Osteoblastoma of the Maxilla: A Case Report

Osteoblastoma of the Maxilla: A Case Report

OOOO Volume 119, Number 3 JUVENILE OSSYFING FIBROMA: A CASE REPORT WITH 6 YEARS OF FOLLOW-UP Ana Carolina Uchoa Vasconcelos, Ana Paula Gomes, Adriana ...

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OOOO Volume 119, Number 3 JUVENILE OSSYFING FIBROMA: A CASE REPORT WITH 6 YEARS OF FOLLOW-UP Ana Carolina Uchoa Vasconcelos, Ana Paula Gomes, Adriana Etges, Marcos Antônio Torriani, Romeu Berlon Fernades Filho, Universidade Federal de Pelotas A 24-year-old woman was referred to the School of Dentistry/ Brazil, in 2008, complaining about a swelling on the right posterior maxilla, with symptoms of nasal obstruction and infra orbital pain. The intraoral examination revealed a vestibular expansion mass, measuring 2.0  1.5 cm. Computed tomography (CT) showed a large, well-demarcated, unilocular and hypodense mass in the posterior right side of maxilla. The patient had a history of previous surgery, in the same site, about 3 years ago, with histopathological diagnosis compatible with JOF. An excisional biopsy was performed, confirming this diagnosis. Microscopically, the neoplasm consisted of a cellular fibrous connective tissue, with several spindle or oval-shaped fibroblasts, presenting large nuclei and cytoplasms with imprecise limits. Mitotic figures, clusters of giant multinucleated cells, and a mineralized component showing spherical concentric lamellated ossicles and trabeculae of cellular woven bone were also observed. Currently, after 6 years, there was still no evidence of recurrence. Keywords: Ossyfing Fibroma, jaw, maxilla

GLOMUS TUMOR: A CASE REPORT Ana Carolina Uchoa Vasconcelos1, Ana Paula Neutzling Gomes1, Adriana Etges1, Guilherme De Marco Antonello1, Maria Cássia Ferreira De Aguiar2, Adriano Mota Loyola3, Vera Cavalcanti De Araújo4, 1 Dental School, Federal University of Pelotas, Pelotas, Brazil; 2Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil; 3Dental School, Federal University of Uberlândia, Uberlândia, Brazil; 4Dental School, São Leopoldo Mandic Institute, São Paulo, Brazil The glomus tumor is derived from the arteriovenous anastomosis apparatus and accounts for less than 2% of soft tissue tumors (1,2,3). A 67-year-old woman was referred to the School of Dentistry/Brazil, in August/2013, complaining about as lightly symptomatic swelling of the upper lip. The intra-oral examination revealed a well-defined submucosal mass measuring 1.0 cm in diameter which was present for 5 years. An excisional biopsy was performed. Microscopically, a pseudo-encapsulated proliferation, characterized by vascular spaces, surrounded by fairly uniform blue cell cells were found. The stroma presented hyaline and occasionally myxoid areas. Individually, the glomus cells were small and rounded with pale and abundant eosinophilic cytoplasm and vesicular round-to oval nuclei. The Schiff periodic acid staining showed a chicken wire pattern, surrounding the proliferating cells. Immunohistochemical staining was positive for smooth muscle actin and negative for cytokeratins 7, 8, 14, 19, AE1/AE3antigen. Currently, there was still no evidence of recurrence. Keywords: glomus tumor, mouth, lip

CORRELATION OF CLINICAL AND RADIOLOGICAL TNM STAGES OF HEAD AND NECK CANCERS AT UCH IBADAN Opeyemi Folorunso Sigbeku1, Bamidele Moronfolu Kolude1, Adenike Temitayo Adeniji Sofoluwe2, Aderemi Adeleke Adeosun3, 1Department of Oral Pathology, University College Hospital/University of Ibadan, Ibadan, Nigeria; 2 Department of Radiology, University College Hospital/University of Ibadan, Ibadan, Nigeria; 3Department of Otorhinolanryngology, University College Hospital/University of Ibadan, Ibadan, Nigeria

ABSTRACTS Abstracts e213 Objective: To correlate clinical with radiological stages of head and neck cancers (HNCs) using CT scan. Study Design: 2-year, Cross sectional, clinico-pathological & radiological study of HNCs at UCH. Results: HNCs included 29 (53.7%) males and 25(46.3%) females. Histologic types were 27.8% SCC, 24.1% nasopharyngeal carcinoma (NPC) and 14.8% mucoepidermoid carcinoma (MEC). SCC & MEC were more in females (66.7 & 62.5% respectively) while NPC was more in males (76.9%). Clinical stages were II ¼ 5.6%; III ¼ 29.6% & IV ¼ 64.9% while radiological stages were III ¼ 9.3% & IV ¼ 90.7%. Difference between the clinical stages and radiological stages of HNCs was significant (X2¼ 366.6; p¼0.00 & r ¼ 0.541). Conclusions: CT scan was a useful tool for tumor size upgrade and detection of hidden cervical node involvement alongside distant metastasis. Radiological (CT scan) TNM staging was more accurate than clinical TNM staging for HNCs and the correlation was significantly positive. Keywords: Clinical, radiological TNM staging, HNCs, CTscan

EFFECT OF BRAZILIAN RED PROPOLIS ON THE DEVELOPMENT AND IMMUNOHISTOCHEMICAL EXPRESSION OF Ki-67 AND p16INK4A IN DMBAINDUCED ORAL SQUAMOUS CELL CARCINOMAS Genecy Calado De Melo1, José Cleveilton Dos Santos1, Esaú Pinheiro Dos Santos1, Danielle Rodrigues Ribeiro Cavalcante2, Juliana Cordeiro Cardoso2, Ricardo Luiz Cavalcanti De Albuquerque Júnior1, 1Department of Oral Pathology, Tiradentes University, Aracaju/SE, Brazil; 2 Laboratory of Morphology and Structural Biology Institute of Technology and Research -ITP, Aracaju/SE, Brazil Objective: To investigate the effect of the oral administration of hydroalcoholic extract of Brazilian red propolis (HERP) on the development and immunoghistochemical expression of Ki-67 and p16INK4A in DMBA-induced oral squamous cell carcinomas (OSCC) in 25 rