laproscopic Surgical Treatment of Achalasia Should Currently Be Considered the Primary Treatment Approach for Patients with Achalasia Marco G. Patti

5:05 Sp505

Summary David R. Urbach

Panel & Audience Discussion

5:10

Panel Discussion and Questions

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ORAL SESSIONS—SCIENTIFIC SESSIONS AASLD Clinical Symposium 4:00 PM - 5:30 PM

S406B McCormick Place

Chairs: Linda Rabeneck, Amit Rastogi

HCV: NEW FRONTIERS IN THERAPY

Sponsored by: Clinical Practice; Gastrointestinal Oncology

Participants will be able to: • Understand rationale for use of specific types of antiviral agents and/ or combinations of agents; • Be familiar with antiviral agents nearing approval and expected outcomes, adverse effects, and realities of clinical use; and • Present to colleagues and patients how these new antiviral agents might be used to treat patients with HCV infection.

COLONOSCOPY: HOW EFFECTIVE IS IT AT PREVENTING COLORECTAL CANCER AND WHY DOES IT FAIL?

Welcome and Introduction

4:05 Sp506

Maximizing Current Therapy: Tailoring Treatment to the Patient Hugo R. Rosen

4:30 Sp507

HCV Virus Replication and Potential Targets for DirectActing Agents (DAAs) Gary L. Davis

4:55 Sp508 5:20

JUNE 1

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM

Chairs: Gary L. Davis, Hugo R. Rosen

4:00

M O N D A Y

S105 McCormick Place

New DAAs in Development for HCV Infection Paul Pockros Panel Discussion

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM

S404 McCormick Place

Chairs: Colin W. Howden, Ronnie Fass Sponsored by: Esophageal, Gastric & Duodenal Disorders; Clinical Practice; Growth, Development & Aging; Neurogastroenterology and Motility

Participants will be able to: • State colonoscopies effectiveness in reducing risk of CRC, and the risk factors for incomplete colonoscopy and tricks to improve completion rates; • Review the epidemiology and potential importance of flat polyps as a cause of missed cancers; and • Define the risk of significant complications including colonoscopic perforation and bleeding; review the peri procedural management of anticoagulants and aspirin products. 4:00 Sp513

How Effective Is Colonoscopy in Preventing CRC? Douglas J. Robertson

4:22 Sp514

Problems Getting to the Cecum & How to Overcome Them Gavin C. Harewood

4:44 Sp515

Problems Seeing Polyps: The Importance of Flat Adenomas and How to Detect Them Douglas K. Rex

5:06 Sp516

Problems Removing Polyps: Avoiding Complications David A. Lieberman

AGA Institute Clinical Symposium 4:00 PM - 5:30 PM

S103D McCormick Place

Chairs: John A. Martin, Sean Koppe

CASE-BASED CLINICAL MANAGEMENT OF DIFFICULT UGI DISORDERS

Sponsored by: Liver & Biliary; Clinical Practice; Gastrointestinal Oncology; Imaging & Advanced Technology; Pancreatic Disorders

Participants will be able to: • Examine the role of acid reflux in extra-esophageal disorders; and • Discuss management of patients with dysphagia.

NEW DIAGNOSTIC MODALITIES FOR THE EARLY DETECTION OF BILIARY CANCERS

4:00 Sp509

Acid Reflux and Sleep Disorders William C. Orr

4:22 Sp510

Extraesophageal GERD and Esophageal Function Michael F. Vaezi

4:44 Sp511

New Perspectives in Management of the Young Patient with Dysphagia Nirmala Gonsalves

5:06 Sp512

Management Options for the Patient with Refractory Dyspepsia Nimish B. Vakil

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Participants will be able to: • Discuss recent radiologic advances to screen for and diagnose biliary cancers; • Evaluate the sensitivity and specificity of endoscopic and serologic approaches for screening for biliary malignancies; and • Examine new surgical options for diagnosing and treating biliary cancers. 4:00 Sp517

Endoscopic Approaches Adam Slivka

4:30

MRI and MRE for Diagnosis

5:00

When Is Surgery Indicated?

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Clinical Symposium 4:00 PM - 5:30 PM

S406A McCormick Place

Chairs: Jean-Frederic Colombel, William J. Sandborn Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases; Clinical Practice

TREATMENT OF IBD: NOW AND THE FUTURE Participants will be able to: • Define current indications and novel approaches to optimizing the use of immune modulators in IBD; • Describe evolving data on treatment paradigms to optimize efficacy and safety of biologic therapy; and • Describe novel therapeutic targets and agents for the treatment of Crohn’s disease and ulcerative colitis.

AGA Institute Committee Sponsored Symposium 4:00 PM - 5:30 PM S501A McCormick Place Sponsored by: Practice Management & Economics Committee; Clinical Practice & Quality Management Committee

TOP 10 REIMBURSEMENT ISSUES AFFECTING THE GI PRACTICE Participants will be able to: • Review the regulations; • Apply the regulations to the operations of the practice; and • Minimize audit exposure. 4:00 Sp526

Top 10 Reimbursement Issues Affecting the GI Practice Cecile Katzoff

4:00 Sp520

Indications and Optimal Use of Immunomodulators in IBD Miles Sparrow

AGA Institute Research Symposium 4:00 PM - 5:30 PM

4:30 Sp521

Optimizing Biologic Therapy in IBD: When and How Brian G. Feagan

Chair: Charles L. Bevins

5:00 Sp522

The IBD Pipeline: Targets and Therapies of the Near and Distant Future Stephan R. Targan

AGA Institute Committee Sponsored Symposium 4:00 PM - 5:30 PM S501BC McCormick Place Chair: Joel V. Brill Sponsored by: Practice Management & Economics Committee

IS YOUR GI PRACTICE CONSIDERING A MERGER? Participants will be able to: • Describe the economic and regulatory pressures that could lead a GI practice to consider a merger and the basic steps involved with conducting a practice assessment; • Discuss the legal issues practices must consider when considering adding new business lines and mergers; and • Assess the financial viability of business lines and potential merger partners and know how to realign your practice (staff, resource allocation, location, etc.) post merger. 4:00 Sp523

GI Practice Mergers: Lessons Learned At Year One Mark H. Kogan

4:30 Sp524

Business Economics When Considering a Practice Merger David Finkelman

5:00 Sp525

Practice Efficiency: Is Regional Consolidation the Pathway to Success? Scott R. Ketover

S401A McCormick Place

Sponsored by: Hormones, Transmitters, Growth Factors & Their Receptors; Esophageal, Gastric & Duodenal Disorders; Growth, Development & Aging; Immunology, Microbiology & Inflammatory Bowel Diseases; Intestinal Disorders; Neurogastroenterology and Motility; Nutrition & Obesity

MOLECULES AND RECEPTORS IN BACTERIAL RECOGNITION IN THE INTESTINE Participants will be able to: • Review how knowledge of the commensal bacteria genome can inform our study of probiotic-epithelial interactions; • Examine the role of soluble factors produced by bacteria in initiating host defense mechanisms; and • Examine the role of receptors in host-bacteria interaction. 4:00 Sp527

Probing the Genome of Commensal Bacteria David A. Mills

4:30 Sp528

Genomic and Metabolic Studies of the Impact of Probiotics On a Model Gut Symbiont and Host Justin Sonnenburg

5:00 Sp529

Innate Immune Responses to Commensal Bacteria in the Gut Epithelium Fang Yan

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M O N D A Y JUNE 1

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute State-of-the-Art Lecture 4:00 PM - 5:00 PM

E450B McCormick Place

4:45 #463

Stimulation of Hepatobiliary Detoxification and Transport Systems in Humans By Combined Treatment with Rifampicin and Ursodeoxycholic Acid Hanns-Ulrich Marschall*, Martin Wagner, Gernot Zollner, Peter Fickert, Ulf Gustafsson, Staffan Sahlin, Michael Trauner

5:00 #464

Differential Expression of Hepatic and Serum Transferrin in Untreated C282Y Homozygote Males John D. Ryan*, Eleanor Ryan, Matthew W. Lawless, Jennifer Russell, Jens Stolte, Martina Muckenthaler, Barry Kelleher, John P. Crowe

5:15 #465

Role of Aberrant Methionine Metabolism in the Pathogenesis of Wilson Disease Valentina Medici*, Farah N. Esfandiari, Maryam Dolatshahi, Maria Catrina D. Virata, Robert D. Cardiff, Peter J. Havel, Soumia Jose, Kusum K. Kharbanda, Kyoungmi Kim, Noreene Mayumi Shibata, Theresa Tonjes, Natalie Torok, Bo Lonnerdal, Charles H. Halsted

Chairs: Nadir Arber, John P. Lynch Sponsored by: Gastrointestinal Oncology; Hormones, Transmitters, Growth Factors & Their Receptors; Growth, Development & Aging; Intestinal Disorders; Pancreatic Disorders; Nutrition & Obesity; Neurogastroenterology and Motility

RECEPTOR TYROSINE KINASES: SIGNALING, SYSTEMS BIOLOGY AND TARGETED THERAPEUTICS IN CANCERS Participants will be able to: • Review the mechanisms of signal transduction of receptor tyrosine kinases; • Explore the systems control and biology of growth factor and their receptors; and • Discuss the principal of targeted approach in cancer therapeutics based on receptor tyrosine kinases. 4:00 Sp530

Receptor Tyrosine Kinases: Signaling, Systems Biology and Targeted Therapeutics in Cancers Yosef Yarden

ASGE Clinical Symposium 4:00 PM - 5:30 PM

M O N D A Y JUNE 1

ADVANCES IN ENDOSCOPIC IMAGING - SEEING AND BELIEVING 4:00 Sp531

Retraining Our Eyes and Our Scope to Detect Flat Colonic Adenomas Roy M. Soetikno

4:25 Sp532

Hunting for Dysplasia in Barrett’s Esophagus Herbert C. Wolfsen

4:50 Sp533

Seeing and Believing Dysplasia in IBD Ralf Kiesslich Video Case and Panel Discussion

AASLD Research Forum 4:00 PM - 5:30 PM

Chairs: Emeran A. Mayer, Gianrico Farrugia Sponsored by: Neurogastroenterology and Motility

S101 McCormick Place

Chairs: Michael B. Wallace, Marcia I. Canto

5:15

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM S403 McCormick Place

DISTINGUISHED ABSTRACTS PLENARY Participants will be able to: • Learn about novel mechanisms involved in the regulation of gastric motility; • Examine a cognitive behavioral intervention in children with chronic abdominal pain; and • Examine novel mechanisms relevant to visceral hypersensitivity. 4:00 #466

RCT Results of a Family-Based Intervention for Children with Chronic Abdominal Pain Rona L. Levy*, William E. Whitehead, Lynn S. Walker, Shelby L. Langer, Joan Romano, Dennis L. Christie, Nader N. Youssef, Andrew D. Feld, Robert W. Jeffery, Sheri A. Ballard, Melissa M. DuPen, Melissa J. Coffey, Melissa Young, Annette Langseder

4:15 #467

COMT Genetic Polymorphism Is Associated with Alterations in Attentional Processing in Patients with IBS and Other Functional Pain Syndromes Trinh T. Truong*, Lisa Kilpatrick, Bruce D. Naliboff, Sugandha Dandekar, Jeanette C. Papp, Johanna Jarcho, Chelsea D. Gilbert, Arlene Licudine, Michelle Craske, Edward M. Ornitz, Emeran A. Mayer, Lin Chang

4:30 #468

Dual Vagal Nerve Recording and Intragastric Pressure Monitoring in Urethane-Anesthetized Rats Reveals Distinct Mechanisms of Inhibition of Gastric Motility By IV CCK-8 vs. Urocortin 2 David W. Adelson*, Shiho Matsumoto-Okano, Yvette Tache

4:45 #469

Carbon Monoxide Reverses Diabetic Gastroparesis in NOD Mice Purna C. Kashyap*, Kyoung Moo Choi, Matthew S. Lurken, Nirjhar Dutta, Joseph H. Szurszewski, Simon J. Gibbons, Gianrico Farrugia

5:00 #470

Immune Cell Supernatants from IBS Patient Subtypes Differentially Affect Visceral Afferent Mechanosensitivity Patrick A. Hughes*, Stuart M. Brierley, Jenny Persson, Tobias Liebregts, Birgit Adam, Gerald Holtmann, L. Ashley Blackshaw

5:15 #471

Post-Infectious Visceral Hypersensitivity Persists in the TRPV1 Knockout Mouse Christopher D. Keating*, David Grundy

S106A McCormick Place

Chairs: Konstantinos Lazaridis, Frank Lammert CHOLESTATIS AND METABOLIC LIVER DISEASE 4:00 #460

4:15 #461

4:30 #462

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Interaction Between Genetic Variants of TNF and CTLA4 Increases the Risk of Primary Biliary Cirrhosis Brian D. Juran*, Elizabeth J. Atkinson, Erik M. Schlicht, Konstantinos Lazaridis Characterization of Mutations Causing ATP8B1 Deficiency and Pharmacological Restoration of ATP8B1 Abundance and Cell Surface Expression Janneke Stapelbroek*, Lieke M. van der Velden, Elmar Krieger, Peter V. van den Berghe, Ruud Berger, Joost C. Holthuis, Roderick Houwen, Leo W. Klomp, Stan F. van de Graaf Aggravation of Intrahepatic Cholestasis of Pregnancy Associated with Hepatobiliary Transporters ABCB4 and ABCB11 Variants Due to Co-Inheritance of Altered FXR Promoter Vincent Zimmer*, Roman Müllenbach, Eva Simon, Frank Lammert

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 4:00 PM - 5:30 PM

S401D McCormick Place

4:15 #479

Myosin Light Chain Kinase Inhibition Decreases the Incidence of Severe Bowel Injury in a Neonatal Mouse Model of Necrotizing Enterocolitis Runlan Tian*, Shirley X. Liu, Cara E. Williams, D. Martin Watterson, Isabelle G. De Plaen

4:30 #480

Knockdown of Occludin or Expression of T403/404A Mutant Occludin Exacerbates Hydrogen PeroxideInduced Disruption of Tight Junctions Ankur Seth*, Geetha Samak, Takuya Suzuki, Radhakrishna (RK) Rao

4:45 #481

The RNA-Binding Protein HuR Regulates Occludin Translation Through Chk2-Dependent HuR Phosphorylation Modulating Intestinal Epithelial Barrier Function Tingxi Yu*, Rao N. Jaladanki, Tongtong Zou, Lan Liu, Lan Xiao, Pengyuan Wang, Xian Zhang, Myriam Gorospe, JianYing Wang

5:00 #482

The Human Milk Factor Erythropoietin Protects Against Necrotizing Enterocolitis (NEC) in Preterm Rats By Maintaining Barrier Function Through Upregulation of Tight Junction Protein Expression Sheng-Ru Shiou*, Yueyue Yu, Renee M. Rodriguez, Elaine O. Petrof, Jun Sun, Erika C. Claud

5:15 #483

Cytoskeletal Regulation and Tight Junction Reorganization During Epithelial Wound Closure In Vivo Aaron L. Hecht*, Amanda M. Marchiando, Jerrold R. Turner

Chairs: James H. Grendell, Timothy B. Gardner Sponsored by: Pancreatic Disorders

CLINICAL ACUTE PANCREATITIS Participants will be able to: • Recognize new strategies in managing complications of acute pancreatitis; and • Understand methods for predicting severity of acute pancreatitis. 4:00 #472

Decreased Mortality in Acute Pancreatitis Related to Early Aggressive Hydration Ian Wall*, Nison Badalov, Jack Braha, Peretz Lock, Darshan J. Patel, Robin Baradarian, Kadirawel Iswara, JianJun Li, Scott M. Tenner

4:15 #473

Timing of Enteral Nutrition in Patients with Predicted Severe Acute Pancreatitis: An Early Start Is Associated with a Reduction in Bacteremia Olaf J. Bakker*, Hjalmar C. van Santvoort, Marc G. Besselink, Kathelijn Fischer, Thomas L. Bollen, Marja A. Boermeester, Hein G. Gooszen

4:30 #474

4:45 #475

Simultaneous Nasogastric Decompression with MidJejunal Feeding Avoids Total Parenteral Nutrition (TPN) and Early Surgery in the Management of Complicated Acute Pancreatitis and Gastric Outlet Obstruction Susan Rolniak*, Amit Raina, Refaat Hegazi, Patty K. CentaWagner, Hossam M. Kandil, Steven J. Hughes, Kenneth K. Lee, A James J. Moser, Toby O. Graham, Stephen J. O’Keefe Pancreas Divisum Is Not a Cause of Pancreatitis By Itself Caroline Bertin, Anne-Laure Pelletier, Marie-Pierre Vullierme, Frédérique Maire, Olivia Hentic, Vinciane Rebours, Pascal Hammel, Philippe B. Ruszniewski, Philippe Levy*

5:00 #476

Intravenous Procaine Is Effective Pain Therapy in Acute Pancreatitis: A Randomized, Placebo-Controlled, Double Blind Study Jutta Keller*, Utah M. Henniges, Matthias Kahl, Irmtraut Koop, Peter H. Layer

5:15 #477

What Is the Risk of Recurrence After a First Episode of Acute Idiopathic Pancreatitis? Joannie Ruel*, Jean-Daniel Baillargeon

AGA Institute Research Forum 4:00 PM - 5:30 PM

S402 McCormick Place

Chairs: Gail A. Hecht, Marshall H. Montrose Sponsored by: Intestinal Disorders

AGA Institute Research Forum 4:00 PM - 5:30 PM Chairs: Lopa Mishra, Carl B. Rountree Sponsored by: Growth, Development & Aging

GASTROINTESTINAL AND LIVER STEM CELL BIOLOGY Participants will be able to: • Understand methodologies for characterization of gut and liver derived stem cells; • Appreciate approaches for identification and mapping of stem cell clones; and • Understand the role of specific growth factors in inducing stem cell differentiation. 4:00 #484

Methylation and Clonality of Human Colonic Crypts Trevor A. Graham*, Adam Humphries, Stuart A. McDonald, Simon Leedham, Nicholas A. Wright

4:15 #485

Transforming Growth Factor-β Induces CD133 Expression and Epithelial-Mesenchymal Transition in Liver Cancer Stem Cells C. B. Rountree* Jr., Hanning You

4:30 #486

Stellate-Like Mesenchymal Stem Cells Cultured from Omentum-Induced Regenerating Liver Tissue Nishit Pancholi*, Mark Kraus, Jilpa Patel, Krishnamurthy P. Gudehithlu, Perianna Sethupathi, George Dunea, Jose A.L. Arruda, Ashok K. Singh

4:45 #487

Mapping Stem Cell Clones in Human Intestinal Crypts Adam Humphries*, Stuart A. McDonald, Paul J. Tadrous, Nicholas A. Wright

5:00 #488

Regeneration of Intestinal Stem Cells Following Doxorubicin Treatment of Mice Christopher M. Dekaney*, Ajay S. Gulati, Michael A. Helmrath, Susan J. Henning

EPITHELIAL BARRIER REGULATION Participants will be able to: • Examine the importance of cellular mechanisms that regulate tight junction gene expression, structure, and function; and • Review the role of tight junctions in maintaining barrier function in models of intestinal injury. 4:00 #478

ZO-1 C-Terminal Domains Are Essential for Tight Junction Assembly and Maintenance Le Shen*, Dan Yu, Jerrold R. Turner

E351 McCormick Place

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M O N D A Y JUNE 1

ORAL SESSIONS—SCIENTIFIC SESSIONS 5:15 #489

PI3K Signaling in the Small Intestine After Ileocecal Resection (ICR) Valeria C. Cohran*, Zheng J. Zhang, Goo Lee, Tatiana Goretsky, Ramanarao Dirisina, Rebecca B. Katzman, Paul Cheresh, Llinheng Li, Terrence A. Barrett

AGA Institute Research Forum 4:00 PM - 5:30 PM

S401BC McCormick Place

Chairs: David C. Metz, Kenneth R. DeVault

4:15 #497

ER Stress Transcription Factor XBP1 Regulates NfκB Activation in Intestinal Epithelial Cells Lukas Niederreiter*, Sebastian Zeissig, Herbert Tilg, Richard S. Blumberg, Arthur Kaser

4:30 #498

Autocrine Intestinal Epithelial Cell GM-CSF Signaling Promotes Homeostatic Responses to Gut Injury Xiaonan Han*, Shila Gilbert, Ingrid Jurickova, Charles M. Samson, Jonathan Gully, Tara Willson, Lee Denson

4:45 #499

Genetic Ablation of Myosin Light Chain Kinase (MLCK) Limits Epithelial Barrier Dysfunction and Attenuates Experimental Inflammatory Bowel Disease (IBD) Liping Su, Sam C. Nalle*, Erika A. Sullivan, Yang-Xin Fu, Jerrold R. Turner

5:00 #500

MTG16 Contributes to Epithelial Integrity in Response to Colonic Injury Christopher S. Williams*, Rupesh Chaturvedi, Mary Kay Washington, Amanda D. Williams, Melissa A. Steapleton, Michael E. Engel, Keith T. Wilson, Scott W. Hiebert

5:15 #501

Hypoxia Inducible Factor (HIF-1α) Plays a Critical Innate Protective Role in Clostridium difficile (Cdif) Toxin-Induced Intestinal Injury and Inflammation Simon A. Hirota*, Jeff Ng, Eikichi Ihara, Yan Li, Daniel Muruve, Glen D. Armstrong, Sean P. Colgan, Daniel C. Chung, Paul L. Beck, Justin A. MacDonald

Sponsored by: Esophageal, Gastric & Duodenal Disorders

GERD: PHARMACOLOGICAL TREATMENT Participants will be able to: • Receive an update on advances in pharmacological treatment of acidrelated disorders.

M O N D A Y

4:00 #490

Arbaclofen Placarbil Monotherapy Decreases GERD Symptoms in Subjects with Previous PPI Therapy Nimish B. Vakil*, F. Jacob Huff, Amy Bian, Drew S. Jones, David Stamler

4:15 #491

What Is the Efficacy of High-Dose Acid Suppression in Chronic Cough?: A Randomized, Double-Blind, PlaceboControlled Trial Nicholas J. Shaheen*, Stephanie D. Bright, Ryan D. Madanick, Robert A. Buckmire, Marion E. Couch, Evan S. Dellon, Joseph Galanko, Virginia Sharpless, Douglas Morgan, Elizabeth E. Carretta, Melissa Spacek, Paris . Heidt, David C. Henke

4:30 #492

Influence of Itopride On Esophageal Function in Man Emidio Scarpellini*, Rita Vos, Pieter Vanden Berghe, Jan F. Tack

4:45 #493

The Prophylactic Effect of STW 5 in An Acute Model of Esophagitis in Rats Heba Abdel-Aziz*, Winfried Neuhuber, Hala Zaki, Olaf Kelber, Dieter Weiser, Mohamed T. Khayyal

JUNE 1 5:00 #494

5:15 Sp533a

Health-Related Quality of Life in Patients with Gastroesophageal Reflux Disease Under Routine Care A 5-Year Follow-Up from the Progerd Study Marc Nocon, Andreas Leodolter*, Joachim Labenz, Daniel Jaspersen, Kai Richter, Michael Vieth, Tore Lind, Peter Malfertheiner, Stefan N. Willich State-of-the-Art Overview Kenneth R. DeVault

AGA Institute Research Forum 4:00 PM - 5:30 PM

E352 McCormick Place

AGA Institute Research Forum 4:00 PM - 5:30 PM

Chairs: N. Nanda Nanthakumar, Deborah C. Rubin Sponsored by: Nutrition & Obesity

NUTRIENTS AND GUT FUNCTION: NUTRIENT ABSORPTION AND NUTRIENT EFFECTS ON CELL SIGNALING AND IMMUNITY Participants will be able to: • Discuss and describe the mechanisms by which nutrients regulate gut function, cell signaling and gut immunity. 4:00 #502

Increased Folate Transport During Folate Deficiency Is Associated with Upregulation of Reduced Folate Carrier and Proton Coupled Folate Transporter in Rat Intestine Nissar Ahmad Wani, Jyotdeep Kaur*

4:15 #503

Glucose-Dependent Insulinotropic Polypeptide (GIP) Increases Dipeptide Transport in Mouse Small Intestine Aaron C. Bartoo*, John H. Schwartz, M. Michael Wolfe, Satish K. Singh

4:30 #504

Alterations in Epidermal Growth Factor (EGF) and Tumor Necrosis Factor Signaling with Total Parenteral Nutrition (TPN): A Potential Mechanism for Mucosal Atrophy Yongjia Feng*, Daniel H. Teitelbaum

4:45 #505

Chylomicron Formation Promotes Oral Tolerance By Promoting Intestinal Absorption and Lymphatic Transport of Dietary Protein Yuehui Wang, Sarbani Ghoshal, Willem J. de Villiers, Jerold G. Woodward, Erik Eckhardt*

5:00 #506

Linking Metabolism and Colitis: The Macrophage Connection Razvan I. Arsenescu*, Violeta Arsenescu, Jian Zhong, Willem J. de Villiers, Munira Nasser

5:15 #507

Polyamines Mediate Glutamine-Dependent Induction of the Intestinal Epithelial Heat Shock Response Toshio Sakiyama*, Mark W. Musch, Hirohito Tsubouchi, Eugene B. Chang

Chairs: Sean P. Colgan, Gerhard Rogler Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

INTESTINAL EPITHELIAL HOMEOSTASIS, REPAIR, DIFFERENTIATION AND RESPONSE TO INFLAMMATION Participants will be able to: • Review the key factors most relevant to intestinal epithelial homeostasis, repair, differentiation and response to inflammation. 4:00 #496

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Matrix Metalloproteinase-9 Regulates Intestinal Cell Differentiation By Activating Notch-1 Anupama Ravi*, Pallavi Garg, Lixin Wang, Didier Merlin, Shanthi V. Sitaraman

S502 McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS ASGE Topic Forum 4:00 PM - 5:30 PM

S104 McCormick Place

4:24 #516

Normalized Distance Along the Colon Centerline: A Method for Correlating Polyp Location On CT Colonography and Optical Colonoscopy Ronald M. Summers*, Jeffrey A. Swift, Andrew J. Dwyer, J. Richard Choi, Perry J. Pickhardt

4:36 #517

The Australian Multicentre Colonic Endoscopic Mucosal Resection Database (AMCEMRD) - Progress Towards a More Comprehensive Understanding of EMR and Its Outcomes for Laterally Spreading Tumors (LSTs) of the Colon in a Western Population Alan Moss*, Michael J. Bourke, Rajvinder Singh, William Tam, Robert Chen, Luke F. Hourigan, Michael P. Swan, Andrew D. Hopper, Stephen J. Williams

4:48 #518

A Multi-Center Retrospective Study of 1,111 Colorectal Endoscopic Submucosal Dissections (ESD) Yutaka Saito*, Toshio Uraoka, Yuichiro Yamaguchi, Kinichi Hotta, Naoto Sakamoto, Hiroaki Ikematsu, Masakatsu Fukuzawa, Nozomu Kobayashi, Junichirou Nasu, Tomoki Michida, Yosuke Otake, Hisatomo Ikehara, Takeshi Nakajima, Takahisa Matsuda, Shigeaki Yoshida

5:00 #519

Colonoscopic Full-Thickness Resection Followed By Tissue Apposition - An Option for Recurrent Colon Polyps Tethered to the Colonic Wall with Scar Tissue Gottumukkala S. Raju*, Advitya Malhotra, Ijaz Ahmed

5:12 Sp535

State-of-the-Art Lecture: Towards Colonoscopic Resection of All Colorectal Neoplasms Roy M. Soetikno

Chairs: Banke Agarwal, Roy K. Wong CLINICALLY RELEVANT ADVANCES IN MANAGEMENT OF GASTRIC NEOPLASMS 4:00 #508

Evaluation of Complications of Endoscopic Submucosal Dissection in Gastric Tumors: Analysis in 482 Patients Seiichiro Arima*, Kotaro Mannen, Naoyuki Tominaga, Nanae Tsuruoka, Yasuhisa Sakata, RYO SHIMODA, Seiji Tsunada, Hiroyuki Sakata, Shinichi Ogata, Ryuichi Iwakiri, Kazuma Fujimoto

4:12 #509

The Diagnostic Usefulness of Immunohistochemical Staining (IHCS) in Submucosa-Invasive Early Gastric Cancer After Endoscopic Submucosal Dissection (ESD) Joo Young Cho, Won Young Cho*, Hyun Gun Kim, Taehee Lee, Youn Sun Park, Wan Jung Kim, Jin-Oh Kim, Joon Seong Lee, So Young Jin, Young Dae Kim, Chan Guk Park

4:24 #510

Clinical and Endoscopic Characteristics of Gastric Cancer Missed By Upper Gastrointestinal Endoscopy Yao-Chun Hsu*, Chia-Yang Hsu, Hwai-Jeng Lin

4:36 #511

Importance of Diagnostic Endoscopic Resection to Compensate Histological Discrepancy Between Endoscopic Forceps Biopsy and Resected Specimens in Superficial Gastric Neoplasms Il Kwun Chung*, Sang Pil Kim, Suck-Ho Lee, Chang Kyun Lee, Sun-Joo Kim, Hong-Soo Kim, Sang-Heum Park, Tae Hoon Lee, Ji-Young Park

4:48 #512

Endoscopic Management of Type I Gastric Carcinoid and Recurrence Rate Elettra Merola, Andrea Sbrozzi-Vanni, Gabriele Capurso, Edith Lahner, Francesco Panzuto, Giancarlo D’Ambra, Emilio Di Giulio, Emanuela Pilozzi, Cesare Bordi, Bruno Annibale, Gianfranco Delle Fave*

5:00 #513

Diagnosis of Chronic Atrophic Fundal Gastritis By Autofluorescence Imaging Videoendoscopy Noriya Uedo*, Takuya Inoue, Ryu Ishihara, Yoji Takeuchi, Koji Higashino, Hiroyasu Iishi, Masaharu Tatsuta, Yasuhiko Tomita, Ervin Toth

5:12 Sp534

State-of-the-Art Lecture: Early Gastric Cancer - Can We Find It? Norman E. Marcon

ASGE Topic Forum 4:00 PM - 5:30 PM

S102 McCormick Place

ASGE Topic Forum 4:00 PM - 5:30 PM Chairs: Kenneth K. Wang, Nicholas J. Shaheen

ENDOSCOPIC APPROACHES TO BARRETT’S ESOPHAGUS 4:00 #520

Endoscopic Radiofrequency Ablation of Barrett’s Esophagus: Safety and Efficacy Outcomes in 429 Patients Treated in a Multi-Center Community Practice Registry William Lyday, F. Scott Corbett, Douglas A. Kuperman, Isaac Kalvaria, Peter G. Mavrelis, Ron E. Pruitt*

4:12 #521

Endoscopic Therapy in 1059 Patients with High Grade Dysplasia and Early Adenocarcinoma in Barrett’s Esophagus- Lessons We Have Learned Oliver Pech*, Hendrik Manner, Andrea May, Juergen Pohl, Christian Ell

4:24 #522

Barrett’s Esophagus Ablation with Multipolar Electrocoagulation; Long Term Follow-Up Harmony Allison*, Maria Alexandra Banchs, Moises Guelrud

4:36 #523

Complications of Endoscopic Mucosal Resection for Barrett’s Esophagus in a Specialized Unit Yutaka Tomizawa*, Ganapathy A. Prasad, Navtej Buttar, Louis-Michel Wong Kee Song, Ngozi I. Okoro, Kelly T. Dunagan, Lynn S. Borkenhagen, Lori S. Lutzke, Kenneth K. Wang

4:48 #524

Results from a Large Prospective Series of Acetic Acid Enhanced Chromoendoscopy in Evaluation of Barrett’s Neoplasia. Is It Time to Change Our Practice? Gaius R. Longcroft-Wheaton*, Moses Duku, Robert Mead, David Poller, Pradeep Bhandari

5:00 #525

What Are the Outcomes of Endoscopic Radiofrequency Ablation for Very Long Segments of Barrett Esophagus Containing Neoplasia? Lorenza Alvarez Herrero*, Roos E. Pouw, Frederike G. van Vilsteren, Carine Sondermeijer, Fiebo J. ten Kate, Paul Fockens, Bas L. Weusten, Jacques Bergman

Chairs: Dayna S. Early, Shin-ei Kudo DIAGNOSTIC AND THERAPEUTIC TECHNIQUES IN THE COLON 4:00 #514

4:12 #515

Safety and Efficacy of Colonoscopy to Treat Diverticular Bleeding - Long-Term Outcomes of a Large Multicenter Cohort Tonya Kaltenbach*, Rabindra R. Watson, Janak N. Shah, Shai Friedland, Kenneth R. McQuaid, Tohru Sato, Amandeep K. Shergill, Roy M. Soetikno Pathology of the 6-9mm Polyp Found in a CT Colonography Screening Program: Implications for CT Polyp Surveillance vs. Resection Parul Dureja*, Deepak V. Gopal, Mark Reichelderfer, Perry J. Pickhardt, David H. Kim, Patrick Pfau

S103ABC McCormick Place

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M O N D A Y JUNE 1

ORAL SESSIONS—SCIENTIFIC SESSIONS 5:12 Sp536

State-of-the-Art Lecture: Ablation of Barrett’s Esophagus in 2009: Ready for Primetime? Kenneth K. Wang

AGA Institute Section Business Meeting ‡ 5:30 PM - 6:30 PM

S404 McCormick Place

Chairs: Mae F. Go, Richard M. Peek Sponsored by: Esophageal, Gastric & Duodenal Disorders

ESOPHAGEAL, GASTRIC & DUODENAL DISORDERS SECTION BUSINESS MEETING AGA Institute Section Business Meeting ‡ 5:30 PM - 6:30 PM

S402 McCormick Place

Chairs: Marshall H. Montrose, Gary D. Wu Sponsored by: Intestinal Disorders

INTESTINAL DISORDERS SECTION BUSINESS MEETING AGA Institute Section Business Meeting ‡ 5:30 PM - 6:30 PM

M O N D A Y JUNE 1

S405 McCormick Place

Chairs: Richard M. Green, Frank A. Anania Sponsored by: Liver & Biliary

LIVER & BILIARY SECTION BUSINESS MEETING AGA Institute Section Business Meeting ‡ 5:30 PM - 6:30 PM

S403 McCormick Place

Chairs: Emeran A. Mayer, Gianrico Farrugia Sponsored by: Neurogastroenterology and Motility

NEUROGASTROENTEROLOGY AND MOTILITY SECTION BUSINESS MEETING AGA Institute Section Business Meeting ‡ 5:30 PM - 6:30 PM

S401A McCormick Place

Chairs: Deborah C. Rubin, Alan L. Buchman Sponsored by: Nutrition & Obesity

NUTRITION & OBESITY SECTION BUSINESS MEETING AGA Institute Section Business Meeting ‡ 5:30 PM - 6:30 PM

S401D McCormick Place

Chairs: Randall K. Pearson, Rodger A. Liddle Sponsored by: Pancreatic Disorders

PANCREATIC DISORDERS SECTION BUSINESS MEETING

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ORAL SESSIONS—SCIENTIFIC SESSIONS SCIENTIFIC SESSIONS ASGE Breakfast with Champions 6:30 AM - 8:00 AM

Sp537

Sp539

ERCP Case Studies (BC06) Peter B. Cotton

CC20AB Hyatt Regency McCormick

EUS Cases: Evolution of a Technology (BC07) CC21AB Maurits J. Wiersema

Hyatt Regency McCormick Sp540

Combined Endoscopic and Transgastric Laparoscopic Resection of Gastric Gastrointestinal Stromal Tumors Craig P. Fischer

8:15 #529

Laparoscopic Total Gastrectomy with Roux-en-Y Esophagojejunostomy for Hereditary Gastric Cancer Gene Carrier Winnie Tong*, Jayleen Grams, Daniel M. Herron

8:30 #530

Single Incision Laparoscopic Colectomy: Right Hemicolectomy Robert B. Lim*, Deborah Nagle

8:45 #531

Laparoscopic Approach to Median Arcuate Ligament Syndrome Yves Borbely*, Branislav Risti, Othmar Schoeb

9:00 #532

Laparoscopic Sigmoid Resection and Rectopexy for Rectal Prolapse: A 3 Step Procedure Philippe Bouchard*, Jacques Heppell, Jonathan E. Efron, Tonia Young-Fadok

Colonoscopy: Optimizing Performance (BC05) Douglas K. Rex

CC10A Hyatt Regency McCormick

Sp538

8:00 #528

GI Bleeding: How to Stop a Leaky Vessel (BC08) Pullman Room Loren A. Laine

Hyatt Regency McCormick AGA Institute Sunrise Session Discussion 7:00 AM - 8:00 AM

S401D McCormick Place

CLINICAL WARD ROUNDS: GASTRIC TUMORS

Sponsored by: Intestinal Disorders

ADVANCES IN EPITHELIAL TRANSPORT Participants will be able to: • Review advances in epithelial transport presented at DDW 2009. Advances in Epithelial Transport Kim E. Barrett, Mrinalini C. Rao

AGA Institute Business Meeting ‡ 7:30 AM - 8:30 AM

S501A McCormick Place

AGA INSTITUTE BUSINESS MEETING SSAT Video Session 7:30 AM - 9:15 AM

S505b McCormick Place

Chair: John T. Mullen

Chairs: Kim E. Barrett, Mrinalini C. Rao

7:00 Sp541

SSAT Conference/Debate/Panel/Symposium 8:30 AM - 9:30 AM

Participants will be able to: • Describe the optimal staging and therapeutic strategies, including the role of preoperative chemoradiation therapy, for the management of locoregionally advanced adenocarcinoma of the stomach; • Detail the optimal surgical management of advanced gastrointestinal tumors of the stomach, including the role and timing of targeted kinase inhibitor therapy; and • Describe the pathogenesis, malignant potential, and optimal management of gastric carcinoid tumors. 8:30 Sp542

Panelists Martin S. Karpeh, Peter W. T. Pisters, Chandrajit P. Raut

DDW Combined Clinical Symposium 8:30 AM - 10:00 AM

S504 McCormick Place

Chairs: Craig P. Fischer, Randall S. Zuckerman VIDEO SESSION II: BREAKFAST AT THE MOVIES Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas. 7:30 #526

Technical Aspects of Duodenal Preserving Pancreatic Head Resections (DPPHR): The Frey and Beger Operations Thomas J. Howard*, Nicholas J. Zyromski, Harish Lavu

7:45 #527

Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Sleeve Gastrectomy - Initial Human Experience in the United States Santiago Horgan*, Lauren J. Fischer, Garth R. Jacobsen, Brian Wong, Adam Spivack, Kari Thompson, Mark A. Talamini

B1 McCormick Place

Chairs: Guadalupe Garcia-Tsao, Loren A. Laine Sponsored by: AASLD; ASGE; AGA Institute

PREDICTING AND TREATING VARICEAL HEMORRHAGE Participants will be able to: • Predict the risk of variceal hemmorage and ways to prevent. 8:30 Sp545

Varices - Predicting Their Presence and Risk of Hemmorrhage Roberto de Franchis

8:45 Sp546

Preventing Varices and First Variceal Hemorrhage Guadalupe Garcia-Tsao

9:00 Sp547

Recurrent Variceal Hemorrhage Agustin Albillos

9:15 Sp548

Acute Variceal Hemorrhage Thomas D. Boyer

9:30

T U E S D A Y JUNE 2

Discussion

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ORAL SESSIONS—SCIENTIFIC SESSIONS AASLD Clinical Symposium 8:30 AM - 10:00 AM

S105 McCormick Place

Chairs: Ariel E. Feldstein, Ramsey C. Cheung

Participants will be able to: • Discuss the role of genetics in outcome prediction in chronic liver diseases; • Summarize the utility of novel fibrosis markers in clinical practice; • Recognize novel approaches to distinguish alcoholic from nonalcoholic fatty liver disease; and • Review novel mechanism-based biomarkers for nonalcoholic steatohepatitis. Welcome and Introduction

8:35 Sp549

Genes and Fibrosis Risk Frank Lammert

8:55 Sp550

Non-Invasive Markers of Fibrosis Fabio Marra

9:15 Sp551

Tests to Distinguish ASH from NASH Vijay Shah

9:35 Sp552

Mechanisms-Based NASH Biomarkers Ariel E. Feldstein

9:55

E450A McCormick Place

Chairs: Todd H. Baron, Peter A. Banks Sponsored by: Pancreatic Disorders; Clinical Practice; Imaging & Advanced Technology

CONTROVERSIES IN CLINICAL PANCREATOLOGY: A CASE BASED DEBATE

T U E S D A Y JUNE 2

Participants will be able to: • Use illustrative cases to define the controversies in management of pancreatic disorders; • Examine the key decisions in the management of severe acute pancreatitis; and • Describe the evidence supporting the current guidelines in management of pancreatic disorders. 8:30 Sp558

Panel Discussion Scott M. Tenner, Suresh T. Chari, Hein G. Gooszen

AGA Institute Translational Symposium 8:30 AM - 10:00 AM

E451B McCormick Place

Chair: Frank A. Anania Sponsored by: Nutrition & Obesity; Clinical Practice; Liver & Biliary

OBESITY AND FATTY LIVER DISEASE Participants will be able to: • Describe the pathogenesis of non-alcoholic fatty liver disease (NAFLD); and • Review the natural history of NAFLD and dietary modification as treatment. 8:30 Sp553

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9:30 Sp557

Role of Fructose in NAFLD and the Metabolic Syndrome Robert H. Lustig

S405 McCormick Place

Chairs: Mack C. Mitchell, Fasiha Kanwal Sponsored by: Clinical Practice; Liver & Biliary; Gastrointestinal Oncology

CURRENT CONCEPTS IN CIRRHOSIS MANAGEMENT: AN UPDATED EVIDENCE-BASED APPROACH TO COMMON CLINICAL ISSUES Participants will be able to: • Review current treatment alternatives—including the role of transjugular intrahepatic portosystemic shunt—in managing patients with ascites; • Review data regarding new methods for diagnosing and treating hepatic encephalopathy; and • Discuss when and how to screen for hepatocellular cancer (HCC); and review recent data regarding diagnostic tests for cirrhosis.

Wrap-Up

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM

Pathology of NAFLD and NASH Elizabeth M. Brunt

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM

NOVEL DIAGNOSTICS IN LIVER DISEASE

8:30

9:00 Sp555

Lipid Metabolism and Fatty Liver Disease Jay D. Horton

8:30 Sp560

Encephalopathy: Clinical Pearls for Diagnosis and Management Thomas D. Boyer

8:52 Sp561

Diagnosis of Advancing Liver Disease. How to Utilize Biopsy, Non-Invasive Markers and Imaging to Determine Who Is At Risk for Cirrhosis F. Fred Poordad

9:14 Sp562

Current Concepts in Ascites Management Arun J. Sanyal

9:36 Sp563

Screening for HCC in Cirrhosis: Who, When, and How? Morris Sherman

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM

S403 McCormick Place

Chairs: Glenn M. Eisen, Ann M. Joyce Sponsored by: Imaging & Advanced Technology; Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Intestinal Disorders

IMAGING THE SMALL BOWEL: NOW THAT WE CAN DO IT - WHAT SHOULD WE USE? Participants will be able to: • Discuss advances in direct and indirect small bowel imaging; • Compare advantages and limitations of small bowel imaging options; and • Review the therapeutic potential of small bowel imaging modalities. 8:30 Sp564

Balloon Enteroscopy Simon K. Lo

8:52 Sp565

Overtube Assisted Enteroscopy Andrew S. Ross

9:14 Sp566

Capsule Endoscopy Blair S. Lewis

9:36 Sp567

CT/MR Enterography Joel G. Fletcher

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Clinical Symposium 8:30 AM - 10:00 AM

S103D McCormick Place

AGA Institute Committee Sponsored Symposium 8:30 AM - 10:00 AM S406A McCormick Place

Chairs: Ernst J. Kuipers, Alan F. Cutler

Chairs: Peter R. Holt, Henry J. Binder

Sponsored by: Esophageal, Gastric & Duodenal Disorders; Clinical Practice; Intestinal Disorders

Sponsored by: International Committee

OPTIMAL THERAPIES FOR H. PYLORI IN A CHANGING ENVIRONMENT: A GLOBAL PERSPECTIVE Participants will be able to: • Evaluate recent research regarding treatment of Helicobacter pylori; • Review research about antimicrobial resistance patterns of Helicobacter pylori; and • Discuss different approaches to treatment of H. pylori based on geographic locale.

BEST OF UEGW VIENNA Participants will be able to: • Summarize and provide selected highlights of the October 2008 United European Gastroenterology Week (UEGW) in Vienna, Austria. 8:30 Sp575

Basic and Translational Clinical Science Mark Hull

8:48 Sp576

Liver Disease Markus Peck-Radosavljevic

8:30 Sp568

United States Perspective Nimish B. Vakil

9:06 Sp577

Inflammatory Bowel Disease Marc Lemann

9:00 Sp569

Asian Perspective Benjamin C.Y. Wong

9:24 Sp578

Endoscopy Jacques Bergman

9:30 Sp570

European Perspective Dino Vaira

9:42 Sp579

Neurogastroenterology and Functional Bowel Disorders Michel Delvaux

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM

S406B McCormick Place

AGA Institute Committee Sponsored Symposium 8:30 AM - 10:00 AM S401BC McCormick Place

Chairs: Michael F. Vaezi, Donald O. Castell

Chair: John I. Allen

Sponsored by: Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Neurogastroenterology and Motility

Sponsored by: Clinical Practice & Quality Management Committee

REFLUX SYMPTOMS NOT RESPONSIVE TO PPIS

PHYSICIAN PROFILING - WHAT YOU DON’T KNOW CAN HURT YOU

Participants will be able to: • State the mechanisms of symptom generation in GERD patients; • List the utility of new diagnostic tests in the management of GERD patients failing PPI therapy; and • Discuss the results of recent randomized controlled trials of currently available GERD therapies. 8:30 Sp571 8:52 Sp572

9:14 Sp573

9:36 Sp574

What Are the Mechanisms of PPI Failure? Ronnie Fass Appropriate Diagnostic Work-Up: The Role of Impedance Testing, BRAVO, and pH in the PPI NonResponsive Patient John E. Pandolfino Imaging and Histology in the PPI Non-Responsive Patient: Can Narrow Band Imaging or Intercellular Spaces Guide Therapy? Prateek Sharma Building a Better Mousetrap: New Therapeutics for GERD Colin W. Howden

Participants will be able to: • Identify the concepts of clinical and economic profiling and their uses by various stakeholders; • Define the value and limitations of profiling databases and to understand what GI profiling systems/programs currently exist and assess their value; and • Be familiar with what GI practices should look for in clinical and economic credentialing programs. 8:30 Sp580

Transparency in Health Care Delivery Bernard M. Rosof

8:54 Sp581

What Are the Value and Limits of Using Administrative Claims for Profiling? Kay Schwebke

9:16 Sp582

What Is Physician Profiling and How Is It Used? Louis Diamond

9:38 Sp583

Assessment of Current GI Profiling Joel V. Brill

JUNE 2

AGA Institute Morton I. Grossman Lectureship 8:30 AM - 10:00 AM S404 McCormick Place Chair: Haile T. Debas FROM WORMS TO MAMMALS: GENES AND CELLS THAT REGULATE THE AGING PROCESS 8:30 Sp584

T U E S D A Y

From Worms to Mammals: Genes and Cells That Regulate the Aging Process Cynthia Kenyon

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ORAL SESSIONS—SCIENTIFIC SESSIONS ASGE Clinical Symposium 8:30 AM - 10:00 AM

S101 McCormick Place

Chairs: Thomas J. Howard, Kaye M. Reid Lombardo

ANTICOAGULANTS AND ANTIPLATELET AGENTS IN THE PATIENT UNDERGOING ENDOSCOPY

PUBLIC POLICY COMMITTEE PANEL: GENOMICS AND CANCER CARE: WHAT EVERY CLINICIAN SHOULD KNOW

8:30 Sp585

Experience from Consensus: Lessons Learned from the Cardiologists David A. Johnson

8:50 Sp586

A Medicolegal View Andrew D. Feld

9:10 Sp587

The New ASGE Guidelines Michelle A. Anderson Questions & Answers

ASGE Clinical Symposium 8:30 AM - 10:00 AM

S102 McCormick Place

Chairs: Karen L. Woods, Mark B. Pochapin GI JOE: TAKING COMMAND OF COLONOSCOPY 8:30 Sp588

Participants will be able to: • Understand how to interpret genetic information from patients with hereditary colon cancer syndromes in order to guide therapy; • Become familiar with the ethical considerations when ordering genetic tests and using their results to guide treatment in patients with hereditary colon cancer syndromes; and • Understand the impact of genetic testing on the cancer patient in light of our current health care policies. 8:30 Sp594

Impact of Genetic Testing On the Cancer Patient C. R. Boland

8:50 Sp595

Treatment Guidelines and Management Implications for Patients with HCCs Kenneth C. Micetich

9:10 Sp596

Ethical Considerations for Genetic Testing Kimberly A. Quaid

9:30

Panel and Audience Discussion

Joe the Quality Inspector - Defining Quality Colonoscopy Thomas M. Deas Jr.

AASLD Research Forum 8:30 AM - 10:00 AM

8:50 Sp589

Joe the Mechanic - Mastering the Technique Douglas K. Rex

Chairs: David H. Adams, Detlef Schuppan

9:10 Sp590

Joe the Plumber - Prepping for Colonoscopy David M. Kastenberg

BASIC LIVER BIOLOGY AND LIVER IMMUNOLOGY

9:30

Questions & Answers

ASGE Special Session 8:30 AM - 10:00 AM

Mouse Strain Differences in Macrophage-Mediated Clearance of Dead Hepatocytes Accounts for Differences in Susceptibility to Liver Fibrosis Yury Popov*, Deanna Sverdlov, Anisha Sharma, Killimangalam Bhaskar, Rohan Akhouri, Thomas Konturek, Michael Tandetnik, Detlef Schuppan

8:45 #534

Effect of HIV Integrase Inhibitor On HIV Protease Inhibitor-Induced ER Stress and Disregulation of Lipid Metabolism in Hepatocytes Risheng Cao*, Yiqiao Hu, Xudong Wu, Lixin Sun, Weibin Zha, Beth S. Pecora, Emily C. Gurley, Elaine Studer, Phillip Hylemon, William M. Pandak Jr., Arun J. Sanyal, Huiping Zhou

9:00 #535

JNK1, But Not JNK2 Promotes Hepatic Fibrogenesis Johannes Kluwe*, Jean-Philippe Pradere, Samuele De Minicis, Christoph Oesterreicher, Ali A. Mencin, Eleanore Ables, Ramon Bataller, Robert F. Schwabe

9:15 #536

PKC-Theta Mediated Degradation of Mcl-1 Is Requisite for Lipoapoptosis Howard Masuoka*, Steven F. Bronk, Nathan W. Werneburg, Gregory J. Gores

9:30 #537

Type I Interferon Induction and Signaling Protect from Liver Injury and Granulomas Through Regulation of IL1 Receptor Antagonist and Dendritic Cell Recruitment in Mice Jan Petrasek*, Angela Dolganiuc, Evelyn A. Kurt-Jones, Gyongyi Szabo

9:45 #538

Bacterial Receptor NOD1 Regulates in the Neutrophil Migration Machinery During Liver Injury Sébastien Dharancy, Mathilde Body-Malapel, Alexandre Louvet, Dominique Berrebi, Philippe Gosset, Jérôme Viala, Dana Philpott, Emilie Gantier, Stephen Girardin, Pierre Desreumaux, Philippe Mathurin, Dubuquoy Laurent*

THE PRACTICE OF GI ENDOSCOPY: THE PRESSURE IS RISING 8:30 Sp591

Maximizing Efficiency in Your Endoscopy Unit Joseph J. Vicari

8:50 Sp592

The Perils of Production Pressure Lawrence B. Cohen

9:10 Sp593

Measuring and Benchmarking the Quality of Your Endoscopy David A. Lieberman

9:30

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S106A McCormick Place

8:30 #533

S103ABC McCormick Place

Chairs: James S. Leavitt, Lawrence B. Cohen

JUNE 2

S505a McCormick Place

Chairs: John L. Petrini, James M. Scheiman

9:30

T U E S D A Y

SSAT Conference/Debate/Panel/Symposium 8:30 AM - 10:00 AM

Questions & Answers

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 8:30 AM - 10:00 AM

E451A McCormick Place

Chairs: Jonathan P. Katz, Navtej Buttar

8:45 #546

Relationship Between Gastroesophageal Reflux Pattern and Severity of Mucosal Damage Albert J. Bredenoord*, Gerrit J. Hemmink, André J. Smout

9:00 #547

A Study On the Intercellular Space of Squamous Epithelium in Lower-Esophagus with Light Microscopy in the Diagnosis of GERD Liya Zhou*, Rongli Cui, Sanren Lin, Yan Xue

9:15 #548

Combined Multichannel Intraluminal Impedance and pH Esophageal Testing Versus pH Alone for Diagnosing Gastro-Esophageal Reflux: A Study On Italian Patients Off Therapy Maura Corsetti, Cristian Vailati*, Sandro M. Passaretti, Chiara Notaristefano, Pier A. Testoni

9:30 #549

Refractory Gastroesophageal Reflux Disease (RGERD) Patients with Normal Upper Endoscopy (EGD) Should Have pH Testing Off Proton Pump Inhibitors (PPIs) Javier Gomez*, Matthew Bohm, Joel Richter

9:45 #550

Conventional Esophageal Manometry Findings and Current Criteria of Ineffective Esophageal Motility Poorly Correlate with Reflux Clearance and Proximal Spread of Gastro-Esophageal Reflux in NERD Patients Mentore Ribolsi*, Sara Emerenziani, Maria Chiara Addarii, Paola Balestrieri, Michele Cicala

Sponsored by: Gastrointestinal Oncology

ESOPHAGEAL NEOPLASMS AND BARRETT’S ESOPHAGUS: BIOLOGY, DIAGNOSIS & TREATMENT Participants will be able to: • Better understand the biology, diagnosis, and treatment of esophageal neoplasms and Barrett’s Esophagus. 8:30 #539

8:45 #540

9:00 #541

9:15 #542

9:30 #543

9:45 #544

The Synergistic Cooperative Interaction of the BMP4 and CDX-2 Enhance Transcription of Intestine Specific Genes During Development of Intestinal Type of Metaplasia or Barrett’s Esophagus Francesca Milano*, Alifiya Pacha, Navtej Buttar, Kausilia K. Krishnadath Epithelial Reconstitution Reveals Regulation of Differentiation and Cell Fate Decisions Through a Novel Interplay Between the Notch Signaling and Essential Cancer Genes in Esophageal Carcinogenesis Shinya Ohashi, Momo Nakagawa*, Mitsuteru Natsuizaka, Douglas B. Stairs, Katharine D. Grugan, Jiri Kalabis, Gabrielle Wong, Yizeng Yang, Andres J. Klein-Szanto, Meenhard Herlyn, Warren S. Pear, Jonathan P. Katz, Hiroshi Nakagawa KLF11 Behaves As a Tumor Suppressor in Barrett’s Mucosa By Transcriptionally Regulating Procarcinogenic cPLA2a-Mediated PGE2 Synthesis via An EGFR-AKTSin3a Pathway Navtej Buttar*, Cathrine J. DeMars, Sumera Ilyas, Zaheer H. Rizvi, Shahrooz Rashtak, Shalini Achra, Gwen A. Lomberk, Raul A. Urrutia Malignant Transformation of Non-Neoplastic Barrett’s Epithelial Cells Through Well-Defined Genetic Manipulations Xi Zhang*, Hui Ying Zhang, Kathy Hormi-Carver, Stuart J. Spechler, Rhonda F. Souza P120ctn Functions As a Bona Fide Tumor Suppressor Gene in Esophageal Cancer Douglas B. Stairs*, Jiri Kalabis, Ben Rhoades, Katharine D. Grugan, Hiroshi Nakagawa, Gabrielle Wong, Andres J. Klein-Szanto, Jonathan P. Katz, Albert B. Reynolds, Anil K. Rustgi A Model for Coordinated Loss of E-Cadherin and TGFβ Receptor Type II Reveals Fibroblast-Dependent Invasion of Esophageal Keratinocytes Claudia Andl

AGA Institute Research Forum 8:30 AM - 10:00 AM

S501A McCormick Place

Chairs: Philip Katz, Joel Richter

AGA Institute Research Forum 8:30 AM - 10:00 AM Chairs: Andrew T. Gewirtz, Nita H. Salzman Sponsored by: Intestinal Disorders

GI INFECTIONS: MOLECULAR MECHANISMS Participants will be able to: • Review mechanisms by which enteropathogenic E. coli invades and damages the intestinal epithelium; and • Examine new advances in the physiology of enterotoxins. 8:30 #551

Shiga Toxin 1 Uptake By Intestinal Epithelial Cells Is CDC-42 Mediated and Clathrin-Independent Irina Malyukova, Edgar C. Boedeker, Mark Donowitz, Olga Kovbasnjuk*

8:45 #552

Intoxication of Zebrafish By Cholera Toxin Involves Flotillin But Not Derlin-1 David E. Saslowsky*, Himani Chinnapen, Jessica Wagner, Daniel Chinnapen, Wayne I. Lencer

9:00 #553

ESPF Promotes EPEC Invasion of Intestinal Epithelial Cells via An Snx9-Dependent, Dynamin-Independent Mechanism Andrew W. Weflen*, Gail A. Hecht

9:15 #554

The Enteropathogenic Escherichia coli Type III-Secreted Protein EspZ Inhibits Host Cell Apoptosis Jennifer L. Roxas, Archana P. Kanteti, V. K. Viswanathan*

9:30 #555

Zinc Protects Rabbit Ileal Loops Against Pathogenic Effects of Shiga-Toxin Producing E. coli (STEC) Mohamed O. Othman*, Wyatt Byrd, Erin K. Okeefe, John K. Crane, Edgar C. Boedeker

9:45 #556

Pathogenic Bacteria Transcriptionally Induce Colonic PepT1 Expression - An Implication in Modulating Bacterial-Epithelial Interaction Hang Thi Thu Nguyen*, Guillaume Dalmasso, Yutao Yan, Kim Powell, Shantanu Bhatt, Daniel Kalman, Andrew T. Gewirtz, Shanthi V. Sitaraman, Didier Merlin

Sponsored by: Esophageal, Gastric & Duodenal Disorders

GERD: DIAGNOSTIC TESTING II Participants will be able to: • Learn advances in GERD diagnostic testing. 8:30 #545

Improving Diagnostic Utility of Ambulatory pH Testing Vladimir Kushnir*, Gregory S. Sayuk, C. Prakash Gyawali

S401D McCormick Place

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T U E S D A Y JUNE 2

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 8:30 AM - 10:00 AM

E450B McCormick Place

Chairs: Remo Panaccione, Uma Mahadevan

Chairs: Mary E. Rinella, Zhiping Li

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

Sponsored by: Liver & Biliary

IMMUNE MODULATORS IN IBD Participants will be able to: • Be familiar with evidence about the utility of metabolite monitoring for thiopurine therapy in IBD; • Be familiar with data regarding risks of infection with immune modulator therapy for IBD, including C. difficile and progressive multifocal leukoencephalopathy; and • Understand treatment outcomes with cyclosporine for severe ulcerative colitis. 8:30 #557

JUNE 2

Colectomy Rate in Hospitalized Ulcerative Colitis Patients Undergoing Therapy with Cyclosporine (CsA) Jenny Sauk, Melissa H. Rosen, Steven Naymagon, Daniel H. Present, Simon Lichtiger, James F. Marion, Asher Kornbluth, Peter Legnani, Adam F. Steinlauf, James George, Anthony A. Weiss, Shuchi Agarwal, Thomas A. Ullman*

8:45 #558

Outcomes After Retreatment with Cyclosporine a (CsA) in Hospitalized Ulcerative Colitis (UC) Patients: A 7Year Review from a Single Institution Jenny Sauk*, Daniel H. Present, Asher Kornbluth, Simon Lichtiger, James George, James F. Marion, Adam F. Steinlauf, Peter Legnani, Anthony A. Weiss, Shuchi Agarwal, Melissa H. Rosen, Steven Naymagon, Thomas A. Ullman

9:00 #559

Fertility and Outcomes of Pregnancies Fathered By Male Patients Exposed to Thiopurines Carlos Teruel*, Antonio López-San Román, Carlos Taxonera, Alicia Algaba, Javier P. Gisbert, Jose L. PerezCalle, María Martín-Arranz, Manuel Van Domselaar, Jesús Estellés, Fernando Bermejo, Pablo M. Linares, Pilar LopezSerrano

9:15 #560

T U E S D A Y

AGA Institute Research Forum 8:30 AM - 10:00 AM

9:30 #561

9:45 #562

P-90

Lack of Usefulness of Systematic Determination of Azathioprine (AZA) Metabolites During Follow-Up of Inflammatory Bowel Disease (IBD) Patients Under Thiopurinic Therapy: Final Results of the Metaza Study Yago Gonzalez-Lama Successive Treatment with Cyclosporine and Infliximab in Severe Ulcerative Colitis (UC) Sarah Leblanc*, Matthieu Allez, Philippe Seksik, Bernard Flourie, Harald Peeters, Jean-Louis Dupas, Guillaume Bouguen, Laurent Peyrin Biroulet, Arnaud Bourreille, Olivier Dewit, Yoram Bouhnik, Pierre F. Michetti, Stanislas Chaussade, Philippe de Saussure, Jean-Frederic Colombel, Marc Lemann A Multi-Center National Prospective Study of Pregnancy and Neonatal Outcomes in Women with Inflammatory Bowel Disease Exposed to Immunomodulators and Biologic Therapy Uma Mahadevan*, Christopher F. Martin, Robert S. Sandler, Sunanda V. Kane, Marla Dubinsky, James D. Lewis, Sylvia Degli-Espositi, William J. Sandborn, Bruce E. Sands

S501BC McCormick Place

METABOLISM AND STEATOPHEPATITIS Participants will be able to: • Examine the pathogenesis of steatohepatitis; • Better manage patients with fatty liver; and • Learn about new potential therapies for NASH. 8:30 #563

Pentoxifylline Improves ALT and Histology in Patients with NASH, a Double Blind Placebo Controlled Trial Mary E. Rinella*, Sean Koppe, Elizabeth M. Brunt, Marc Elias, Jeanne Gottstein, Richard M. Green

8:45 #564

Parent-Specific Inheritance of Insulin Resistance and NAFLD in Axb Mice Regulated By Sex Chromosomes Arlin B. Rogers*, James G. Fox

9:00 #565

Acute Reversal of the Lysosomal Transport Defect in the Liver of the Niemann Pick Type C Mouse Benny Liu*, Charina M. Ramirez, Stephen D. Turley, John M. Dietschy

9:15 #566

An Apoptosis Panel for Nonalcoholic Steatohepatitis Diagnosis Tarek I. Abu-Rajab Tamimi*, Michael P. Berk, Naim Alkhouri, Lisa M. Yerian, Rocio Lopez, Nizar N. Zein, Ariel E. Feldstein

9:30 #567

Hepatic Iron Overload in Patients with Alcoholic Liver Disease Is Due to Inadequate Hepcidin Induction Gunda Millonig*, Gabi N. Waite, Martina Muckenthaler, Helmut-Karl Seitz, Sebastian Mueller

9:45 #568

Small Intestinal Bacterial Overgrowth (SIBO) and Lipoploysaccharide (LPS) Receptors in Non-Alcoholic Steatohepatitis (NASH) Ahmed Abu-Shanab*, Paul Scully, Eileen Murphy, Liam O’Mahony, Orla M. Crosbie, Martin J. Buckley, Eamonn M. Quigley

AGA Institute Research Forum 8:30 AM - 10:00 AM

E352 McCormick Place

Chairs: Steven H. Itzkowitz, Beth B. McConnell Sponsored by: Gastrointestinal Oncology

MODULATORS FOR INFLAMMATION AND PROLIFERATION IN GI CANCERS Participants will be able to: • Understand the roles of inflammation and modulators of proliferation in GI cancers. 8:30 #569

Increased Dietary Iron Increases the Level of Chronic Intestine Inflammation and the Development of Colonic Tumourogenesis in the Mouse Borut Klopcic, Anita Chua, Lyn L. Loh, Debbie Trinder, Ian C. Lawrance*

8:45 #570

Annurca Apple Polyphenol Extracts (APE) Suppress Polyp Development in Apcmin/+ Mice Fed Western or Balanced Diets Lucia Fini*, Michael Selgrad, Giulia Piazzi, Yahya Daoud, Melissa Garcia, Vincenzo Fogliano, Giulia Graziani, Paola Vitaglione, Susanne W. Carmack, Robert M. Genta, C. R. Boland, Luigi Ricciardiello

ORAL SESSIONS—SCIENTIFIC SESSIONS 9:00 #571

Adiponectin As An Inhibitor of Colorectal Cancer Growth Soo Jung Park*, Jeong-Sik Byeon, Jin-Yong Jeong, Mi Jung Kim, Sun-Mi Lee, Won-Hee Nam, Jeung Hye Han, Jongha Park, Mi-Young Kim, Jeong Hoon Lee, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim

AGA Institute Research Forum 8:30 AM - 10:00 AM

9:15 #572

Haploinsufficiency of Krüppel-Like Factor 5 (KLF5) Reduces Intestinal Adenoma Formation in KRasV12G/ Apcmin/+ Mice Mandayam O. Nandan*, Amr Ghaleb, Beth B. McConnell, Vincent W. Yang

Sponsored by: Neurogastroenterology and Motility

9:30 #573

Colon Cancer-Derived Factors Activate NF-κB in Myeloid Cells via TLR2 to Link Inflammation and Tumorigenesis Shin Maeda*, Yohko Hikiba, Kei Sakamoto, Hayato Nakagawa, Yoku Hayakawa, Yoshihiro Hirata, Keiji Ogura, Masao Omata

9:45 #574

Transgenic Epithelial Expression of TLR4 Results in Duodenal Adenoma and Colitis-Associated Neoplasia Masayuki Fukata*, Limin Shang, Yasmin Hernandez, Keith J. Breglio, Noam Harpaz, Harry S. Cooper, John P. Sotolongo, Lory Hayes, Ryan Ungaro, Stephanie Dahan, Sergio A. Lira, Maria T. Abreu

AGA Institute Research Forum 8:30 AM - 10:00 AM

S501D McCormick Place

Chairs: Stuart J. Spechler, Stephen J. Meltzer

Chairs: Daniel Sifrim, Reza Shaker

MOTILITY AND FUNCTIONAL DISORDERS OF THE ESOPHAGUS Participants will be able to: • Review the regulation of upper and lower esophageal sphincters; • Learn about possible mechanisms underlying esophageal dysfunction in Parkinson’s disease and in functional chest pain; and • Examine new diagnostic techniques for esophageal disease. 8:30 #580

The M2 Muscarinic Receptor Plays a Greater Role in Mediating Contraction of Sling and Clasp Fibers Than Esophageal Smooth Muscle Fibers Alan S. Braverman*, Larry S. Miller, Anil K. Vegesna, Mansoor I. Tiwana, Ronald J. Tallarida, Michael R. Ruggieri Sr.

8:45 #581

Chili Improves Gastroesophageal Reflux Symptoms in Patients with Non Erosive Gastroesophageal Reflux Disease (NERD) Sukprasert Jutaghokiat*, Boonlert Imraporn, Sutep Gonlachanvit

9:00 #582

Manometry and Impedance Characteristics of the Esophagus in Patients with Early Stage of Idiopathic Parkinson’s Disease Myung-Gyu Choi*, Jae Myung Park, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, In-sik Chung, Hye Young Sung, Joong-Seok Kim, Jae Hyuck Chang, Chul Hyun Lim

9:15 #583

The Role of Adenosine in Esophageal Nociception in Patients with Functional Chest Pain Jose Maria Remes Troche*, Ashok Attaluri, Syed Hashmi, Jessica A. Paulson, Satish S. Rao

Sponsored by: Esophageal, Gastric & Duodenal Disorders

MOLECULAR AND CELLULAR EVENTS IN THE DEVELOPMENT OF BARRETT’S ADENOCARCINOMA Participants will be able to: • Understand molecular and cellular events in the development of Barrett’s related adenocarcinoma.

S503 McCormick Place

8:30 #575

Generation and Validation of a Prognostic Gene Signature for Esophageal Adenocarcinoma Christopher J. Peters*, Jonathan R. Rees, James S. Hardwick, Chunsheng Zhang, Richard H. Hardwick, Rebecca C. Fitzgerald

9:30 #584

An Optimal Dysphagia-Sensitive Algorithm for Assessing Deglutitive Intrabolus Pressure Using Esophageal HighResolution Manometry Sudip K. Ghosh*, Nathan Schmulewitz, Jonathan P. Kushner, Michael D. Crowell

8:45 #576

Contribution of Bone Marrow Derived Mesenchymal Cells to Barretts Adenocarcinoma in Mice and Men Jean Marie Houghton*, Bilal Piperdi, Stephen Lyle, Bjorn Stenstrom, Lloyd Hutchinson

9:45 #585

9:00 #577

Combination Chemoprevention Reveals a Novel Hedgehog Independent Role of GLI1 in Esophageal Carcinogenesis Sumera Ilyas, Cathrine J. DeMars*, Andrea Comba, Vladimir Gainullin, Jing Jing Han, Lori S. Lutzke, Martin E. Fernandez-Zapico, Navtej Buttar

Upper Esophageal Sphincter Response During Transient Lower Esophageal Sphincter Relaxation (TLESR) Is Dependent On the Posture & Nature of Refluxate: Assessed By Concurrent High Resolution Manometry, pH & Impedance Arash Babaei*, Ravinder K. Mittal

9:15 #578

MEK1 Kinase and Rho Kinase ROCK2 Mediate AcidInduced NOX5-S Expression and H2O2 Production in Barrett’s Esophageal Adenocarcinoma Cells Jie Hong, Jose Behar, Murray Resnick, Li Juan Wang, Ronald A. DeLellis, Jack R. Wands, Weibiao Cao*

9:30 #579

Increased Expression, Secretion and Activation of IL-6 During the Neoplastic Progression of Barrett’s Esophagus Hui Ying Zhang*, Xi Zhang, Xiaofang Huo, Kathy HormiCarver, Stuart J. Spechler, Rhonda F. Souza

9:45 Sp597

State-of-the-Art Overview Rhonda F. Souza

AGA Institute Research Forum 8:30 AM - 10:00 AM

E350 McCormick Place

Chairs: Lee Denson, Elke Cario Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

MUCOSAL INNATE IMMUNE FUNCTION AND INNATE HOST DEFENSE Participants will be able to: • Identify and examine key information and recent advances in mucosal innate immune function and innate host defense. 8:30 #586

Toll-Like Receptor 3 (TLR3) Signaling Improves Intestinal Mucosal Defense Against Pathogens John P. Sotolongo, Andrea Echeverry, Cecilia Espana, Rebecca Adkins, Arunan S. Vamadevan, Lory Hayes, Julia Zaias, Masayuki Fukata*

P-91

T U E S D A Y JUNE 2

ORAL SESSIONS—SCIENTIFIC SESSIONS 8:45 #587

A Computational Modelling Approach to Host-Microbe Interactions in the Gut: The in Silico Dendritic Cell Response to Microbes Liam O’Mahony*, L. T. Herren, David Groeger, John Bienenstock, Fergus Shanahan

9:00 #588

Distinct Dendritic Cell Subtypes with Dichotomous Phenotypes Are Associated with the Murine Small Intestinal Epithelium Leroy W. Wheeler* II, Manreet Kaur, Keely McDonald, Rodney D. Newberry

AGA Institute Research Forum 8:30 AM - 10:00 AM

Granulocyte-Macrophage Colony Stimulating Factor Is Required for Homeostatic Responses to Intestinal Injury in the CARD15 Deficient Host Charles M. Samson*, Ingrid Jurickova, Joshua Colliver, Erin L. Bonkowski, Xiaonan Han, Lee Denson

Sponsored by: Gastrointestinal Oncology

9:15 #589

9:30 #590

9:45 #591

Physiologic TLR9-CpG-DNA Interaction Is Essential for the Homeostasis of the Intestinal Immune System Claudia Hofmann*, Nadja Dunger, Nicole Grunwald, Jurgen Scholmerich, Werner Falk, Florian Obermeier

9:45 #597

Chairs: Samuel B. Ho, Linda Rabeneck

SCREENING, SURVEILLANCE AND DIAGNOSIS OF GI CANCERS II Participants will be able to: • Understand the role, factors and yield of colorectal cancer screening tests. Factors Associated with Distal and Proximal Adenoma Recurrence Among Participants in the Polyp Prevention Trial Adeyinka O. Laiyemo*, Chyke Doubeni, Paul Pinsky, Vincent P. Doria-Rose, Pamela Marcus, Amanda J. Cross, Elaine Lanza, Arthur Schatzkin

8:45 #599

Women Who Are Obese (BMI≥30) or Smoke, Two Distinct Potent Risk Factors, Account for a Large Percentage of Women with Advanced Adenomas in An Asymptomatic Average Population ≥ 50 Years of Age Joseph C. Anderson*, Benjamin Stein

9:00 #600

Are Hyperplastic Polyps Precursors of Colorectal Cancer? A Long-Term, Retrospective Study Marielle Bouwens*, Eveline Rondagh, Bjorn Winkens, Ann Driessen, Adriaan P. de Bruine, Ad Masclee, Silvia Sanduleanu

9:15 #601

The Facilitative Glucose Transporter GLUT-2 Is UpRegulated By Mucosal Leptin Through AMPK Involved Mechanisms in the Small Intestine Yassine Sakar*, Amal Ait Omar, Corinne Nazaret, Arieh Gertler, Robert A. Ducroc, André Bado

Advanced Neoplasia of the Left Hemicolon Are Better Detected By Fit Than Right Sided Lesions Frank A. Oort*, René W. van der Hulst, Jochim S. Terhaar sive Droste, Henk van Heukelem, Ruud J. Loffeld, Eric C. Wesdorp, Ruud Duijkers, Rosalie Ooteman, Zaldy D. Valdehueza, Madelon Q. Wentink, Veerle M. Coupe, Gerrit A. Meijer, Chris J. Mulder

9:30 #602

Enteric Nematode Infection Induces a “Lean” Epithelial Cell Phenotype Through Differential Regulation of Glucose Transporter Expression Kathleen B. Madden*, Diana C. Riera, Aiping Zhao, Jennifer A. Stiltz, Ildy M. Katona, Joseph F. Urban Jr., Terez SheaDonohue

Fecal Immunochemical Test Is More Cost-Effective Than Guaiac Fecal Occult Blood Test. Comparison Between Two Colorectal Cancer Screening Programs Rodrigo Jover*, Fernando Carballo, Teresa Sala, Pedro Zapater, Emilio Torrella, Marta Ponce, Francisco PerezRiquelme, Jose Cruzado, Dolores Salas

9:45 #603

Comparison of the Yield of Flexible Sigmoidoscopy (FSG) At 3 vs. 5 Years After a Negative Exam Robert E. Schoen*, Joel Weissfeld, Adeyinka O. Laiyemo, Vincent P. Doria-Rose, Robert S. Bresalier, Timothy R. Church, Lance Yokochi, Barbara O’Brien, Paul Pinsky

Plasmacytoid Dendritic Cells in Control of Regulatory T Cell Function in Intestinal Inflammation Bayasi Guleng*, Seiji Arihiro, Carmen Alonso Cotoner, Rajat Madan, Sonal Gupta, Jan H. Niess, Joel V. Weinstock, Christopher L. Karp, Hans-Christian Reinecker

S401A McCormick Place

Chairs: Kelly A. Tappenden, Michael A. Helmrath Sponsored by: Nutrition & Obesity

NUTRIENT ABSORPTION/NUTRIENTS AND GUT FUNCTION Participants will be able to: • Discuss nutrient regulation of gut function and mechanisms of nutrient absorption.

T U E S D A Y JUNE 2

8:45 #593

9:00 #594

Translocation of Transfected GLUT2 to the Apical Membrane in Rat Intestinal IEC-6 Cells Ye Zheng*, Judith A. Duenes, Hisham G. Qandeel, Michael G. Sarr

9:15 #595

The Role of Luminal Tastants and Olfactants in the Regulation of Gut Neuroendocrine Cell Secretion and the Implications for Gastrointestinal Health and Disease Irvin M. Modlin*, Bjorn I. Gustafsson, Zakiya-Luna Siddique, Ignat Drozdov, Roswitha Pfragner, Mark Kidd

9:30 #596

Decreased Phospho-AKT Signaling in a Mouse Model of Total Parenteral Nutrition (TPN): A Potential Mechanism for the Development of Intestinal Mucosal Atrophy Yongjia Feng*, Jonathan E. McDunn, Daniel H. Teitelbaum

P-92

S502 McCormick Place

8:30 #598

AGA Institute Research Forum 8:30 AM - 10:00 AM

8:30 #592

Corticosteroids Phase-Shift Intestinal Clocks and Diurnal Functional Rhythms Adam T. Stearns*, Anita Balakrishnan, Kamran Abolmaali, David B. Rhoads, Stanley W. Ashley, Ali Tavakkolizadeh

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 8:30 AM - 10:00 AM

S402 McCormick Place

Chairs: Simon J. Gibbons, Kirsteen N. Browning Sponsored by: Neurogastroenterology and Motility; Hormones, Transmitters, Growth Factors & Their Receptors

NOVEL MEMBRANE RECEPTOR-ACTIVATED SIGNALING CASCADES Participants will be able to: • Examine signaling cascades that are activated by surface receptors; and • Examine how membrane receptor signaling controls GI function. 8:30 #604

H2S Induces Analgesia Is Mediated In Vivo Activation of μ Opioid Receptor and PI3K/AKT Pathway Activation Eleonora Distrutti*, Sabrina Cipriani, Barbara Renga, Marco Migliorati, Andrea Mencarelli, Stefano Fiorucci

8:45 #605

Synergistic Interaction Between Leptin and CCK in the Nodose Ganglia to Mediate Short-Term Satiety Involves JAK/STAT3, SRC, and PI3 Kinase Signaling Pathways Andrea Heldsinger*, Gintautas Grabauskas, Il Song, Chung Owyang

9:00 #606

Contribution of Na-K-2Cl Cotransporter to GammaAmino Butyric Acid (GABAA) Receptor-Mediated Membrane Depolarization in Guinea Pig Myenteric Neurons Sumei Liu*, Wei Ren, Mei-Hua Qu, Hong Xue, Tuo Ji, Jinxia Zhu, Jackie D. Wood

9:15 #607

Caveolae-Dependent Internalization and Homologous Desensitization of VIP/PACAP Receptor, VPAC2 in Gastrointestinal Smooth Muscle Jennifer Kim*, Sally Fayed, Sunila Mahavadi, Gracious R. Ross, Syed R. Ahmed, Mohammed Khaleduzzaman, Karnam S. Murthy

9:30 #608

Upregulation of Vagal NK1 Receptor By Cisplatin Facilitates the Interaction of Substance P and Serotonin in the Vagal Afferent Neurons: Implication in the Emesis Related to Chemotherapy Xiaoyin Wu, Jing Fan, Chung Owyang, Ying Li*

9:45 #609

Tumor Necrosis Factor-α and Lymphotoxin-α1β2 Induce Enteric Neuronal Differentiation Through the NfκB Signaling Pathways Rachel L. Poole*, William Yen, Fang Li, Shanthi Srinivasan, Wenhui Hu

ASGE Topic Forum 8:30 AM - 10:00 AM

8:54 #612

3D Imaging of Intrahepatic Strictures During Endoscopic Retrograde Cholangiography (ERC): First Clinical Data Katja Wirths*, Said Gannoun, Thomas Zoepf

9:06 #613

Adding Balloon Sphincteroplasty to Sphincterotomy in Endoscopic Removal of Large Bile Duct Stones - A Randomized Controlled Trial Frances K. Cheung*, Bing Hu, Ya Min Pan Jr., Yu Bao Zhou III, Philip W. Chiu, Enders K. Ng, Justin Wu, Francis K. L. Chan, Joseph J. Sung, James Y. Lau

9:18 #614

Intraductal Ultrasonography Can Discriminate Between Sclerosing Cholangitis Associated with Autoimmune Pancreatitis and Primary Sclerosing Cholangitis kensuke kubota*, Shingo Kato, Noritoshi Kobayashi, Atsushi Nakajima

9:30 #615

Video Cholangiopancreatoscopy (CP) with Narrow Band Imaging (NBI): Spectrum of Mucosal and Vascular Patterns in Patients with Pancreaticobiliary (PB) Pathology Raj J. Shah*, Yang K. Chen

9:42 Sp598

State-of-the-Art Lecture: Gourmet Cholangiography Gregory G. Ginsberg

ASGE Topic Forum 8:30 AM - 10:00 AM Chairs: Banke Agarwal, Julia J. Liu

HEMOSTASIS IN ENDOSCOPY: HOW TO STOP THE FLOOD 8:30 #616

Endoscopic Hemostasis with High-Frequency Soft Coagulation for Bleeding Gastric Ulcer: Comparison with Metallic Hemoclips in a Prospective, Randomized Study Seiichiro Arima*, Shinichi Ogata, Naoyuki Tominaga, Nanae Tsuruoka, Kotaro Mannen, Yasuhisa Sakata, RYO SHIMODA, Seiji Tsunada, Hiroyuki Sakata, Ryuichi Iwakiri, Kazuma Fujimoto

8:42 #617a

Effect of Type of Endoscopic Hemostasis and Adjuvant Intravenous Esomeprazole On Peptic Ulcer Re-Bleeding Joseph J. Sung*, Alan N. Barkun, Ernst J. Kuipers, Joachim Mössner, Dennis M. Jensen, Robert Stuart, James Y. Lau, Henrik Ahlbom, Tore Lind, Jan Kilhamn

8:48 #617b

Is There a Subgroup of Patients with Forrest IB (Oozing) Peptic Ulcer Bleeding At Increased Risk of ReBleeding? Dennis M. Jensen*, Robert Stuart, Henrik Ahlbom, Stefan Eklund, Alan N. Barkun, Ernst J. Kuipers, Joachim Mössner, James Y. Lau, Joseph J. Sung

8:54 #618

Optimizing Monopolar Coagulation Therapy for NonVariceal Upper Gastrointestinal Bleeding John R. Saltzman*, Trevor H. Stenson, Aducio Thiesen, Julia J. Liu

9:06 #619

The Use of N-2-Butyl Cyanoacrylate As a Rescue Therapy for Re-Bleeding and Uncontrollable Bleeding from Esophageal Varices Wael Safwat

9:18 #620

Magnification Endoscopy Can Help in Improving Characterization of Visible Vessels in Peptic Ulcer Bleeding: A Pilot Study Livio Cipolletta, Gianluca Rotondano*, Maria A. Bianco, Riccardo Marmo, Fabio Cipolletta, Roberto Piscopo, Antonio Prisco, Stefano Sansone

S100 McCormick Place

Chairs: Sreenivasa S. Jonnalagadda, Paul P. Kortan BEYOND BREAD AND BUTTER CHOLANGIOGRAPHY 8:30 #610

Diagnostic Accuracy of a New Shortened Peroral Cholangioscope in Indeterminate Biliary Stricures and Filling Defects Christian Prinz*, Steffi Goeke, Andreas Weber, Alexander Meining, Roland M. Schmid, Eckart Frimberger

8:42 #611

It Looks Like Cholangiocarcinoma - But Is It? Cholangioscopy Using a Cholangioscopy System for Diagnosis of Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis Alexander Dechene*, Philip A. Hilgard, Amr El Fouly, Guido Gerken, Thomas Zoepf

S104 McCormick Place

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ORAL SESSIONS—SCIENTIFIC SESSIONS 9:30 #621

Long-Term Endoscopic Obliteration with Cyanoacrylate Glue for Isolated Gastric Variceal Bleeding - A 15-Year Prospective Evaluation Hiroaki Iwase*, Masaaki Shimada, Noboru Hirashima, Tomoyuki Tsuzuki, Hidemi Goto

9:42 Sp599

State-of-the-Art Lecture: Hemostasis in Endoscopy: It’s Much Better But Is the Best Yet to Come? Richard C.K. Wong

AGA Institute Committee Sponsored Symposium 8:30 AM - 12:00 PM E351 McCormick Place Chair: John F. Kuemmerle Sponsored by: Education & Training Committee

SSAT Plenary Session 10:00 AM - 11:15 AM Chairs: Richard A. Hodin, Rebecca M. Minter

BASIC SCIENCE PLENARY (PLENARY SESSION IV) Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 10:00 #622

Triptolide and Anti-Death Receptor 5: An Effective Combination That Activates Both the Intrinsic and Extrinsic Apoptotic Pathways in Pancreatic Cancer Cells Daniel Borja-Cacho*, Yumi Yokoyama, Rohit Chugh, Vikas Dudeja, Ashok K. Saluja, Selwyn M. Vickers

10:15 #623

Induced Expression of Interaction Molecule 1 (STIM1) Sensitizes Intestinal Epithelial Cells to Apoptosis By Modulating Store-Operated CA2+ Influx Jennifer A. Timmons*, Jaladanki N. Rao, Tongtong Zou, Lan Liu, Lan Xiao, Pengyuan Wang, Douglas J. Turner, JianYing Wang

10:30 #624

Influence of Colonic Bacteria On the Expression of Host Intestinal Tract Genes Which Regulate Water and Electrolyte Absorption Gail Cresci*, Muthusamy Thangaraju, Kebin Liu, John D. Mellinger, Vadivel Ganapathy

10:45 #625

Expression of Chemokine Receptor CCR9 in Pancreatic Intraepithelial Neoplasia and Its Progression to Invasive Cancer and Liver Metastasis Brian A. Mailey*, Xiaoming Shen, Joshua Khalili, Nicelio Sanchez-luege, Andrew M. Lowy, Joseph Kim

11:00 #626

Anti-ERBB2 SI- and sh-RNAs Suppress Cell Growth in ERBB2-Overexpressing Upper Gastrointestinal Adenocarcinomas Amanda K. Arrington*, Julia Davydova, Selwyn M. Vickers, Masato Yamamoto

ABIM MAINTENANCE OF CERTIFICATION PROGRAM MADE EASY Participants will be able to: • Obtain a thorough understanding of the requirements of the ABIM MOC program; • Comfortably complete ABIM MOC modules A4-E (07-01) and A4-F (08-01) after review of AGA Institute monographs; and • Discuss new and upcoming AGA Institute tools to facilitate MOC. 8:30 Sp600

GI SEP Module Completion John F. Kuemmerle, Jane E. Onken, C. Prakash Gyawali, Richard K. Sterling

SSAT Conference/Debate/Panel/Symposium 9:30 AM - 11:00 AM

S504 McCormick Place

Chairs: Thomas J. Howard, Mark P. Callery Sponsored by: AHPBA

SSAT/AHPBA JOINT SYMPOSIUM: MANAGING COMPLICATIONS OF ACUTE PANCREATITIS

T U E S D A Y JUNE 2

Participants will be able to: • Understand the important distinction between infected and sterile pancreatic necrosis and the current surgical approaches to management in each setting; • Recognize the radiographic and clinical characteristics of pancreatic pseudocysts that distinguish them from benign peripancreatic fluid collections and the rationale for deciding on therapeutic intervention; and • Decide the best treatment option— internal drainage or pancreatic resection—for the resolution of a pancreatic fistula from an isolated disconnected pancreatic segment. 9:30 Sp604

Introduction Mark P. Callery

9:35 Sp605

Infected Pancreatic Necrosis - Minimally Invasive Approaches Are Here, Are They Better? Karen D. Horvath

9:50 Sp606

Symptomatic Sterile Necrosis - Is Débridement Beneficial? Thomas E. Clancy

10:05 Sp607

Pancreatic Pseudocyst Drainage - When, How, and Most Importantly Why? Kevin E. Behrns

10:20 Sp608

Pancreatic Neck Necrosis with An Isolated Disconnected Segment - Resection or Drainage? William H. Nealon

10:35

Case Presentations

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S505a McCormick Place

SSAT Quick Shots 10:00 AM - 11:15 AM

S505b McCormick Place

Chairs: Wayne Frederick, Daniel J. Scott QUICK SHOTS SESSION I Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 10:00 #627

SELDI-TOF Mass Spectroscopy of Serum Predicts Hepatocellular Carcinoma in Patients Prior to Liver Transplantation C. Max Schmidt*, Lacey Dobrolecki, Avinash Agarwal, A Joseph Tector III, Michele T. Yip-Schneider, Jesus M. Matos, Robert J. Hickey

ORAL SESSIONS—SCIENTIFIC SESSIONS 10:06 #628

Selective Management of Patients with Acute Gallstone Pancreatitis Kimberly Bowman, Dana A. Telem*, John Hwang, Celia M. Divino

SSAT Video Session 10:00 AM - 11:15 AM

10:12 #629

Should Elective Repair of Intrathoracic Stomach Be Encouraged? Marek Polomsky*, Boris Sepesi, Matthew O’Connor, Alexi Matousek, Virginia R. Litle, Daniel Raymond, Carolyn E. Jones, Thomas J. Watson, Jeffrey H. Peters

Chairs: Brian J. Dunkin, Blair A. Jobe

10:18 #630

Laparoscopic Versus Open Liver Resection: A MatchedPair Case Control Study Kaori Ito*, Hiromichi Ito, William R. Jarnagin, Yuman Fong, Ronald P. DeMatteo, Michael D’Angelica

10:24 #631

Characteristics At Presentation and Oncologic Outcomes for IBD Patients with Colorectal Cancer Wisam Khoury*, Feza H. Remzi, Ian Lavery, James M. Church, Victor W. Fazio, Pokala R. Kiran

10:31 #632

Variation in Number of Lymph Nodes Assessed in Colorectal Cancer Resection: Surgeon, Pathologist, or Hospital? Hari Nathan*, Andrew D. Shore, Robert A. Anders, Susan L. Gearhart, Timothy M. Pawlik

S503 McCormick Place

VIDEO SESSION III: NOTES APPENDECTOMY - READY, SET.....GO? Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas. 10:00 #639

NOTES Transvaginal Appendectomy Santiago Horgan*, Lauren J. Fischer, Kari Thompson, Adam Spivack, Garth R. Jacobsen, Brian Wong, Mark A. Talamini

10:15 #640

Transrectal Endoscopic Appendectomy in a Cadaveric Model Sonia Ramamoorthy*, Adam Spivack, Kari Thompson, Lauren J. Fischer, Brian Wong, Santiago Horgan, Mark A. Talamini, Garth R. Jacobsen

10:30 #641

Transrectal Simulated Appendectomy in a Porcine Model with Novel Balloon Dilation in Retroperitoneum Sonia Ramamoorthy*, Garth R. Jacobsen, Kari Thompson, Adam Spivack, Lauren J. Fischer, Brian Wong, Mark A. Talamini, Santiago Horgan

10:37 #633

Laparoscopic Cholecystectomy in the UK: A Decade of Litigation Bilal Alkhaffaf*, Bart Decadt

10:43 #634

Angiotensin II Regulates the Expression of Monocyte Chemoattractant Protein-1 in Pancreatic Cancer Cells Navdeep Chehl, Galina Chipitsyna, Qiaoke Gong, Charles J. Yeo, Hwyda A. Arafat*

10:45 #642

Laparo-Endoscopic Single Site (LESS) Appendectomy with the Endoscope Kevin M. McGill*, Nikalesh Ippagunta, Glenn Forrester, Julio Teixeira, Steven Binenbaum

10:50 #635

Acute Pancreatitis (AP) in Aging Animals- Loss of PAP Protection? Sophia Fu*, Albert Stanek, Ehab Hassanain, Okiremute Oyiborhoro, Cathy M. Mueller, Nefertiti A. Brown, Chongmin Huan, Michael E. Zenilman

11:00 #643

Rigid and Flexible Trocars for NOTES Access in Human Anatomy Monika E. Hagen*, Oliver J. Wagner, Philippe Morel, Santiago Horgan, Mark A. Talamini, Paul Swain

10:56 #636

Role of Vagal Innervation in Diurnal Rhythm of Intestinal Peptide Transporter 1 (PEPT1) Hisham G. Qandeel*, Fernando Alonso, David J. Hernandez, Judith A. Duenes, Ye Zheng, Michael G. Sarr

11:02 #637

EP300 - A miRNA Regulated Metastasis Suppressor Gene in Ductal Adenocarcinomas of the Pancreas Soeren Torge Mees*, Wolf A. Mardin, Claudia Wendel, Nicole Baeumer, Edith Willscher, Norbert J. Senninger, Mario Colombo-Benkmann, Joerg Haier

11:08 #638

The Rate of Post Operative Infections Is Not Reduced By Peroperative Antibiotics in Elective Cholecystectomy. An Analysis of 10927 Operations Registered in the Swedish Register for Gallstone Surgery and ERCP (GallRiks) Gunnar Persson*, Patrik Lundstrom, Johanna Osterberg, Bodil Svennblad, Gabriel Sandblom

AASLD State-of-the-Art Lecture 10:30 AM - 11:30 AM

S106A McCormick Place

Chair: Hugo R. Rosen LIVER IMMUNOLOGY UPDATE: THE UNFOLDING MYSTERIES Participants will be able to: • Understand the basic role of cells of the innate and adaptive immune system in hepatitis and liver damage; • Understand how immune and parenchymal cells in the liver recognize bacterial and viral pathogens and endogenous danger signals through pattern recognition receptors and the relevance of these signals to inflammation and clinical liver disease; and • Appreciate immunotolerance in the liver and interactions between dendritic cells and T cell populations including regulatory T cells. 10:30 Sp609

Liver Immunology Update: The Unfolding Mysteries Gyongyi Szabo

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ORAL SESSIONS—SCIENTIFIC SESSIONS The Rome Foundation/AGA Institute Lectureship 10:30 AM - 11:30 AM E450B McCormick Place Chairs: Lin Chang, Douglas A. Drossman MOTILITY ASSESSMENTS FOR FUNCTIONAL GI DISORDERS: HOW FAR DOES IT GET US? Participants will be able to: • Review current motility tests used for functional gastrointestinal and motility disorders; • Discuss novel diagnostic techniques to assess gastrointestinal function which are applicable to functional gastrointestinal disorders; and • Discuss the utility of motility assessments in the diagnosis and management of these conditions from both a research and clinical practice perspective. 10:30 Sp610

Motility Assessments for Functional GI Disorders: How Far Does It Get Us? Juan R. Malagelada

DDW Combined Clinical Symposium 10:30 AM - 12:00 PM

B1 McCormick Place

Chairs: Mitchell L. Shiffman, Adrian M. Di Bisceglie Sponsored by: AASLD; AGA Institute; SSAT

MANAGEMENT OF HEPATITIS C NON-RESPONDERS AND RELAPSERS Participants will be able to: • Define patterns of non-response; and • Identify the role of viral suppression on inflammation and outcomes.

T U E S D A Y JUNE 2

11:14 Sp616

Inflammatory Bowel Disease Ralf Kiesslich

11:36 Sp617

Colorectal Neoplasia Roy M. Soetikno

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM

S406B McCormick Place

Chairs: Gary R. Lichtenstein, Thomas A. Ullman Sponsored by: Clinical Practice; Intestinal Disorders; Immunology, Microbiology & Inflammatory Bowel Diseases; Gastrointestinal Oncology

ULCERATIVE COLITIS: HAVE WE IMPROVED THE NATURAL HISTORY Participants will be able to: • Interpret data on the relationship between mucosal healing in ulcerative colitis and change in natural history including dysplasia and colectomy; • Integrate an algorithm for diagnosing and treating patients with severe ulcerative colitis including surgery and its outcomes; and • Differentiate the new endoscopic and DNA based technologies for the early detection of dysplasia and cancer in ulcerative colitis and when surgery is appropriate. 10:30 Sp618

Mucosal Healing in Ulcerative Colitis: Does It Change Outcomes? Maria T. Abreu

11:00 Sp619

Managing the Patient with Severe Ulcerative Colitis Asher Kornbluth

11:30 Sp620

Evolving Technologies for the Detection of Dysplasia and What to Do When You Find It David T. Rubin

10:30 Sp611

Approaches to Retreatment with Conventional Therapy Gregory T. Everson

10:50 Sp612

Is There Still a Role for Maintenance Therapy? Adrian M. Di Bisceglie

AGA Institute Committee Sponsored Symposium 10:30 AM - 12:00 PM S501BC McCormick Place

11:10 Sp613

Retreatment with Protease and Polymerase Inhibitors Paul Kwo

Chairs: Deborah D. Proctor, Suzanne Rose

11:30

Panel Discussion

Sponsored by: Womens Committee; Education & Training Committee

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM

S403 McCormick Place

Chairs: Marcia I. Canto, Norman S. Nishioka Sponsored by: Imaging & Advanced Technology; Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Growth, Development & Aging; Immunology, Microbiology & Inflammatory Bowel Diseases; Intestinal Disorders; Neurogastroenterology and Motility

IMAGING ADVANCES FOR GI DISEASE Participants will be able to: • Review emerging technologies for Barrett’s dysplasia detection; • Identify new information and recent advances in imaging technology; and • Discuss advances in esophageal imaging. 10:30 Sp614

Barrett’s Esophagus Roy K. Wong

10:52 Sp615

Celiac Disease Peter H. Green

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DIGESTIVE DISEASES AND HEALTH IN WOMEN Participants will be able to: • Assess the interaction of pregnancy with liver diseases and identify unusual liver diseases unique to pregnancy; • Review colon cancer screening in female patients; and • Determine how to better evaluate and manage fecal incontinence, pelvic pain and gynecological problems including endometriosis. 10:30 Sp621

Pregnancy and Liver Disease Rebecca W. Van Dyke

11:00 Sp622

Colon Cancer in Women Jennifer A. Christie

11:30 Sp623

Fecal Incontinence and Endometriosis of the GI Tract Asma Khapra

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Translational Symposium 10:30 AM - 12:00 PM

S502 McCormick Place

11:00 #646

Mortality and Liver Related Mortality in Patients with Chronic Liver Disease: Association with Components of Metabolic Syndrome (MS) Maria Stepanova, Nila Rafiq, Heshaam M. Mir, Ine-Mari Bornman, Zobair M. Younossi*

11:15 #647

Preventive Effects of Highly Purified Eicosapentaenoic Acid On Development of Steatosis and Hepatic Fibrosis Induced By a Methionine- and Choline-Deficient Diet in Rats Akiko Kawashima*, Tsuyoshi Harada, Satoshi Kajikawa, Kazunori Imada, Kiyoshi Mizuguchi

11:30 #648

Liver Specific L-FABP Knockdown Abrogates and Reverses High Fat Diet-Induced Obesity and Steatosis Elizabeth P. Newberry*, Susan Kennedy, Jianyang Luo, Roeaanne M. Crooke, Mark J. Graham, Nicholas O. Davidson

11:45 #649

Downregulation of Survivin Could Be a Potential Marker in Human Nonalcoholic Fatty Liver Disease (NAFLD) Progression? José T. Stefano*, Claudia P. Oliveira, Iberê C. Soares, Maria Lucia Correa-Giannella, Marcia S. Kubrusly, Marta BellodiPrivato, Vicencia M. Lima, Telesforo Bachella, Venancio A. Alves, Flair J. Carrilho

Chairs: James H. Grendell, Matthew J. DiMagno Sponsored by: Pancreatic Disorders; Gastrointestinal Oncology; Hormones, Transmitters, Growth Factors & Their Receptors; Nutrition & Obesity

EFFECTS OF NUTRIENTS ON THE PANCREAS Participants will be able to: • Describe the effects of TPN on pancreatic function; • Evaluate the effects of protein deficiency on the exocrine pancreas; and • State how nutritional support can be used to treat pancreatic diseases. 10:30 Sp624

Effects of Total Parenteral Nutrition On the Pancreas Guy E. Groblewski

11:00 Sp625

Protein Malnutrition and the Pancreas John A. Williams

11:30 Sp626

Nutritional Support in Human Pancreatitis Stephen J. O’Keefe

ASGE Clinical Symposium 10:30 AM - 12:00 PM

S101 McCormick Place

Chairs: William R. Brugge, Brenda J. Hoffman DECISION-MAKING IN PANCREATIC CYSTIC NEOPLASMS 10:30 Sp627

The Size of the Cyst Should Dominate Decision-Making R. Matthew Walsh

10:45 Sp628

Cyst Fluid Analysis Should Determine When to Resect a Cyst John M. DeWitt

11:00 Sp629

The Radiologic Appearance Is Key in Decision-Making Munazza Anis

11:15 Sp630

Resection of IPMN Should Be Based On Symptoms, Cytology and Cross-Sectional Imaging C. Max Schmidt

11:30

Questions & Answers

AASLD Topic Forum 10:30 AM - 12:00 PM

S105 McCormick Place

AGA Institute Research Forum 10:30 AM - 12:00 PM

Chairs: Jonathan A. Leighton, Willem J. de Villiers Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

ENDOSCOPY AND IMAGING TO EVALUATE CROHN’S DISEASE Participants will be able to: • Be familiar with the extent of exposure to ionizing radiation from imaging in IBD; • Be familiar with the utility of novel imaging methods to assess crohn’s disease, including small bowel ultrasound, CT and MR enterography, PET/CT; and • Be familiar with the cost-effectiveness and accuracy of wireless capsule endoscopy vs. imaging modalities in Crohn’s disease. 10:30 #650

Patients with IBD Are Exposed to Potentially Serious Excesses of Ionizing Radiation Karen Kroeker*, Simon Lam, Iain W. Birchall, Richard N. Fedorak

10:45 #651

Small Bowel Ultrasound and Computed Tomography Enterography: Characteristics of Bowel Wall and Mesenteric Tissue in the First Diagnosis of Ileal Crohn’s Disease Chiara Trattenero, Alessandra Losco*, Mirella Fraquelli, Laura Virginia Forzenigo, Valentina Sciola, Dario Conte, Guido Basilisco

Chairs: Mary E. Rinella, Stavra Xanthakos STEATOSIS AND STEATOHEPATITIS: CLINICAL AND EXPERIMENTAL 10:30 #644

Toll-Like Receptor (TLR) 9 Mediates Steatosis and Fibrosis Through Il1β in Diet-Induced Steatohepatitis in Mice Kouichi Miura*, Ekihiro Seki, Yuzo Kodama, Sayaka Inokuchi, David A. Brenner

10:45 #645

The Framingham Risk Score Accurately Predicts the Higher Risk of Coronary Heart Disease in Patients with Nonalcoholic Fatty Liver Disease Sombat Treeprasertsuk*, Paul Angulo, Leon A. Adams, Keith D. Lindor

S406A McCormick Place

11:00 #652

Ultrasound Assessment of the Degree of Transmural Lesions Predicts the Severity of Endoscopic Lesions of the Ileo-Colonic Anastomosis After “Curative” Ileal Resection in Crohn’s Disease Nadia Pallotta*, Fausto Barberani, Maurizio Giovannone, Alessandro Gigliozzi, Alfredo Covotta, Daria Piacentino, Naima Abdulkadir Hassan, Marilia Carabotti, Barbara Ciccantelli, Giuseppina Vincoli, Mauro Tosoni, Enrico Corazziari

11:15 #653

Cost-Effectiveness of Alternative Diagnostic Strategies for Patients with Suspected Small-Bowel Crohn’s Disease Barrett G. Levesque*, Lauren E. Cipriano, Steven L. Chang, Keane K. Lee, Douglas K. Owens, Alan M. Garber

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ORAL SESSIONS—SCIENTIFIC SESSIONS 11:30 #654

11:45 #655

Detection and Differentiation of Inflammatory Versus Fibromatous Crohn’s Disease Strictures -Results of a Prospective Comparison of 18F-FDG-PET/CT, MREnteroclysis and Transabdominal Ultrasound vs. Endoscopic/Histologic Evaluation Frank Lenze, Johannes Wessling, Janbernd Bremer, Hansjoerg Ullerich, Tilmann Spieker, Andreas Luegering, Sarid Gonschorrek, Jan Heidemann, Emile Rijcken, Wolfram W. Domschke, Torsten F. Kucharzik, Christian Maaser* Jejunal Lesions Seen By Wireless Capsule Endoscopy in Crohn’s Disease: Prevalence and Clinical Significance Caroline Trang*, Mathurin Flamant, Marc Le Rhun, Olivier Maillard, Sylvie Sacher-Huvelin, Jean-Paul Galmiche, Arnaud Bourreille

AGA Institute Research Forum 10:30 AM - 12:00 PM

S401A McCormick Place

AGA Institute Research Forum 10:30 AM - 12:00 PM Chairs: Gary D. Wu, Ralph A. Giannella Sponsored by: Intestinal Disorders

INTESTINAL MICROBIOTA Participants will be able to: • Examine novel technological applications that can be used to characterize the gut microbiome; • Examine new relationships between host metabolism and the gut microbiome; and • Review the role of the intestinal microbiome in host immune and barrier functions. 10:30 #662

High Fat Diet Determines the Composition of the Gut Microbiome Independent of Host Genotype and Phenotype Marie A. Hildebrandt*, Christian Hoffmann, Micah Hamady, Ying-Yu Chen, Rob Knight, Frederic D. Bushman, Rexford S. Ahima, Gary D. Wu

FECAL INCONTINENCE, ANORECTAL AND PELVIC FLOOR DISORDERS

10:45 #663

Participants will be able to: • Learn about mechanisms involved in the maintenance of rectal continence; • Learn about possible mechanisms involved in altered anorectal function in diabetes; and • Learn about mechanoelastic properties of the colorectum.

A Secreted Polysaccharide from Bifidobacterium Infantis 35624 Promotes Development of FOXP3+ T Regulatory Cells in Gnotobiotic Mice In Vivo. Liam O’Mahony*, David O’Mahony, Anne Lyons, David Groeger, Ray Grant, Linda Drummond, Frances O’Brien, Barry Kiely, Fergus Shanahan

11:00 #664

Sub-Therapeutic Antibiotic Treatment Alters the Murine Gut Microbiome and Affects Early-Life Metabolism and Body Composition Ilseung Cho*, Barbara Methe, Sean Raj, Yael R. Nobel, Martin J. Blaser

11:15 #665

The Role of the Intestinal Microbiota in Colonic Barrier Dysfunction Induced By Neonatal Stress Adam J. Moeser*, Anthony T. Blikslager, Susan L. Tonkonogy, Temitope O. Keku

11:30 #666

Molecular Detection of Bacterial Contamination in Gnotobiotic Rodent Units Christopher D. Packey*, Ian M. Carroll, Maureen A. Bower, Susan L. Tonkonogy, R. Balfour Sartor

11:45 #667

Temporal Stability of Faecal Microbiota By Inter Spacer rDNA Bacterial Profiling (IS-pro) Matthijs E. Grasman*, Andries E. Budding, Chris J. Mulder, Paul H. Savelkoul, Adriaan A. van Bodegraven

Chairs: Adil E. Bharucha, Jose Maria Remes Troche Sponsored by: Neurogastroenterology and Motility

10:30 #656

10:45 #657 11:00 #658

T U E S D A Y

S401BC McCormick Place

Tissue Characterisation and Strength of the Puborectalis Muscle in Women with Faecal Incontinence Dave R. Chatoor*, Anton V. Emmanuel, Richard Cohen, Enrico De Vita, Ernest B. Cady, Alan Bainbridge, Clive Bartram, Steve Halligan, Stuart A. Taylor Cyclooxygenase Type 1 (COX-1) As a Determinant of the Basal Tone in the Internal Anal Sphincter Satish C. Rattan*, Neeru Rattan, Marcio A. de Godoy Chronic Hyperglycemia in Diabetes Alters Electrophysiological Properties of a Subset of DRG Neurons in Rats. Implication in Disturbed Anorectal Functions in Diabetes Gintautas Grabauskas*, Chung Owyang

11:15 #659

Altered Rectal and Sigmoid Compliance in Upper and Lower Motor Neurone Spinal Cord Injury Prateesh M. Trivedi*, Paul Boulos, Michael D. Craggs, Anton V. Emmanuel

11:30 #660

Successful Implantation of Physiologically Functional Bioengineered Mouse Internal Anal Sphincter Shreya Raghavan*, Mohamed Hashish, Eiichi A. Miyasaka, Sita Somara, Robert R. Gilmont, Daniel H. Teitelbaum, Khalil N. Bitar

JUNE 2 11:45 #661

Do Rectoanal Pressures Predict Rectal Balloon Expulsion in Chronic Constipation? Karthik Ravi*, Alan R. Zinsmeister, Adil E. Bharucha

AGA Institute Research Forum 10:30 AM - 12:00 PM Chairs: Yoshio Yamaoka, Steven F. Moss

Sponsored by: Esophageal, Gastric & Duodenal Disorders

MICROBIAL FACTORS IN H. PYLORI PATHOGENESIS Participants will be able to: • Understand the bacterial factors that contribute to H. pylori-induced diseases. 10:30 #668

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S103D McCormick Place

Regulation of Urease Membrane Recruitment and Activation By the Cytoplasmic Histidine Kinase, HP0244 of Helicobacter pylori: A Rapid Response to Acidity George Sachs*, Yi Wen, Jing Feng, Siddharth Singh, Elizabeth A. Marcus, David R. Scott

ORAL SESSIONS—SCIENTIFIC SESSIONS 10:45 #669

11:00 #670

11:15 #671

H. pylori Peptide HP(2-20) Promotes Healing of Injured Gastric Mucosa By Interacting with Formyl-Peptyde Receptors Marco Romano*, Nella Prevete, Francesca W. Rossi, Felice Rivellese, Fiamma Salerno, Gabriele Delfino, Bianca Liccardo, Stefania Staibano, Giuseppe D’Argenio, Gianni Marone, Amato De Paulis cagA SHP2 Binding in Natural Infections By Western and East Asian Helicobacter pylori Strains Hiroaki Ogiwara, Mitsushige Sugimoto*, Ellen J. Beswick, Victor E. Reyes, David Y. Graham, Yoshio Yamaoka Increased L-Arginine Availability Enhances Helicobacter pylori Colonization in the Chronic Mouse Model Daniel P. Barry*, Mohammad Asim, Nuruddeen D. Lewis, Thibaut de Sablet, M. Blanca Piazuelo, Rupesh Chaturvedi, Keith T. Wilson

11:30 #672

Need for H. pylori Adhesins in Colonization of the Primate Stomach Hui Liu, Cristina Semino-Mora, D. Scott Merrell, Steven Mog, Thomas Borén, Andre Dubois*

11:45 Sp631

State-of-the-Art Overview John C. Atherton

AGA Institute Research Forum 10:30 AM - 12:00 PM

S401D McCormick Place

AGA Institute Research Forum 10:30 AM - 12:00 PM Chairs: Guy E. Boeckxstaens, Aiping Zhao

Sponsored by: Neurogastroenterology and Motility

NEUROIMMUNE REGULATION OF GUT FUNCTION Participants will be able to: • Examine the role of the autonomic nervous system in the regulation of intestinal inflammation; and • Examine mechanisms of the host immune response. 10:30 #679

Acetylcholine Drives Immature Dendritic Cells Towards An Anti-Inflammatory Phenotype via nAChR Activation Laurens Nijhuis*, Marleen Verstege, Monika Wolkers, Guy E. Boeckxstaens, Wouter J. de Jonge

10:45 #680

Elevated Chemokine mRNA in Rectal Mucosa Following Gastrointestinal Infection and in Irritable Bowel Syndrome Robin C. Spiller*, Klara Garsed, Joanne Cox, Fiona M. Kelly, Abed M. Zaitoun, George E. Dukes, Margaret Hastings, Keith R. Neal, Yashwant R. Mahida, Marguerite G. Richards, Ian Hall, Peter J. Whorwell, Jonathan I. Wilde

11:00 #681

Differential Immune and Genetic Responses Mediate Suppression of Circular Smooth Muscle Contractility in Rat Models of Crohn’s Colitis and Ulcerative Colitis Xuan-Zheng P. Shi*, Barun K. Choudhury, Sushil K. Sarna

11:15 #682

Enteric Neuronal Development As a Determinant of Intestinal Inflammation Kara J. Gross*, Nima Karamooz, Alcmène Chalazonitis, Ankur Ahuja, Zhishan Li, Sarah Carter, Michael D. Gershon

11:30 #683

Mast Cell Induced Bacterial Translocation in the Pathogenesis of Postoperative Ileus Susanne A. Snoek*, Oana I. Stanisor, Olaf Welting, Cornelis van ’t Veer, Rene M. van den Wijngaard, Guy E. Boeckxstaens, Wouter de Jonge

11:45 #684

Vagus Nerve Efferent Activity Enhances Bacterial Uptake and Potentiates TGF-Beta Signaling in Intestinal Lamina Propria Macrophages Wouter de Jonge*, Caroline Verseyden, Susanne A. Snoek, Kevin Lee, Rene M. van den Wijngaard, Guy E. Boeckxstaens

Chairs: Daniel C. Chung, Christopher S. Williams Sponsored by: Gastrointestinal Oncology

MICROENVIRONMENT AND REGULATORS OF TUMOR GROWTH IN GI CANCERS Participants will be able to: • Examine the role of the microenvironment and regulation of tumor growth in GI cancers. 10:30 #673

FHL2 Promotes Epithelial Mesenchymal Transition in Colon Cancer Through Modulating the Composition of E-Cadherin/β-Catenin Complex Wenjing Zhang*, Jide Wang, Bing Zou, Juan Ma, Qing Gu, Liang Qiao, Hui Y. Lan, Benjamin C.Y. Wong

10:45 #674

Interleukin-1β Induces COX-2 in Colonic Fibroblasts: Roles of Paracrine Amphiregulin and Autocrine PGE2 Reba Mustafi*, Hongyan Zhu, Apameh Pezeshk, Hardik B. Shah, Zhiqun Song, Loren J. Joseph, Maria Sibilia, Alessandro Fichera, Marc Bissonnette

S405 McCormick Place

AGA Institute Research Forum 10:30 AM - 12:00 PM

E350 McCormick Place

11:00 #675

Chromatin Remodeling Tumor Suppressor Inhibitor of Growth 2 (P33ING2) As a Novel Mediator of Transforming Growth Factor-β-Dependent Responses Hiromi Kataoka*, Takashi Joh, Karl Riabowol, Shirin Bonni

Chairs: Marcelo F. Vela, Michael F. Vaezi

11:15 #676

The β-Trcp Ubiquitin Ligase Targets PHLPP1 for Ubiquitin-Dependent Degradation Xin Li*, Jianyu Liu, Tianyan Gao

NEW INSIGHTS INTO EXTRAESOPHAGEAL GERD

11:30 #677

Claudin-1 Regulates E-Cadherin Expression Through ZEB-1 in Colon Cancer Amar B. Singh, Moorthy Krishnan, Robert D. Beauchamp, Punita Dhawan*

11:45 #678

A Novel Role for Cell Adhesion Signaling Molecule BVES in Colorectal Carcinoma Christopher S. Williams*, Jin-Long Yang, Sai H. Presley, Daniel O. Rosenblatt, Mary Kay Washington, Min Chang

JUNE 2

Sponsored by: Esophageal, Gastric & Duodenal Disorders

Participants will be able to: • Learn about new developments related to extra-esophageal GERD. 10:30 #685

T U E S D A Y

A Randomized Double-Blind Placebo-Controlled Study of Acid Suppression for Isolated Chronic Postnasal Drip Michael F. Vaezi*, David D. Hagaman, James C. Slaughter, S. Bobo Tanner, James A. Duncavage, Christine Allocco, Christy C. Sparkman, Lynn Clement, Cynthia M. Wasden, Dana C. Wirth, Marion Goutte, Barbara A. McCafferty, Farnoosh Farrokhi

P-99

ORAL SESSIONS—SCIENTIFIC SESSIONS 10:45 #686

A High Acid Reflux Recording During the Beginning of the Supine Period Is a Sleep Initiation Phenomenon Larissa M. Allen*, Isaac B. Malagon, Anita Gasiorowska, Tomas Navarro-Rodriguez, Choo Hean Poh, Jeannette Powers, Bridget Moty, Marcia R. Willis, Ronnie Fass

11:00 #687

Fundoplication in Patients with Extraesophageal Reflux (EER) Refractory to PPI Therapy: Trust Clinical Judgment Over Impedance or pH Christen M. Klochan*, James C. Slaughter, Eric P. Trawick, Michael Holzman, Michael F. Vaezi

AGA Institute Research Forum 10:30 AM - 12:00 PM

Effect of Gastric Juice from Patients “On” Acid Suppressive Therapy (PPI) On Human Bronchial Epithelial Cells Veerle Mertens*, Kathleen Blondeau, Ans Pauwels, Robin Vos, Bart M. Vanaudenaerde, Dirk E. Van Raemdonck, Geert M. Verleden, Lieven Dupont, Daniel Sifrim

Sponsored by: Hormones, Transmitters, Growth Factors & Their Receptors

Weakly Acidic Pharyngeal Gas Reflux and SwallowInduced Pharyngeal Acidic Reflux Are Incresed in Patients with Chronic Cough That Responds to PPI Osamu Kawamura*, Yasuyuki Shimoyama, Hiroko Hosaka, Atsuto Nagoshi, Hiroaki Zai, Motoyasu Kusano, Masatomo Mori

Participants will be able to: • Review the involvement of receptors and different mechanisms underlying intestinal inflammation.

11:15 #688

11:30 #689

11:45 #690

Conscious Arousals Associated with Acid Reflux Are Very Common During Sleep But Are Rarely Symptomatic Choo Hean Poh*, Larissa M. Allen, Anita Gasiorowska, Tomas Navarro-Rodriguez, Jeannette Powers, Bridget Moty, Marcia R. Willis, Ronnie Fass

AGA Institute Research Forum 10:30 AM - 12:00 PM

S402 McCormick Place

11:45 #696

RECEPTORS IN INTESTINAL INFLAMMATORY PROCESSES: IS THERE A COMMON SIGNALING PATHWAY?

10:30 #697

Extracellular Calcium-Sensing Receptor (CaSR) and CaSR-Mediated Wnt5a and Ror2 Inhibits TNFα Signaling in Macrophages, Colonic Myofibroblasts, and Epithelia Panida Lungchukiet, R. John MacLeod*

10:45 #698

Cartonectin (CORS-26) Suppresses Both Fibrotic and Inflammatory Responses of Primary Colonic Fibroblasts Isolated from Strictures of Crohn’s Disease Patients Ning Chen, Claudia Hofmann*, Manuela Stieber-Gunckel, Werner Falk, Jurgen Scholmerich, Christa Buechler, Andreas Schaeffler, Florian Obermeier

11:00 #699

The Role of Endothelin Converting Enzyme 1 (ECE1) in Intestinal Inflammation Fiore Cattaruzza, Gregory Gai, Long Hang, Daniel P. Poole, Arthur Blum, Graeme S. Cottrell, Tommy Setiawan, Mary Pat Moyer, Charalabos Pothoulakis, Joel V. Weinstock, Nigel W. Bunnett, Eileen F. Grady*

11:15 #700

Protease-Activated Receptor-4 (PAR4) Activation: Evidences for Its Role and Activation in the Pathogenesis of Colitis and in Inflammatory Bowel Diseases Perrine Rousset, Nicolas Cenac, Daniela Balz-Hara, Samuel Asfaha, Jose G. Ferraz, Paul L. Beck, Remo Panaccione, Janick Selves, Laurent Alric, Jean-Pierre Vinel, Nathalie Vergnolle*

11:30 #701

Protective Activity of Apelin On Experimentally-Induced Colitis Guiyun Wang, Ramendra K. Kundu, Song Han, Xiang Qi, Ella W. Englander, Thomas Quertermous, George H. Greeley* Jr.

11:45 #702

Transient Receptor Potential Ankyrin-1 (TRPA1) Has a Major Role in Visceral Pain Fiore Cattaruzza*, Walter E. Sipe, Eileen F. Grady, Nigel W. Bunnett

Sponsored by: Gastrointestinal Oncology

Participants will be able to: • Discover new potential approaches to therapy for GI cancers.

T U E S D A Y

10:30 #691

The Role of PPARγ Modulation in the Growth Inhibition of Hepatocellular Carcinoma Cells Jun Yu, Bo Shen, Shiyan Wang, Chung-Wah Wu, Cleo NY Lam, Hai Feng, Alfred S. Cheng, Henry Lik-Yuen Chan, Joseph J. Sung*

10:45 #692

Targeted Inhibition of CDK4 Enhances TGF-β Signaling and Suppresses Growth in Human Hepatocellular Cancer Cells, Possibly Through a Rescue in β-Spectrin (ELF) and SMAD3 Function. Shaoxian Yang, Majed El Zouhairi, Sang S. Kim, Anthony Kang, Bibhuti Mishra, Premkumar Reddy, Lopa Mishra, Michael Pishvaian*

JUNE 2 11:00 #693

A Novel Anti-CD24-Toxin Immunoconjugate for Targeted Therapy of Colorectal and Pancreatic Cancers Shiran Shapira, Sarah Kraus, Diana Kazanov, Assaf Shapira, Peter Altevogt, Itay Benhar, Nadir Arber*

11:15 #694

The Tubulin-Targeting Agent T0070907 Promotes Tubulin Degradation and Inactivates the TubulinSequestering Protein Stathmin/Op18 Gianni Harris, Katherine L. Schaefer*

11:30 #695

Sulforaphane Sensitizes Colorectal Cancer Cells to Oxaliplatin Induced Cell Growth Inhibition: Key Role of p38 MAPK Bettina M. Ecker*, Jurgen Stein, Sandra Ulrich

P-100

S501D McCormick Place

Chairs: Stephen A. Wank, Charalabos Pothoulakis

Chairs: Hidekazu Suzuki, Nadir Arber

NOVEL APPROACHES TO TREATMENT OF GI CANCERS

Resveratrol Sensitizes Colorectal Cancer Cells to Oxaliplatin-Induced Cell Death via Intracellular Polyamine Depletion Sandra Ulrich*, Jurgen Stein

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 10:30 AM - 12:00 PM

E352 McCormick Place

AGA Institute Topic Forum 10:30 AM - 12:00 PM

S404 McCormick Place

Chairs: Paul L. Beck, David G. Binion

Chairs: Douglas J. Robertson, Sameer D. Saini

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

Sponsored by: Clinical Practice; Gastrointestinal Oncology

REGULATION OF MUCOSAL IMMUNE RESPONSES AND MESENCHYMAL CELL FUNCTION Participants will be able to: • Identify and examine key information and recent advances in regulation of mucosal immune responses and mesenchymal cell function.

Reduction in LDL Cholesterol Levels During Statin Therapy Is Associated with a Reduced Incidence of Advanced Colon Polyps Mahir Patel, Amar Mahgoub, Stuart J. Spechler, Ali Siddiqui*, Hector E. Nazario

10:45 #710

Risk of Advanced Proximal Neoplasia (APN) Among 10,124 Index Screening Colonoscopies: Implications for Colorectal Cancer (CRC) Screening Thomas F. Imperiale*, Elizabeth A. Glowinski, Ching Y. Lin-Cooper, Brian J. Linder, Kristine Courtney, David F. Ransohoff

11:00 #711

Effect of Screening Colonoscopy On Colorectal Cancer Incidence and Mortality Charles J. Kahi*, Thomas F. Imperiale, Beth E. Juliar, Douglas K. Rex

11:15 #712

Mutations in the Microsomal Triglyceride Transfer Protein Lead to a Defect in CD1D-Restricted Antigen Presentation and Impaired Activation of Natural Killer T Cells in Patients with Abetalipoproteinemia Sebastian Zeissig*, Stephanie K. Dougan, Yvonne Junker, Zhangguo Chen, Xiuxu Chen, Susan Kennedy, Madelyn M. Ho, Hannah Mandel, Simon C. Yue, Jenny E. Gumperz, Mark A. Exley, Nicholas O. Davidson, Richard S. Blumberg

Flat Colonic Neoplasia Are Left Undetected By Fecal Immunochemical Tests (FIT) and Will Be Missed in Colorectal Cancer Screening Frank A. Oort*, Jochim S. Terhaar sive Droste, René W. van der Hulst, Henk van Heukelem, Ruud J. Loffeld, Eric C. Wesdorp, Quirinus J. Voorham, Gerrit A. Meijer, Chris J. Mulder

11:30 #713

Immunoregulatory Role of Increased PD-L1 Expression By Colonic Myofibroblasts/Fibroblasts in Ulcerative Colitis Iryna V. Pinchuk*, Jamal I. Saada, Sahil Mittal, Julia Brenmoehl, Suimin Qiu, Joseph H. Sellin, Gottumukkala S. Raju, Gerhard Rogler, Victor E. Reyes, Don W. Powell

False Negative Immunochemical Faecal Occult Blood Tests Due to Delayed Sample Return in Colorectal Cancer Screening. Leo G. van Rossum*, Anne Floortje van Rijn, Martijn G. van Oijen, Paul Fockens, Robert J. Laheij, Jan B. Jansen, Evelien Dekker

11:45 #714

Quantitative Colonoscopic Evaluation of Relative Efficiencies of a Quantified Immunochemical Fecal Occult Blood Test and a Sensitive Guaiac Test for Detecting Significant Colorectal Neoplasms Paul Rozen*, Zohar Levi, Rachel Hazazi, Amal Waked, Alex Vilkin, Eran Maoz, Shlomo Birkenfeld, Yaron Niv

Aberrant Antigen Presenting Cells Activate Effector T Cells and Inhibit Regulatory T Cell Function Deanna D. Nguyen*, Michelle Eston, Elisa K. Boden, Bayasi Guleng, Hans-Christian Reinecker, Scott B. Snapper

10:45 #704

Helminths Regulate Colitis and Protect from Fatal Acute Graft Versus Host Disease M. Nedim Ince*, Hung-lin Chen, Adrian N. Holm, Rami G. ElAbiad, Joseph F. Urban Jr., Paul B. Rothman, David E. Elliott

11:00 #705

Induction and Modulation of T Cell Regulatory Function By Intestinal Fibroblasts: Inhibitory Effect of Intestinal Inflammation Franco Scaldaferri*, Melanie Rhee, Florian Rieder, Anja Schirbel, Gail West, Sergio Rutella, Silvio Danese, Claudio Fiocchi

11:30 #707

11:45 #708

Participants will be able to: • Discuss factors effecting the yield of colorectal cancer screening; and • Be familiar with the limitations of current screening practices. 10:30 #709

10:30 #703

11:15 #706

EFFICACY AND YIELD OF COLORECTAL CANCER SCREENING

In-Vivo Detection By Confocal Endomicroscopy of Two Distinct Structural Abnormalities in Angioarchitecture and Increased Vascular Permeability in Colonic Mucosa of Patients with IBD in Remission: Mechanistic Implications. Andrzej S. Tarnawski*, Emmanuel Coron, Jean-François Mosnier, Amrita Ahluwalia, Marc Le Rhun, Jean-Paul Galmiche, Tamara Matysiak-Budnik

T U E S D A Y JUNE 2

P-101

ORAL SESSIONS—SCIENTIFIC SESSIONS 10:54 #723

A Prospective Randomized Controlled Trial (RCT) of Water Infusion in Lieu of Air Insufflation vs. Usual Air Insufflation in Scheduled Unsedated Colonoscopy in United States (US) Veterans Felix W. Leung*, Guy Jackson, Kate E. Okamoto, Omid M. Behbahani, Judith O. Harker, Nora J. Jamgotchian, H. S. Aharonian, Paul H. Guth, Surinder K. Mann, Joseph W. Leung

RECEPTORS AND INTESTINAL DISORDERS

11:06 #724

Participants will be able to: • Describe the role that muscarinic receptors play in the development of neoplasia; • Recognize various animal model systems that can be used to study cell signaling pathways important in the development of tumors; and • Examine pharmacologic approaches for the treatment of altered intestinal motility.

Can Quality Indicators for Colonoscopy Be Derived from Administrative Data? Identifying Predictors of New or Missed Cancers After Colonoscopy Nancy N. Baxter*, Rinku Sutradhar, Shawn Forbes, Lawrence Paszat, Refik Saskin, Linda Rabeneck

11:18 #725

Efficacy of Oblique Transparent Cap with Colonoscope for Trainees Analyzed with Magnetic Endoscope Imaging (MEI): A Preliminary Report Koichiro Sato*, Koichi Hirahata, Tsukasa Furuhata, Tadayoshi Kakemura, Sumio Fujinuma, Iruru Maetani

11:30 #726

Comprehensive Validation of the Boston Bowel Preparation Scale Audrey H. Calderwood*, Brian C. Jacobson

11:42 Sp632

State-of-the-Art Lecture: Achieving Quality At Colonoscopy Brian P. Saunders

AGA Institute Topic Forum 10:30 AM - 12:00 PM

E451A McCormick Place

Chairs: John P. Lynch, Karnam S. Murthy Sponsored by: Intestinal Disorders; Hormones, Transmitters, Growth Factors & Their Receptors

10:30 #715

10:45 #716

11:00 #717

T U E S D A Y JUNE 2

In the APCMIN/+ Murine Model of Intestinal Neoplasia, Both Tumor Formation and Perturbation of Cell Differentiation Require Expression of M3 Muscarinic Receptors (M3R) Jasleen Shant*, Kunrong Cheng, Guofeng Xie, Nirish Shah, Brian Shiu, Cinthia Drachenberg, Jean-Pierre Raufman Efficacy of Ipamorelin, a Novel Ghrelin Mimetic, in a Rat Model of Postoperative Ileus Kalina M. Venkova*, William Mann, Richard Nelson, Beverley Greenwood-Van Meerveld Calcium Mobilization Signaled By CXCL12 Regulates Integrin Activation and Cellular Migration in Intestinal Epithelial Cells Rebecca A. Vongsa*, Kimberle Agle, Michael B. Dwinell

11:15 #718

Intestinal Epithelial Cell (IEC)-Specific Deletion of Suppressor of Cytokine Signaling 3 (SOCS3) in Interleukin-10 Null Mice Promotes Duodenal Tumors Independent of Inflammation: Detection with a Cathepsin-B Activatable Molecular Probe Brooks Scull*, Rachael J. Rigby, Victoria A. Newton, Kathryn Hamilton, Douglas Morgan, Pauline K. Lund

11:30 #719

Characterization of Ductular Reaction in Azoxymethane (AOM)-Treated Mice: Role of M3 Muscarinic Receptors Nirish Shah*, Brian Shiu, Roxana Samimi, Cinthia Drachenberg, Jasleen Shant, Kunrong Cheng, Jean-Pierre Raufman, Sandeep Khurana

11:45 #720

The Absence of LPA2 Attenuates Tumor Formation in Both An Animal Model of Colitis-Associated Cancer and APCMIN/+ Mice Songbai Lin*, Amr Ghaleb, Hyunsuk Shim, Vincent W. Yang, Jerold Chun, C. Chris Yun

ASGE Topic Forum 10:30 AM - 12:00 PM

ASGE Topic Forum 10:30 AM - 12:00 PM

Chairs: V. Raman Muthusamy, Waqar A. Qureshi ENDOSCOPIC ALTERNATIVES TO SURGICAL THERAPY 10:30 #727

Randomized Comparative Trial of Transesophageal Endoscopic Versus Thoracoscopic Removal of Marked Mediastinal Lymphnodes in a Long-Term Animal Survival Study Annette Fritscher-Ravens*, Olufemi A. Olagbaiye, Christopher Holland, Amir Ghanbari, Klaus-Gerd Hadeler, Bjoern Jacobsen, Frauke Seehusen, Kesava R. Mannur

10:42 #728

Endoscopic Magnetic Anastomosis Device for Palliation of Malignant Gastric Outlet Obstruction: Short Term Results of a Prospective Multicenter Study Jeanin E. van Hooft*, Rogier P. Voermans, Jacques Devière, Olivier Le Moine, Peter D. Siersema, Frank P. Vleggaar, Alessandra Bizzotto, Guido Costamagna, Paul Fockens

10:54 #729

Use of a New Multi-Tasking Platform for Endoscopic Full Thickness Resection (EFTR) in a Porcine Model Keiichi Ikeda*, Kazuki Sumiyama, Hisao Tajiri

11:06 #730

T-Bar Assisted Endoscopic Submucosal Dissection (ESD): A New Technique Makoto Nishimura*, Susumu Shinoura, Reiko Ashida, Raman Muthusamy, John G. Lee, Kenneth J. Chang

11:18 #731

A Novel Lumenal Apposition Device for Therapeutic Endoscopy Kenneth F. Binmoeller*, Janak N. Shah, John Lunsford, Hoang G. Phan, Fiona Sander

11:30 #732

Endoscopic Closure of Duodenal Perforations By Means of An Over the Scope Clip (OTSC): A Randomized Controlled Porcine Study Daniel von Renteln, Hans U. Rudolph*, Arthur R. Schmidt, Maria Gieselmann, Tamara E. Gutmann, Karel Caca

11:42 Sp633

State-of-the-Art Lecture: The Gastroenterologist as Surgeon: What Do You Want to Be When You Grow Up? Pankaj J. Pasricha

S104 McCormick Place

Chairs: Jonathan Cohen, Russell D. Yang BEST PRACTICES: QUALITY IN COLONOSCOPY 10:30 #721

Optical Biopsy At Colonoscopy: Are We Ready? DISCARD Study: Early Results Ana Ignjatovic*, Noriko Suzuki, Maggie Vance, Thomas Guenther, Nicky Palmer, Brian P. Saunders

10:42 #722

More Large Polyps Are Seen On Screening Colonoscopy with Deep Sedation Compared with Moderate Conscious Sedation Katherine M. Hoda*, Jennifer L. Holub, Glenn M. Eisen

P-102

S103ABC McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS ASGE Topic Forum 10:30 AM - 12:00 PM

S102 McCormick Place

ASGE Poster Grand Rounds 12:15 PM - 1:00 PM Sp637

Chairs: Vivek Kaul, Reza Shaker

Biliary & Pancreatic ERCP Milton T. Smith

S102 McCormick Place

ESOPHAGEAL POTPOURRI 10:30 #733

First Clinical Experience of Submucosal Endoscopic Esophageal Myotomy for Esophageal Achalasia with No Skin Incision Haruhiro Inoue*, Hitomi Minami, Hitoshi Satodate, Shin-ei Kudo

10:42 #734

Predictive Factor of Local Recurrence After Endoscopic Resection of Large Esophageal Squamous Cell Carcinoma Ryu Ishihara*, Yoji Takeuchi, Noriya Uedo, Hiroyasu Iishi, Koji Higashino, Masaharu Tatsuta

10:54 #735

Long-Term Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Cell Neoplasms Satoshi Ono*, Mitsuhiro Fujishiro, Keiko Niimi, Osamu Goto, Shinya Kodashima, Nobutake Yamamichi, Masao Omata

11:06 #736

Erroneous EGD-Guided Placement of the pH Capsule Is Common - Time to Hold the Applause? Siva Doma*, Sushmita Palladugu, Henry P. Parkman, Frank K. Friedenberg

11:18 #737

Benign Refractory Esophageal Strictures: Preliminary Results from the BEST (Biodegradable Esophageal Stent) Study Alessandro Repici*, Frank P. Vleggaar, Alessandra Carlino, Petra G. van Boeckel, Fabio Romeo, Peter D. Siersema

11:30 #738

Complications of Long-Term Esophageal Stenting in the Management of Benign Perforations Nicoline C. van Heel*, Jelle Haringsma, Manon Spaander, Ernst J. Kuipers

11:42 Sp634

State-of-the-Art Lecture: New Horizons in Endoscopic Therapy Ram Chuttani

SSAT Address/Oration/Lecture 11:15 AM - 12:00 PM

S504 McCormick Place

MAJA AND FRANK G. MOODY STATE-OF-THE-ART LECTURE 11:15 Sp635

The Evolving Era of Surgeon Shortage George Sheldon

ASGE Hands-on Workshop 12:00 PM - 2:00 PM

Sp638

S103ABC McCormick Place

DDW Meet-the-Investigator Luncheons 12:30 PM - 1:45 PM

Participants will be able to: • Identify new scientific and clinical information relevant to digestive diseases; • Engage in scholarly and dynamic discussions of specific clinical topics; and • Engage in scholarly and dynamic discussions of specific investigative topics. Sp639

Interstitial Cells of Cajal: Form and Function (M29) CC10D Kenton M. Sanders

Hyatt Regency McCormick Sp640

Intestinal Microbial Pathogenesis (M30) Beth McCormick

CC10C Hyatt Regency McCormick

Sp641

Models of Pancreatic Carcinogenesis (M31) Craig D. Logsdon

CC10B Hyatt Regency McCormick

Sp642

Update On Liver Fibrosis (M32) Natalie Torok

CC12A Hyatt Regency McCormick

DDW Meet-the-Professor Luncheons 12:30 PM - 1:45 PM

Participants will be able to: • Identify new scientific and clinical information relevant to digestive diseases; • Engage in scholarly and dynamic discussions of specific clinical topics; and • Engage in scholarly and dynamic discussions of specific investigative topics. Sp643

Acute Liver Failure Management (M33) R. Todd Stravitz, Robert J. Fontana

CC10A Hyatt Regency McCormick

N228 McCormick Place

Chair: Herbert C. Wolfsen

Sp644

Sp645

ADVANCES IN ESOPHAGEAL THERAPIES 12:00 Sp636

Endoscopic Ultrasound (EUS) Mohamad A. Eloubeidi

Advances in Esophageal Therapies Marcia I. Canto, Gregory G. Ginsberg, Bruce D. Greenwald, Seth A. Gross, Ralf Kiesslich, Charles J. Lightdale, Drew B. Schembre, Michael B. Wallace, Louis-Michel Wong Kee Song

Sp646

Barrett’s Esophagus (M34) Richard E. Sampliner

S401A McCormick Place

Capsule Endoscopy Update (M35) Sponsored by the ASGE CE SIG Glenn M. Eisen

S401BC McCormick Place

Cochrane Guidelines for Management of UGI Bleeding (M36) Paul Moayyedi, Grigoris Leontidis CC20C

Hyatt Regency McCormick Sp647

Deep Enteroscopy: Balloons and Tubes (M37) Sponsored by the ASGE SBE SIG Drew B. Schembre

S401D McCormick Place P-103

T U E S D A Y JUNE 2

ORAL SESSIONS—SCIENTIFIC SESSIONS Sp648

Sp649

Difficult Esophageal Strictures (M38) Sponsored by the ASGE ETED SIG Janak N. Shah

Sp666

S402 McCormick Place

Emerging Treatments for Pediatric GI Motility and Functional Disorders (M39) Carlo Di Lorenzo, Shanthi Srinivasan CC12D

Technical Tricks to Avoid Anastomotic Complications in Colorectal Procedures (M56) Neil H. Hyman CC21A

Hyatt Regency McCormick Sp667

Treatment Strategies for NASH (M57) Paul Angulo, Leon A. Adams

CC12B Hyatt Regency McCormick

Hyatt Regency McCormick Sp650

Endoscopic Sedation Issues in 2009 (M40) Lawrence B. Cohen

CC23A Hyatt Regency McCormick

Sp651

Sp652

EUS in Chronic Pancreatitis (M41) Maurits J. Wiersema

S403 McCormick Place

Sp668

Sp669

Functional Disorders in Children (M43) Colin D. Rudolph

CC21C Hyatt Regency McCormick

Sp654

CC12C Hyatt Regency McCormick

Sp655

Hepatitis C: Treatment Strategies and Liver Transplantation (M45) F. Fred Poordad Improving Quality in Colonoscopy (M46) Douglas K. Rex

S501A McCormick Place

Sp657

Sp671

Lunch At the Movies: Colonoscopy (M48) Douglas B. Nelson

S501D McCormick Place

Sp659

T U E S D A Y

Lunch At the Movies: GI Bleeding (M49) Alan N. Barkun

S502 McCormick Place

Sp660

Management of Varices and Portal Hypertensive Bleeding: What’s New? (M50) Guadalupe Garcia-Tsao

S503 McCormick Place

Sp661

JUNE 2

Non-Pharmacologic Treatments for Functional GI Disorders (M51) Jeffrey M. Lackner, Kirsten Tillisch CC20B

Hyatt Regency McCormick Sp662

Sp663

NOTES® (M52) David W. Rattner, Patricia Sylla

S505b McCormick Place

Nutritional Issues in Inflammatory Bowel Disease (M53) CC20A Miguel A. Gassull

Hyatt Regency McCormick Sp664

Optimizing Efficiency of An Endoscopic Practice (M54) Sponsored by the ASGE AEC SIG Klaus Mergener, Frank J. Chapman CC22C

Hyatt Regency McCormick Sp665

P-104

Crohn’s Disease and Eosinophilic Esophagitis: What’s Going On? (LL10) Harland S. Winter CC24B

Hyatt Regency McCormick Sp672

Fluctuating Cholestasis in a 51 Year Old Man with Renal Transplant: A Diagnostic Dilemma (LL08) Helen M. Shields CC24A

Hyatt Regency McCormick

Laparoscopic Sleeve Gastrectomy for Obesity (M47) S501BC Paul T. Cirangle

McCormick Place Sp658

Colorectal Cancer Surveillance in Inflammatory Bowel Disease: Controversies and Management 2008 (LL06) Meeting Suite #3 Francis A. Farraye

Hyatt Regency McCormick

CC21B Hyatt Regency McCormick

Sp656

An Evidence Based Approach to the Management of Irritable Bowel Syndrome (LL09) Philip S. Schoenfeld Meeting Suite #4

Hyatt Regency McCormick Sp670

GI Neuroendocrine Tumors (M44) Daniel C. Chung

47 Year Old Patient with Dysplasia in Barrett’s Esophagus (LL07) Prateek Sharma, Peter Malfertheiner

CC24C Hyatt Regency McCormick

Extra-Esophageal Manifestations of GERD (M42) Michael F. Vaezi CC22A

Hyatt Regency McCormick Sp653

AGA Institute Problem-Based Learning Luncheons 12:30 PM - 1:45 PM

Short Gut Syndrome (M55) Brad W. Warner

CC22B Hyatt Regency McCormick

AGA Institute Curbside Consultant 12:30 PM - 2:00 PM

S103D McCormick Place

CURBSIDE CONSULTANT, DIFFICULT IBD CASES Participants will be able to: • Provide participants with a chance to answer specific questions and/ or seek clinical guidance in the management of a variety of complex gastrointestinal disorders; • Exchange educational and research information informally among gastroenterologists; and • Encourage camaraderie and academic and potential research ties between senior AGA consultants and AGA members and provide faculty with thought-provoking ideas for continued study and research; and inspire new gastroenterologists to the highest levels of professionalism. 12:30 Sp673

Curbside Consultant, Difficult IBD Cases Sunanda V. Kane

ASGE Fellows Luncheon ‡ 12:30 PM - 2:00 PM

Regency A Hyatt Regency McCormick

ASGE FELLOWS LUNCHEON Participants will be able to: • Engage in a roundtable discussion with ASGE governing board, training and membership committee members.

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute State-of-the-Art Lecture 2:15 PM - 3:15 PM

S503 McCormick Place

Chairs: Kim E. Barrett, Michael B. Dwinell Sponsored by: Intestinal Disorders; Esophageal, Gastric & Duodenal Disorders; Gastrointestinal Oncology; Growth, Development & Aging

EPITHELIAL ADHESION, POLARITY AND REPAIR Participants will be able to: • Define the importance of epithelial polarity in the function of the intestine; • Discuss new insights into the molecular mechanisms that establish and maintain epithelial polarity; and • Delineate how epithelial polarity is disrupted and/or restored, and disease implications; and, orientate the distribution of epithelial polarity signaling complexes and membrane traffic in threedimensional space. 2:15 Sp674

Epithelial Adhesion, Polarity and Repair W. James Nelson

DDW Combined Clinical Symposium 2:15 PM - 3:45 PM

B1 McCormick Place

Chairs: Robynne K. Chutkan, Neena S. Abraham Sponsored by: ASGE; AGA Institute; SSAT

3:25

Participants will be able to: • Articulate a rational, evidence-based management strategy for acute gastrointestinal and hepatologic emergencies; and • Appreciate changes in best practice recommendations for the acute management of gastrointestinal and hepatologic emergencies. 2:15 Sp675

Variceal and Nonvariceal Upper GI Bleeding Loren A. Laine

2:38 Sp676

Fulminant Colitis in the IBD Patient David T. Rubin

3:01 Sp677

Fulminant Hepatic Failure Norman L. Sussman

3:23 Sp678

Acute and Necrotizing Pancreatitis Grace H. Elta

Evolving Endoscopic Therapies for Morbid Obesity Steven A. Edmundowicz Case Discussion

AASLD Clinical Symposium 2:15 PM - 3:45 PM

S105 McCormick Place

Chairs: Kittichai Promrat, Hal F. Yee APPROACHES TO WEIGHT LOSS IN NASH: WHEN AND HOW AGGRESSIVE? Participants will be able to: • Become familiar with different approaches to weight loss; • Review current scientific evidence of the effects of weight loss on NASH; and • Provide evidence-based recommendations regarding weight loss techniques for patients with NASH. 2:15 Sp682

Overview of Weight Loss in NASH Hal F. Yee Jr.

2:30 Sp683

Lifestyle Intervention in the Management of NASH Kittichai Promrat

2:50 Sp684

Pharmaceutical Weight Loss for Management of NASH Dawn M. Torres

3:10 Sp685

Effect of Bariatric Surgery On NASH Raphael B. Merriman

3:30

911 FOR GASTROENTEROLOGISTS (GI EMERGENCIES)

DDW Combined Clinical Symposium 2:15 PM - 3:45 PM

3:05 Sp681

Panel Discussion

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM

S404 McCormick Place

Chairs: Jeffrey M. Marks, Richard I. Rothstein Sponsored by: Imaging & Advanced Technology; Clinical Practice; Esophageal, Gastric & Duodenal Disorders

ADVANCES IN NOTES Participants will be able to: • Examine the emerging field of NOTES; • Appreciate the opportunities for and limitations of NOTES; and • Explain the nuances of research and training in NOTES.

S100 McCormick Place

Chairs: Steven A. Edmundowicz, Christopher C. Thompson Sponsored by: ASGE; AGA Institute; SSAT

2:15 Sp686

Transition from Lab to Clinical Practice Anthony N. Kalloo

2:37 Sp687

Gathering Momentum or Moss? David W. Rattner

2:59 Sp688

Developing Tools for the Endoscopist Christopher J. Gostout

3:21 Sp689

State of the Art Lecture - NOTES 2009 Robert H. Hawes

JUNE 2

BARIATRICS FOR THE ENDOSCOPIST: BYPASSES, ROADBLOCKS AND DETOURS Participants will be able to: • Review endoscopic techniques and treatments for bariatic patients. 2:15 Sp679

Access Techniques to the Papilla and Excluded Stomach in Bariatric Patients Patrick I. Okolo III

2:35 Sp680

Endoscopic Management of Complications of Bariatric Surgery Christopher C. Thompson

T U E S D A Y

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ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Clinical Symposium 2:15 PM - 3:45 PM

S406B McCormick Place

AGA Institute Committee Sponsored Symposium ‡ 2:15 PM - 3:45 PM E351 McCormick Place

Chairs: John E. Pandolfino, Nicholas J. Shaheen

Chair: Ronald P. Fogel

Sponsored by: Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Neurogastroenterology and Motility

Sponsored by: Practice Management & Economics Committee; Public Affairs and Advocacy Committee; Clinical Practice & Quality Management Committee

CLINICAL CHALLENGES IN UGI DISORDERS Participants will be able to: • Discuss the management options for refractory GERD and extraesophageal symptoms; • Identify the pathophysiology of non obstructive dysphagia; and • Discuss the approaches to low grade dysplasia in Barrett’s Esophagus. 2:15 Sp690

When PPI Therapy Fails in GERD Patients Peter J. Kahrilas

2:37 Sp691

When Is Hoarseness Due to GERD Philip Katz

2:59 Sp692

What to Do with Low Grade Dysplasia in Barrett’s Esophagus John M. Inadomi

3:21 Sp693

How to Deal with Non Obstructive Dysphagia Ajay Bansal

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM

S406A McCormick Place

THE NEW ENVIRONMENT IN HEALTH CARE: A SURVIVAL GUIDE TO THE NEW ADMINISTRATION FOR GASTROENTEROLOGISTS Participants will be able to: • Discuss who in the new administration and in congress are making key decisions that affect GIS; • Review key issues affecting GI that are being proposed by the new administration and congress and how GIS can have an impact on these deliberations; and • Describe how to structure a GI practice in order to maximize the possibility of being economically viable in the future; and be aware of the activities and likely outcomes of other mechanisms and bodies that determine the reimbursement levels of GI services. 2:15 Sp697

The White House and Congressional Agendas: Threats and Opportunities for GI Ronald P. Fogel

2:33 Sp698

The Successful GI Practice of the Future John I. Allen

2:51 Sp699

Who’s Looking At You, Baby? How the RAC Process Will Change Our Lives Joel V. Brill

3:09 Sp700

AGA PAC and Your Role in Fighting for the Future of GI Ralph A. Giannella

3:27 Sp701

Who Are the New Powerbrokers in Health Care? Health Policy Advisor to the President of the U.S.

Chairs: James D. Lewis, Gilaad G. Kaplan Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases; Clinical Practice; Gastrointestinal Oncology; Intestinal Disorders

INFECTIONS IN IBD: DIAGNOSIS, CONSEQUENCES AND MANAGEMENT

T U E S D A Y JUNE 2

Participants will be able to: • Discuss the diagnosis and treatment of cytomegalovirus in exacerbations of inflammatory bowel disease; • Describe the evolving epidemiology of C. difficile infection in patients with Crohn’s disease and ulcerative colitis, and to review current approaches to diagnosis and treatment; and • Review current understanding of the role of Epstein-Barr virus infection in lymphomas arising in immune suppressed patients, including patients with inflammatory bowel disease. 2:15 Sp694

CMV in IBD: Pathogen or Innocent Bystander? Alan C. Moss

2:45 Sp695

C. difficile: Update On Epidemiology, Diagnosis and Treatment David G. Binion

3:15 Sp696

EBV and Lymphoma in Immune Suppressed Patients David Weinstock

P-106

AGA Institute Research Symposium 2:15 PM - 3:45 PM

S403 McCormick Place

Chairs: Dirk Haller, Sean P. Colgan Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases; Esophageal, Gastric & Duodenal Disorders; Gastrointestinal Oncology; Growth, Development & Aging; Intestinal Disorders

ENDOPLASMIC RETICULUM STRESS/UNFOLDED PROTEIN RESPONSES IN INTESTINAL INFLAMMATION Participants will be able to: • Discuss the physiologic role of ER stress/unfolded protein response; • Explain how defective ER stress/ UPR can lead to intestinal inflammation; and • State how MUC2 deficiency can lead to ER stress. 2:15 Sp702

Overview of the ER Stress/Unfolded Protein Response Ann-Hwee Lee

2:45 Sp703

Role of XBP1 in Intestinal Inflammation Richard S. Blumberg

3:15 Sp704

ER Stress Responses in MUC-2 Deficient Mice Michael A. McGuckin

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Symposium 2:15 PM - 3:45 PM

E352 McCormick Place

AGA Institute Translational Symposium 2:15 PM - 3:45 PM

E450B McCormick Place

Chairs: Lopa Mishra, Richard A. Hodin

Chairs: Detlef Schuppan, Peter H. Green

Sponsored by: Growth, Development & Aging; Esophageal, Gastric & Duodenal Disorders; Gastrointestinal Oncology; Intestinal Disorders

Sponsored by: Intestinal Disorders; Growth, Development & Aging; Nutrition & Obesity

THE MOLECULAR MECHANISMS OF CELL PATTERNING IN GASTROINTESTINAL DEVELOPMENT Participants will be able to: • Describe signaling pathways in cell patterning in gastric epithelium; • Explain the development of the esophageal epithelium; and • Discuss the role of APC/Wnt signaling on patterning in the intestine. 2:15 Sp705

Mechanisms of Anterior-Posterior Patterning of the GI Tract Klaus H. Kaestner

2:45 Sp706 3:15 Sp707

ADVANCES IN CELIAC DISEASE Participants will be able to: • Review an update on four major areas of celiac disease research, clinics and translational developments; • Assess where major advances have been achieved or will be achieved in the near future; and • Improve the diagnosis and management of patients with complicated celiac disease and participate in a wrap-up discussion with the four experts of this session. 2:15 Sp711

Innate Immunity Bana Jabri

Molecular Mechanisms of Development in the Gastric Epithelium Ramesh A. Shivdasani

2:37 Sp712

Transepithelial Gluten Transport Joerg D. Schulzke

APC/Wnt Signalling in Intestinal Patterning Sylvie Robine

2:59 Sp713

Refractory Celiac Disease/EATL Chris J. Mulder

3:21 Sp714

Novel Therapies Detlef Schuppan

AGA Institute Research Symposium 2:15 PM - 3:45 PM

S405 McCormick Place

Chairs: Barbara H. Jung, Mohammad A. Wehbi Sponsored by: Gastrointestinal Oncology; Clinical Practice; Imaging & Advanced Technology; Growth, Development & Aging

THE SERRATED POLYP PATHWAY IN COLORECTAL CANCER Participants will be able to: • Review the genetic pathogenesis of serrated adenomas; and • Discuss the histological differences between serrated polyps and other polyps. 2:15 Sp708

Molecular Pathogenesis of Serrated Polyps Barbara A. Leggett

2:45 Sp709

Histopathology of Serrated Lesions of the Colorectum: How Does One Tell? Henry D. Appelman

3:15 Sp710

Serrated vs. Hyperplastic Polyps: Risk for Colorectal Cancer Michael J. O’Brien

AGA Institute Translational Symposium 2:15 PM - 3:45 PM

S401BC McCormick Place

Chairs: Kenton M. Sanders, Tamas Ordog Sponsored by: Neurogastroenterology and Motility; Gastrointestinal Oncology; Growth, Development & Aging; Hormones, Transmitters, Growth Factors & Their Receptors; Intestinal Disorders; Esophageal, Gastric & Duodenal Disorders

DEVELOPMENT, REGENERATION AND NEOPLASIA OF INTERSTITIAL CELLS OF CAJAL (ICC) Participants will be able to: • Describe the development and regeneration of ICC as they pertain to intestinal motility disorders; • State the role of ICC in the development of gastrointestinal stromal tumors; and • Identify the role of ICC in intestinal motility disorders and certain GI tumors. 2:15 Sp715

Development of ICC In Vivo and from Embryonic Stem Cells Shigeko Torihashi

2:37 Sp716

ICC Turnover from Tissue Progenitors Tamas Ordog

2:59 Sp717

Regulation of ICC Proliferation Gianrico Farrugia

3:21 Sp718

Gastrointestinal Stromal Tumors Brian P. Rubin

P-107

T U E S D A Y JUNE 2

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Translational Symposium 2:15 PM - 3:45 PM

S501D McCormick Place

Chairs: Roberto De Giorgio, Bruno L. Bonaz

Chairs: David Shibata, Andrew M. Lowy

Sponsored by: Hormones, Transmitters, Growth Factors & Their Receptors; Esophageal, Gastric & Duodenal Disorders; Immunology, Microbiology & Inflammatory Bowel Diseases; Intestinal Disorders; Liver & Biliary; Neurogastroenterology and Motility; Nutrition & Obesity

CONTROVERSIES IN GI SURGERY B

ENDOCANNABINOIDS AS THERAPEUTIC TARGETS FOR GI DISORDERS AND ENERGY HOMEOSTASIS Participants will be able to: • Describe how endocannabinoids regulate gastrointestinal functions and energy homeostasis; • Explore the mechanisms underlying endocannabinoids modulation of intestinal inflammation; and • Discuss possible therapeutic applications of endocannabinoids in metabolic and GI disorders. 2:15 Sp719

Endocannabinoids As Modulators of Intestinal Inflammation Keith A. Sharkey

2:45 Sp720

Endocannabinoids and Energy Balance Daniele Piomelli

3:15 Sp721

Endocannabinoids and the Control of GI Functions George Kunos

ASGE Clinical Symposium 2:15 PM - 3:45 PM

S101 McCormick Place

CAPSULE ENDOSCOPY IN 2009: TOP TO BOTTOM

JUNE 2

S505b McCormick Place

Participants will be able to: • Debate 3: Discuss the advantages and disadvantages of simultaneous and staged approaches to the resection of synchronously diagnosed primary tumor and liver metastases for colorectal cancer; Discuss the use of systemic chemotherapy in the perioperative management of resectable synchronously diagnosed liver metastases from colorectal cancer; and Formulate treatment algorithms for the multidisciplinary management of resectable synchronously diagnosed colorectal cancer liver metastases; and • Debate 4: understand the group of patients with pancreatic cancer in whom surgery should be discussed; understand the potential benefits and drawbacks of surgical intervention for patients with pancreatic cancer; and define the role of surgery in the multimodality management of pancreatic cancer.

DEBATE 3: SYNCHRONOUS COLORECTAL CANCER LIVER METASTASES: SIMULTANEOUS VS. STAGED RESECTIONS 2:15 Sp729

Frame the Issue: Synchronous Colorectal Cancer Liver Metastases: Simultaneous vs. Staged Resections David Shibata

2:20 Sp730

Simultaneous Resections for Synchronous Colorectal Cancer Liver Metastases Michael D’Angelica

2:30 Sp731

Staged Resections for Synchronous Colorectal Cancer Liver Metastases Bryan M. Clary

2:40

Chairs: Simon K. Lo, Virender K. Sharma

T U E S D A Y

SSAT Conference/Debate/Panel/Symposium 2:15 PM - 3:45 PM

Panel and Audience Discussion

DEBATE 4: DO WE REALLY HELP PEOPLE WITH RESECTION FOR PANCREATIC CANCER?

2:15 Sp722

Esophageal and Colonic Capsules - Where Are We Today Otto S. Lin

3:00 Sp732

Frame the Issue: Do We Really Help People with Resection for Pancreatic Cancer? Andrew M. Lowy

2:35 Sp723

Small Bowel Capsule - Where Are We Today Virender K. Sharma

3:05 Sp733

Surgery Has a Major Impact Mark S. Talamonti

2:55 Sp724

Balloon Assisted Endoscopy - Where Are We Today Carol E. Semrad

3:15 Sp734

Surgery Has a Minimal Impact Douglas S. Tyler

3:15 Sp725

Capsule Imaging of the Whole Gut - Present and Future Simon K. Lo

3:25

Panel and Audience Discussion

3:35

AASLD Topic Forum 2:15 PM - 3:45 PM

Questions & Answers

ASGE Clinical Symposium 2:15 PM - 3:45 PM

S102 McCormick Place

Chairs: David A. Johnson, Klaus Mergener REAL ISSUES FOR CT COLONOGRAPHY 2:15 Sp726

CTC - Clinical Update and Review of CRC Screening Guidelines David A. Johnson

2:35 Sp727

Business Models, Reimbursement, and Regulatory Issues Klaus Mergener

2:55 Sp728

CTC - Training, Credentialing, and Related Legal Issues Brooks D. Cash

3:15

P-108

Questions & Answers

S106A McCormick Place

Chairs: David E. Kaplan, Kirti Shetty CLINICAL HEPATOBILIARY NEOPLASIA AND LIVER IMAGING 2:15 #739

Outcomes of Screening for Hepatocellular Carcinoma in the United States Jessica A. Davila*, Peter Richardson, Robert O. Morgan, Xianglin L. Du, Katherine A. McGlynn, Hashem B. El-Serag

2:30 #740

Hepatocellular Adenomas (HCA) Are Not All the Same: Analysis of 135 Surgically Treated Hca Cases According to the Phenotype Classification; the Bordeaux Experience Charles Balabaud*, Sandra Rebouissou, Hervé Laumonier, Gabrielle Cauchy, Cristophe Laurent, Antonio Sa Cunha, Jean-Frederic Blanc, Gaelle Cubel, Jean Saric, Hervé Trillaud, Jessica Zucman-Rossi, Paulette Bioulac-Sage

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:45 #742

Comorbidities and Treatment Practices of Patients Newly Diagnosed with Hepatocellular Carcinoma (HCC): A Retrospective Study Arun J. Sanyal*, Erick Moyneur, Victoria Barghout

AGA Institute Late-Breaking Abstract Session 2:15 PM - 3:45 PM E451B McCormick Place

3:00 #743

Intrahepatic Cholangiocarcinoma: Impact of Demographic Patterns On Increase in Frequency Ashwani K. Singal*, Jean-Nicolas Vauthey, John R. Stroehlein

Chairs: Glenn M. Eisen, Philip S. Schoenfeld

3:15 #744

Ultrasound-Guided Treatments Under Low Acoustic Power Contrast Harmonic Imaging with Sonazoid Is Effective for Hepatocellular Carcinomas Undetected By B-Mode Ultrasonography Hitoshi Maruyama*, Masanori Takahashi, Hiroyuki Ishibashi, Shinichiro Okabe, Masaharu Yoshikawa, Osamu Yokosuka

3:30 #745

The Role of Selective Internal Radiotherapy with Yttrium-90 Glass Microspheres in Advanced Hepatocellular Carcinoma +/- Portal Vein Thrombosis A European Pilot Phase II Study Amr El Fouly*, Judith Ertle, Gerald Antoch, Monia Hamami, Andreas Bockisch, Guido Gerken, Philip A. Hilgard

AASLD Topic Forum 2:15 PM - 3:45 PM

LATE BREAKING ABSTRACT FORUM Participants will be able to: • Receive information about the latest clinical trials examining new treatments for Clostridium difficile, hepatitis C and IBD, as well as new endoscopic techniques for detecting polyps in the right colon. 2:15 #751a

OPT-80 versus Vancomycin in Clostridium difficile Infection: Results of a Randomized Clinical Trial Mark Miller

2:30 #751b

Phase II Efficacy of Human Monoclonal Antibody Treatment to Prevent C. difficile Recurrence Israel Lowy

2:45 #751c

Effectiveness of the Third Eye Retroscope for Detecting Polyps in the Right Colon Jerome Waye

3:00 #751d

SVR Results of PROVE3, a Phase 2b Clinical Trial Assessing Safety and Efficacy of Telaprevir in Hepatitis C Genotype-1-Infected Patients with Prior Non-response, Viral Breakthrough or Relapse to Peginterferon-Alfa-2a/b and Ribavirin Therapy Adrian Di Bisceglie

3:15 #751e

Adalimumab Induces and Maintains Mucosal Healing in Patients with Moderate to Severe Ileocolonic Crohn’s Disease - First Results of the EXTENDED Trial Paul Rutgeerts

3:30 #751f

One Year Data from the SONIC Study: A Randomized, Double-Blind Trial Comparing Infliximab and Infliximab plus Azathioprine to Azathioprine in Patients with Crohn’s Disease Naïve to Immunomodulators and Biologic Therapy William Sandborn

S104 McCormick Place

Chairs: Daryl Lau, Stuart C. Gordon HEPATITIS C EPIDEMIOLOGY AND DIAGNOSIS 2:15 #746

2:30 #747

2:45 #748

3:00 #749

Impact of the Revised CDC Recommendations On HIV Testing of Patients with Chronic Hepatitis C Virus Infection Sameer Dhalla*, Craig Tenner, Edmund J. Bini Decision Making in Clinical Hepatology Using the 13C Methacetin Breath Test: Results of a 614 Patient Clinical Trial Gadi Lalazar*, Beat Müllhaupt, Tomer Adar, Oliver Goetze, Meir Mizrahi, Ehud Zigmond, Nilla Hemed, Mina Rowe, Yaron Ilan United States Multicenter Study of Ultrasonic TRANSIENT ELASTOGRAPHY (FibroScan) for the Diagnosis of Cirrhosis and Fibrosis in Patients with Hepatitis B and C Nezam H. Afdhal*, Bruce R. Bacon, Keyur Patel, Eric J. Lawitz, Stuart C. Gordon, David R. Nelson, Tracy Challies, Imad Nasser, John McHutchison Role of the Cirrhosis Risk Score (CRS) for the Prediction of Fibrosis Progression in Hepatitis C Patients with Minimal Liver Disease Pierre Pradat*, Eric Trépo, Andrej Potthoff, Rakesh Bakshi, Bradford Young, Robert Lagier, Christophe Moreno, Arnaud Lemmers, Thierry Gustot, Christian Trepo, Michael Adler, Heiner Wedemeyer

3:15 #750

Paired Biopsy Comparison of Two Liver Fibrosis Marker Panels (HCV FibroSure and HepaScore) in Following Histological Response to Antiviral Therapy for Chronic Hepatitis C (CHC) Alexander J. Thompson*, Laine Elliott, Hans L. Tillmann, John McHutchison, Keyur Patel

3:30 #751

CD4 Counts in HCV Monoinfected Patients:Relationship to Fibrosis and Pegylated Interferon Sara Rashkin, Susan Rouster, Kenneth E. Sherman*

AGA Institute Research Forum 2:15 PM - 3:45 PM

S402 McCormick Place

Chairs: Scott M. Tenner, Santhi Swaroop Vege Sponsored by: Pancreatic Disorders

CLINICAL CHRONIC PANCREATITIS Participants will be able to: • Understand the genetic predisposition and outcomes in chronic pancreatitis; and • Recognize the value and limitations of the diagnostic approaches to chronic pancreatitis. 2:15 #752

Total Pancreatectomy with Islet Cell Transplantation vs Intrathecal Narcotic Pump Infusion for the Control of Intractable Pain in Patients with Chronic Pancreatitis: A Case Control Series Mohamad Mokadem*, Thomas J. Howard, Lee McHenry Jr., Stuart Sherman, Evan L. Fogel, James L. Watkins, Glen A. Lehman

2:30 #753

Vitamin D Status in Chronic Pancreatitis Neeraj Prasad*, Peter Selby, Alistair J. Makin

P-109

T U E S D A Y JUNE 2

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:45 #754

Endoscopic Ultrasonography (EUS) of the Pancreas Predicts Pancreatic Exocrine Insufficiency (PEI) and Need for Enzyme Substitution Therapy in Patients with Chronic Pancreatitis (CP) Enrique Dominguez-Munoz*, Ana Alvarez-Castro, Jose Larino, Laura Nieto, Julio Iglesias-Garcia

3:00 #755

Immunosuppressive Therapy in Immunoglobulin G4Associated Systemic Disease (ISD): A Single Center Experience of 58 Patients Rahul Pannala*, Suresh T. Chari, Jonathan E. Clain, Michael J. Levy, Randall K. Pearson, Santhi Swaroop Vege, Mark D. Topazian, Thomas C. Smyrk, Naoki Takahashi, Thomas E. Witzig

3:15 #756

3:30 #757

Symptoms Are Earlier from Generation to Generation in Patients with Hereditary Pancreatitis (HP) Vinciane Rebours*, Olivia Hentic, Frédérique Maire, Cédric Le Maréchal, Claude Férec, Pascal Hammel, Philippe B. Ruszniewski, Philippe Levy Genetic and Phenotypic Characterization of Patients with Chronic or Recurrent “Genetic” Pancreatitis Coralie Hamoir, Xavier Pepermans, Karin Dahan, Pierre H. Deprez*

AGA Institute Research Forum 2:15 PM - 3:45 PM

3:30 #763

AGA Institute Research Forum 2:15 PM - 3:45 PM

Sponsored by: Neurogastroenterology and Motility

Sponsored by: Gastrointestinal Oncology

GENETIC SUSCEPTIBILITY AND POLYMORPHISMS IN GI CANCERS Participants will be able to: • Understand the role of genetic polypmorphisms and genotypes in GI cancers. 2:15 #764

Causal Relationship Between Loss of β-Spectrin (ELF), Its TGF-β Signaling Adaptor Function and a Hereditary Human Gastrointestinal Cancer Syndrome: Beckwith Wiedemann Syndrome (BWS) Zhixing Yao*, Wilma S. Jogunoori, Geeta Upadhyay, Wenguo Yao, Bibhuti Mishra, Lopa Mishra

2:30 #765

Sprouty-2 Is Up-Regulated in Human Colon Cancers and Functions As An Oncogene: Role of C-MET Cory Holgren, Urszula Dougherty, Francis Edwin, Dario Cerasi, Ieva Taylor, Alessandro Fichera, Marc Bissonnette, Sharad Khare*

2:45 #766

The Overexpression of the Thyroid Hormone Receptor Trα1 in the Mouse Intestinal Epithelium Leads to Tumor Development Elsa Kress, Michela Plateroti*

3:00 #767

Genotype-Phenotype Correlation of Genetic Susceptibility Variants Identified Through Genome-Wide Association Studies for Colorectal Cancer Anna Abulí*, Xavier Bessa, Clara Ruiz-Ponte, Ceres Fernandez-Rozadilla, Angel Carracedo, Lucas Ilzarbe, Xavier Llor, Rodrigo Jover, Jenifer Muñoz, Antoni Castells, Sergi Castellvi-Bel, Montserrat Andreu

3:15 #768

Novel SNP Associations with Colorectal Cancer On 8q24 and 5q in African and European Americans Sonia Kupfer*, Jada Benn Torres, Stanley Hooker Jr., Jeffrey R. Anderson, Nathan A. Ellis, Rick Kittles

3:30 #769

Effect of Polymorphisms in the 3’ Untranslated Region (3’-UTR) of Vascular Endothelial Growth Factor (VEGF)Gene On Gastric Carcinogenesis in Japanese Population Tomomitsu Tahara*, Tomoyuki Shibata, Ichiro Hirata, Tomiyasu Arisawa

FUNCTIONAL GI DISORDERS: PSYCHOSOCIAL AND PSYCHOTHERAPY Participants will be able to: • Examine the relationship of depression and irritable bowel syndrome; • Discuss the role of the hypothalamic pituitary adrenal axis in IBS; and • Review the role of early life and adult stress on IBS. 2:15 #758

T U E S D A Y JUNE 2

2:30 #759

Early Adverse Life Events Are Associated with Increased Responsiveness of the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Individuals with and Without IBS Mopelola A. Adeyemo, Elizabeth J. Videlock*, Minou Mayer, Gordon V. Ohning, Arlene Licudine, Emeran A. Mayer, Lin Chang Determinants of Comorbid IBS and Chronic Fatigue in Functional Dyspepsia: Gastric Sensorimotor Function, Psychosocial Factors and Somatization? Lukas Van Oudenhove*, Lieselot Holvoet, Rita Vos, Raf Bisschops, Joris Arts, Philip Caenepeel, Dominiek De Wulf, Koen Demyttenaere, Jan F. Tack

2:45 #760

Expressive Writing Is a Promising Therapeutic Modality for Irritable Bowel Syndrome (IBS) Albena Halpert*, Denis Rybin

3:00 #761

Chronic Abdominal Pain Predicts Suicidality in Adolescents Independent of Depression Miranda A. Van Tilburg*, Naomi J. Spence, David Goldston, William E. Whitehead

3:15 #762

Symptom Attitudes and Beliefs Predict Severity and Quality of Life in Irritable Bowel Syndrome and Partially Mediate the Effect of Depression On Quality of Life Elizabeth J. Videlock*, Bruce D. Naliboff, Emeran A. Mayer, Lin Chang

P-110

S401A McCormick Place

Chairs: Andrew T. Chan, Temitope O. Keku

S502 McCormick Place

Chairs: Lukas Van Oudenhove, Peter J. Whorwell

A History of Sexual Abuse and Catastrophizing Have An Impact On IBS Symptom Severity That Is Unrelated to Psychological Distress Motoyori Kanazawa*, Olafur S. Palsson, Miranda A. Van Tilburg, Marsha J. Turner, Syed Ismail M. Thiwan, Lisa M. Gangarosa, Denesh K. Chitkara, Shin Fukudo, Douglas A. Drossman, William E. Whitehead

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 2:15 PM - 3:45 PM

E350 McCormick Place

2:45 #778

Cytokeratin Assisted Laser Scanning Cytometry (LSC) Permits Fully Automated Detection of Aneuploidy in Fixed Barrett’s Biopsies Ajay Bansal*, Joyce G. Slusser, Sharad C. Mathur, Amit Rastogi, Sachin B. Wani, Vikas Singh, Mandeep Singh, Prateek Sharma

3:00 #779

Targeting of Intra-Epithelial Neoplasia in Barrett’s Esophagus with Fluorescence-Labeled Peptide Yong M. Kwon*, Cyrus R. Piraka, Richard S. Kwon, Henry D. Appelman, Thomas D. Wang

3:15 #780

Quantitative In Vivo Assessment of Vascular Permeability in Human Colonic Mucosa Using Confocal Endomicroscopy: Clinical Implications for Colonic Neoplasia Tamara Matysiak-Budnik*, Emmanuel Coron, Jean-François Mosnier, Marc Le Rhun, Jean-Paul Galmiche, Amrita Ahluwalia, Andrzej S. Tarnawski

3:30 Sp741

State-of-the-Art Overview Herbert C. Wolfsen

Chairs: Radu Tutuian, Ikuo Hirano Sponsored by: Esophageal, Gastric & Duodenal Disorders

GERD TREATMENT: BEYOND PPI Participants will be able to: • Review current advances in pharmacological treatment of GERD. 2:15 #770

Effect of Single Doses of Capromorelin and Ghrelin On Esophageal Reflux Parameters and Esophageal Function: A Randomized, Double-Blind, Placebo-Controlled Study Amit Agrawal*, Jeremy D. Gale, Neeraj Sharma, Wojciech Blonski, Kate Hargreaves, Richard Allan, Janice Freeman, Donald O. Castell

2:30 #771

Influence of Baclofen On the Postprandial Acid Pocket At the Gastro-Esophageal Junction Emidio Scarpellini*, Rita Vos, Raf Bisschops, Dominiek De Wulf, Jan F. Tack

2:45 #772

Effect of AZD3355, a Novel GABAB Receptor Agonist, On Transient Lower Esophageal Sphincter Relaxations in Healthy Subjects Guy E. Boeckxstaens*, Hans Rydholm, John Adler, Magnus Ruth

3:00 #773

Does the Presence of a Hiatal Hernia Affects the Efficacy of the Reflux Inhibitor Baclofen? Hanneke Beaumont*, Guy E. Boeckxstaens

3:15 #774

Effect of mGluR5 Inhibition with ADX10059, On Day and Night Time Reflux and Clinical Symptoms, in Patients with Gastro-Esophageal Reflux Disease (GERD): A Proof of Concept Study Charlotte Keywood*, Jan F. Tack

3:30 #775

Influence of the Cannabinoid Type 1 Receptor Antagonist Rimonabant On Esophageal Function in Man Emidio Scarpellini*, Rita Vos, Pieter Vanden Berghe, Jan F. Tack

AGA Institute Research Forum 2:15 PM - 3:45 PM

E451A McCormick Place

AGA Institute Research Forum 2:15 PM - 3:45 PM Chairs: Francis K. L. Chan, Francis Megraud

Sponsored by: Esophageal, Gastric & Duodenal Disorders

UNIQUE APPROACHES TO MANAGEMENT OF HELICOBACTER PYLORI-ASSOCIATED CARCINOGENESIS AND EXTRA-GASTRIC DISEASES Participants will be able to: • Understand the relationship between H. pylori and systemic illness; and • Review research about H. pylori and cancer that develops exogenous to the gastric niche. 2:15 #781

Effect of Celecoxib On the Suppression of Gastric LowGrade MALT Lymphoma Induced By Helicobacter heilmannii Infection Masahiko Nakamura*, Tetsufumi Takahashi, Hidenori Matsui, Shin’ichi Takahashi, Toshifumi Hibi, Kanji Tsuchimoto

2:30 #782

The Platelet Count Increase Associated with H. pylori Eradication Is Accomplished By a Reversal of TH1 Cytokine Profile Dulciene M. Queiroz*, Andreia Maria C. Rocha, Fabricio F. Melo, Gifone A. Rocha, Cláudia Souza, Isadora S. Saraiva, Marília C. Marino, Nelma C. Clementino

2:45 #783

H. pylori Infection Is As Important in Proximal As in Distal Gastric Cancer Jan Bornschein*, Michael Selgrad, Maren Warnecke, Doerthe Kuester, Thomas Wex, Peter Malfertheiner

Chairs: Nalini M. Guda, Brian C. Jacobson Sponsored by: Imaging & Advanced Technology

IMAGE-BASED DETECTION OF MALIGNANCY Participants will be able to: • Identify new information and recent advances in image-based detection of malignancy; and • Review novel imaging techniques for early and enchanced malignancy diagnosis. 2:15 #776

Novel Fluorescence-Labeled Peptide for Targeting IntraEpithelial Neoplasia in Barrett’s Esophagus Meng Li*, Chris M. Komarck, Yong M. Kwon, Thomas D. Wang

2:30 #777

Label-Free Nuclear Morphology Measurements of Dysplasia in the Egda Rat Model Using Angle-Resolved Low Coherence Interferometry Adam Wax*, Yizheng Zhu, Neil G. Terry, Xiaoxin L. Chen, Steven C. Gebhart, William J. Brown

S501A McCormick Place

3:00 #784

Suppression of Lymphangiogenesis By Flt-4 Antibody in Gastric Low-Grade MALT Lymphoma Induces Tumor Regression Masahiko Nakamura*, Tetsufumi Takahashi, Hidenori Matsui, Shin’ichi Takahashi, Kanji Tsuchimoto

3:15 #785

Study of the Seroconversion of Helicobacter pylori Infection Among US Military Deployed in Operation Iraqi Freedom Ruben D. Acosta*, Jayde E. Kurland, Stephanie Sincock, Cara H. Olsen, Andre Dubois

3:30 Sp742

State-of-the-Art Overview Kenneth E. McColl

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T U E S D A Y JUNE 2

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 2:15 PM - 3:45 PM

S401D McCormick Place

2:27 #793

Utility of Endoscopic Retrograde Pancreatogram (ERP) to Diagnose Autoimmune Pancreatitis (AIP): An International, Double Blind, Randomized, Multicenter Study Aravind Sugumar*, Michael J. Levy, Terumi Kamisawa, Myung-Hwan Kim, Felicity Enders, Zahir Amin, Todd H. Baron, Michael H. Chapman, Nicholas I. Church, Jonathan E. Clain, Naoto Egawa, Gavin J. Johnson, Kazuichi Okazaki, Randall K. Pearson, Stephen P. Pereira, Bret T. Petersen, Samantha Read, Raghuwansh P. Sah, Neomal S. Sandanayake, Naoki Takahashi, Mark D. Topazian, Kazushige Uchida, Santhi Swaroop Vege, George Webster, Suresh T. Chari

2:39 #794

The Therapeutic Strategy for Autoimmune Pancreatitis Is Subject to Endoscopic Features of the Duodenal Papilla kensuke kubota*, Shingo Kato, Noritoshi Kobayashi, Atsushi Nakajima

2:51 #795

Idiopathic Recurrent Pancreatitis (IRP): Long Term Success of Pancreatic Endotherapy Marc F. Catalano*, Michael H. Lee, Vivaik Tyagi, Nalini M. Guda, Roberto M. Gamarra, Joseph E. Geenen

3:03 #796

Pancreatic Stent-Induced Ductal Injury: Clinical Presentation and Outcomes of Endoscopic Therapy Yan Bakman*, Martin L. Freeman

3:15 #797

A Randomized, Controlled, Double-Blind Trial of Air vs Carbon Dioxide Insufflation During ERCP Evan S. Dellon*, Arumugam Velayudham, Bridger W. Clarke, Kim L. Isaacs, Lisa M. Gangarosa, Joseph Galanko, Ian S. Grimm

3:27 Sp743

State-of-the-Art Lecture: To Stent or Not to Stent: Is There Still a Question? Evan L. Fogel

Chairs: Mitchell L. Schubert, Duan Chen Sponsored by: Esophageal, Gastric & Duodenal Disorders; Hormones, Transmitters, Growth Factors & Their Receptors

REGULATION OF GASTRODUODENAL BICARBONATE SECRETION Participants will be able to: • Understand transport mechanisms that regulate bicarbonate secretion. 2:15 #786

2:30 #787

2:45 #788

3:00 #789

3:15 #790

T U E S D A Y JUNE 2

3:30 #791

NBCn1 (Slc4a7) Is a Major HCO3- Importer in Murine Duodenum and Essential for Basal and Stimulated HCO3- Secretion In Vivo Mingmin Chen*, Jeppe Praetorius, Wen Zheng, Jian Wang, Nicole Stieger, Brigitte Riederer, Anja Krabbenhöft, Janina Bonhagen, Brigitte Rausch, Regina Engelhardt, Ulrike Dringenberg, Christian Aalkjaer, Ursula E. Seidler Deletion of the Chloride/Base Exchanger Slc26a7 Impairs Gastric Acid Secretion and Causes Distal Renal Tubular Acidosis Jie Xu, Penghong Song, Suguru Nakamura, Marian L. Miller, Sharon Barone, Seth L. Alper, Hassane Amlal, Ursula Seidler, Manoocher Soleimani* Effect of Genetic Ablation of the Acid/Base Transporters PNBC1, NHE1, NHE2, and Slc26a7, On Gastric Epithelial Functions Penghong Song, Zhe Feng, Brigitte Riederer, Anja Krabbenhöft, Brigitte Rausch, Matthias Anstätt, Heike Bantel, Jutta Lamlé, Arndt Vogel, Manoocher Soleimani, Gary E. Shull, Marian L. Miller, Ursula Seidler* Gender Difference in Duodenal HCO3- Response to Mucosal Acidification in Rats: Importance of UpRegulation of ASIC3 By Estradiol Yumi Ohashi, Hironori Takasuka*, Kento Takahashi, Eitaro Aihara, Koji Takeuchi

ASGE Topic Forum 2:15 PM - 3:45 PM

Muscarinic Acetylcholine Receptor Subtypes Involved in Carbachol-Induced HCO3- Secretion in Mouse Duodenum In Vitro Kento Takahashi*, Kazutomo Kita, Eitaro Aihara, Shusaku Hayashi, Minoru Matsui, Koji Takeuchi

INTERVENTIONAL EUS OUTCOMES - HERE’S THE BEEF

Paradoxical Transcriptional Activation of the Secretin Gene By the Co-Repressor Protein, CtBP Subir K. Ray*, Joyce Li, Andrew B. Leiter

ASGE Topic Forum 2:15 PM - 3:45 PM

S103D McCormick Place

Chairs: Kenneth J. Chang, Asif Khalid

2:15 #798

Enhanced Harmonic Endoscopic Ultrasonography for Assessment of Pancreaticobiliary Malignancies Kazuki Sumiyama*, Hiroo Imazu, Hisao Tajiri

2:27 #799

EUS-Guided Ethanol Lavage with Paclitaxel Injection (EUS-EP) for Cystic Tumors of the Pancreas (CTP): Long-Term (More Than One Year) Follow-Up Hyoung-Chul Oh*, Dong Wan Seo, Tae Jun Song, SungHoon Moon, Do Hyun Park, Sang Soo Lee, Sung Koo Lee, Myung-Hwan Kim

2:39 #800

Accuracy of Endoscopic Ultrasound (EUS), Endobronchial Ultrasound (EBUS), and Bronchoscopy (TBNA) Guided Fine Needle Aspiration (FNA) in Patients with Enlarged Anterior vs. Posterior Mediastinal Lymph Nodes Noelia Cubero de Frutos, Laith H. Jamil*, Kanwar R. Gill, Seth A. Gross, Jorge M. Pascual, Massimo Raimondo, Timothy A. Woodward, Julia Crook, Michael G. Heckman, John Odell, Michael B. Wallace

2:51 #801

EUS-Guided Biliary Drainage with One-Step Placement of Newly Designed Fully Covered Metal Stent for Malignant Biliary Obstruction: A Prospective Feasibility Study Do Hyun Park*, Sung-Hoon Moon, Sang Soo Lee, Dong Wan Seo, Sung Koo Lee, Myung-Hwan Kim

Chairs: Kenneth F. Binmoeller, Evan L. Fogel CONTROVERSIAL ISSUES IN PANCREATIC ENDOTHERAPY 2:15 #792

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Endoscopic Pancreatic Sphincterotomy and Stenting for Preoperative Prophylaxis of Pancreatic Fistula After Distal Pancreatectomy Bernhard Rieder*, Daniel Krampulz, Jost Adolf, Albrecht Pfeiffer

S103ABC McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS 3:03 #802

Single-Operator EUS-Guided Cholangiopancreatography (EUSCP) for Difficult Pancreaticobiliary Access: A Single Center’s 5-Year Experience Brian C. Brauer*, Yang K. Chen, Norio Fukami, Roy Yen, Daniel A. Ringold, Raj J. Shah

3:15 #803

Is Endoscopic Ultrasound Guided Brachytherapy (EUSBrTx) Useful for the Treatment of Recurrent Malignant Lymph Nodes? Reiko Ashida*, Susumu Shinoura, Makoto Nishimura, Raman Muthusamy, John G. Lee, Kenneth J. Chang

3:27 Sp744

State-of-the-Art Lecture: Interventional EUS Outcomes EUS Goes Mainstream Richard A. Erickson

SSAT Plenary Session 2:15 PM - 3:45 PM

S505a McCormick Place

Chairs: Jason B. Fleming, Magesh Sundaram PLENARY SESSION V Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 2:15 #804

2:30 #805

2:45 #806

3:00 #807

3:15 #808

3:30 #809

Does Neoadjuvant Chemotherapy with FOLFOX- or FOLFIRI Improve the Disease-Free Interval or Survival of Patients with Colorectal Metastases? Sarah Y. Boostrom*, David Nagorney, John H. Donohue, Florencia G. Que, Michael L. Kendrick, Kaye Reid Lombardo Pre-Operative Nomogram to Predict Risk of PeriOperative Mortality Following Pancreatic Resections for Malignancy Chantal Afuh*, Lynette M. Smith, Fred Ullrich, Chandrakanth Are Characteristics and Outcome of Patients Undergoing Debridement of Pancreatic Necrosis Sebron W. Harrison*, Desiree E. Morgan, Manasi S. Kakade, Justin A. Parden, John D. Christein Repeat Curative Intent Liver Surgery Is Safe and Effective for Recurrent Colorectal Liver Metastases: Results from An International Multi-Institutional Analysis Mechteld C. de Jong*, Carlo Pulitano, Alessandro Ferrero, Jennifer Strub, Michael A. Choti, Richard D. Schulick, Gilles Mentha, Lorenzo Capussotti, Timothy M. Pawlik Readmission After Pancreatectomy for Pancreatic Cancer in Medicare Patients Deepthi M. Reddy*, Courtney M. Townsend Jr., William H. Nealon, Yong Fang Kuo, Jean L. Freeman, Taylor S. Riall Does Size Really Matter in the Resection of Primary Cystic Neoplasms of the Pancreas? Eugene P. Ceppa*, Sebastian G. de la Fuente, Srinevas K. Reddy, Sandra Stinnett, Bryan M. Clary, Douglas S. Tyler, Theodore N. Pappas, Rebekah White

SSAT Conference/Debate/Panel/Symposium 2:15 PM - 5:00 PM

S504 McCormick Place

Chair: George A. Sarosi Sponsored by: AGA Institute; ASGE

SSAT/AGA/ASGE STATE-OF-THE-ART CONFERENCE: BARRETT’S ESOPHAGUS, DYSPLASIA, AND EARLY ESOPHAGEAL ADENOCARCINOMA: MANAGING THE TRANSITION Participants will be able to: • The molecular carcinogensis of Barrett’s adenocarcinoma and the role of molecular markers in risk asessement; • The role of antireflux therapy in managing patients with Barrett’s Esophagus; and • The therapeutic options for patients with be and early esophageal cancer including endoscopic therapy and minimally invasive surgery. 2:15 Sp745

Introduction George A. Sarosi Jr.

2:20 Sp746

The Molecular Basis of Carcinogenesis in Barrett’s Esophagus Rhonda F. Souza

2:50 Sp747

Reflux, Barrett’s and Adenocarcinoma: Can We Disrupt the Pathway? Steven R. DeMeester

3:20 Sp748

Endoscopic Therapy of Barrett’s Esophagus and Early Esophageal Cancer Kenneth K. Wang

3:50 Sp749

Minimally Invasive Esophagectomy for Barrett’s with High Grade Dysplasia and Early Adenocarcinoma of the Esophagus James D. Luketich

4:20

Case Presentations

4:40

Q&A

SSAT Conference/Debate/Panel/Symposium 4:00 PM - 5:00 PM

S505b McCormick Place

Chair: Mark L. Welton CLINICAL WARD ROUNDS: ANORECTAL DISORDERS Participants will be able to: • Understand the evaluation and treatment of complicated anorectal abscess fistulous disease; • Be familiar with the current approaches to complicated anorectal crohn’s disease; and • Discuss current controversies surrounding diagnosis, treatment and prevention of anal dysplasia and cancer. Sp750

Panelists Elisa H. Birnbaum, Harry T. Papaconstantinou, Janice F. Rafferty

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T U E S D A Y JUNE 2

ORAL SESSIONS—SCIENTIFIC SESSIONS SSAT Quick Shots 4:00 PM - 5:00 PM

DDW Combined Clinical Symposium 4:00 PM - 5:30 PM

S100 McCormick Place

Chairs: Bridget N. Fahy, Timothy M. Pawlik

Chairs: Michael J. Levy, David H. Adams

QUICK SHOTS SESSION II

Sponsored by: ASGE; AASLD; AGA Institute

Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract.

AUTOIMMUNE DISORDERS OF THE PANCREAS AND BILIARY TRACT - AN ENLARGING SPECTRUM

4:00 #810

T U E S D A Y

S505a McCormick Place

Molecular Predictors of Response to Neoadjuvant Topotecan and Radiation for Rectal Cancer: Correlative Study to a Phase I Trial Alfredo A. Santillan*, William Dinwoodie, Timothy J. Yeatman, Steven A. Eschrich, Daniel Sullivan, Caio S. Rocha-Lima, Harvey M. Greenberg, Catherine Chodkiewicz, Andy Trotti III, Jorge Marcet, Sophie Dessureault, Philippe Legenne, Paul Wissel, Preeta Tyagi, David Shibata

4:07 #811

Population-Based Analysis and Growth Factor Receptor Expression of GI Carcinoid Tumors Kanika A. Bowen*, Scott R. Silva, Taylor S. Riall, Hung Q. Doan, B. M. Evers

4:13 #812

Can the Frey Procedure Relieve Biliary Obstruction in Chronic Pancreatitis Without a Separate Drainage Procedure? H Ramesh*, George Jacob

4:20 #813

Immediate Versus Tailored Immunoprophylaxis After Surgery for Crohn’s Disease (CD) Liliana Bordeianou*, Sharon L. Stein, Vanessa P. Ho, Bruce E. Sands, Joshua R. Korzenik, Vinita E. Jacob, Brian P. Bosworth, Richard A. Hodin

4:27 #814

Management Algorithm for Pneumatosis Intestinalis and Portal Venous Gas Erik Wayne*, Matthew Ough, Andrew Wu, Junlin Liao, Kelli Andresen, David M. Kuehn, Neal Wilkinson

4:33 #815

Success- and Complication Rates from 4997 ERCP Examinations in Sweden 2007. Data from the Swedish Register for Gallstone Surgery and ERCP (GallRiks) Lars Enochsson*, Fredrik Swahn, Urban Arnelo, Magnus Nilsson, Matthias Löhr, Gunnar Persson

4:40 #817

Does Octreotide Has Any Beneficial Effect in Patients with High Risk to Develop Pancreatic Fistula After Pancreaticoduodenectomy: A Prospective Randomized Trial Andre S. Matheus*, Andre L. Montagnini, José Jukemura, Marcos V. Perini, Luciana B. Haddad, Emerson S. Abe, Sonia Penteado, José Eduardo M. Cunha

JUNE 2 4:47 #818

4:53 #819

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A Broad Assessment of Clinical Outcomes After Laparoscopic Antireflux Surgery Brant K. Oelschlager, Kevin C. Ma, Renato V. Soares*, Martin I. Montenovo, Juan E. Munoz Oca, Carlos A. Pellegrini Is Laparoscopic Heller Myotomy Still Indicated in Stage IV Sigmoid Megaesophagus? Martina Ceolin*, Mario Costantini, Renato Salvador, Lisa Zanatta, Emanuele Di Fratta, Elena Finotti, Christian Rizzetto, Loredana Nicoletti, Giovanni Zaninotto, Ermanno Ancona

Participants will be able to: • Review autoimmune disorders of the pancreas and biliary tract. 4:00 Sp753

Immune Pathogenesis of Autoimmune Cholangiopathies David H. Adams

4:15 Sp754

Autoimmune Pancreatitis (AIP): Clinical Features and Serology George Webster

4:30 Sp755

Autoimmune Cholangiopathies (AIC): Association with Autoimmune Cholangitis & Pancreatitis Jenny Heathcote

4:45 Sp756

Imaging Features of AIP and AIC Michael J. Levy

5:00 Sp757

Approach to Diagnosis and Therapy Suresh T. Chari

5:15 Sp758

Case Presentations and Panel Discussion Randall K. Pearson, Suresh T. Chari, E. Jenny Heathcote, Naoki Takahashi, Michael J. Levy, Gregory Y. Lauwers, Carlos Fernandez del-Castillo

DDW Combined Clinical Symposium 4:00 PM - 5:30 PM

B1 McCormick Place

Chairs: Michael E. Zenilman, Suzanne Rose Sponsored by: SSAT; AGA Institute; ASGE

GASTROINTESTINAL SURGERY IN THE ELDERLY Participants will be able to: • Identify concerns unique to the elderly population. describe demographic trends and impact of co-morbidities in the evaluation for surgery; • Recognize options and considerations particularly related to colonoscopy and gastrointestinal surgery including minimally invasive alternatives; and • Predict complications and select strategies to reduce errors and complications for surgery in the elderly population. 4:00 Sp759

GI Surgery in the Elderly: Demographics and Special Considerations Karen E. Hall

4:23 Sp760

Screening, Diagnostic and Therapeutic Colonscopy in the Elderly Grace H. Elta

4:46 Sp761

Elective High-Acvity Surgery in the Elderly - Pancreatic Resection as a Paradigm Charles M. Vollmer

5:08 Sp762

Techniques: Laparoscopy, NOTES® Sandhya A. Lagoo-Deenadayalan

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Clinical Symposium 4:00 PM - 5:30 PM

S404 McCormick Place

AGA Institute Translational Symposium 4:00 PM - 5:30 PM

S406B McCormick Place

Chairs: Lee M. Kaplan, Shelby A. Sullivan

Chairs: Stuart J. Spechler, Rebecca C. Fitzgerald

Sponsored by: Nutrition & Obesity; Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Liver & Biliary

Sponsored by: Esophageal, Gastric & Duodenal Disorders; Clinical Practice; Imaging & Advanced Technology; Gastrointestinal Oncology

INVASIVE AND NON-INVASIVE MANAGEMENT OF OBESITY Participants will be able to: • List currently available dietary and medical interventions for obesity; • Describe the role of the endoscopist in current and future management of obesity; and • Review the medical and surgical complications of bariatric surgery. 4:00 Sp763

Update On Dietary and Pharmacologic Therapy of Obesity Samuel Klein

4:30 Sp764

Invasive Therapies for Obesity - Endoscopy and Endoscopic Management of Complications Jacques M. Deviere

5:00 Sp765

Invasive Therapies for Obesity: Bariatric Surgery and Management of Medical and Surgical Complications Bruce M. Wolfe

MULTIMODALITY APPROACH TO DETECTION AND INTERVENTION IN BARRETT’S ESOPHAGUS Participants will be able to: • Examine the role of biomarkers in Barrett’s Esophagus; and • Describe new diagnostic techniques in Barrett’s Esophagus. 4:00 Sp770

Molecular and Immune Biomarkers in Barrett’s Esophagus Rhonda F. Souza

4:22 Sp771

Endoscopic Detection of Barrett’s Esophagus Prateek Sharma

4:44 Sp772

Medical Intervention in Barrett’s Esophagus George Triadafilopoulos

5:06 Sp773

Endoscopic Intervention in Barrett’s Esophagus Nicholas J. Shaheen

AGA Institute Committee Sponsored Symposium 4:00 PM - 5:30 PM S401BC McCormick Place

ASGE Special Session 4:00 PM - 5:30 PM

Chairs: John I. Allen, Joel V. Brill

Chairs: John M. Inadomi, Patrick I. Okolo, III

Sponsored by: Clinical Practice & Quality Management Committee

HEALTHCARE DISPARITIES: WHAT IT MEANS TO THE ENDOSCOPIST?

TRANSITIONING YOUR PRACTICE FROM PAPER TO AN EMR - WHY, WHO AND HOW Participants will be able to: • Discuss the requirements/criteria for an ambulatory GI practice electronic medical record (EMR) and how vetted EMR products meet those criteria; • Review the issues that need to be considered and how to successfully interface your EMR with labs, pathology and ASCs; and • Describe the issues to consider before, during and following the EMR implementation and how to minimize the pain and evaluate the impact of public policy, payors and industry on EMRs. 4:00 Sp766

S101 McCormick Place

4:00 Sp774

Disparities in Colorectal Cancer Screening: A National Perspective Laura Seeff

4:25 Sp775

The Root of Disparities: Access Versus Utilization John M. Inadomi

4:50 Sp776

Disparities in Demographics Among Patients with Pancreatitis-Related Mortality Patrick I. Okolo III

5:15

Questions & Answers

The AGA Institute’s EMR Criteria - The Process and Results John I. Allen

ASGE Clinical Symposium 4:00 PM - 5:30 PM

4:22 Sp767

How to Interface with Labs, Pathology and ASC Carolyn Hartley

Chairs: Michael L. Kochman, Anthony N. Kalloo

4:44 Sp768

Implementation of the GI EMR Lawrence R. Kosinski

NOTES®: ARE WE THERE YET?

5:06 Sp769

The Impact of the 2009 Legislation on Health It - What it Means to the Practicing Gastroentero Kevin J. Ryan

E350 McCormick Place

T U E S D A Y JUNE 2

4:00 Sp777

NOTES®: Where Are We with Current Technology? Samuel A. Giday

4:12 Sp778

Clinical Experience in Asia D. Nageshwar Reddy

4:24 Sp779

Clinical Experience in Europe Jacques Marescaux

4:36 Sp780

Clinical Experience in the U.S. Mark A. Talamini

4:48 Sp781

Clinical Experience in the South Americas Ricardo Zorron

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ORAL SESSIONS—SCIENTIFIC SESSIONS 5:00 Sp782 5:12

NOTES®: Are We Really Here? Jeffrey L. Ponsky

4:45 #829

Ribavirin Population Pharmacokinetics in African American and Caucasian American Patients Infected with Chronic Hepatitis C Genotype 1 Runyan Jin*, Michael J. Fossler, Thomas Dowling, Charles D. Howell

5:00 #830

U.S. Multicenter Pilot Study of Daily Consensus Interferon (Infergen) Plus Ribavirin for “Difficult-toTreat” HCV Genotype 1 Patients: Final Results Samuel B. Ho*, Eric Dieperink, Bashar Aqel, Shanglei Liu, Lori L. Tetrick, Yngve Falck-Ytter, Charles DeComarmond, Coleman I. Smith, Daniel P. McKee, Anastasios A. Mihas, William Boyd, Clark C. Kulig, Edmund J. Bini, Marcos C. Pedrosa

5:15 #831

FibroTest (Ft) Baseline Value Is An Independent Predictor of Early (EVR) and Sustained Virological Response (SVR) in Non-Responders Patients Re-Treated with Pegylated Interferon Alfa-2B (PEG-2B) and Ribavirin in EPIC3 Thierry Poynard*, Eugene R. Schiff, Ruben Terg, Ricardo Moreno-Otero, Steven L. Flamm, Warren N. Schmidt, Thomas Berg, Fernando L. Goncales Jr., Jenny Heathcote, Moises Diago, Thomas McGarrity, Pierre Bedossa, Honghong Zhou, Pabak Mukhopadhyay, Louis H. Griffel, Margaret Burroughs, Clifford A. Brass, Janice Albrecht

Questions & Answers

AASLD Research Forum 4:00 PM - 5:30 PM

S106A McCormick Place

Chairs: Vicky L. Ng, Randolph P. Matthews PEDIATRIC LIVER DEVELOPMENT AND DISEASE

T U E S D A Y

4:00 #820

P21WAF1/CIP1 Is Required for Dextrose-Mediated Inhibition of Mouse Liver Regeneration Alexander Weymann*, Eric Hartman, Vered Gazit, Martin Glauber, Yumirle P. Turmelle, David A. Rudnick

4:15 #821

Defects in Planar Cell Polarity Pathway Activity Are Associated with Developmental Biliary Anomalies Shuang Cui, Louis M. Capecci, Randolph P. Matthews*

4:30 #822

Genetic Interactions in the Notch Pathway: Persistence of the Ductal Plate in Mice Heterozygous for Radical Fringe and Jag1 Alleles Matthew Ryan*, Christina Bales, Emily McComb, Lara A. Underkoffler, Anthony Nelson Jr., Kathleen M. Loomes

4:45 #823

Activation of the Hedgehog Signal Transduction Pathway During the Development of Biliary Atresia in a Mouse Model Huiqi Yang, Ton Lisman, Annette SH Gouw, Robert J. Porte, Henkjan J. Verkade, Jan B. Hulscher*

5:00 #824

Humoral Immunity to Rotavirus-Infected Human Cholangiocytes in Biliary Atresia Maria Grazia Clemente*, John T. Patton, Robert A. Anders, Kathleen B. Schwarz

5:15 #825

Prevalence and Characterization of Thyroid Abnormalities in Children and Young Adults Treated with Combination Therapy for Chronic Hepatitis C At a Single Center Krithiha Devi Ramaswamy Raghunaathan*, Dolores M. Galacki, Judith Quan, Paul D. Mitchell, Maureen M. Jonas

AASLD Topic Forum 4:00 PM - 5:30 PM

S105 McCormick Place

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM S403 McCormick Place Chairs: Philip S. Schoenfeld, Nicholas J. Shaheen Sponsored by: Clinical Practice

CLINICAL PRACTICE DISTINGUISHED ABSTRACT PLENARY Participants will be able to: • Know the utility of screening for celiac disease; and • Be familiar with the relative efficacies of oral rehydration solutions in cholera. 4:00 #832

Evaluation of Safety and Efficacy of a New Device Intended to Decrease Pain and Discomfort Associated with NG Tube Use Samuel N. Adler

4:15 #833

Nationwide Trends in Hospital Admissions for Diverticulitis: A Rising Health Burden Among Those Under Age 65 in the United States Geoffrey C. Nguyen*, Justina J. Sam

4:30 #834

Cost Effectiveness of Mass Screening for Celiac Disease Is Determined By Time-Delay to Diagnosis and Quality of Life On a Gluten Free Diet Tiberiu Hershcovici*, Moshe Leshno, Eran Goldin, Raanan Shamir, Eran Israeli

4:45 #835

Insulin Treatment and the Risk of Hepatocellular Carcinoma in Patients with Diabetes Hashem B. El-Serag*, Christine Hachem, Michael L. Johnson, Robert O. Morgan

5:00 #836

Comparative Efficacy of Oral Rehydration Solutions (ORS) Containing Amylase Resistant Starch and Rice Based Oral Rehydration Solution in the Treatment Severely Malnourished Children with Cholera Nur H. Alam*, Sufia Islam Islam, Shirajum Monira, Remy F. Meier, Niklaus E. Gyr

Chairs: Samuel B. Ho, TBA HCV: PATHOGENESIS AND CLINICAL TRIALS 4:00 #826

JUNE 2 4:15 #827

4:30 #828

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Phenotypic and Genotypic Differences in a Child with Vertically-Acquired Severe HCV Liver Disease and His Mother Aparna Roy*, Chuanxi Wang, Chunhua Li, Ling Lu, Curt H. Hagedorn, Kathleen B. Schwarz Early Results of a Phase II RCT Trial of Adding Fluvastatin to Peginterferon Alfa 2a and Ribavirin Ted Bader*, Diane Hughes, Javid Fazili, Monica Dunnam, Joe Cardello, Michael Bronze “Rescue Treatment” for On Treatment Nonresponders to Full Dose of Peginterferon / Ribavirin Combination Therapy By Intravenous Silibinin Karoline Rutter*, Peter Ferenci, Sandra Beinhardt, Heidrun Kerschner, Thomas-Matthias Scherzer, Harald Hofer, Theresia Popow-Kraupp, Petra Steindl-Munda

ORAL SESSIONS—SCIENTIFIC SESSIONS 5:15 #837

Preoperative Biliary Drainage Versus Direct Operation for Pancreatic Tumors Causing Obstructive Jaundice Niels Anthony Van Der Gaag*, Erik Rauws, Casper H. van Eijck, Marco Bruno, Erwin van der Harst, Josephus J. Gerritsen, J. W. M. Greve, Michael F. Gerhards, Ignace H. de Hingh, Jean H. Klinkenbijl, Chung Y. Nio, Steve M. de Castro, Olivier R. Busch, Thomas M. Van Gulik, Patrick M. Bossuyt, Dirk J. Gouma

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM S401A McCormick Place Chairs: Mark Lowe, Eric Sibley Sponsored by: Growth, Development & Aging

GROWTH, DEVELOPMENT & AGING PLENARY SESSION AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM S502 McCormick Place Chairs: John M. Carethers, Vincent W. Yang Sponsored by: Gastrointestinal Oncology

GASTROINTESTINAL ONCOLOGY PLENARY Participants will be able to: • Obtain new information from various studies on aspects of oncology and gastroenterology. 4:00 #838

Synergism Between EGFR and Mutant p53 Facilitates Epithelial-Mesenchymal Transition By Negating Oncogene-Activated Cellular Senescence in Transformed Human Esophageal Cells Shinya Ohashi*, Mitsuteru Natsuizaka, Carmen Z. Michaylira, Gabrielle Wong, Christie M. Gutierrez, Charles G. Miller, Hideki Harada, Jiri Kalabis, Katharine D. Grugan, Douglas B. Stairs, Anil K. Rustgi, Hiroshi Nakagawa

4:15 #839

The Identification of Host Genetic Polymorphisms for H. pylori Infection: A Genome Wide Association Study Lisette Capelle*, Annemarie C. de Vries, Lisette Stolk, Michael Verbiest, Leon M. Moons, Joyce van Meurs, André Uitterlinden, Ernst J. Kuipers

4:30 #840

Role of EZH2-Mediated Epigenetic Silencing in Hepatocellular Carcinoma Alfred S. Cheng*, Nathalie Wong, Kwong W. Choy, Jun Yu, Ka Fai To, Joseph J. Sung

4:45 #841

Mechanism for Selectivity of Specific Exonic Activin Receptor 2 (ACVR2) Frameshift Mutation in Colorectal Cells with Defective DNA Mismatch Repair (MMR) Heekyung Chung*, Claudia G. Lopez, Dennis J. Young, Betty L. Cabrera, Deena Ream-Robinson, John M. Carethers

5:00 #842

Cancer-Derived Myofibroblasts Promote Tumor Initiating Cell Expansion in Colorectal Cancer Randy C. Mifflin*, Iryna V. Pinchuk, Jamal I. Saada, Sahil Mittal, Suimin Qiu, Don W. Powell

5:15 #843

Expression of GRP and Its Receptor Is Associated with Improved Survival in Patients with Colon Cancer Claudio A. Rivera*, Ned C. Ahlberg, Lauren Taglia, Mayank Kumar, Adam Blunier, Richard V. Benya

Participants will be able to: • Learn about new therapies for functional constipation; • Understand the mechanisms of signalling and transcriptional pathways in intestinal development and repair; and • Appreciate the role of multichannel intraluminal impedance evaluation of extraesophageal symptoms of GER. 4:00 #844

Multichannel Intraluminal Impedance(MII) and Extraesophageal Manifestations of Gastroesophageal Reflux (GER) in Pediatrics Melanie K. Greifer*, Kenneth Ng, Jeremiah J. Levine

4:15 #845

GATA Factors Are Required for Paneth Cell Differentiation in Mature Small Intestine Eva Beuling*, Stephen A. Duncan, Stephen D. Krasinski

4:30 #846

Treatment of Rectal Fecal Impaction a Randomized Controlled Trial: Rectal Enemas Versus High Doses of Oral PEG 3350 Noor L. Bekkali*, Marcel G. Dijkgraaf, Maartje M. van den Berg, Michiel P. van Wijk, Marloes E. Bongers, Olivia Liem, Marc A. Benninga

4:45 #847

Differentiating Pancreatic Endocrine Cells Respond to Notch Signaling and Adopt Alternate Cell Fates Archana Kapoor*, Maryann Giel-Moloney, Guido Rindi, Andrew B. Leiter

5:00 #848

An Open Label Follow-Up Study of Prucalopride Solution in Pediatric Subjects with Functional Fecal Retention Harland S. Winter*, Jannie Ausma, Lieve Vandeplassche

5:15 #850

RNA-Binding Protein HuR Regulates XIAP mRNA Stability and Translation and Plays a Role in Regulating Intestinal Epithelial Homeostasis Xian Zhang*, Rao N. Jaladanki, Tongtong Zou, Lan Liu, Lan Xiao, Pengyuan Wang, Eric D. Strauch, Jian-Ying Wang

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM S405 McCormick Place Chairs: Glenn M. Eisen, William R. Brugge Sponsored by: Imaging & Advanced Technology

IMAGING & ADVANCED TECHNOLOGY DISTINGUISHED ABSTRACT PLENARY Participants will be able to: • Identify new information and recent advances in imaging technology. 4:00 #851

Field Carcinogenesis Detection By Rectal Spectral Markers Accurately Identifies Patients Harboring Proximal Advanced Adenomas Hemant K. Roy*, Vladimir Turzhitsky, Young L. Kim, Michael J. Goldberg, Jeremy D. Rogers, Andrew Gomes, Mohammed Jameel, Nahla Hasabou, Tat-Kin Tsang, Vadim Backman

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ORAL SESSIONS—SCIENTIFIC SESSIONS 4:15 #853

Accuracy of Second-Generation Endoscopic Ultrasound (EUS) Elastography for the Differential Diagnosis of Solid Pancreatic Masses: A Quantitative Analysis of Tissue Stiffness Julio Iglesias-Garcia*, Jose Larino, Enrique DominguezMunoz

4:45 #860

Natural Killer T Cells Bearing IL-13rα2, Producing IL13 and Having Cytotoxicity for Epithelial Cells Populate the Mucosa in Ulcerative Colitis Ivan J. Fuss*, Bharat Joshi, Manijeh Phillips, Zhiqiong Yang, Chuli Yi, Catherine Groden, Peter J. Mannon, Claudio Fiocchi, Raj K. Puri, Warren Strober

4:30 #854

Probe-Based Confocal Endomicroscopy Is Equivalent to Standard Four-Quadrant-Stepwise Biopsy Technique for Diagnosis of Neoplasia Arising from Barrett’s Esophagus Alexander Meining*, Michael Vieth, Thomas Rosch, Stephan Miehlke, Valentin Becker, Mario Anders, Heiko Pohl, Ahmed Madisch, Tibor Schuster, Monther Bajbouj, Roland M. Schmid

5:00 #861

Safety and Efficacy of Pf-00547,659, a Fully Human Anti-MAdCAM Antibody, in Ulcerative Colitis. Results of a First in Human Study Severine Vermeire*, Subrata Ghosh, Julian Panes, Jens Frederik Dahlerup, Andreas Luegering, Jana Sirotiakova, U. Strauch, G. Burgess, J. Spanton, W. Niezychowski

4:45 #855

The Use of High Definition White Light Colonoscopy Leads to Higher Adenoma Detection Rates Compared to Standard Definition White Light Colonoscopy. An Effectiveness Study in 2011 Patients Anna M. Buchner*, Muhammad W. Shahid, Kanwar R. Gill, Anthony Schore, Marwan Ghabril, Seth A. Gross, Muhammad K. Hasan, Massimo Raimondo, Michael F. Picco, David S. Loeb, Kenneth R. DeVault, Herbert C. Wolfsen, Michael B. Wallace

5:15 #862

The NALP-3 Inflammasome Plays a Critical Innate Immune Protective Role in Intestinal Homeostasis and Inflammation Simon A. Hirota*, Jeff Ng, Maitham A. Khajah, Kuljit (Ken) Parhar, Yan Li, Donna-Marie McCafferty, Justin A. MacDonald, Jurg Tschopp, Daniel Muruve, Paul L. Beck

5:00 #856

5:15 #852

Remote Magnetic Manipulation of a Wireless Capsule Endoscope in the Esophagus and Stomach of Man Paul Swain*, Arifa Toor, Bertram Manz, Frank Volke, Jeremy Gerber, Elisha Rabinovitz, Richard I. Rothstein In Vivo Imaging of Shedding Cells Induced By Enteral Bacteria Using Confocal Endomicroscopy in Humans Driffa Moussata*, Martin Goetz, Alastair J. Watson, Arthur Hoffman, Jean-Christophe Saurin, Bernard Flourie, Cristina Trovato, Cristiano Crosta, Peter R. Galle, Markus F. Neurath, Ralf Kiesslich

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM S406A McCormick Place

AGA Institute Distinguished Abstract Plenary 4:00 PM - 5:30 PM S501BC McCormick Place Chairs: Helen Raybould, Catia Sternini Sponsored by: Hormones, Transmitters, Growth Factors & Their Receptors

REGULATION OF GASTROINTESTINAL CELL HOMEOSTASIS, DEVELOPMENT AND PROLIFERATION Participants will be able to: • Examine mechanisms and factors regulating cell growth and differentiation. 4:00 #863

XBP1 Is Required for the Maturation and the Maintenance of Digestive-Enzyme Secreting Zymogenic (Chief) Cells Won Jae Huh*, Emel Esen, Andrew Bredemeyer, Guanglu Shi, Ann-Hwee Lee, Stephen F. Konieczny, Laurie H. Glimcher, Jason C. Mills

4:15 #864

Regulation of Gastric Epithelial Homeostasis By Bone Morphogenetic Protein Signaling Masahiko Shinohara, Piangwarin Phaosawasdi, Maria Y. Mao, Linda C. Samuelson, Kathryn A. Eaton, Deborah L. Gumucio, Andrea Todisco*

4:30 #865

Math1 Regulates Epithelial-Mesenchymal Crosstalk in the Intestine to Alter Mesenchymal Development and Hedgehog Signaling Kelli L. VanDussen*, Linda C. Samuelson

4:45 #866

Sonic Hedgehog Regulates Mucous Neck to Zymogenic Cell Lineage Specification Mohamad El Zaatari*, Milena Saqui-Salces, Meghna Waghray, Arthur Tessier, Longchuan Bai, Juanita L. Merchant

5:00 #867

The Intestinal Epithelial Insulin-Like Growth Factor-1 Receptor Is Required for Acute Intestinal Adaptive Growth Effects But Not Activation of Canonical Wnt Signaling By Glucagon-Like Peptide-2 Katherine J. Rowland*, Shivangi Trivedi, Patricia L. Brubaker

5:15 #868

Fibroblast Growth Factor Receptor 3 (FGFR3) Modulates Paneth Cell Lineage Allocation Through a βCatenin/Tcf-4 Dependent Signaling Mechanism Brooks B. Brodrick*, Alda Vidrich, Leigh Bradley, Jenny M. Buzan, Steven M. Cohn

Chairs: R. Balfour Sartor, Bruce E. Sands Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

T U E S D A Y

IMMUNOLOGY, MICROBIOLOGY & INFLAMMATORY BOWEL DISEASES DISTINGUISHED ABSTRACT PLENARY Participants will be able to: • Identify and examine new information and recent advances in immunology, microbiology and inflammatory bowel diseases. 4:00 #857

Genetic Predictors of Medically Refractive Ulcerative Colitis (UC) Requiring Colectomy Talin Haritunians*, Kent D. Taylor, Jerome I. Rotter, Andrew Ippoliti, Marla Dubinsky, Eric A. Vasiliauskas, Gil Y. Melmed, Bruce M. Psaty, Stephan R. Targan, Phillip Fleshner, Dermot P. McGovern

4:15 #858

Effect of Loss of Tolerance in a TH17 Mediated Mouse Model of ER Stress Induced Colitis Sharyn B. Tauro*, Rajaraman D. Eri, Penny Jeffery, Rachel J. Adams, Thu V. Tran, Deborah Roche, Timothy H. Florin, Michael A. McGuckin

4:30 #859

Small Bowel Imaging Comparing MR Enteroclysis, Capsule Endoscopy and Double-Balloon Enteroscopy in Patients with (Suspected) Crohn’s Disease; the COMRADE Study Bart Wiarda*, Peter Mensink, Dimitri G. Heine, Mark F. Stolk, Jaap Stoker, Christien J. van der Woude, Ernst J. Kuipers

JUNE 2

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ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 4:00 PM - 5:30 PM

S402 McCormick Place

Chairs: Michael Camilleri, Christine Feinle-Bisset Sponsored by: Neurogastroenterology and Motility

4:30 #877

A Novel Multiplex PCR Assay for Detection of TCDA, TCDB, TCDC, TCDD and Edu2 Genes from Clostridium difficile Genomic DNA Xiangwen Meng*, Hongjun Zhang, Tat-Kin Tsang

4:45 #878

Enteric Coated Aspirin Causes Small Bowel Damage: Randomized, Double-Blinded, Placebo-Controlled Pilot Study Akiko Shiotani*, Ken Haruma, Ryuji Nishi, Keisuke Honda, Manabu Ishii, Noriaki Manabe, Tomoari Kamada, Hiroaki Kusunoki, Jiro Hata, David Y. Graham

5:00 #879

The MACE Procedure in the Netherlands: Outcomes, Complications and Quality of Life Lisette Hoekstra*, Daniel C. Aronson, Marc A. Benninga

5:15 #880

Rebamipide Prevents NSAID-Induced Small Intestinal Injury: A Prospective, Double-Blind, Randomized Controlled Trial Using Capsule Endoscopy Shunji Fujimori*, Tsuguhiko Seo, Yoko Takahashi, Katya Gudis, Atsushi Tatsuguchi, Akihito Ehara, Tsuyoshi Kobayashi, Keigo Mitsui, Shu Tanaka, Choitsu Sakamoto

FOOD INTAKE, OBESITY AND BRAIN GUT INTERACTIONS Participants will be able to: • Review mechanisms involved in the regulation of food intake and satiety; • Examine meal related symptoms in IBS; and • Discuss vagal mechanisms involved in gastric function. 4:00 #869

Differential Vagal Afferent and Efferent Neuronal Responses to IV CCK Indicate Distinct Functional Roles and Fiber Compositions in Proximal vs. Distal Branches of the Ventral Gastric Vagus Nerve in UrethaneAnesthetized Rats Shiho Matsumoto-Okano*, Yvette Tache, David W. Adelson

4:15 #870

Maximum Caloric Intake Capacity, As Measured By a Standard Nutrient Drink Test, Helps to Predict Weight Loss After Bariatric Surgery Lucas Ilzarbe*, Sandra Torra Alsina, Jordi Muñoz Galitó, Ines Ibañez, José Manuel Ramon Moros, Albert Goday Arnó, Felipe Bory, Montserrat Andreu, Sílvia Delgado-Aros

4:30 #871

Gastric Electrical Stimulation with Wider Pulses Inhibits Food Intake and Gastric Motility in Dogs Geng-Qing Song*, Hongbing Zhu, Yong Lei, Charlene Yuan, Warren Starkebaum, Jiande Chen

4:45 #872

Decrease of Ghrelin Secretion in Hypothalamus Is Involved in Anorexia Induced By the Anticancer Agent Koji Yakabi*, Susumu Kurosawa, Mitsuko Ochiai, Shino Ohno, Shoki Ro, Tsuneko Onouchi, Chiharu Sadakane, Tomohisa Hattori, Mitsutoshi Yuzurihara

5:00 #873

Emotional Regulation of Satiation Braden Kuo*, Vitaly Napadow

5:15 #874

Visceral Hypersensitivity and Somatization Are of Importance for Meal-Related GI Symptom Severity in Irritable Bowel Syndrome Jenny Gunnarsson*, Iris Posserud, Hasse Abrahamsson, Stine Störsrud, Magnus Simren

AGA Institute Research Forum 4:00 PM - 5:30 PM

AGA Institute Research Forum 4:00 PM - 5:30 PM

Chairs: V.K. Viswanathan, Radhakrishna (RK) Rao Sponsored by: Intestinal Disorders

INTESTINAL TRANSPORT: ABSORPTION AND MALABSORPTION Participants will be able to: • Examine how the Na+/H+ exchanger, NHE3, may play a role in the pathogenesis of diarrhea; • Review new molecular mechanisms of intestinal monosaccharide transport; and • Examine advances in gene regulation and protein trafficking of ion transporters and exchangers. 4:00 #881

The Slc2a5 (Glut5) Is Essential for the Absorption of Fructose in the Intestine and Generation of FructoseInduced Hypertension Sharon Barone, Stacey J. Fussell, Anurag K. Singh, Jie Xu, Hassane Amlal, Ursula E. Seidler, Jian Zuo, Manoocher Soleimani*

4:15 #882

D-Glucose/SGLT1 Stimulates NHE3 Activity in Intact Mouse Jejunum, a Contributor to the Effect of Ors, By An AKT Dependent Process Rong Lin*, Rakhilya Murtazina, Olga Kovbasnjuk, Rafiquel Sarker, Boyoung Cha, Nicholas C. Zachos, Ming Tse, Mark Donowitz

4:30 #883

Transcriptional Regulation of Intestinal Apical Cl-/OHExchanger DRA By Lysophosphatidic Acid (LPA) Amika Singla*, Ali Esmaili, Nikhil Bansal, Seema Saksena, Ravinder K. Gill, Waddah A. Alrefai, Krishnamurthy Ramaswamy, Pradeep K. Dudeja

4:45 #884

Regulation of NKCC1 Surface Expression By PKC Involves Dynamin II and Clathrin-Dependent Endocytic Machinery Andreas Mykoniatis*, Le Shen, Jun Tang, Xu Tang, Jerrold R. Turner, Karl S. Matlin, Patrice Bouyer, Jeffrey B. Matthews

5:00 #885

Preserved Abundance But Functional Dysregulation of Na+/H+ Exchanger Isoform NHE3 in the Small and Large Intestine in CD45RBhigh Transfer Colitis Mice with Diarrhea Sunil Yeruva*, Julia Goldstein, Maria Lünnemann, Mingmin Chen, Anurag K. Singh, Brigitte Riederer, Marcus Gereke, Dunja Bruder, Michael P. Manns, Ursula E. Seidler

E451A McCormick Place

Chairs: Mark T. Worthington, Carol E. Semrad Sponsored by: Intestinal Disorders

INTESTINAL CLINICAL DISORDERS Participants will be able to: • Examine how prebiotics can be used to treat diarrhea; • Identify NSAID-induced small intestinal injury; and • Review advances in the diagnostics and therapy of specific intestinal disorders. 4:00 #875

4:15 #876

Green Banana Supplemented Diet in the Management of Childhood Diarrhea At Home: A Randomized, Controlled, Field Trial in Bangladeshi Children Golam H. Rabbani*, Charles P. Larson, Rafiqul Islam Dietary Poorly Absorbed Short-Chain Carbohydrates (FODMAPs) Increase the Volume and Fermentable Substrate Content of Ileal Output Jacqueline S. Barrett*, Richard B. Gearry, Peter M. Irving, Jane G. Muir, Melissa L. Haines, Peter R. Gibson

S501D McCormick Place

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ORAL SESSIONS—SCIENTIFIC SESSIONS 5:15 #886

Do Mutations of NHE3 At the Site of Poorly Functioning NHE3 Polymorphisms Contribute to Diarrhea of Congenital Na Diarrhea? Xinjun Cindy Zhu*, Rafiquel Sarker, Tong Jingjing, Tian-e Chen, Ming Tse, Ian W. Booth, Steven R. Brant, Mark Donowitz, Xuhang Li

AGA Institute Research Forum 4:00 PM - 5:30 PM

E351 McCormick Place

Chairs: John Y. Kao, Sarah E. Keates Sponsored by: Esophageal, Gastric & Duodenal Disorders

AGA Institute Research Forum 4:00 PM - 5:30 PM

S103D McCormick Place

Chairs: Nirmala Gonsalves, Glenn T. Furuta Sponsored by: Esophageal, Gastric & Duodenal Disorders

MECHANISMS IN THE PATHOGENESIS OF EOSINOPHILIC ESOPHAGITIS Participants will be able to: • Understand the role of tissue remodeling and fibrosis in development of EoE. 4:00 #887

4:15 #888

Quality of Life Assessment in Adults with EoE At Baseline and After Treatment with Dietary Therapy: Is the Treatment Worse Than the Disease? Nirmala Gonsalves*, Ikuo Hirano

4:30 #889

Macrophage Migration Inhibitory Factor (MIF) and Chemokine Receptor 3 (CCR3) Correlate to Eosinophil Infiltration and Basal Cell Hyperplasia in Eosinophilic Esophagitis Claudio Tortori, Morgana T. Castelo-Branco, Celeste C. Elia, Heitor Souza*

4:45 #890

T U E S D A Y JUNE 2

Integrated Pathways of Fibrogenesis in Eosinophilic Esophagitis: Active Secretion of Th2 Cytokines and TGF-β1, and Binding of Activated Eosinophils Promote Collagen I and Fibronectin Production By Human Esophageal Mesenchymal Cells Florian Rieder*, Ilche T. Nonevski, Zhufeng Ouyang, Gail West, Franco Scaldaferri, John R. Goldblum, Tracey L. Bonfield, Gary W. Falk, Claudio Fiocchi

5:00 #891

5:15 Sp783

Reversibility of Esophageal Fibrosis in Response to Various Therapies in Children with Eosinophilic Esophagitis Mirna Chehade*, Oksana Yershov, Lloyd Mayer, Margret Magid, Raffaella A. Morotti, Hugh Sampson

NOVEL MODEL SYSTEMS OF H. PYLORI PATHOGENESIS Participants will be able to: • Identify new models that are available for defining mechanisms of H. pylori-induced injury. 4:00 #892

Helicobacter pylori Reciprocally Alter Expression of JAMA and Claudin-7 in Gastric Epithelial Cells Lydia E. Wroblewski*, Seth R. Ogden, Toni Nagy, Shannon S. Allen, Judith Romero-Gallo, Dawn Israel, Richard M. Peek

4:15 #893

The Immunoregulatory Properties of Helicobacter pylori DNA On Conventional Dendritic Cells Stephanie Y. Owyang*, Jose Antony Paul, Min Zhang, John Y. Kao

4:30 #894

Global Loss of DNA Methylation and Decrease in Methyl Donors Correlates with Progression in a Transgenic Model of Gastric Cancer Tamas A. Gonda*, Mary V. Gamble, Kyoung J. Sohn, Shigeo Takaishi, Young-In J. Kim, Timothy C. Wang, Benjamin Tycko

4:45 #895

Increased Gastric Dyplasia and Carcinoma in Gerbils Infected with Helicobacter pylori Strains from Regions of High Versus Low Risk for Gastric Cancer in Colombia Thibaut de Sablet*, Rupesh Chaturvedi, Judith RomeroGallo, M. Blanca Piazuelo, Mary Kay Washington, Alberto G. Delgado, Mohammad Asim, Barbara G. Schneider, Liviu A. Sicinschi, Dawn Israel, Richard M. Peek, Pelayo Correa, Keith T. Wilson

5:00 #896

Helicobacter pylori Infection of Human Gastric Mucosal Biopsies Inhibits H,K-ATPase-Dependent Proton Pump Adam J. Smolka*, Charles E. Hammond, Craig C. Beeson, Arindam Saha

5:15 Sp784

Summary and Overview Jean Marie Houghton

Eosinophilic Ileitis and Tissue Remodeling in the SAMP1/SkuSlc Mouse Strain Joanne C. Masterson*, Sophie Fillon, Samantha A. Woodruff, Vincent A. Mukkada, Zachary Robinson, Joanna Grenawalt, Cheryl A. Protheroe, Eoin N. McNamee, Colm Collins, Joshua D. Wermers, Matthew D. Lebsack, James J. Lee, Jesus Rivera-Nieves, Glenn T. Furuta

AGA Institute Research Forum 4:00 PM - 5:30 PM

State-of-the-Art Overview Barry K. Wershil

SHORT BOWEL SYNDROME AND INTESTINAL TRANSPLANTATION

E352 McCormick Place

Chairs: Alan L. Buchman, Miguel A. Gassul Sponsored by: Nutrition & Obesity

Participants will be able to: • Describe current and future management of patients with short bowel syndrome, intestinal failure and those with an intestinal transplant; and • Describe contemporary management of short bowel syndrome and intestinal transplantation. 4:00 #897

P-120

Teduglutide, a Novel GLP-2 Analogue, Decreases Fecal Wet Weight, Sodium and Potassium Excretion in Short Bowel Syndrome (SBS) Patients Dependent On Parenteral Nutrition (PN) Palle B. Jeppesen*, Kelly A. Tappenden, Richard Gilroy, Stephen J. O’Keefe, Douglas L. Seidner, Nancy McGraw, Henry Chu, Bernard Messing

ORAL SESSIONS—SCIENTIFIC SESSIONS 4:15 #898

Citrulline: A Potential Predictor of Reductions in Parenteral Nutrition Achieved in Chronic Parenteral Nutrition Dependant Patients with Short Bowel Syndrome (SBS) Treated with Teduglutide Richard Gilroy*, Stephen J. O’Keefe, Nancy McGraw, Henry Chu, Khursheed N. Jeejeebhoy, Bernard Messing

4:30 #899

Pectin Supplementation Increases Colonic Short Chain Fatty Acid Production(SCFA) in Patients with Short Bowel Syndrome(SBS) Antwan Atia*, Meena Rammohan, Chul Ahn, Xavier Hebuterne, Fernand Girard-Pipau, Alan L. Buchman

4:45 #900

13C-Methionine Breath Test to Assess Intestinal Failure Associated Liver Disease Debora Duro*, Shimae C. Fitzgibbons, Clarissa Valim, Lori J. Bechard, Yong-Ming Yu, Christopher Duggan, Tom Jaksic

5:00 #901

Do the Current Intestinal Transplant Criteria Predict Mortality in Patients On Home Parenteral Nutrition? A Longitudional Assessment in a Single Centre Aravinth U. Murugananthan*, Parthivan Paskaran, David A. Lloyd, Stephen Middleton, Simon M. Gabe

5:15 #902

Prognostic Indicators in Jaundiced Patients On Total Parenteral Nutrition for Intestinal Failure Ramya Kalaiselvan*, Salil Singh, Salman Heydari Khajehpour, Jonathan Shaffer, Gordon L. Carlson

AGA Institute Research Forum 4:00 PM - 5:30 PM

S501A McCormick Place

5:15 #908

AGA Institute Topic Forum 4:00 PM - 5:30 PM

VISCERAL HYPERSENSITIVITY Participants will be able to: • Examine mechanisms of upper gastrointestinal hypersensitivity; and • Examine the role of mast cells and fatty acids in visceral sensitivity. 4:00 #903

4:15 #904

Impaired Accommodation Is a Feature of Functional Dyspepsia Patients with Postprandial Distress Syndrome, Not with Epigastric Pain Syndrome Sebastien Kindt*, Raf Bisschops, Rita Vos, Lieselot Holvoet, Philip Caenepeel, Joris Arts, Dominiek De Wulf, Jan F. Tack Identification of Vagal Mechano-Nociceptor Endings in the Guinea Pig Esophagus Simon J. Brookes*, Noemi A. Montes, Brenton J. Reynolds

4:30 #905

TRPA1 in Mast Cell Activation-Induced MechanoHyperexcitability of Vagal Afferent C Fibers in Guinea Pig Esophagus: A Novel Mechanism of Visceral Peripheral Sensitization Shaoyong Yu*, Guofeng Gao, Blaise Peterson, Ann Ouyang

4:45 #906

Pelvic Afferents Are Preferentially Sensitized to Chemical Stimuli During the Chronic Phase of TNBS Colitis: A Potential Role of Sensitized Mast Cells in the Maintenance of Chronic Visceral Pain Elena Ustinova, Dmitriy W. Gutkin, Matthew O. Fraser, Michael A. Pezzone*

5:00 #907

Inhibition of Fatty Acid Amide Hydrolase (FAAH) Activity Enhances the Analgesic Action of the Endocannabinoid Anandamide On Visceral Pain Mikael Brusberg, Daiwu Kang, Håkan Larsson, Erik Lindström, Vicente Martinez*

S401D McCormick Place

Chairs: Guy E. Groblewski, Stephen J. Pandol Sponsored by: Pancreatic Disorders; Gastrointestinal Oncology

PANCREATIC PHYSIOLOGY AND PATHOBIOLOGY Participants will be able to: • Examine the cell biology and physiology of the pancreas; • Review neural regulation of pancreatic inflammation secretion; and • Discuss the growth regulation of the pancreas. 4:00 #909

A Role for Complexin 2 and the Calcium Sensing Protein, Synaptotagmins -1, in Modulating CalciumDependent Exocytosis in Pancreatic Acinar Cells Michelle Falkowski*, Diana D. Thomas, Lee A. Linstroth, Guy E. Groblewski

4:15 #910

Transgenic Expression of Pancreatic Secretory Trypsin Inhibitor-I Rescues Spink3 Deficient Mice and Restores a Normal Pancreatic Phenotype Joelle Romac, Masaki Ohmuraya, Cathy M. Bittner, M. Faraz . Majeed, Thomas Wartmann, Ken-ichi Yamamura, Rodger A. Liddle*

4:30 #911

Characterization of TRPV1 and TRPA1 in Pancreatic Nodose and Dorsal Root Ganglion Neurons Erica S. Schwartz*, Julie A. Christianson, Klaus Bielefeldt, Brian M. Davis, Gerald F. Gebhart

4:45 #912

Growth Factor Withdrawal Stimulates Autophagy and Apoptosis Through AKT Inhibition Claudia J. Nitsche*, Ryan M. Moore, Mouad Edderkaoui, Markus M. Lerch, Anna S. Gukovskaya

5:00 #913

Development of a Mouse Model of InflammationDependent Pancreatic Cancer Zhigang Song*, Govind Bhagat, Gwang Ho Baik, Shanisha A. Gordon, Anthony Mitchell Jr., Chun-Mei Zhao, Duan Chen, Andrew Dannenberg, Timothy C. Wang

Chairs: L. Ashley Blackshaw, Million Mulugeta Sponsored by: Neurogastroenterology and Motility

CRH-Receptor Antagonism Prevents the Development of Stress-Induced Visceral Hypersensitivity But Fails to Affect Established Hypersensitivity Rene M. van den Wijngaard*, Oana I. Stanisor, Sophie A. van Diest, Olaf Welting, Wouter J. de Jonge, Guy E. Boeckxstaens

5:15 #914

Johanson-Blizzard-Syndrom - UBR-1 Target Identification By Proteome Analysis and Pathophysiological Relevance Julia Mayerle*, Narasihma K. Karanam, Martin Zenker, Burkhard Krüger, Susanne Bauhuber, Frank U. Weiss, Uwe Völker, Markus M. Lerch

ASGE Topic Forum 4:00 PM - 5:30 PM

S102 McCormick Place

Chairs: Andrew Y. Wang, Lee McHenry, Jr. DEEP ENTEROSCOPY: OUTCOMES AND THERAPEUTICS 4:00 #915

Prospective Multicenter Trial Comparing Double Balloon Enteroscopy (DBE) and Single Balloon Enteroscopy (SBE) in Patients with Suspected Small Bowel Disorder Andrea May*, Michael Färber, Insa Aschmoneit, Juergen Pohl, Hendrik Manner, Erich Lotterer, Oliver Moeschler, Liebwin Gossner, Klaus Mönkemüller, Martin Raithel, Stephan Miehlke, Christian Ell

4:12 #916

Severe Complications of Spiral Enteroscopy in the First 1750 Patients Paul A. Akerman*, Daniel Cantero

P-121

T U E S D A Y JUNE 2

ORAL SESSIONS—SCIENTIFIC SESSIONS 4:24 #917

Spiral Enteroscopy: Prospective Multicenter U.S. Trial in Patients with Small Bowel Disorders Douglas Morgan*, Bennie R. Upchurch, Peter V. Draganov, Kenneth F. Binmoeller, Oleh Haluszka, Sreenivasa S. Jonnalagadda, Patrick I. Okolo III, Ian S. Grimm, Michael V. Chiorean

4:36 #918

Influence of Fluoroscopy On Insertion Depth, Proceeding Duration and Diagnostic Yield During Double-Balloon Enteroscopy via the Oral Route: Results of a Prospective Randomized Trial in 156 Patients Hendrik Manner*, Andrea May, Juergen Pohl, Christian Ell

4:48 #919

5:00 #920

5:12 Sp785

30-Month Follow-Up After Double Balloon Enteroscopy in Patients with Obscure Gastrointestinal Hemorrhage Lauren B. Gerson*, Sharese Newsom, Andrew S. Ross, Carol E. Semrad Findings and Clinical Impact of Primary Balloon Assisted Enteroscopy in Patients with Obscure Gastrointestinal Bleeding Mark F. Godeschalk, Peter Mensink*, Henk R. van Buuren, Ernst J. Kuipers State-of-the-Art Lecture: Deep Small Bowel Endoscopy: Standard and Innovations Andrea May

ASGE Topic Forum 4:00 PM - 5:30 PM

S103ABC McCormick Place

Chairs: Mohammad R. Anees, Marcia I. Canto

5:00 #926

Ratio of Pancreatic Duct Caliber to Width of Pancreatic Gland By Endosonography Is Predictive of Pancreatic Cancer Mohamad A. Eloubeidi*, Ashutosh Tamhane, Mahboob A. Khan, Leticia P. Luz, C. Mel Wilcox

5:12 Sp786

State-of-the-Art Lecture: Early Diagnosis and Targeted Therapy - The Future of EUS Paul Fockens

ASGE Topic Forum 4:00 PM - 5:30 PM Chairs: Bo Shen, Gerard A. Isenberg

IMAGE-ENHANCED COLONOSCOPY: FROM THE PATHOGENESIS TO THE DIAGNOSIS OF COLONIC DISORDERS 4:00 #927

Is Hood-Assisted Colonoscopy More Effective Than Narrow Band Imaging for Colorectal Adenoma Detection? Akira Horiuchi*, Yoshiko Nakayama

4:12 #928

In Vivo Molecular Imaging of VEGF in Gastrointestinal Cancer Using Confocal Laser Endomicroscopy Sebastian Foersch, Ralf Kiesslich, Maximilian Waldner, Peter R. Galle, Markus F. Neurath, Martin Goetz*

4:24 #929

Usefullness of Our Endocytoscopic Classification in the Colorectum Shin-ei Kudo*, Kunihiko Wakamura, Hiroshi Kashida, Nobunao Ikehara, Keita Sasajima, Yoshiki Wada, Hideyuki Miyachi, Orie Takemura, Hironari Shiwaku, Yuichi Mori, Haruhiro Inoue, Shigeharu Hamatani

4:36 #930

Confocal Laser Endomicroscopy for the In Vivo Identification, Localization and Quantification of Tissue Based Bacteria in Patients with Different Types of Colitis Driffa Moussata*, Martin Goetz, Alastair J. Watson, Marcus Kerner, Annabel Gloeckner, Arthur Hoffman, Stefan Biesterfeld, Jean-Christophe Saurin, Bernard Flourie, Peter R. Galle, Markus F. Neurath, Ralf Kiesslich

4:48 #931

A Prospective Randomized Study On Computed Virtual Chromoendoscopy Versus Conventional Colonoscopy for Detection of Small Colorectal Adenomas Jae Myung Cha*, Joung Il Lee, Kwang Ro Joo, Sung Won Jung, Hyun Phil Shin

5:00 #932

High Definition Plus Colonoscopy Combined with IScan Is Superior in the Detection and Characterization of Colorectal Neoplasias Compared to Standard Video Colonoscopy - A Prospective Randomized Trial Arthur Hoffman*, Fachrie Sar, Martin Goetz, Jonas Mudter, Stefan Biesterfeld, Peter R. Galle, Markus F. Neurath, Ralf Kiesslich

5:12 Sp787

State-of-the-Art Lecture: Bringing New Colonoscopic Imaging Technology Into Everyday Practice Douglas K. Rex

EUS POTPOURRI

T U E S D A Y JUNE 2

4:00 #921

A Simple Scoring System Predicts Which Patients with Esophageal Cancer Benefit from Endoscopic Ultrasound for Lymph Node Classfication Gregory Zuccaro* Jr., Thomas W. Rice, John J. Vargo, John A. Dumot, Tyler Stevens, Rocio Lopez

4:12 #922

Endoscopic Ultrasonography (EUS) Strain Ratio (SREUS) vs. Contrast-Enhanced EUS (CE-EUS) for the Diagnosis of Focal Pancreatic Solid Lesions Fatima A. Figueiredo*, Marc Giovannini, Erwan Bories, Christian Pesenti, Fabrice Caillol, Genevieve Monges, Jean Robert Delpero

4:24 #923

4:36 #924

4:48 #925

Endoscopic Ultrasound-Guided Fine Needle Aspiration in Solid Pancreatic Tumors: A Prospective Randomized Comparison of 19-Gauge and 22-Gauge Aspiration Needles Tae Jun Song*, Sang Soo Lee, Ji Hoon Kim, Do Hyun Park, Sung-Hoon Moon, Dong Wan Seo, Se Jin Jang, Sung Koo Lee, Myung-Hwan Kim The Yield of Endoscopic Ultrasound-Guided Fine Needle Aspiration with a 19-Gauge Needle for the Diagnosis of Autoimmune Pancreatitis Takuji Iwashita*, Ichiro Yasuda, Shinpei Doi, Masanori Nakashima, Tuyoshi Mukai, Keisuke Iwata, Eiichi Tomita, Hisataka Moriwaki EUS FNA of Distant Extra-Vascular Migratory Metastasis (EVMM) and Tumor Thrombosis Michael J. Levy*, Ferga C. Gleeson, Jonathan E. Clain, Amy C. Clayton, Michael Henry, Michael L. Kendrick, Michael B. Farnell, Randall K. Pearson, Bret T. Petersen, Elizabeth Rajan, Santhi Swaroop Vege, Naoki Takahashi, Mark D. Topazian, Kenneth K. Wang, Maurits J. Wiersema, Suresh T. Chari

S503 McCormick Place

AGA Institute Section Business Meeting ‡ 5:30 PM - 6:30 PM

S502 McCormick Place

Chairs: John M. Carethers, Vincent W. Yang Sponsored by: Gastrointestinal Oncology

GASTROINTESTINAL ONCOLOGY SECTION BUSINESS MEETING

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ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Section Business Meeting ‡ 5:30 PM - 6:30 PM

S401A McCormick Place

Chairs: Mark E. Lowe, Eric Sibley Sponsored by: Growth, Development & Aging

GROWTH, DEVELOPMENT & AGING SECTION BUSINESS MEETING AGA Institute Section Business Meeting ‡ 5:30 PM - 6:30 PM

S501BC McCormick Place

Chairs: Helen E. Raybould, Catia Sternini Sponsored by: Hormones, Transmitters, Growth Factors & Their Receptors

HORMONES, TRANSMITTERS, GROWTH FACTORS & THEIR RECEPTORS SECTION BUSINESS MEETING AGA Institute Section Business Meeting ‡ 5:30 PM - 6:30 PM

S405 McCormick Place

Chairs: Glenn M. Eisen, William R. Brugge Sponsored by: Imaging & Advanced Technology

IMAGING & ADVANCED TECHNOLOGY SECTION BUSINESS MEETING AGA Institute Section Business Meeting ‡ 5:30 PM - 6:30 PM

S406A McCormick Place

Chairs: R. Balfour Sartor, Bruce E. Sands Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

IMMUNOLOGY, MICROBIOLOGY & INFLAMMATORY BOWEL DISEASES SECTION BUSINESS MEETING

T U E S D A Y JUNE 2

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W E D N E S D A Y JUNE 3

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION POSTGRADUATE COURSE/SPECIAL SESSION ASGE Postgraduate Course 2:00 PM - 6:00 PM

S100 McCormick Place

Chairs: Ian M. Gralnek, David A. Greenwald, Klaus Mergener ASGE POSTGRADUATE COURSE - ENDOSCOPY AT HOME AND AROUND THE WORLD: NEW DEVELOPMENTS AND INNOVATIONS FOR YOUR PRACTICE - DAY 1 Participants will be able to: • Discuss endoscopic methods and principles from a national and international perspective, highlighting different diagnostic and management approaches to gastrointestinal disorders; • Describe potential complications of gastrointestinal endoscopy and their management. discuss current and emerging techniques and technologies in gastrointestinal endoscopy, and how to use these to enhance care of patients with gastrointestinal disease; and • Identify the role of gastrointestinal endoscopy in the identification and management of patients with malignancies and other GI disorders. 2:00 Sp788

Welcome Ian M. Gralnek, David A. Greenwald, Klaus Mergener

Chair: Ian M. Gralnek SESSION ONE - GI BLEEDING: GOING BEYOND THE BASICS 2:10 Sp789

Top Ten Tips for the Management of UGI Bleeding Alan N. Barkun

2:30 Sp790

Small Bowel Endoscopy for Obscure GI Bleeding: When to Do It, How to Do It, and What to Do with It Patrick I. Okolo III

2:50 Sp791

Lower GI Bleeding: Keys to Successful Endoscopic Therapy Thomas J. Savides

3:05 Sp792

Managing Endoscopic Bleeding Complications: Getting Yourself Out of a Bind Joseph J.Y. Sung

3:20 3:35 Sp793 3:55

Taking It Home: Roundtable and Q&A KEYNOTE LECTURE - Periprocedural Management of Anticoagulants and Antiplatelet Agents John L. Petrini Jr. Refreshment Break

Chair: John L. Petrini SESSION TWO - CHALLENGES IN TISSUE REMOVAL: TECHNIQUES AND QUALITY PRACTICE 4:15 Sp794

Quality in Colonoscopy: Assuring Excellent Outcomes Jason A. Dominitz

4:30 Sp795

The Polyp Potpourri: Safe Removal of Difficult Lesions Douglas K. Rex

4:50 Sp796

Techniques of Removing Tissue: From EMR to Full Thickness Resection Anthony N. Kalloo

5:05 5:20 Sp797

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Taking It Home: Roundtable and Q&A BASIL I. HIRSCHOWITZ, MD ENDOWED LECTURE Colorectal Cancer Screening: Best Practice in 2009 David A. Lieberman

5:40 Sp798

6:00

CRYSTAL BALL ROUNDTABLE - Getting Ready for the Next 10 Years of Endoscopic Practice Klaus Mergener, Peter B. Cotton, Robert A. Ganz, Anthony N. Kalloo, Thomas Roesch, Thierry Ponchon Adjourn

ORAL SESSIONS—SCIENTIFIC SESSIONS

W E D N E S D A Y

SCIENTIFIC SESSIONS BARIATRIC

ASGE Breakfast with Champions 6:30 AM - 8:00 AM

Sp799

Ablation of Barrett’s Esophagus (BC09) Kenneth K. Wang

CC10A Hyatt Regency McCormick

Sp800

ERCP: Taking On the Pancreas (BC11) Grace H. Elta

CC20AB Hyatt Regency McCormick

Sp802

Luminal Stenting (BC12) Todd H. Baron

CC21AB Hyatt Regency McCormick

AGA Institute Sunrise Session Discussion 7:00 AM - 8:00 AM

Prevention Ninh T. Nguyen

8:07 Sp808

Evaluation and Treatment John C. Alverdy

8:16

S103ABC McCormick Place

8:21 Sp809

Prevention Nathaniel J. Soper

8:30 Sp810

Evaluation and Treatment Gary C. Vitale

8:39

8:44 Sp811

Prevention Keith D. Lillemoe

8:53 Sp812

Evaluation and Treatment Jeffrey B. Matthews

ADVANCES IN CELIAC DISEASE SUNRISE SESSION Participants will be able to: • Review the advances in celiac disease presented at DDW 2009.

9:07 Sp813

Prevention James W. Fleshman

9:16 Sp814

Evaluation and Treatment Tonia Young-Fadok

9:25

Advances in Celiac Disease Carol E. Semrad, Robert P. Anderson

S504 McCormick Place

Sponsored by: ISDS

SSAT/ISDS JOINT SYMPOSIUM: PREVENTION, EVALUATION, AND TREATMENT OF LEAKS AFTER GASTROINTESTINAL SURGERY

PRESIDENT’S PLENARY SESSION 8:00

Prevention Brant K. Oelschlager

7:44 Sp806

Evaluation and Treatment Donald E. Low

7:53

Audience Discussion

Welcome

SESSION 1 8:05 #945

Detection of Metaplasia (IM) and Neoplasia in Patients with Barrett’s Esophagus (BE) Using High-Definition White Light Endoscopy (HD-WLE) Versus Narrow Band Imaging (NBI): A Prospective, Multi-Center, Randomized, Crossover Trial Prateek Sharma*, Ajay Bansal, Robert H. Hawes, Amit Rastogi, Mandeep Singh, Wouter L. Curvers, Matthew Hall, Sharad C. Mathur, Sachin B. Wani, Vikas Singh, Akshra Verma, April D. Higbee, Paul Fockens, Jacques Bergman

8:27 #939

A Multi-Center Randomized Trial Comparing Stepwise Radical Endoscopic Resection Versus Radiofrequency Ablation for Barrett Esophagus Containing High-Grade Dysplasia and/or Early Cancer Frederike G. van Vilsteren*, Roos E. Pouw, Stefan Seewald, Lorenza Alvarez Herrero, Carine Sondermeijer, Fiebo J. ten Kate, Paul Fockens, Karl C. Yu Kim Teng, Thomas Rosch, Nib Soehendra, Bas L. Weusten, Jacques Bergman

8:39 #944

Is Endoscopic Biopsy Safe in Patients Receiving AntiPlatelet Agents? Andrew E. Dikman*, Shefali Sanyal, Caroline von Althann, Matthew J. Whitson, Jay C. Desai, Neville D. Bamji, Lawrence B. Cohen, Kenneth M. Miller, James Aisenberg

ESOPHAGUS 7:35 Sp805

S100 McCormick Place

Chairs: John L. Petrini, Jacques Van Dam, M. Brian Fennerty

Participants will be able to: • Describe the prevention, the diagnosis, and the treatment of leaks after gastrointestinal procedures involving the esophagus, the stomach, the biliary tract, the pancreas, and the colon; and • Choose the best technique to avoid leaks and to diagnose and properly treat them when they occur. Introduction Marco G. Patti

Audience Discussion

ASGE Plenary Session 8:00 AM - 12:00 PM

Chairs: Susan Galandiuk, Marco G. Patti

7:30 Sp804

Audience Discussion

COLON

Sponsored by: Intestinal Disorders

SSAT Conference/Debate/Panel/Symposium 7:30 AM - 9:30 AM

Audience Discussion

PANCREATIC

9:02

Chairs: Carol E. Semrad, Robert P. Anderson

7:00 Sp803

JUNE 3

Audience Discussion

BILIARY

Colonoscopy Issues 2009 (BC10) David A. Lieberman

CC10B Hyatt Regency McCormick

Sp801

7:58 Sp807

P-125

W E D N E S D A Y

ORAL SESSIONS—SCIENTIFIC SESSIONS 8:51 #938

9:03 #940

JUNE 3

9:15

A Long-Term Randomized Controlled Trial of a Novel Nanopowder Hemostatic Agent for Control of Severe Upper Gastrointestinal Bleeding in a Porcine Model Samuel A. Giday*, Yongsik Kim, Devi Mukkai Krishnamurty, David B. Liang, Richard Ducharme, Eun Ji Shin, Xavier Dray, Gianfranco Donatelli, Anthony N. Kalloo Comparison of Sensitivity and Diagnostic Accuracy of Capsule Endoscopy (CE), CT Enterography (CTE) and Double-Balloon Enteroscopy (DBE) for Detection of Small Bowel (SB) Lesions Shabana F. Pasha*, Virender K. Sharma, J Scott Kriegshauser, Amy K. Hara, Ananya Das, M. Edwyn Harrison, G. A. Decker, Anitha Yadav, Isaac B. Malagon, Jonathan A. Leighton J. EDWARD BERK, MD, DSC, FASGE STATE-OF-THEART ENDOWED LECTURE: Adverse Events in Endoscopy - Developing a New Lexicon Glenn Eisen

SESSION 2 9:35 #937

Long-Term Results of Endoscopic Submucosal Dissection for Early-Stage Gastrointestinal Tumors Mariko Man-I*, Takashi Toyonaga, Yoshinori Morita, Hideto Inokuchi, Hiromu Kutsumi, Takeshi Azuma

9:47 #934

Does Wire-Guided Cannulation Prevent Post-ERCP Pancreatitis? A Meta-Analysis Mohammad Madhoun, Charles C. Te, Julie Stoner, John T. Maple*

9:59 #936

Overall Survival in Locally Advanced Pancreatic Cancer Patients Treated with a Biologic Using Endoscopic Ultrasound (EUS) FNI or CT-Guided Injection: A Single Institution Experience Kenneth J. Chang*, Reiko Ashida, Raman Muthusamy, David K. Imagawa, Randall Holcombe, Homayoon Sanati, Jason A. Zell, Jeffrey V. Kuo, Gretta L. Blatner, Sentelle Eubanks, John G. Lee

10:11 #935

10:23 #933

10:35

Results of the First, Randomized, Double Blind, ShamControlled Trial of EUS-Guided Celiac Plexus Neurolysis (EUS-CPN) for Pain Due to Newly Diagnosed, Inoperable Pancreatic Cancer Jonathan M. Wyse*, Marco Carone, Mariana Usatii, Sarto C. Paquin, Anand Sahai Covered (CSEMS) Versus Uncovered (uSEMS) Nitinol Self-Expandable Metal Stent in the Palliative Treatment of Malignant Distal Biliary Obstruction: Preliminary Results from a Randomized Controlled Multicenter Trial Eric P. Kullman*, Claes Söderlund, Stefan Linder, Farshad Frozanpor, Per Sandström, Ervin Toth, Gert Lindell, Eduard Jonas, Jacob Freedman, Martin Ljungman, Piotr Tracz, Bo Ohlin, Rebecka Zacharias, Carl-Eric Leijonmarck, Kalev Teder, Anders Ringman, Eric Svartholm, Gunnar Persson, Mehmet Gözen The Rudolf V. Schindler Award Presented by 2009-10 ASGE President, Jacques Van Dam, MD, Phd, FASGE

10:39

Presidential Address: ASGE State-of-the-Society John L. Petrini

10:59

Inauguration of 2009-2010 President Jacques Van Dam

SESSION 3 11:04 #941

P-126

Follow Up Recommendations in Patients with Positive CT Colonography and Negative Optical Colonoscopy Exams Mark E. Benson*, Deepak V. Gopal, Mark Reichelderfer, Patrick Pfau

11:16 #943

Colon Cancer Miss Rates in Medicare Population Amanpal Singh*, Yong Fang Kuo, Jean L. Freeman, Taylor S. Riall, Gottumukkala S. Raju, James S. Goodwin

11:28 #942

High Dose Bisacodyl As Part of a Colonoscopy Preparation May Cause Colon Ischemia Patrick O’Reilly*, Lawrence Burgart, Paul M. Vargo

11:40

JACK A. VENNES, MD AND STEPHEN E. SILVIS, MD STATE-OF-THE-ART ENDOWED LECTURE: TBD Gary W. Falk

12:00

Close of Session

AGA Institute Committee Sponsored Symposium 8:30 AM - 10:00 AM S401A McCormick Place Sponsored by: Practice Management & Economics Committee; Clinical Practice & Quality Management Committee

GI CODING AND COMPLIANCE UPDATE FOR 2009 Participants will be able to: • Master coding and compliance with CMS and other payors; • Recognize the changes in medicare coding and reimbursement policy; and • Review how to correctly code all procedures to achieve appropriate reimbursement. 8:30 Sp815

GI Coding and Compliance Update for 2009 Cecile Katzoff

AGA Institute Clinical Symposium 8:30 AM - 10:00 AM

S404 McCormick Place

Chairs: Brian E. Lacy, Philip S. Schoenfeld Sponsored by: Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Neurogastroenterology and Motility

NEW AND EMERGING APPROACHES TO THE MANAGEMENT OF IRRITABLE BOWEL SYNDROME Participants will be able to: • Discuss the utility of new diagnostic tests in the management of IBS; • State the results of recent randomized controlled trials of currently available IBS therapies; and • Identify the results of recent phase II-III randomized controlled trials of IBS therapies under investigation. 8:30 Sp816

Utility of New Diagnostic Tests in IBS Patients Brennan M. Spiegel

9:00 Sp817

New Data On Available IBS Treatments Philip S. Schoenfeld

9:30 Sp818

The Future of IBS Therapy Lin Chang

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Clinical Symposium 8:30 AM - 10:00 AM

S102 McCormick Place

AGA Institute Overarching Basic Science Symposium 8:30 AM - 10:00 AM S105 McCormick Place

Chairs: David E. Fleischer, Louis Y. Korman

Chairs: Richard M. Peek, John M. Carethers

Sponsored by: Imaging & Advanced Technology; Clinical Practice; Gastrointestinal Oncology

UBIQUITIN-PROTEASOME SYSTEM IN HUMAN DISEASES AND DRUG TARGETING

COLORECTAL CANCER SCREENING - ARE WE ENDOSCOPISTS, RADIOLOGISTS OR BYSTANDERS?

Participants will be able to: • Examine the role of ubiquitin-mediated degradation and treatment of diseases of the gastrointestinal tract; • Discuss the ubiquitin-proteosome pathway and its involvement in human disease; and • Examine how compounds might improve ubiquitin-proteosome derived diseases.

Participants will be able to: • Discuss the advances in colonic imaging; • Recall issues related to quality and standardization of screening colonoscopy; and • Describe the significance of small polyps detected during CT colonography and summarize the most recent update on the guidelines of screening colonoscopy. 8:30 Sp819

Advances in Standard Colonoscopy Jerome D. Waye

8:52 Sp821

Self Propelled Colonoscopes Nadir Arber

9:14 Sp823

CT Colonography Brooks D. Cash

9:36 Sp825

Quality Is the Issue Irving M. Pike

AGA Institute Committee Sponsored Symposium ‡ 8:30 AM - 10:00 AM S501BC McCormick Place Chair: Mitchell L. Schubert Sponsored by: Ethics Committee

THE AGA’S SOCIAL RESPONSIBILITY: CREATING A BETTER TOMORROW Participants will be able to: • Review the initiatives of the AGA Institute’s social conscience task force; • Discuss strategies for transferring information and education relating to domestic and global health; and • Identify specific ways by which AGA Institute members might become more socially responsible and improve the lives of those who are underserved and underinsured. 8:30 Sp820

Introduction and Overview Mitchell L. Schubert

8:40 Sp822

The American Gastroenterological Association’s Social Conscience Task Force Carla H. Ginsburg

9:00 Sp824

Strategic Opportunities to Improve Global Health Joseph C. Kolars

9:20 Sp826

Colorectal Disparities in American Indians and Alaska Natives David G. Perdue

9:40

Panel Discussion Q&A

8:30 Sp827

Ubiquitin-Proteasome System in Human Diseases and Drug Targeting Aaron Ciechanover

AGA Institute Research Symposium 8:30 AM - 10:00 AM

S403 McCormick Place

Chair: Timothy C. Wang Sponsored by: Hormones, Transmitters, Growth Factors & Their Receptors; Esophageal, Gastric & Duodenal Disorders; Growth, Development & Aging; Gastrointestinal Oncology; Intestinal Disorders; Liver & Biliary; Neurogastroenterology and Motility

INDUCED PLURIPOTENT STEM CELLS AND REPROGRAMMING: NEW STRATEGIES FOR GENERATING PATIENT-SPECIFIC STEM CELLS? Participants will be able to: • Examine models for human intestinal stem cells and their progeny; • Review cell pluripotency and epigenetic reprogramming; and • Discuss potential clinical application of pluripotent cells for the treatment of GI disorders. 8:30 Sp828

The Adult Drosophila Midgut: A Model for Human Intestinal Stem Cells Benjamin Ohlstein

9:00 Sp829

Development of Pluripotent Stem Cells from Liver and Stomach Cells Tsutomu Chiba

9:30 Sp830

Epigenetic Reprogramming Robert Blelloch

SSAT Conference/Debate/Panel/Symposium 8:30 AM - 10:00 AM

S505b McCormick Place

Chair: Jeffrey L. Ponsky EDUCATION COMMITTEE PANEL: ADVANCING ENDOSCOPY IN GI SURGERY Participants will be able to: • Discuss training opportunities and skill sets necessary to safely perform therapeutic endoscopy and NOTES; and • Understand the current use and potential of endoscopy simulators.

TRAINING: HOW MUCH IS ENOUGH? 8:30 Sp831

ABS General Surgery Requirements Jo Buyske

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W E D N E S D A Y JUNE 3

W E D N E S D A Y JUNE 3

ORAL SESSIONS—SCIENTIFIC SESSIONS SKILLS SET FOR ADVANCED ENDOSCOPIC APPLICATIONS: WHAT’S NEEDED NEXT?

AGA Institute Research Forum 8:30 AM - 10:00 AM

S402 McCormick Place

8:45 Sp832

Therapeutic Endoscopy Fellowships for Surgeons Ram Chuttani

9:00 Sp833

Bariatric Surgery Eric J. DeMaria

Sponsored by: Neurogastroenterology and Motility

9:15 Sp834

Colorectal Surgery Steven Wexner

ANIMAL MODELS OF NEUROMUSCULAR DISORDERS

9:30 Sp835

NOTES Jeffrey L. Ponsky

9:45

Participants will be able to: • Examine which animal models are available to study human disease; and • Examine key molecular targets for treatment of neuromuscular disorders.

Q&A

AGA Institute Research Forum 8:30 AM - 10:00 AM

Chairs: Beverley Greenwood-Van Meerveld, Grant W. Hennig

S501D McCormick Place

8:30 #952

Corticotropin-Releasing Factor Binding Protein (CRF-bp) in the Rat Brainstem Autonomic Nuclei and Colon: Expression, Localization and Regulation By StressInduced Stimulation in Colonic Motility Pu-Qing Yuan*, Lixin Wang, Anhthu Bui, Million Mulugeta, Yvette Tache

8:45 #953

Clock Genes Mediate Circadian Changes in Colonic Motility Willemijntje A. Hoogerwerf*, Vahakn Shahinian, Jonathon M. Bostwick, John Timm, Vincent M. Cassone

9:00 #954

Weakened Gastric Motor Activity and Enhanced Peripheral Dopaminergic System in the Rodent Model of Parkinson’s Disease Li-Fei Zheng*, Xin-Liang Mi, Xiao-Hui Zhang, Yue Zhang, Jin-Xia Zhu

9:15 #955

Contribution of Hyperglycemia, HO-1 Expression and Inflammation to Loss of nNOS and c-KIT Expression in the Spontaneously Diabetic Biobreeding-Rat Sebastien Kindt*, Werend Boesmans, Tatsuhiro Masaoka, Pieter Vanden Berghe, Jan F. Tack

9:30 #956

Anti-Hyperalgesic Effect of Nociceptin/Orphanin/FQ in a Rat Model of Narcotic Bowel Sydrome Simona Agostini*, Helene Eutamene, Maria Broccardo, Giovanna Improta, Carla Petrella, Vassilia Theodorou, Lionel Bueno

9:45 #957

Enteric Neuronal Adenosine Receptor 2B (A2BAR) Modulates Murine Distal Colonic Inhibitory Neurotransmission Bindu P. Chandrasekharan*, Vasantha L. Kolachala, Guillaume Dalmasso, Didier Merlin, Shanthi V. Sitaraman, Shanthi Srinivasan

Chairs: Laurel Fisher, Suzanne Rose Sponsored by: Growth, Development & Aging

AGING: PHYSIOLOGY AND CLINICAL GASTROENTEROLOGY Participants will be able to: • Review the role of signalling pathways in aging of the GI tract; • Examine how aging affects GI motility; and • Discuss risk factors for constipation in the elderly. 8:30 #946

Schlafen-3, a Novel Gene Plays a Role in Regulating Colonic Mucosal Growth During Aging Bhaumik B. Patel*, Yingjie Yu, Jianhua Du, Edi Levi, Adhip N. Majumdar

8:45 #947

Hydrotalcite- Gastroprotective and Ulcer Healing Compound Reverses Aging-Related Impairment of Angiogenesis By Activating VEGF and VEGFR2 Genes. Therapeutic Implications for Aging-Related Dysfunction. Andrzej S. Tarnawski*, Vipal Gandhi, Amrita Ahluwalia

9:00 #948

Age-Associated Down Regulation of the PI3K Regulatory Subunit, P85, in Pancreatic Acinar Cells Hitoshi Takahashi*, Hiroshi Saito, B. M. Evers

9:15 #949

Impact of Age On Upper Gastrointestinal Function in Healthy and Gastroparetic Populations, As Measured By a Non-Invasive Wireless Capsule Whitney Michalek, Maria C. Bucur, Richard McCallum, Kenneth L. Koch, Michael D. Sitrin, William D. Chey, William L. Hasler, Henry P. Parkman, Satish S. Rao, John R. Semler, Braden Kuo*

9:30 #950

Assessment of Colonic, Whole Gut and Regional Transit in Elderly Constipated and Healthy Subjects with a Novel Wireless pH/Pressure Capsule (SmartPill®) Satish S. Rao*, Jessica A. Paulson, Richard J. Saad, Richard McCallum, Henry P. Parkman, Braden Kuo, Jack Semler, William D. Chey

9:45 #951

Association Between Risk Factors for Constipation and Severity of Stool Retention As Analyzed By Abdominal X-Ray Steve Walston*, Michael Finamore, Christopher P. Varacallo, Victor Heh, Jen-Jung Pan, Tzu-Cheg Kao, Jen-Tzer Gau

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ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 8:30 AM - 10:00 AM

S406A McCormick Place

AGA Institute Research Forum 8:30 AM - 10:00 AM

Chairs: David T. Rubin, Gary R. Lichtenstein

Chairs: Luca Frulloni, Sanjay B. Jagannath

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

Sponsored by: Pancreatic Disorders

ANTI-TNFS IN IBD Participants will be able to: • Review the possible utility of human anti-chimeric antibodies in understanding loss of response to infliximab; • Examine current data on hepatosplenic T cell lymphoma occurrence in IBD; and • Review outcomes of treatment strategies that explore distinct combinations or sequential uses of anti-TNF agents and immune modulators. 8:30 #958

Case Report of Trisomy 13 in Bone Marrow in a Case of Hepatosplenic T-Cell Lymphoma (HSTCL) and Inflammatory Bowel Disease (IBD) David Kotlyar*, Wojciech Blonski, Manuel Mendizabal, Ming V. Lin, Gary R. Lichtenstein

8:45 #959

Maintenance of Response to Biologic Therapy in Crohn’s Disease Is Improved with “Early Use” V. “Step Up” Treatment Using Health Claims Data David T. Rubin*, Robert Sederman

9:00 #960

Certolizumab Use in Pregnancy: Low Levels Detected in Cord Blood Uma Mahadevan*, Maria T. Abreu

9:15 #961

Infliximab Discontinuation in Crohn’s Disease Patients in Stable Remission On Combined Therapy with Immunosuppressors: A Prospective Ongoing Cohort Study Edouard Louis*, Gwenola Vernier-Massouille, Jean-Charles Grimaud, Yoram Bouhnik, David Laharie, Jean-Louis Dupas, Hélène Pillant, Laurence Picon, Michel Veyrac, Mathurin Flamant, Guillaume Savoye, Raymond Jian, Martine De Vos, Gilles Paintaud, Eric Piver, Jean-Frederic Colombel, JeanYves Mary, Marc Lemann

9:30 #962

9:45 #963

Clinical Utility of Measuring Infliximab and Human Anti-Chimeric Antibody Levels in Patients with Inflammatory Bowel Disease Waqqas Afif*, Edward V. Loftus Jr., William A. Faubion, Karen A. Hanson, William J. Sandborn Results from a Prospective Study Combining Infliximab, Surgery, and Methotrexate in Severe Fistulising AnoPerineal Crohn’s Disease Pauline Roumeguere, Dominique Bouchard, Francois Pigot, Frederic Juguet, Alain Castinel, Elise Chanteloup, Delphine Gaye, Maylis Capdepont, Frank Zerbib, David Laharie*

S401D McCormick Place

CLINICAL PANCREATIC NEOPLASIA

W E D N E S D A Y JUNE 3

Participants will be able to: • Describe new developments in the diagnostic approach to indeterminant pancreatic cysts and pancreatic cancer; and • Recognize advances in understanding the natural history and malignant potential of IPMN. 8:30 #964

Multiple Salivary Biomarkers for Pancreatic Cancer Detection James J. Farrell*, Lei Zhang, M. Sugimoto, A. Hirayama, T. Soga, H. Zhou, David Elashoff, K. Gao, B. Paster, M. Tomita, David T. Wong

8:45 #965

Comparative Yield of Endosonography and Magnetic Resonance Imaging in Individuals At High-Risk for Pancreatic Cancer Femme Harinck*, Irma Kluijt, Jan-Werner Poley, Annemieke Cats, Cora M. Aalfs, Dirk J. Gouma, Chung Y. Nio, Paul Fockens, Marco Bruno

9:00 #966

Prevalence of Pancreatic Cysts in Individuals Undergoing Preventive Medical Examination By Magnetic Resonance Imaging (MRI) Koen de Jong*, Chung Y. Nio, John Hermans, Marcel G. Dijkgraaf, Dirk J. Gouma, Casper H. van Eijck, Eddy van Heel, Gunter Klaβ, Paul Fockens, Marco Bruno

9:15 #967

Main-Duct and Combined IPMNs Are the Same Clinical Entity and Distinct from Branch-Duct IPMNs Stefano Crippa*, Carlos Fernandez del-Castillo, Roberto Salvia, Dianne M. Finkelstein, Claudio Bassi, Ismael Dominguez, Paola Capelli, Mari Mino-Kenudson, Gregory Y. Lauwers, Massimo Falconi, Sarah P. Thayer, Stefano Partelli, Paolo Pederzoli, Andrew L. Warshaw

9:30 #968

Performance Characteristics of Cyst Fluid CEA Analysis for the Diagnosis of Mucinous Cysts of the Pancreas Satish Nagula*, Timothy J. Kennedy, Mark A. Schattner, Murray F. Brennan, Hans Gerdes, Arnold J. Markowitz, Laura H. Tang, Peter J. Allen

9:45 #969

Proteomic Analysis of Cyst Fluid Mucin Expression Is Significantly More Accurate Than Conventional Cyst Fluid Analyses in the Clinical Assessment of Pancreatic Cystic Lesions Karolina Sjöberg*, Malin E. Johansson, Anders G. Hyltander, Evangelos Kalaitzakis, Morteza Shafazand, Jan Hansen, Henrik Sjovall, Gunnar C. Hansson, Riadh Sadik

P-129

W E D N E S D A Y JUNE 3

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 8:30 AM - 10:00 AM

S103ABC McCormick Place

9:00 #977

Sitafloxacin and Garenoxacin, New-Generation Quinolones, Can Overcome the Antibiotic Resistance of H. pylori with gryA Mutations Hidekazu Suzuki*, Juntaro Matsuzaki, Hiroe Muraoka, Toshihiro Nishizawa, Yoshimasa Saito, Eisuke Iwasaki, Toshifumi Hibi

9:15 #978

Standard Clarithromycin-Based Triple Therapy Is Superior to Levofloxacin-Based Triple Therapy As FirstLine Treatment for Helicobacter pylori Eradication in a Chinese Population Ivan F. Hung*, Pierre Chan, Axel Hsu, David But, Walter Wai Kay Seto, Chi Kuen Chan, Siu-Yin Wong, Teresa Tong, Benjamin C.Y. Wong

9:30 #979

Randomized Multicenter Study of Esomeprazole, Moxifloxacin and Amoxicillin for Second-Line or Rescue Treatment of Helicobacter pylori Infection - Impact of Treatment Duration Marco Berning*, Susanne Krasz, Wulf Schneider-Brachert, Ahmed Madisch, Martin W. Laass, Holger Knoth, Eberhard Kuhlisch, Michael Neumeyer, Claus Jebens, Christian Haferland, Enno Jacobs, Michael Vieth, Manfred Stolte, Andrea Morgner, Stephan Miehlke

9:45 Sp837

Summary and Overview Talk Gerhard Treiber

Chairs: Richard H. Holloway, Nimish B. Vakil Sponsored by: Esophageal, Gastric & Duodenal Disorders

DISEASE ASSOCIATIONS AND THERAPEUTIC RESPONSES FOR DYSPEPSIA Participants will be able to: • Increase understanding of treatments for dyspepsia; and • Understand emerging disease associations in patients with dyspepsia. 8:30 #970

A 13-Nation Population Survey of Upper Gastrointestinal Symptoms: Age and Gender Sebastian Haag*, Jane M. Andrews, Judith D. Gapasin, Andreas Keller, Gerald Holtmann

8:45 #971

Abnormal Esophageal pH Study As Predictor of Treatment Response to Proton Pump Inhibitor (PPI) in Patients with Functional Dyspepsia (FD) Justin Wu*, Pui Kuan Cheong, Yawen Chan, Sau Fong E. Lee, Larry Lai, Joseph J. Sung, Francis K. L. Chan

9:00 #972

Yield of Diagnostic Tests for Celiac Disease in Dyspepsia: Systematic Review and Meta-Analysis Alexander C. Ford*, Emily Ching, Paul Moayyedi

9:15 #973

9:30 #974

9:45 Sp836

Prevalence of Irritable Bowel Syndrome in Individuals with Dyspepsia: Systematic Review and Meta-Analysis Alexander C. Ford*, Avantika Marwaha, Allen Lim, Paul Moayyedi A Randomized Omeprazole Controlled Trial Comparing Famotidine, Mosapride or Teprenone in Patients with Uninvestigated Dyspepsia- the J-FOCUS Study Ken Haruma*, Kouichi Sakurai, Akihito Nagahara, Katsuhiro Mabe, Junichi Akiyama, Kazuma Fujimoto, Yoshikazu Kinoshita, Hiroto Miwa State-of-the-Art Overview Nimish B. Vakil

AGA Institute Research Forum 8:30 AM - 10:00 AM

AGA Institute Research Forum 8:30 AM - 10:00 AM Chairs: David L. Boone, Atsushi Mizoguchi

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

MECHANISMS OF EXPERIMENTAL INTESTINAL INFLAMMATION Participants will be able to: • Identify and examine key information and recent advances in mechanisms of experimental intestinal inflammation. 8:30 #980

Heme Oxygenase-1 Expression and Function Is Protective Against Innate Immune Responses to the Enteric Microbiota Shehzad Z. Sheikh*, Katsuyoshi Matsuoka, Jennifer K. Uno, Fengling Li, Scott E. Plevy

8:45 #981

Clostridium difficile (Cdif) Toxin-Induced Intestinal Injury Is Modulated By Nalp Signaling and Activation of the Inflammasome Jeffrey A. Ng*, Simon A. Hirota, Yan Li, Justin A. MacDonald, Daniel Muruve, Paul L. Beck

9:00 #982

The Transcription Factor NFATC2 Controls Apoptosis and Activation of T Cells By IL-6 in Colitis Benno Weigmann*, Hans-Anton Lehr, Peter R. Galle, Markus F. Neurath

9:15 #983

Clc-5 Knockout Mice Are More Susceptible to Dextran Sulphate Sodium (DSS) Induced Colitis Philip Alex*, Thuan Nguyen, Jennifer Sipes, Liberty Gonzales, Mei Ye, Chaim Golfeiz, Zubin Arora, Ting Zhang, Michael Centola, Sandra E. Guggino, Xuhang Li

9:30 #984

A Transient Breach in the Epithelial Barrier Is Associated with Increased IL-17 and IL-10 Production and Reduction of IL-23 Antonello Amendola, Alessia Butera, Massimo Sanchez, Monica Boirivant*

S103D McCormick Place

Chairs: Benjamin D. Gold, Naoki Chiba Sponsored by: Esophageal, Gastric & Duodenal Disorders

IDENTIFICATION AND TREATMENT OF PERSONS AT HIGH RISK FOR H. PYLORI-INDUCED DISEASE Participants will be able to: • Examine new diagnostic techniques to identify persons at increased risk for H. pylori disease and appropriate treatment regimens for such patients. 8:30 #975

Virulence Genotyping of Helicobacter pylori Using Stool DNA Samples from Colombian Children Liviu A. Sicinschi*, Pelayo Correa, Richard M. Peek, John T. Loh, M. Blanca Piazuelo, Alberto G. Delgado, Christian M. Shaffer, Benjamin D. Gold, Dexter T. Thompson, Luis E. Bravo, Barbara G. Schneider

8:45 #976

H. pylori Seropositivity Before Age 40 and Subsequent Risk of Stomach Cancer: A Glimpse of the True Relationship? Christina Persson*, Yanbin Jia, Helena Pettersson, Joakim Dillner, Weimin Ye

P-130

S405 McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS 9:45 #985

Substance P Mediates Colonic Fibrosis in Chronic Trinitrobenzene Sulfonic Acid (TNBS)-Treated Mice and Collagen Synthesis in Human Colonic Fibroblasts Hon Wai Koon*, Dezheng Zhao, Aatish Kumar, Hua Xu, Mary Pat Moyer, Charalabos Pothoulakis

AGA Institute Research Forum 8:30 AM - 10:00 AM

E350 McCormick Place

Chairs: Henry P. Parkman, Ronnie Fass Sponsored by: Esophageal, Gastric & Duodenal Disorders

NEW TECHNOLOGIES IN THE DIAGNOSIS AND TREATMENT OF NON-REFLUX ESOPHAGEAL DISORDERS Participants will be able to: • Discuss advances in the technology for non-reflux esophageal disorders. 8:30 #986

8:45 #987

9:00 #988

Esophageal Shortening: In Vivo Studies to Validate Ultrasound Measurements of Esophageal Wall Thickness As a Method to Assess Esophageal Longitudinal Muscle Contraction Werend Boesmans*, Pieter Vanden Berghe, Daniel Sifrim A Sham-Controlled Study of Injection of Botulinum Toxin in Non-Achalasia Esophageal Hypermotility Disorder Tim Vanuytsel*, Raf Bisschops, Lieselot Holvoet, Kostas Mimidis, Dominiek De Wulf, Joris Arts, Philip Caenepeel, Daniel Sifrim, Jan F. Tack Pressure Topography Thresholds for Bolus Transit: A Study Utilizing High-Resolution Manometry and Impedance William J. Bulsiewicz*, Peter J. Kahrilas, Monika A. Kwiatek, Sudip K. Ghosh, Albert Meek, John E. Pandolfino

AGA Institute Topic Forum 8:30 AM - 10:00 AM

S401BC McCormick Place

Chairs: Alberto Travagli, Sylvie Bradesi Sponsored by: Hormones, Transmitters, Growth Factors & Their Receptors; Neurogastroenterology and Motility

ENTERIC NERVOUS SYSTEM AND BRAIN GUT INTERACTIONS

W E D N E S D A Y JUNE 3

Participants will be able to: • Examine how enteric neurons and brain gut axis control gastrointestinal functions from development to adulthood and in health and disease. 8:30 #992

Roles of Neuronal 5-HT Biosynthesis in Development of Enteric Dopaminergic Neurons and Gastrointestinal Motility: Analysis of Single and Double Knockout Mice Lacking Tryptophan Hydroxylase 1 and 2 Zhishan Li*, Alcmène Chalazonitis, Yung-yu Huang, John J. Mann, Kara J. Gross, Francine Côté, Jacques J. Mallet, Michael D. Gershon

8:45 #993

Expression and Function of the Bile Acid Receptor GpBAR1 in the Enteric Nervous System Daniel P. Poole*, Cody B. Godfrey, Graeme S. Cottrell, Jacob G. Kirkland, Juan C. Pelayo, Nigel W. Bunnett, Carlos U. Corvera

9:00 #994

Upregulation of the Two Pore K+ Channel TRESK in the Nodose Ganglia (NG) Is Responsible for Impaired Gastrointestinal Functions Mediated By Vago-Vagal Reflex in Diabetes Gintautas Grabauskas*, Ying Li, Shi-Yi Zhou, Xiaoyin Wu, Yuanxu Lu, Chung Owyang

9:15 #995

Role of Nesfatin-1, the Novel Satiety Hormone, in the Mechanism of Gastric Mucosal Defense. Importance of Endogenous Prostaglandins and Sensory Afferent Nerves Tomasz Brzozowski*, Peter C. Konturek, Alexandra Szlachcic, Agata Ptak-Belowska, Danuta Drozdowicz, Wladyslaw Bielanski, Stanislaw Konturek, Wieslaw W. Pawlik

9:15 #989

Functional Esophagogastric Junction Obstruction: A Distinct Manometric Diagnosis in Patients Experiencing Dysphagia and/or Chest Pain John R. Scherer*, Brittany M. Mitchell, Hyon C. Kim, Monika A. Kwiatek, John E. Pandolfino, Peter J. Kahrilas

9:30 #990

High Resolution Manometry Differentiates Acid Sensitivity from Reflux Disease in Non-Cardiac Chest Pain Vladimir Kushnir*, C. Prakash Gyawali

9:30 #996

Netrin Biosynthesized By Enteric Neurons Mediates the Attraction of Vagal Sensory Axons to the Fetal Gut Elyanne Ratcliffe*, Rajka Borojevic, Alcmène Chalazonitis, Michael D. Gershon

9:45 #991

High-Resolution Esophageal Manometry Identifies Important Esophageal Motor Dysfunction in Lung Transplant Candidates Harmik J. Soukiasian*, Jeffrey L. Conklin, Mark Pimentel, Sinan Simsir, George Chaux, Sam-Ryong Jee, Edy E. Soffer, Neel R. Joshi, Edward H. Phillips

9:45 #997

Enteric Nitrergic Neuron Defect and Gut Dysfunction in a Rat Model of Parkinson’s Disease Mario Colucci*, Roberto De Giorgio, Fabio Blandini, Barbara Balestra, Giovanna Levandis, Marila Cervio, Cristina Tassorelli, Rosaria Greco, Simone Vigneri, Marisa Faniglione, Michael Schemann, Marcello Tonini

P-131

W E D N E S D A Y JUNE 3

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Topic Forum 8:30 AM - 10:00 AM

E351 McCormick Place

AGA Institute Topic Forum 8:30 AM - 10:00 AM

S104 McCormick Place

Chair: Nicholas J. Talley

Chairs: Carlo Di Lorenzo, Manu R. Sood

Sponsored by: Intestinal Disorders; Neurogastroenterology and Motility

Sponsored by: Growth, Development & Aging; Neurogastroenterology and Motility

IBS DETECTION AND CHARACTERIZATION

PEDIATRIC FUNCTIONAL AND MOTILITY DISORDERS

Participants will be able to: • Examine genetic markers and polymorphisms that are associated with IBS; • Review how transcriptome and proteomic profiling can be used to identify biomarkers associated with IBS; and • Examine physiologic assays that can be used to study patients with IBS.

Participants will be able to: • Evaluate therapeutic options for constipation in children; • Define diagnostic modalities for pediatric constipation; and • Discuss tools for evaluation of abdominal pain in children.

8:30 #998

Detection of Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: Comparison of Lactulose Hydrogen Breath Test with Scintigraphic Oro-Cecal Transit Study Derek Yu*, Frank Cheeseman, Stephen J. Vanner

8:45 #999

Gastrointestinal Permeability (GIPerm) Is Increased in Family Members of Children with Functional Abdominal Pain (FAP) and Irritable Bowel Syndrome (IBS) Mark E. McOmber*, Robert J. Shulman

9:00 #1000

Transcriptional and Proteomic Profiling of the Intestinal Mucosa of Diarrhea-IBS Patients Reveals Enhanced Active Cellular Pathways Compared to Healthy Subjects Cristina Martinez*, Maria Vicario, Beatriz Lobo, Jose L. Mosquera, Laura Ramos, Carmen Alonso, Mar Guilarte, Ines de Torres, Esteban Saperas, Javier Santos

9:15 #1001

Fine Mapping of the Genetic Risk Factors for PostInfectious Irritable Bowel Syndrome (PI-IBS) in the Walkerton Outbreak of Waterborne Gastroenteritis (GE) Alexandra-Chloe Villani*, Mathieu Lemire, Marroon Thabane, Stephen M. Collins, John K. Marshall, Denis Franchimont

9:30 #1002

The Role of 5-HTT LPR and Gnβ3 825c>T Polymorphisms and Gene-Environment Interactions in Irritable Bowel Syndrome (IBS) Yuri A. Saito*, Joseph J. Larson, Elizabeth J. Atkinson, Brooke L. Fridley, Janice Zimmerman, Ann E. Almazar Elder, Gloria M. Petersen, Nicholas J. Talley

9:45 #1003

A Coding Variant in the Serotonin Receptor 3C Subunit Is Associated with Diarrhea-Predominant Irritable Bowel Syndrome Johannes Kapeller, Lesley A. Houghton, Jutta Walstab, Heinz Boenisch, Gudrun Rappold, Beate Niesler*

8:30 #1004

Cortical Activation During Rectal Distension in Children Is Similar to Adult and Elderly Subjects Manu R. Sood*, Mark Kern, Colin D. Rudolph, Alan Silverman, Sally Tarbell, Reza Shaker

8:45 #1005

Impact of Abdominal Pain. 5000 Questionnaires Later, Do We Still Think Is Benign? Miguel Saps*, Deepasriya Kumar, Papa Adams, Carlo Di Lorenzo

9:00 #1006

Muscularis Mucosae of the Rectum in Children with Hirschsprung’s Disease & Functional Constipation Noor L. Bekkali*, Merit Tabbers, Jim C. Wilde, Matthijs W. Oomen, Marc A. Benninga, Fiebo J. Ten Kate

9:15 #1007

Feasibility and Efficacy of Pilot Study Investigating a School Nurse Administered Guided Imagery Program for Childhood Functional Abdominal Pain Nader N. Youssef*, Miranda A. Van Tilburg, Elias N. Matta, Annette Langseder, William E. Whitehead

9:30 #1008

A Multicenter Randomized Double Blind Placebo Controlled Study On the Efficacy of Amitriptyline in Functional Abdominal Pain in Children: Effect of Seasonal Variation Miguel Saps*, Nader N. Youssef, Adrian Miranda, Samuel Nurko, Paul E. Hyman, Jose T. Cocjin, Carlo Di Lorenzo

9:45 #1009

Prevalence of ADHD in Children with Constipation and Its Effect On Outcome Megan E. Sander*, Sally Tarbell, Manu R. Sood

SSAT Plenary Session 8:30 AM - 10:00 AM

S505a McCormick Place

Chairs: Oscar J. Hines, Sharon M. Weber TRANSLATIONAL SCIENCE PLENARY (PLENARY SESSION VI) Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 8:30 #1010

P-132

Infection Rates in a Large Investigational Trial of Sacral Nerve Stimulation for Fecal Incontinence Steven Wexner*, Richard McCallum, Anders Mellgren, John A. Coller, Ghislain Devroede, Tracy L. Hull, Jennifer Ayscue, Michael J. England, David A. Margolin, S. Abbas Shobeiri, Howard S. Kaufman, William J. Snape Jr., Ece Mutlu, Paul Pettit, Joe Tjandra

ORAL SESSIONS—SCIENTIFIC SESSIONS 8:45 #1011

9:00 #1012

9:15 #1013

9:30 #1014

9:45 #1015

[18F]-Fluorodeoxyglucose-Positron Emission Tomography for the Assessment of Histopathologic Response and Prognosis After Completion of Neoadjuvant Chemotherapy in Gastric Cancer Daniel Vallbohmer*, Arnulf H. Hölscher, Paul M. Schneider, Matthias Schmidt, Markus Dietlein, Elfriede Bollschweiler, Stephan E. Baldus, Jan Brabender, Ralf Metzger, Stefan Monig Transvaginal Cholecystectomy Without Laparoscopic Support Using Prototype Flexible Endoscopic Instruments Shean Satgunam*, Brent W. Miedema, Klaus Thaler Immunonutrition with Long Chain Fatty Acids Prevents Activation of Macrophages in the Gut Wall Petra Jacob, Julia Frick, Maximilian Feilitzsch, Mario H. Mueller, Markus A. Küper, Helen Raybould, Alfred Konigsrainer, Jorg Glatzle* Plectin-1 As a Biomarker in Malignant Pancreatic Intraductal Papillary Mucinous Neoplasms Dirk Bausch*, Mari Mino-Kenudson, Carlos Fernandez delCastillo, Andrew L. Warshaw, Kimberly Kelly, Sarah P. Thayer Enhancing Detection of Free Peritoneal Cancer Cells in Gastric Cancer Using Newcastle Disease Virus Joyce Wong*, Allison Schulman, Kaitlyn Kelly, Dmitriy Zamarin, Peter Palese, Yuman Fong

SSAT Video Session 9:45 AM - 11:45 AM

S504 McCormick Place

Chairs: Nathaniel J. Soper, Lee L. Swanstrom VIDEO SESSION IV: NOTES - SINGLE PORT ACCESS SURGERY Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas. 9:45 #1016

Transoral Gastroplasty. A Novel Technique for Incisionless Weight Loss Surgery Gregg K. Nishi*, Simon K. Lo, Edward H. Phillips

10:02 #1017

Single Incision Laparoscopic Surgery (SILS): Cholecystectomy Parag Butala, Brian Jacob*, Neil Cambronero, George D. Xipoleas, Mark A. Reiner

10:19 #1018

Natural Orifice Surgery for Early Stage Esophageal Malignancy: Proof of Concept Bart P. Witteman*, Andres Gelrud, George M. Eid, Alejandro Nieponice, Stephen F. Badylak, Blair A. Jobe

10:36 #1019

Optical Coherence Tomography of the Colon and Its Mesentery (Including Virtual Sentinel Node Biopsy) By Natural Orifice Transluminal Endoscopic Surgery (N.O.T.E.S.) Ronan A. Cahill*, Mitsuhiro Asakuma, Joseph A. Trunzo, Steve J. Schomisch, Joel Leroy, Bernard Dallemagne, Jacques Marescaux, Jeffrey M. Marks

10:54 #1020

Dissection Techniques for NOTES Cholecystectomy with the Flexible Endoscope Kevin M. McGill*, Nikalesh Ippagunta, Glenn Forrester, Julio Teixeira

11:11 #1021

Endoscopic Assisted Transgastric Removal of An Eroded Verticle Gastric Band Steven Hodgett*, J Christopher Eagon

11:28 #1022

Laparoscopic Assisted Transanal Sigmoidectomy (LATAS): A Bridge to NOTES? Joep Knol*, Eric J. Dozois

DDW Combined Clinical Symposium 10:30 AM - 12:00 PM

B1 McCormick Place

Chairs: James W. Fleshman, Satish S. Rao

JUNE 3

Sponsored by: SSAT; AGA Institute

COMMON APPROACHES TO PELVIC FLOOR ABNORMALITIES Participants will be able to: • Provide an update on epidemiology, clinical evaluation and diagnostic criteria for common pelvic floor disorders; • Review the latest and upcoming diagnostic modalities for evaluation of pelvic floor problems; and • Discuss neuromuscular training (biofeedback) and novel surgical approaches for management of these disorders. 10:30 Sp838

Epidemiology, Pathophysiology & Evaluation of Urogynecological Disorders of the Pelvic Floor-An Update from PFDN Linda Brubaker

10:48 Sp839

Advances in Diagnostic Evaluation of Pelvic Floor Disorders Adil E. Bharucha

11:06 Sp840

Behavioral Therapies for Fecal Incontinence and Dyssynergic Defecation-Are They Effective? Satish S. Rao

11:24 Sp841

What’s New in Surgical Therapies for Pelvic Floor Disorders Marc Singer

11:42

Discussion

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM

W E D N E S D A Y

S503 McCormick Place

Chairs: Gregory G. Ginsberg, Herbert C. Wolfsen Sponsored by: Imaging & Advanced Technology; Pancreatic Disorders; Clinical Practice

ENDOSCOPIC OPTICAL BIOPSY TECHNIQUES Participants will be able to: • Learn about the use and techniques of confocal endomicroscopic imaging; and • Review the potential utility of this optical biopsy technique in various GI disease states. 10:30 Sp842

Confocal Endomicroscopy: The Best of GI Imaging? Sharmila Anandasabapathy

10:52 Sp843

Endoscope vs. Probe Marcia I. Canto

11:14 Sp844

Detection of Dysplasia Martin Goetz

11:36 Sp845

Biliary Imaging Alexander Meining

P-133

W E D N E S D A Y JUNE 3

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Clinical Symposium 10:30 AM - 12:00 PM

S102 McCormick Place

AGA Institute Committee Sponsored Symposium 10:30 AM - 12:00 PM S402 McCormick Place

Chairs: Nirmala Gonsalves, Evan S. Dellon

Chairs: Michael Camilleri, Colin W. Howden

Sponsored by: Clinical Practice; Esophageal, Gastric & Duodenal Disorders; Growth, Development & Aging

Sponsored by: Publications Committee; Nutrition & Obesity; Growth, Development & Aging

EOSINOPHILIC ESOPHAGITIS: NEW DATA ON AN EMERGING CLINICAL ENTITY

TREATING OVERWEIGHT AND OBESE PATIENTS: MAXIMIZING YOUR SUCCESS (OR MAKE A DIFFERENCE IN 15 MINUTES)

Participants will be able to: • Explain the pathogenesis of EoE; • Identify the appropriate management of EoE; and • Describe the work-up for subjects with suspected EoE.

Participants will be able to: • Describe effective approaches that promote and support patient weight loss; • Review techniques to motivate your child, teen, and adult patients to make lifestyle changes; and • Discuss when to consider surgery and how to maximize benefits; and describe predictors of successful long-term weight loss maintenance.

10:30 Sp846

Allergy? Genetics? Acid?: Pathogenesis of EoE David A. Katzka

10:52 Sp847

What’s in a Number?: Diagnosis of EoE Glenn T. Furuta

11:14 Sp848

Pharmacologic and Endoscopic Treatment of EoE Evan S. Dellon

10:30 Sp854

Engaging and Motivating Patients in 15 Minutes or Less Robert F. Kushner

11:36 Sp849

Brothers, Cousins, or Total Strangers: The Relationship of EoE to GERD Stuart J. Spechler

10:52 Sp855

Simple, Low-Sacrifice Lifestyle Changes for Weight Loss in Children, Teens, and Adults Miriam Vos

11:14 Sp856

Selecting Patients for Bariatric Surgery: What, Who, and When? Michael L. Kendrick

11:36 Sp857

Keeping It Off: What Works for the Long Term Suzanne Phelan

AGA Institute Clinical Symposium 10:30 AM - 12:00 PM

S103ABC McCormick Place

Chair: Miguel A. Gassull Sponsored by: Nutrition & Obesity; Growth, Development & Aging; Immunology, Microbiology & Inflammatory Bowel Diseases; Intestinal Disorders

AGA Institute Research Symposium 10:30 AM - 12:00 PM

WHEN THE GUT FAILS IN CROHN’S DISEASE

Chairs: Scott E. Plevy, Michael T. Lotze

Participants will be able to: • List the indications and complications of intestinal transplantation; • Describe appropriate nutritional and fluid management of the patient with IBD; and • Review the current status of the artificial gut and list growth factors that may have a role in the management of IBD.

Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases; Gastrointestinal Oncology; Growth, Development & Aging; Intestinal Disorders

10:30 Sp850

Intestinal Transplantation: A Cure for Crohn’s Disease or a Cure for Complications of Crohn’s Disease? Jonathan P. Fryer

10:52 Sp851

Lessons Learned from the Medical Management of Intestinal Failure Applied to IBD Alan L. Buchman

11:14 Sp852

Intestinal Constructs: On Our Way to An Artificial Gut Edward E. Whang

11:37 Sp853

Growth Factors in IBD and Intestinal Rehabilitation Palle B. Jeppesen

P-134

S403 McCormick Place

DAMAGE - ASSOCIATED MOLECULAR PATTERNS (DAMPS) AND ALARMINS IN INTESTINAL INFLAMMATION Participants will be able to: • Demonstrate how DAMPs activate immune and inflammatory responses; • State how HMGB1, RAGE and s100 mediate immune responses; and • Explain how DAMPs interact with autophagy and cell death. 10:30 Sp858

You Eat What You Are: DAMPs and Autophagy Michael T. Lotze

11:00 Sp859

High - Mobility Group Box 1 (HMGB1) and S100 Proteins in Inflammation: Linking Innate and Adaptive Immunity Marco E. Bianchi

11:30 Sp860

Hypoxia As An Alarm Signal During Intestinal Inflammation Sean P. Colgan

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute State-of-the-Art Lecture 10:30 AM - 11:30 AM

S405 McCormick Place

SSAT Quick Shots 10:30 AM - 11:45 AM

Chairs: Rodger A. Liddle, Roland M. Schmid

Chairs: Ellen J. Hagopian, Amy L. Halverson

Sponsored by: Pancreatic Disorders; Growth, Development & Aging; Hormones, Transmitters, Growth Factors & Their Receptors; Gastrointestinal Oncology

QUICK SHOTS SESSION III

GENOMIC ANALYSIS OF PANCREATIC CANCER Participants will be able to: • Examine the genetic profiling of pancreatic cancer; and • Review the genetic processes regulating pancreatic growth and neoplasia.

S505b McCormick Place

Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 10:30 #1023

High Resolution Manometry Has Less Interobserver Variability Than Conventional Manometry Attila Dubecz, Renato Salvador*, Marek Polomsky, Oliver Gellersen, Daniel Raymond, Carolyn E. Jones, Thomas J. Watson, Jeffrey H. Peters

10:36 #1024

Sponsored by: Gastrointestinal Oncology; Imaging & Advanced Technology; Clinical Practice; Immunology, Microbiology & Inflammatory Bowel Diseases; Growth, Development & Aging; Hormones, Transmitters, Growth Factors & Their Receptors; Nutrition & Obesity; Esophageal, Gastric & Duodenal Disorders

The National Mortality Burden and Significant Factors Associated with Open and Laparoscopic Cholecystectomy: 1997-2006 James P. Dolan*, Brian S. Diggs, Brett C. Sheppard, John G. Hunter

10:42 #1025

Murine Functional Liver Mass Is Reduced Following Partial Small Bowel Resection Zhaohua Qiu, Shannon W. Longshore*, Brad W. Warner, David A. Rudnick

CHEMO - AND DIETARY PREVENTION OF GI CANCER

10:48 #1026

Participants will be able to: • Review nutraceuticals that may have activity for the prevention of GI cancer; • Examine potential mechanisms for natural compounds to prevent GI neoplasia; and • Discuss new compounds that may have a role in chemoprevention for GI neoplasia.

Predicting Organ Space Surgical Site Infection with a Nomogram Luiz F. Lobato*, Brian Wells, Elizabeth Wick, Kevin T. Pronty, Pokala R. Kiran, Feza H. Remzi, Jon D. Vogel

10:55 #1027

Impact of KIT and PDGFRA Gene Mutations On Prognosis of Patients with Gastrointestinal Stromal Tumors After Complete Primary Tumor Resection Andrea Frilling*, Ying Hou, Florian Grabellus, Frank Weber, Christoph E. Broelsch

11:01 #1028

Management of Symptomatic Intraabdominal Collections After 672 Hepatic Resections Pedro Mastrodomenico*, Vin Yael, Sofocleous T. Constantinos, Mithat Gonen, Peter J. Allen, Ronald P. DeMatteo, Yuman Fong, Leslie H. Blumgart, William R. Jarnagin, Michael D’Angelica

11:07 #1029

Mortality After Nonhepatic General Surgery in Patients with Concomitant Liver Cirrhosis: An Analysis of 138 Operations in the 2000s Using Child- and MELD Scores Frank Makowiec, Dimitri Mariaskin, Hans-Christian Spangenberg, Ulrich T. Hopt*

11:13 #1030

Major Complications After Laparoscopic Cholecystectomy:a Simple Risk Score Melissa M. Murphy*, Shimul A. Shah, Jessica P. Simons, Nicholas Csikesz, Sing Chau Ng, Zheng Zhou, Jennifer F. Tseng

11:20 #1031

Survival After Proximal, Local and Distal Resection of Extrahepatic Cholangiocarcinoma: Analysis of Prognostic Factors Niels Anthony Van Der Gaag*, Jaap Kloek, Jacob de Bakker, Boudewijn Musters, Olivier R. Busch, Dirk J. Gouma, Thomas M. Van Gulik

11:26 #1032

Fine Needle Aspiration Cytology from Pancreatic CystsLimited Utility in Surgical Decision Making Craig P. Fischer*, Bridget N. Fahy, Thomas A. Aloia, Isaac Raijman, Alberto O. Barroso, Peter J. Schwarz, Barbara L. Bass

10:30 Sp862

Genomic Analysis of Pancreatic Cancer Nickolas Papadopoulos

AGA Institute Translational Symposium 8:30 AM - 10:00 AM

S101 McCormick Place

Chairs: Paul J. Limburg, Courtney W. Houchen

8:30 Sp863

Anticancer Activities of Curcumin and Its Derivatives Shrikant Anant

9:00 Sp864

Cancer Prevention and Treatment By Green Tea Ingredients Chung S. Yang

9:30 Sp865

S-Adenosylmethionine (SAM) As An Anticancer Agent for GI Cancers Shelly C. Lu

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W E D N E S D A Y JUNE 3

W E D N E S D A Y JUNE 3

ORAL SESSIONS—SCIENTIFIC SESSIONS 11:32 #1033

Inhibition of IκB Kinase Attenuates Lipopolysaccharide Induced Hepatic Injury Jeremy L. Ward*, Jordan L. Pleitz, Daniel L. MacDougall, David W. Mercer

11:38 #1034

Frequency of CASH and Its Effect On Surgical Outcomes After Neoadjuvant FOLFOX Therapy for the Treatment of Colorectal Metastasis to the Liver Kaye Reid Lombardo*, Vishal Chandan, William S. Harmsen, Christina M. Wood, David Nagorney

AGA Institute Translational Symposium 10:30 AM - 12:00 PM

S502 McCormick Place

Chairs: Alessio Fasano, Declan F. McCole

11:14 Sp872

Evidence for Nociceptive Afferents in Vagal Pathways from the Upper Gut Marian Kollarik

11:36 Sp873

Interoception - How the Brain Puts It All Together Emeran A. Mayer

AGA Institute Research Forum 10:30 AM - 12:00 PM Chairs: Amitabh Chak, Lauren B. Gerson

Sponsored by: Esophageal, Gastric & Duodenal Disorders

BARRETT’S ESOPHAGUS: DIAGNOSIS AND MANAGEMENT: METAPLASIA TO DYSPLASIA TO CANCER

Sponsored by: Intestinal Disorders; Esophageal, Gastric & Duodenal Disorders; Gastrointestinal Oncology; Hormones, Transmitters, Growth Factors & Their Receptors; Immunology, Microbiology & Inflammatory Bowel Diseases; Neurogastroenterology and Motility

Participants will be able to: • Review advances in progression of Barrett’s to malignancy. 10:30 #1035

The Use of FISH in a Multi-Center Blinded Study to Predict Development of Neoplasia in Barrett’s Esophagus Kenneth K. Wang*, Emily Barr Fritcher, Kevin C. Halling, Mark A. Nelson, Achyut K. Bhattacharyya, Yingye Zheng, Jessie Gu, Nicholas J. Shaheen, Marcia I. Canto, Jean S. Wang, Herbert C. Wolfsen, Lori S. Lutzke, Yvonne Romero, Stephen J. Meltzer, Ivan Y. Ding, Richard E. Sampliner

10:45 #1036

Prospective Randomized Controlled Trial of Biomarkers to Predict Response to Ablation Therapy in Barrett’s Esophagus (BE) with High Grade Dysplasia (HGD) Kenneth K. Wang*, Shannon M. Brankley, Ganapathy A. Prasad, Louis-Michel Wong Kee Song, Navtej Buttar, Emily Barr Fritcher, Lori S. Lutzke, Lynn S. Borkenhagen, Kevin C. Halling, Marlys Anderson

11:00 #1037

Brush Cytology Versus Endoscopic Biopsy for Surveillance of Barrett’s Esophagus Arthi Kumaravel*, Rocio Lopez, Jennifer Brainard, Gary W. Falk

11:15 #1038

Clinical and Biomarker Predictors of Recurrence Following Endoscopic Therapy of Mucosal Esophageal Adenocarcinoma in Barrett’s Esophagus Ganapathy A. Prasad*, Navtej Buttar, Louis-Michel Wong Kee Song, Emily Barr Fritcher, Kevin C. Halling, Lori S. Lutzke, Kelly T. Dunagan, Lynn S. Borkenhagen, Kenneth K. Wang

11:30 #1039

How Durable Is the Reversion to Neosquamous Epithelium in Subjects Undergoing Radiofrequency Ablation for Dysplastic Barrett’s Esophagus? Two Year Follow-Up of the AIM-Dysplasia Randomized ShamControlled Trial Nicholas J. Shaheen*, Prateek Sharma, Bergein F. Overholt, Herbert C. Wolfsen, Richard E. Sampliner, Kenneth K. Wang, Mary P. Bronner, John R. Goldblum, Ana E. Bennet, Glenn M. Eisen, M. Brian Fennerty, David E. Fleischer, Virender K. Sharma, Robert H. Hawes, Brenda J. Hoffman, Richard I. Rothstein, Hiroshi Mashimo, Kenneth J. Chang, Raman Muthusamy, Steven A. Edmundowicz, Stuart J. Spechler, Anthony Infantolino, Gary W. Falk, Michael B. Kimmey, Charles J. Lightdale

11:45 #1040

Predictors for Neoplastic Progression in Patients with Barrett Esophagus: A Prospective Cohort Study Marjolein Sikkema*, Marjon Kerkhof, Caspar W. Looman, Ernst J. Kuipers, Peter D. Siersema

MECHANISMS AND IMPACT OF BARRIER DYSFUNCTION IN INTESTINAL DISEASE Participants will be able to: • Name the components that define the intestinal barrier and mechanisms by which barrier loss may occur; • Describe the potential mechanisms by which barrier loss may be caused by and contribute to disease; and • List opportunities for therapeutic intervention. 10:30 Sp866

Molecular Determinants of Barrier Function James M. Anderson

10:52 Sp867

Clinical Measures of Barrier Function Jonathan B. Meddings

11:14 Sp868

Cytoskeletal Mechanisms of Barrier Regulation Jerrold R. Turner

11:36 Sp869

Role of Protease-Induced Barrier Dysfunction in IBS Lionel Bueno

AGA Institute Translational Symposium 10:30 AM - 12:00 PM

S501D McCormick Place

Chairs: David Grundy, Klaus Bielefeldt Sponsored by: Neurogastroenterology and Motility; Esophageal, Gastric & Duodenal Disorders; Hormones, Transmitters, Growth Factors & Their Receptors; Intestinal Disorders; Pancreatic Disorders

SENSATIONAL PHYSIOLOGY Participants will be able to: • Describe how sensory neurons in the gut encode gastrointestinal signals; • Explain how gastrointestinal signals are transmitted to and modulated by the brain; and • Identify how altered perception of these signals plays a role in gastrointestinal disease. 10:30 Sp870

How Many Types of Sensory Neurons Innervate the GI Tract? Simon J. Brookes

10:52 Sp871

Splanchnic and Pelvic Pathways Convey Different Information from the GI Tract L. Ashley Blackshaw

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S401A McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS AGA Institute Research Forum 10:30 AM - 12:00 PM

S401D McCormick Place

10:45 #1047

Chromoendoscopy Is Superior to Standard Surveillance Techniques for Both High and Low Risk Patients for the Detection of Dysplasia: Analysis of a Prospective Controlled Trial Jennifer Katz*, Asher Kornbluth, James F. Marion, Jerome D. Waye, Daniel H. Present, Yuriy Israel, Carol A. Bodian, Noam Harpaz, Mark L. Chapman, Steven H. Itzkowitz, Adam F. Steinlauf, Maria T. Abreu, Thomas A. Ullman, James Aisenberg, Lloyd Mayer

11:00 #1048

Which Activity Index for Ulcerative Colitis (UC)? Evaluation of Inter-Observer Variation in Clinical, Endoscopic and Composite Indices Alissa J. Walsh*, Oliver Brain, Satish Keshav, Otto C. Buchel, Brent Merrin, Michal Rolinski, Sally Thomas, Lydia White, Axel von Herbay, Bryan F. Warren, Douglas G. Altman, Simon Travis

11:15 #1049

Identification of Items to Be Included in An Ulcerative Colitis Endoscopic Index of Severity (UCEIS) Simon Travis*, William J. Sandborn, Stephen B. Hanauer, Marc Lemann, Bruce E. Sands, Philippe Marteau, JeanFrederic Colombel, Maria T. Abreu, Gary R. Lichtenstein, Brian G. Feagan, Douglas G. Altman, Jean-Yves Mary, Daniel Schnell, Bruce Yacyshyn, Piotr Krzeski, Christian A. Bernhardt

Chairs: Emad M. El-Omar, Andrew S. Day Sponsored by: Esophageal, Gastric & Duodenal Disorders

CARCINOGENIC EPITHELIAL SIGNALING INDUCED BY H. PYLORI Participants will be able to: • Recognize the mechanisms that regulate H. pylori-induced gastric cancers. 10:30 #1041

Helicobacter pylori CagL-Mediated ADAM17 Activation Represses H,K-ATPase α Subunit Expression Arindam Saha*, Adam J. Smolka, Charles E. Hammond, Monika Gooz

10:45 #1042

Helicobacter pylori Transactivation of EGFR Induces COX-2 Expression in Gastric Epithelial Cells Stuart Hobbs*, Seth R. Ogden, Richard M. Peek, Robert H. Whitehead, Peter J. Dempsey, D. Brent Polk

11:00 #1043

Helicobacter pylori-Induced Shedding of C-MET By AGS Gastric Epithelial Cells Is Mediated By ADAM-17 Andrew C. Keates, Richard M. Peek, Simon C. Robson, Sarah E. Keates*

11:30 #1050

11:15 #1044

Epidermal Growth Factor Receptor Activation By Helicobacter pylori Results in a Population of Gastric Epithelial Cells with Oxidative DNA Damage That Are Resistant to Apoptosis: Implications for Gastric Carcinogenesis Rupesh Chaturvedi*, Fang Yan, Richard M. Peek, D. Brent Polk, Keith T. Wilson

Which Non-Invasive Disease Activity Index Should Be Used in Ulcerative Colitis? A Systematic Head-to-Head Psychometric Comparison Dan Turner*, Cynthia H. Seow, Mark S. Silverberg, Gordon R. Greenberg, Anne M. Griffiths, A. Hillary Steinhart

11:45 #1051

Assessment of Wireless Capsule Endoscopy in Patients with Ulcerative Colitis David T. Rubin*, Marc Schwartz, Jami A. Rothe, Bonnie L. Surma, Sam Gavzy, Alana P. Bunnag, Andrew S. Ross

11:30 #1045

Helicobacter pylori Decreases Gastric Epithelial P27 Through Inhibiting Histone Acetylation of the P27 Promoter Sung Soo Kim*, Sang Won Byun, Hyung Keun Kim, In-sik Chung, Chang Hyeok An, Steven F. Moss

11:45 Sp874

State-of-the-Art Overview Nicola L. Jones

AGA Institute Research Forum 10:30 AM - 12:00 PM

S401BC McCormick Place

Chairs: Lars Agreus, Brennan M. Spiegel Sponsored by: Neurogastroenterology and Motility

S406A McCormick Place

Chairs: Peter D. Higgins, Anne M. Griffiths Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

CLINICAL EVALUATION OF ULCERATIVE COLITIS Participants will be able to: • Be familiar with disease activity assessment instruments and their validity in ulcerative colitis; • Describe the yield of surveillance methods, including random biopsy and chromoendoscopy, for colonic dysplasia in ulcerative colitis; and • Discuss with the yield of wireless capsule endoscopy in assessing for small bowel lesions in ulcerative colitis. 10:30 #1046

AGA Institute Research Forum 10:30 AM - 12:00 PM

Low Yield of Neoplasia and Lack of Clinical Consequences of Random Biopsies Do Not Warrant Their Use in Colonoscopic Surveillance of Patients with Ulcerative Colitis Frank J. van den Broek*, Robin P. Boltjes, Simone C. Wolfkamp, Paul Fockens, Cyriel Ponsioen, Pieter Stokkers, Evelien Dekker

FUNCTIONAL GASTROINTESTINAL DISORDERS: EPIDEMIOLOGY AND SYMPTOMS Participants will be able to: • Explain the possible role of intestinal microbes in IBS; • Discuss the role of environmental factors and menstrual cycles in FGD symptoms; and • Identify ans dysfunction in cyclical vomiting syndrome. 10:30 #1052

Abnormal Counts of Small Bowel Bacteria or Abnormal Lactulose Hydrogen Breath Test in Irritable Bowel Syndrome: Relevance for Symptoms? Iris Posserud*, Per-Ove Stotzer, Hasse Abrahamsson, Magnus Simren

10:45 #1053

Risk Exposures for Functional Dyspepsia Versus IBS in Latin America: A Population-Based Study in Nicaragua Edgar M. Peña, Loreto Cortes, Rodolfo Pena, Paris Heidt, Douglas Morgan*

11:00 #1054

Prevalence of Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: Systematic Review and MetaAnalysis Alexander C. Ford*, Nicholas J. Talley, Brennan M. Spiegel, Paul Moayyedi

11:15 #1055

Non-Specific Abdominal Pain and Air Pollution: A Novel Association Gilaad G. Kaplan*, Brian H. Rowe, Martin Storr, Mieczyslaw Szyszkowicz

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W E D N E S D A Y JUNE 3

ORAL SESSIONS—SCIENTIFIC SESSIONS 11:30 #1056

Reduced Symptoms and Visceral Sensitivity Is Related to Menstrual Cycle Changes in IBS Miranda A. Van Tilburg*, Marsha J. Turner, Olafur S. Palsson, Motoyori Kanazawa, William E. Whitehead

AGA Institute Research Forum 10:30 AM - 12:00 PM

11:45 #1057

A Prospective Study of Autonomic Nerve Function in Adults with Cyclic Vomiting Syndrome Thangam Venkatesan*, Alexandru Barboi, Thomas Prieto, Walter J. Hogan, Abigail Schroeder, B. U. Li, Safwan Jaradeh

Chairs: Ellen M. Zimmermann, Suzanne Rose

AGA Institute Research Forum 10:30 AM - 12:00 PM

S103D McCormick Place

Chairs: Manoocher Soleimani, Jonathan D. Kaunitz

Sponsored by: Clinical Practice

TRAINING THE GASTROENTEROLOGIST OF THE FUTURE Participants will be able to: • Know the metrics for assessing competency in endoscopy; and • Be familiar with the utility of observed standardized clinical encounters in training gastroenterology fellows. 10:30 #1063

Prospective Assessment of the Appropriateness and Timeliness of Gastrointestinal Inpatient Consultation Requests At a U.S. Teaching Hospital Lukejohn W. Day*, John P. Cello, Erin Madden, Mark Segal

10:45 #1064

Teaching the Competencies: Using Observed Standardized Clinical Encounters (OSCES) for Faculty Development David Alevi, Peter J. Baiocco, Sita S. Chokhavatia, Donald P. Kotler, Michael A. Poles, Sondra Zabar, Colleen Gillespie, Tavinder K. Ark, Elizabeth H. Weinshel*

11:00 #1065

Changes in the University of Michigan Gastroenterology Fellowship Over Two Decades Jennifer Jorgensen*, Ellen M. Zimmermann, Andrea Todisco, Chung Owyang

11:15 #1066

Gastroenterology Fellow Training in Colonoscopy: Does 140 Equal Competence? Bret J. Spier*, Mark E. Benson, Patrick Pfau, Michael R. Lucey, Eric A. Gaumnitz

11:30 #1067

Improving Hand-Off Communication in Gastroenterology Training Lisa Malter*, Elizabeth H. Weinshel

11:45 Sp876

Building a Better Gastroenterologist: The Future of GI Training Ellen M. Zimmermann

Sponsored by: Esophageal, Gastric & Duodenal Disorders

REGULATION OF GASTRIC ACID SECRETION Participants will be able to: • Understand mechanisms involved in acid-peptic lesions of the upper GI tract; and • Identify transport mechanisms that regulate acid secretion. 10:30 #1058

Differentiation of Gastric ECL Cells in CCK 1+2 Receptor Double Knockout Mice Chun-Mei Zhao*, Yosuke Kodama, Arne Sandvik, Duan Chen

10:45 #1059

Activation of Muscarinic Acetylcholine Receptor Subtype 4 Is Essential for Carbachol- Induced Acid Secretion in Mice: Relation to D Cells/Somatostatin Nobuaki Takahashi, Kohei Yamazaki*, Kikuko Amagase, Minoru Matsui, Susumu Okabe, Koji Takeuchi

11:00 #1060

Involvement of Somatostatin/SST2 Receptors in Decreased Acid Secretion of Damaged Stomachs Mediated By Prostacyclin/IP Receptors Maya Honda*, Hikaru Nishio, Michitaka Ogura, Shinichi Kato, Koji Takeuchi

11:15 #1061

Gastric KNCQ1 Channels Provide Luminal K+ to the H+/K+ ATPase, Whereas Kir 4.1 Channels Are Involved in Secretory Membrane Recycling Penghong Song*, Stephanie Groos, Brigitte Riederer, Zhe Feng, Anja Krabbenhöft, Michael P. Manns, Adam J. Smolka, Susan J. Hagen, Clemens Neusch, Ursula Seidler

11:30 #1062

Expression of the NKCC2 in the Parietal Cells and Its Possible Role On the Gastric H+ Secretion Hong Xue*, Tuo Ji, Zhangfeng Dou, Yue Zhang, Jin Song, Yue Xu, Jinxia Zhu

11:45 Sp875

State-of-the-Art Overview Gordon V. Ohning

P-138

S104 McCormick Place

AGA Institute Topic Forum 10:30 AM - 12:00 PM

E351 McCormick Place

Chairs: Stephen J. Meltzer, Tushar Patel Sponsored by: Gastrointestinal Oncology; Hormones, Transmitters, Growth Factors & Their Receptors

MICRORNA AND DIGESTIVE CANCERS Participants will be able to: • Better understand the role of MicroRNA in digestive organ cancers. 10:30 #1068

EGFR and c-MYC Suppress Mir-143 and Mir-145 in Colonic Tumorigenesis: Roles of G1 Cell Cycle Regulators As miRNA Targets Hongyan Zhu*, Urszula Dougherty, Loren J. Joseph, Victoria Robinson, Jiang Wu, Zhiqun Song, Reba Mustafi, Alessandro Fichera, Marc Bissonnette

10:45 #1069

MicroRNA-143 Is a Potential Tumor Suppressor Targeting DNA Methyltransferases 3a in Colorectal Cancer Enders Ko Ng, Wing Pui Tsang, Simon S. Ng, Hongchuan Jin, Jun Yu, Christoph Röcken, Matthias Pa Ebert, Joseph J. Sung*, Tim Tak Kwok

ORAL SESSIONS—SCIENTIFIC SESSIONS 11:00 #1070

11:15 #1071

Differential Expression of MicroRNAs in Plasma of Colorectal Cancer Patients: A Potential Marker for Colorectal Cancer Screening Joseph J. Sung*, Wai Sing Chong, Hongchuan Jin, Emily Ky Lam, Vivian Y. Shin, Jun Yu, Terence Cw Poon, Simon S. Ng, Enders Ko Ng

SSAT Plenary Session 10:30 AM - 12:00 PM

Chromatin Remodeling At Alu Repeats By Epigenetic Therapy Activates Silenced MicroRNAs in Human Gastric Cancer Cells Yoshimasa Saito*, Hidekazu Suzuki, Hitoshi Tsugawa, Izumi Nakagawa, Toshifumi Hibi

PLENARY SESSION VII

11:30 #1072

Mir-449 Inhibits Growth of Gastric Cancer Cells Partly By Inhibiting the Expression of Met and Amphiregulin Lennart Friis-Hansen*, Ewa Futoma, Finn C. Nielsen

11:45 #1073

Micro-RNA 21 Is Overexpressed and Can Accurately Diagnose Human Cholangiocarcinoma Florin M. Selaru*, Alexandru Olaru, Vikesh Singh, Takatsugu Kan, Stefan David, Yulan Cheng, Yuriko Mori, Jian Yang, Bogdan C. Paun, Zhe Jin, Rachana Agarwal, James P. Hamilton, John M. Abraham, Michael Torbenson, Anirban Maitra, Paul J. Thuluvath, Gregory J. Gores, Stephen J. Meltzer

AGA Institute Topic Forum 10:30 AM - 12:00 PM

S501A McCormick Place

Chairs: Jonathan F. Critchlow, Vic Velanovich

Participants will be able to: • Discuss current investigations and novel strategies in the management of patients with surgical conditions relating to the gastrointestinal tract, liver and pancreas; • Discuss current basic science investigation relating to the gastrointestinal tract, liver and pancreas; and • Discuss current studies in clinical outcomes for patients with surgical disorders of the gastrointestinal tract. 10:30 #1080

The Effects of Sympathetic and Parasympathetic Denervation On Distal Colon Motility in Conscious Rats Timothy J. Ridolfi*, Toku Takahashi, Lauren Kosinski, Kirk A. Ludwig

10:45 #1081

Comparison of the Prognostic Value of Inflammation Based Pathological and Biochemical Criteria in Colorectal Cancer Campbell Roxburgh*, Jonathan M. Salmond, Karin Oien, Paul G. Horgan, Donald C. McMillan

11:00 #1082

National Trends in Esophageal Surgery - Are Outcomes As Good As We Believe? Geoffrey P. Kohn*, Joseph A. Galanko, Michael O. Meyers, Richard H. Feins, Timothy M. Farrell

11:15 #1083

Preoperative Gastric Acid Secretion Defines a Subgroup of Patients with High-Risk to Develop Barrett’s Esophagus in the Esophageal Stump After Esophagectomy for End Stage Chagasic Achalasia Julio R. da Rocha*, Ulysses Ribeiro Jr., Sérgio Szachnowicz, Elisa R. Baba, Adriana V. Safatle-Ribeiro, Kiyoshi Iriya, Ary Nasi, Rubens Sallum, Ivan Cecconello

11:30 #1084

Lack of Association Between a Self-Administered Questionnaire, GERDQ, and Objective GERD Findings Diagnosed By 24-Hour Esophageal pH Monitoring Kevin Chan*, Geoffrey Liu, Linda Miller, Clement Ma, Wei Xu, Gail Darling

11:45 #1085

Surgical Resection for Locoregional Esophageal Cancer Is Underutilized in the United States Attila Dubecz*, Boris Sepesi, Renato Salvador, Marek Polomsky, Carolyn E. Jones, Virginia R. Litle, Daniel Raymond, Thomas J. Watson, Juan P. Wisnivesky, Jeffrey H. Peters

Chairs: D. Brent Polk, R. Balfour Sartor Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases; Intestinal Disorders; Neurogastroenterology and Motility; Nutrition & Obesity

PREBIOTICS AND PROBIOTICS Participants will be able to: • Review the key factors most relevant to prebiotics and probiotics. 10:30 #1074

Lactobacillus GG Secretes Small Peptides That Inhibit the Growth of Antibiotic-Resistant Bacteria Ruiliang Lu*, Alessio Fasano

10:45 #1075

Gut Microbiota Affects Toll-Like Receptors (TLR) and Cannabinoid 2 Receptor (CB2) Expression in the Intestine of Rats Evangelina Teran, Maite Martin, Ferran Jardi, Patri Vergara, Vicente Martinez*

11:00 #1076

Clinical and Physiological Effects of Yogurt Drink Containing the Probiotic Bacteria Bifidobacterium lactis Bb12 and Prebiotic Inulin in Subjects with Functional Bowel Symptoms. Tamar Ringel-Kulka*, Olafur S. Palsson, Joseph Galanko, Danielle M. Maier, Yehuda . Ringel

11:15 #1077

Bifidobacterium bifidum in a Rat Model of Necrotizing Enterocolitis: Changes in Toll-Like Receptors and Inflammatory Cytokines Ludmila Khailova, Kelly M. Arganbright, Andrew Maynard, Amber Johnson, Melissa Halpern, Toshi Kinouchi, Masako Yajima, Bohuslav Dvorak*

11:30 #1078

Pediatric Intervention Study with a Probiotic Mixture (Bacilac Forte) in Acute Gastroenteritis Gigi Veereman*, Sofie Staelens, Jan Wijffels

11:45 #1079

A Probiotic Treatment (Lactobacillus farciminis) Attenuates the Hypothalamic-Pituitary-Adrenal (HPA) Axis Response to Acute Stress in Rats Afifa Ait-Belgnaoui*, Helene Eutamene, Christel SalvadorCartier, Henri Durand, Eric Houdeau, Jean Fioramonti, Lionel Bueno, Vassilia Theodorou

S505a McCormick Place

ASGE Hands-on Workshop 12:00 PM - 2:00 PM

N228 McCormick Place

Chair: Gottumukkala S. Raju ENDOLUMINAL TISSUE APPROXIMATION AND PERFORATION CLOSURE 12:00 Sp877

Endoluminal Tissue Approximation and Perforation Closure Todd H. Baron, Brenna C. Bounds, Brian J. Dunkin, Peter B. Kelsey, Sreeram V.J. Parupudi, Elizabeth Rajan, Roy M. Soetikno, Shou Jiang Tang, Christopher C. Thompson

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W E D N E S D A Y JUNE 3

W E D N E S D A Y JUNE 3

ORAL SESSIONS—SCIENTIFIC SESSIONS SSAT Conference/Debate/Panel/Symposium 12:00 PM - 3:00 PM

Sp888

S504 McCormick Place

Chairs: David M. Mahvi, C. Daniel Smith

McCormick Place Sp889

Sponsored by: SAGES

SSAT/SAGES JOINT SYMPOSIUM: THE ENDOSCOPE AS A SURGICAL TOOL Participants will be able to: • Apply endoscopic surgical techniques to esophageal dysplasia and early carcinoma; • Discuss the role of endoscopic therapeutics in the management of pancreatitis; and • Outline the indications and patients selection for transanal microsurgery.

Sp890

Sp891

Celiac Disease (M60) Peter H. Green CT Colonography (M61) Perry J. Pickhardt

S401A McCormick Place

Endoscopic Ablation of Barrett’s Esophagus (M62) Sponsored by the ASGE ETED SIG Prateek Sharma, Banapathy Prasad S401BC

Sp892

ERCP: Predicting and Limiting Complications (M63) Martin L. Freeman, Nalini Guda S401D

McCormick Place

12:00 Sp878

Endoscopic Fundoplication: Real or Fantasy? Blair A. Jobe

12:15 Sp879

Endoscopic Mucosal Resection Jeffrey H. Peters

12:30 Sp880

Transmediastinal Endoscopic Intervention Denise W. Gee

12:45

Panel Discussion

Sp893

Sp894

Endoscopic Management of Pancreatic Necrosis Jeffrey L. Ponsky

1:15 Sp882

Endoscopic Management of Chronic Pancreatitis Gary C. Vitale

1:30 Sp883

NOTES Cholecystectomy Nathaniel J. Soper

Genetics and the Management of Pancreatic Cancer (M65) David C. Whitcomb CC21A

Hyatt Regency McCormick Sp895

1:00 Sp881

Gastrointestinal Stromal Tumors (M64) George Demetri

CC21C Hyatt Regency McCormick

PANCREATOBILIARY

Lunch At the Movies: Imaging the Small Intestine: Enteroscopy and Capsule (M66) Sponsored by the ASGE SBE SIG Carol E. Semrad, Christina A. Tennyson S501BC

McCormick Place Sp896

Management of Fecal Incontinence (M67) Adil E. Bharucha, Jose Maria Remes Troche

CC10D Hyatt Regency McCormick

Sp897

Panel Discussion

Management of Functional Gastrointestinal Disorders (M68) Nicholas J. Talley CC20B

Hyatt Regency McCormick

COLORECTAL 2:00 Sp884

Colonic ESD & EMR: Techniques to Avoid Segmental Resection Richard L. Whelan

2:15 Sp885

TEMS: Indications & Technique John R. T. Monson

2:30 Sp886

TEM As a Platform for NOTES John H. Marks

2:45

CC12C Hyatt Regency McCormick

McCormick Place

FOREGUT

1:45

Be All the Colonoscopist You Can Be: Optimizing Technique (M59) Jonathan Cohen S501A

Sp898

Hyatt Regency McCormick Sp899

Medical Therapy of Crohn’s Disease (M70) Daniel C. Baumgart

CC10C Hyatt Regency McCormick

Sp900

Panel Discussion

Managing Co-Morbidities in NASH: Where Does the Gastroenterologist Fit in? (M69) CC10B Kittichai Promrat, Janus Ong

Medical Therapy of Ulcerative Colitis (M71) Scott E. Plevy, Adam Cheifetz

CC20C Hyatt Regency McCormick

DDW Meet-the-Professor Luncheons 12:30 PM - 1:45 PM

Sp901

Minimally Invasive Pancreatic Surgery: When? (M72) S501D Attila Nakeeb

McCormick Place Participants will be able to: • Identify new scientific and clinical information relevant to digestive diseases; • Engage in scholarly and dynamic discussions of specific clinical topics; and • Engage in scholarly and dynamic discussions of specific investigative topics. Sp887

Autoimmune Pancreatitis (M58) Markus M. Lerch, Tooru Shimosegawa

Sp902

Sp903

NOTES® Update (M73) Christopher C. Thompson

S502 McCormick Place

NSAIDs, Coxibs, SSRIs and GI Tract Injury (M74) CC12B Jay L. Goldstein

Hyatt Regency McCormick Sp904

Nutrition Support in the Obese Patient (M75) Robert F. Kushner

CC12D Hyatt Regency McCormick

CC21B Hyatt Regency McCormick Sp905

Radiofrequency Ablation of Barrett’s Esophagus (M76) S503 Blair A. Jobe

McCormick Place P-140

ORAL SESSIONS—SCIENTIFIC SESSIONS Sp906

Sleep Disorders and GERD (M77) Ronnie Fass

CC12A Hyatt Regency McCormick

Sp907

Targeted Molecular Therapies of HCC for the Gastroenterologist (M78) Tbd Tbd

CC10A Hyatt Regency McCormick

Sp908

The Endoscopist’s Role in Nutrition (M79) John C. Fang

CC20A Hyatt Regency McCormick

AGA Institute Problem-Based Learning Luncheons 12:30 PM - 1:45 PM

Sp909

Cut By Ockham’s Razor: Man with Multiple Causes of Obscure GI Bleeding (LL13) Lance T. Uradomo Meeting Suite #4

Hyatt Regency McCormick Sp910

Questions and Some Answers About Life in Practice (LL11) J. Sumner Bell III, F. Taylor Wootton, III CC24A

Hyatt Regency McCormick Sp911

Unresponsive GERD Versus Eosinophilic Esophagitis in a 15 Year Old Male (LL12) Laurie N. Fishman, Elizabeth J. Hait Meeting Suite #3

Hyatt Regency McCormick DDW Combined Clinical Symposium 2:15 PM - 3:45 PM

B1 McCormick Place

Chairs: Steven H. Itzkowitz, Jonathan P. Terdiman Sponsored by: AGA Institute; ASGE; SSAT

DETECTING AND MANAGING COLONIC DYSPLASIA IN IBD: NOW AND THE FUTURE Participants will be able to: • Identify and review treatment options to manage IBD Dysplasia.

AGA Institute Clinical Symposium 2:15 PM - 3:45 PM Chairs: Girish Mishra, John M. DeWitt

Sponsored by: Clinical Practice; Pancreatic Disorders

THERAPEUTIC INTERVENTIONS IN PANCREATICOBILIARY DISEASES Participants will be able to: • Define the indications for and limitations of endotherapy in chronic pancreatitis and pancreatic pseudocysts; • Recognize indications for urgent biliary decompression or manipulation; and • Appreciate the emerging role of minimally invasive pancreatic surgery. 2:15 Sp916

What Is the Role of Endotherapy in the Treatment of Chronic Pancreatitis? Stuart Sherman

2:37 Sp917

When Is the Emergent ERCP Really Urgent? Nageshwar Reddy

2:59 Sp918

Nuts and Bolts of Endoscopic Pseudocyst Drainage Michel Kahaleh

3:21 Sp919

Early Surgical Intervention for Chronic Pancreatitis: Why Not a Minimally Invasive Approach? Brian J. Dunkin

AGA Institute Committee Sponsored Symposium 2:15 PM - 3:15 PM S501BC McCormick Place EVIDENCE-BASED ANSWERS AT THE POINT-OF-CARE Participants will be able to: • Recognize the frequency of clinical questions and the impact of unanswered questions on quality care; and • Identify resources to get evidence-based answers to questions at the point-of-care. 2:15 Sp920

Evidence-Based Answers At the Point-of-Care Benjamin Krevsky

2:15 Sp912

Understanding Dyplasia Steven H. Itzkowitz

AGA Institute Research Forum 2:15 PM - 3:45 PM

2:30 Sp913

Interpreting Dysplasia Robert D. Odze

Chairs: Stuart A. McDonald, Wael M. El-Rifai

2:45 Sp914

Finding Dysplasia Ralf Kiesslich

Sponsored by: Gastrointestinal Oncology

3:00 Sp915

So, How Do I Manage IBD Dysplasia? Thomas A. Ullman

3:15

Panel Discussion

S406A McCormick Place

S503 McCormick Place

GASTRIC CANCER: BIOLOGY, DIAGNOSIS & TREATMENT Participants will be able to: • Describe the biology, diagnosis and treatment of gastric neoplasms. 2:15 #1086

The Clonal Origins of Dysplasia from Metaplasia in the Human Stomach Lydia Gutierrez, Manuel Rodriguez-Justo, Simon Leedham, David Stoker, Ian Mitchell, Marco Novelli, Janusz A. Jankowski, Nicholas A. Wright, Stuart A. McDonald*

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W E D N E S D A Y JUNE 3

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:30 #1087

Hypermethylation of Let-7 Promoter Is Involved in cagA-Induced RAS Upregulation in Gastric Epithelial Cells Yoshito Hayashi*, Masahiko Tsujii, Shingo Tsuji, Ying Jin, Takahiro Inoue, Jumpei Kondo, Sachiko Nakajima, Toshiyuki Yoshio, Shuji Ishii, Shinichiro Shinzaki, Satoshi Egawa, Tsutomu Nishida, Kenji Watabe, Hideki Iijima, Shusaku Tsutsui, Sunao Kawano, Tetsuo Takehara, Norio Hayashi

2:45 #1088

Role of MicroRNA-29c in the Chemoprevention of Gastric Cancer By a Selective COX-2 Inhibitor Yoshimasa Saito*, Hidekazu Suzuki, Izumi Nakagawa, Juntaro Matsuzaki, Eisuke Iwasaki, Hitoshi Tsugawa, Hiroyuki Imaeda, Toshifumi Hibi

3:00 #1089

Promoter Hypermethylation Mediates Downregulation of Thiamin Receptor SLC19A3 But Not SLC19A2 in Gastric Cancer Xin Liu*, Hongchuan Jin, Emily Ky Lam, Xian Wang, Yun W. Lam, Yuen Yee Cheng, Jun Yu, Francis K. L. Chan, Joseph J. Sung

3:15 #1090

The Aurora Kinase a Regulates GSK-3β/β-Catenin/Tcf Complex Signaling in Gastric Cancer Cells Abbes Belkhiri*, Altaf A. Dar, Mohammed Soutto, M. Blanca Piazuelo, Pelayo Correa, Mary Kay Washington, Wael M. El-Rifai

3:30 #1091

Celecoxib Inhibits Apurinic/Apyrimidinic Endonuclease1 Expression and Prevents Gastric Cancer in Helicobacter pylori-Infected Mongolian Gerbils Seiji Futagami*, Tetsuro Kawagoe, Tomotaka Shindo, Akane Horie, Tatsuhiko Hamamoto, Masafumi Kusunoki, Kazumasa Miyake, Katya Gudis, Taku Tsukui, Sheila E. Crowe, Choitsu Sakamoto

AGA Institute Research Forum 2:15 PM - 3:45 PM

E351 McCormick Place

3:15 #1096

Antigen Presenting Cells (APC) from Crohn’s Patients Are Less Susceptible to Yeast Mannan-Induced Immunomodulation Compared to Healthy APC Thomas Schaffer*, Stefan Mueller, Frank Seibold

3:30 #1097

Butyrate Enhances LPS-Stimulated Conventional Dendritic Cell TH17 Induction Bradford E. Berndt*, Teresa W. Wang, Stephanie Y. Owyang, Min Zhang, John Y. Kao

AGA Institute Research Forum 2:15 PM - 3:45 PM Chairs: Hubert Moennikes, Steven J. Coen

Sponsored by: Neurogastroenterology and Motility

NETWORKS AND SIGNALING SYSTEMS IN THE HUMAN BRAIN Participants will be able to: • Identify brain circuits involved in emotional arousal and attention; • Analyze the role of neurotransmitter systems in brain responses to visceral stimuli; and • Describe interaction between mood states and intestinal inflammation. 2:15 #1098

Central Serotonin Neurotransmission Disorders Correlate with Visceral Perception and Psychological Characteristics in Patients with Functional Dyspepsia Kazunari Tominaga*, Chikako Tsumoto, Suzuka Ataka, Hirotoshi Okazaki, Hirokazu Yamagami, Tetsuya Tanigawa, Kenji Watanabe, Toshio Watanabe, Yasuhiro Fujiwara, Nobuhide Oshitani, Susumu Shiomi, Yasuyoshi Watanabe, Tetsuo Arakawa

2:30 #1099

Evidence for Altered Central Noradrenergic Modulation in Irritable Bowel Syndrome (IBS) Steven M. Berman*, Brandall Y. Suyenobu, Bruce D. Naliboff, Joshua A. Bueller, Jean Stains, Heng Y. Wong, Mark Mandelkern, Gordon V. Ohning, Kirsten Tillisch, Emeran A. Mayer

2:45 #1100

Evidence for Altered Brain Circuits Underlying Selective Attention to Negative Emotional Stimuli in IBS Kristen Coveleskie*, Jennifer S. Labus, Eduardo Vianna, Johanna Jarcho, Joshua A. Bueller, Brandall Y. Suyenobu, Bruce D. Naliboff, Kirsten Tillisch, Emeran A. Mayer

3:00 #1101

Impact of Serotonin-3 Receptor Gene Polymorphism On Brain Activation By Rectal Distention in Human Shin Fukudo*, Norio Ozaki, Satoshi Watanabe, Michiko Kano, Yasuhiro Sagami, Tomotaka Shoji, Yuka Endo, Motoyori Kanazawa, Michio Hongo

3:15 #1102

Neural Correlates of Sensory & Affective Pain Dimensions in Functional Dyspepsia: A H215O-PET Study Lukas Van Oudenhove*, Joris U. Vandenberghe, Patrick Dupont, Brecht Geeraerts, Guy Bormans, Dominique Vanderghinste, Koen Van Laere, Stijn Dirix, Rita Vos, Koen Demyttenaere, Jan F. Tack

3:30 Sp921

Functional Brain Imaging of Visceral Pain: Is It All in the Mind? Qasim Aziz

Chairs: Takanori Kanai, Giovanni Monteleone Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

IMMUNE ACTIVATION AND REGULATION IN INTESTINAL INFLAMMATION Participants will be able to: • Identify and examine key information and recent advances in immune activation and regulation in intestinal inflammation. 2:15 #1092

Altered Macrophage Function Contributes to Colitis Development in PI3K P110δ Mutant Mice Jennifer K. Uno*, Kavitha N. Rao, Katsuyoshi Matsuoka, Shehzad Z. Sheikh, Fengling Li, Scott E. Plevy

2:30 #1093

The Absence of Functional PI3Kγ Has a Protective Effect On DSS-Induced Colitis in Mice Willemijn A. van Dop*, Stefano Marengo, Anje A. Te Velde, Fiebo J. ten Kate, Daniel Hommes, Guy E. Boeckxstaens, Emilio Hirsch, Gijs R. van den Brink

2:45 #1094

The Impact of HDAC Inhibition On CD4+ T Cells in Chronic Intestinal Inflammation Rainer Glauben*, Elena Sonnenberg, Thorsten Stroh, Inka Fedke, Paolo Mascagni, Martin Zeitz, Britta Siegmund

3:00 #1095

Neutrophil Accumulation and Bacterial Clearance Is Delayed in Patients with Crohn’s Disease Bu’Hussain Hayee*, Farooq Rahman, Andrew M. Smith, Daniel J. Marks, Trevor J. Sweeting, Stuart L. Bloom, Anthony Segal

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S502 McCormick Place

ORAL SESSIONS—SCIENTIFIC SESSIONS 2:27 #1110

A Prospective Randomized Trial and a CostEffectiveness Analysis of Plastic Versus Covered SelfExpandable Metal Stent in Patients with Benign Biliary Stricture Everson L. Artifon*, Carlos K. Furuya Jr., Atul Kumar, Eduardo B. da Silveira, Dayse P. Aparicio, Decio S. Couto Jr., Renato Baracat, Andre Lino, Wellington Cunha, Christiano Sakai, Alexandre M. Brabo, Jose B. Paione

PREDICTING PROGNOSIS IN IBD

2:39 #1111

Participants will be able to: • Be familiar with new knowledge about the utility of biomarkers, such as C-reactive protein, fecal inflammatory markers, serology and gene expression profiles, in predicting disease outcomes in IBD; and • Increase knowledge of the ability of clinical factors and multifactorial models to predict disease outcomes in IBD.

Risk of Post-ERCP Pancreatitis with Placement of SelfExpandable Metallic Stents: A Retrospective, Cohort Analysis Gregory A. Cote*, Michael Ansstas, Nitin Kumar, Andrew Reinink, Steven A. Edmundowicz, Sreenivasa S. Jonnalagadda, Daniel Mullady, Riad R. Azar

2:51 #1112

A Comparison of Outcomes Among Secondary Covered, Uncovered Metalic and Plastic Stent for Occluded Biliary Metallic Stent for Malignant Distal Biliary Obstruction Jae Hee Cho*, Yoon Jae Kim, Hee Man Kim, Semi Park, Sung Pil Hong, Tae Joo Jeon, Seung Woo Park, Jae Bock Chung, Si Young Song, Seungmin Bang

3:03 #1113

A Multicenter Analysis of Safety and Outcome of Removal of Covered Self-Expandable Metal Stents (CSEMS) During Endoscopic Retrograde Cholangiopancreatography (ERCP) John A. Kasher*, James G. Corasanti, Paul R. Tarnasky, Lee McHenry Jr., Glen A. Lehman, John T. Cunningham

3:15 #1114

Uncovered Versus Covered Self-Expanding Metallic Stents for Inoperable Malignant Distal Biliary Obstruction: A Prospective Randomized Multicenter Study Young Deok Cho*, Young Koog Cheon, Kyo-Sang Yoo, Sung-Jo Bang, Chang Duck Kim, Jae Seon Kim, Myung Hwan Roh, Ho Gak Kim

3:27 Sp922

State-of-the-Art Lecture: Metal Stents: A Panacea? Guido Costamagna

AGA Institute Research Forum 2:15 PM - 3:45 PM

S105 McCormick Place

Chairs: A. Hillary Steinhart, Corey A. Siegel Sponsored by: Immunology, Microbiology & Inflammatory Bowel Diseases

2:15 #1103

2:30 #1104

Predictive Value of C-Reactive Protein Level Changes On the Long Term Outcome of Infliximab in Crohn’s Disease Matthias Jürgens*, Fabian Schnitzler, Kristel Van Steen, Jestinah Mahachie, Vera Ballet, Maja Noman, Ilse Hoffman, Gert A. Van Assche, Paul J. Rutgeerts, Severine Vermeire A Prospective Analysis of Clinical Variables, Serologic Factors and Outcome of Ileal Pouch-Anal Anastomosis in Patients with Backwash Ileitis Evan White, Marla Dubinsky, Gil Y. Melmed, Eric A. Vasiliauskas, Andrew Ippoliti, Dermot P. McGovern, Zuri A. Murrell, Stephan R. Targan, Phillip Fleshner*

2:45 #1105

Serum gASCA, Anti-L and Smoking Status Are Associated with Crohn’s Disease-Like Phenotype After Pelvic Pouch Surgery for Ulcerative Colitis Diane Verbeeten*, Raquel Milgrom, Wei Xu, Joanne M. Stempak, A. Hillary Steinhart, Gordon R. Greenberg, Robin S. McLeod, Z. Cohen, Mark S. Silverberg

3:00 #1106

A Prospective Population Based Study of Triggers of Flares of IBD Charles N. Bernstein*, Sunny Singh, Lesley A. Graff, John R. Walker, Mary S. Cheang

3:15 #1107

3:30 #1108

Gene Expression Profiles Associated with Lack of Response to Intravenous Corticosteroids in Children with Severe Ulcerative Colitis Boyko Kabakchiev*, Dan Turner, Jeffrey S. Hyams, David R. Mack, Neal S. LeLeiko, Wallace Crandall, James Markowitz, Anthony R. Otley, Wei Xu, Pingzhao Hu, Anne M. Griffiths, Mark S. Silverberg A Prediction Tool to Help Children with Crohn’s Disease and Their Parents Understand Individualized Risks of Disease Complications and Response to Therapy Corey A. Siegel*, Lori S. Siegel, Jeffrey S. Hyams, Subra Kugathasan, James Markowitz, Joel R. Rosh, Neal Leleiko, David R. Mack, Wallace Crandall, Jonathan Evans, David J. Keljo, Anthony R. Otley, Maria Oliva-Hemker, Christine R. Langton, Iwona T. Wrobel, Ghassan Wahbeh, Antonio Quiros, Gary Silber, Ron J. Bahar, Bruce E. Sands, Marla Dubinsky

ASGE Topic Forum 2:15 PM - 3:45 PM

METAL STENTING: THE GOOD, THE BAD, AND THE UGLY Full Covered Metal Biliary Stents for Treatment of Biliary Complications After Liver Transplantation Mario Traina*, Ilaria Tarantino, Luca Barresi, Ioannis Petridis, Riccardo Volpes

S103ABC McCormick Place

Chairs: Raj J. Shah, Nalini M. Guda NEW AND EMERGING TECHNOLOGIES IN EUS: WHAT’S HOT? 2:15 #1115

Endoscopic Ultrasound-Guided Drainage of Pelvic and Prostatic Abscesses Rajesh Puri*, Mohamad A Eloubeidi, Randhir Sud, Mandhir Kumar, Parvesh Kumar Jain

2:27 #1116

EUS-Guided Fiducial Placement Prior to Targeted Radiation Therapy in Obese Prostate Cancer Patients As An Alternative to Abdominal US Prostate Localization: Results of a Single-Center Experience Julie Yang*, May Abdel-Wahab, Afonso C. Ribeiro

2:39 #1117

Forward-View, Forward-Array Curvilinear Echoendoscope to Diagnose and Sample Right-Sided Colonic Lesions Thai Nguyen-Tang*, Janak N. Shah, Andres Sanchez Yague, Kenneth F. Binmoeller

2:51 #1118

A New Alternative for TIPSS: EUS-Guided Creation of Intrahepatic Porto-Systemic Shunt Sergey V. Kantsevoy*, Jonathan M. Buscaglia, Xavier Dray, Eun Ji Shin, Priscilla Magno, Devi Mukkai Krishnamurty, Kevin Chmura, Vihar Surti, Travis Dillon, Richard Ducharme, Gianfranco Donatelli, Paul J. Thuluvath, Samuel A. Giday

S103D McCormick Place

Chairs: Milton T. Smith, Adam Slivka

2:15 #1109

ASGE Topic Forum 2:15 PM - 3:45 PM

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W E D N E S D A Y JUNE 3

W E D N E S D A Y JUNE 3

ORAL SESSIONS—SCIENTIFIC SESSIONS 3:03 #1119

EUS-Guided Therapy of Bleeding Gastric Varices Andres Sanchez Yague*, Janak N. Shah, Thai Nguyen-Tang, Kenneth F. Binmoeller

3:15 #1120

EUS-Guided In Vivo Microdialysis of Pancreas: A Novel Technique of Potential Diagnostic and Therapeutic Application Masayuki Kitano*, Hiroki Sakamoto, Takamitsu Komaki, Masatoshi Kudo

3:27 Sp923

State-of-the-Art Lecture: Interventional EUS: From Needle to NOTE(U)S Annette Fritscher-Ravens

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ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION POSTGRADUATE COURSE/SPECIAL SESSION ASGE Postgraduate Course 7:30 AM - 12:10 PM

S100 McCormick Place

Chairs: Ian M. Gralnek, David A. Greenwald, Klaus Mergener

ASGE Postgraduate Course Luncheon Breakout Sessions 12:20 PM - 1:10 PM

Sp932

ASGE POSTGRADUATE COURSE - ENDOSCOPY AT HOME AND AROUND THE WORLD: NEW DEVELOPMENTS AND INNOVATIONS FOR YOUR PRACTICE - DAY 2 7:30 Sp924

Welcome Ian M. Gralnek, David A. Greenwald, Klaus Mergener

Chair: Douglas B. Nelson

S104 McCormick Place

Sp933

Screening and Surveillance of Barrett’s Esophagus: What’s New? M. Brian Fennerty

7:50 Sp926

Endoscopic Therapy for Barrett’s Esophagus: EMR, RFA and More Steven A. Edmundowicz

8:05 8:15 Sp927

Sp934

Sp935

8:35 Sp928

9:50

Live from New York Lawrence J. Brandt, Robert A. Enns, Martin L. Freeman, Robert H. Hawes, Gregory B. Haber, Jerome D. Waye, Charles J. Lightdale, Peter D. Stevens, Jacques M.E. Deviere, Guido Costamagna, Richard A. Kozarek, Bret T. Petersen, Gregory G. Ginsberg, Douglas A. Howell, Horst Neuhaus

Sp936

Sp937

Luminal Stenting in the Esophagus, Duodenum and Colon: Bridging the Way to Better Outcomes Todd H. Baron

10:30 Sp930

Malignant Biliary Strictures: Keys to Success Robert A. Enns

10:45

Taking It Home: Panel Roundtable and Q&A

Chair: Ian M. Gralnek SESSION SIX - LIVE FROM NEW YORK 10:55 Sp931

Live from New York Todd H. Baron, Robynne K. Chutkan, D. Nageshwar Reddy, Douglas K. Rex, Gregory B. Haber, Jerome D. Waye, Charles J. Lightdale, Peter D. Stevens, Jacques M.E. Deviere, Guido Costamagna, Richard A. Kozarek, Bret T. Petersen, Gregory G. Ginsberg, Douglas A. Howell, Horst Neuhaus

12:10

Break (Pick up Box Lunch)

06 - Balloon-Assisted Enteroscopy: Should You Get Involved and How? Steven A. Edmundowicz, Patrick I. Okolo III S102A

McCormick Place Sp938

07 - Feeding Tubes (PEG, PEJ): Selecting the Correct Patients and Avoiding Complications S102D Todd H. Baron

McCormick Place Sp939

08 - The Difficult ERCP: Tips and Tricks to Get You Out of a Tough Spot John Baillie, Martin L. Freeman S106B

McCormick Place Sp940

SESSION FIVE - STENTING: PRACTICAL TIPS TO INCREASING YOUR CONFIDENCE IN STENTING 10:15 Sp929

05 - Capsule Endoscopy: Established and Emerging Indications Robynne K. Chutkan, Robert A. Enns S106A

McCormick Place

Refreshment Break

Chair: Steven A. Edmundowicz

04 - EMR/ESD: Which Techniques to Use and When to Apply Them Jonathan Cohen, D. Nageshwar Reddy S102BC

McCormick Place

Chair: David A. Greenwald SESSION FOUR - LIVE FROM NEW YORK

03 - Endoscopic Therapies for Barrett’s Esophagus: When and How to Treat S103BC Thierry Ponchon, Kenneth K. Wang

McCormick Place

Taking It Home: Roundtable and Q&A STATE-OF-THE-ART LECTURE - Advances in Endoscopic Optical Imaging: “Gazing” Into Everyone’s Future Kenneth K. Wang

02 - Optimal Management of the Difficult UGI Bleeder S105A Alan N. Barkun, Ian M. Gralnek

McCormick Place

SESSION THREE - MANAGING THE BARRETT’S EPIDEMIC 7:35 Sp925

01 - The Difficult Polyp: Strategies for Safe and Successful Polypectomy Douglas B. Nelson, Douglas K. Rex

09 - Perfecting Your EUS Skills: All About Sharp Eyes and Sharp Needles Michael J. Levy, Thomas Roesch S103A

McCormick Place Sp941

10 - You and Your GI Pathologist: Getting the Most Out of the Relationship S103D Wilfred M. Weinstein

McCormick Place Sp942

11 - The “Bottom” Line: Management of Anorectal Problems Lawrence J. Brandt S105D

McCormick Place Sp943

12 - Endoscopy in Your IBD Patients: Evidence for Screening and Surveillance Strategies in 2009 Charles N. Bernstein, Jason A. Dominitz S105BC

McCormick Place

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T H U R S D A Y JUNE 4

ORAL SESSIONS—POSTGRADUATE COURSE/SPECIAL SESSION ASGE Postgraduate Course General Session 1:10 PM - 5:30 PM S100 McCormick Place Chair: John Baillie SESSION SEVEN - THE EUS/ERCP INTERFACE

T H U R S D A Y JUNE 4

1:10 Sp944

Pancreatic Cystic Lesions: What Do I Do Now? William R. Brugge

1:25 Sp945

Avoiding ERCP Complications: How to Stay Out of Trouble Martin L. Freeman

1:40 Sp946

ERCP, EUS, MRCP: When to Use What and Why Michael J. Levy

1:55 2:10 Sp947

Taking It Home: Roundtable and Q&A KEYNOTE LECTURE - Obesity Meets Endoscopy Christopher C. Thompson

ASGE Postgraduate Course 2:30 PM - 4:20 PM

S100 McCormick Place

Chair: David A. Greenwald SESSION EIGHT - LIVE FROM NEW YORK 2:30 Sp948

3:45 4:00 Sp949

Live from New York Christopher C. Thompson, M. Brian Fennerty, Douglas B. Nelson, Thierry Ponchon, John Baillie, Gregory B. Haber, Jerome D. Waye, Charles J. Lightdale, Peter D. Stevens, Jacques M.E. Deviere, Guido Costamagna, Richard A. Kozarek, Bret T. Petersen, Gregory G. Ginsberg, Douglas A. Howell, Horst Neuhaus Refreshment Break STATE-OF-THE-ART LECTURE - Optimal Endoscopic Sedation: The Science and the Politics John J. Vargo

Chair: Jonathan Cohen SESSION NINE - ENDOSCOPIC EMERGENCIES 4:20 Sp950

Foreign Body Removal: Tricks of the Trade David A. Greenwald

4:35 Sp951

Acute Pancreatitis and Cholangitis John Baillie

4:50 Sp952

Closing the Gap: Endoscopic Management of Perforations and Fistulae Thomas Roesch

5:05 5:15 Sp953 5:30

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Taking It Home: Roundtable and Q&A That’s a Wrap: Lessons Learned from the NY Live Cases Ian M. Gralnek, David A. Greenwald, Klaus Mergener Adjourn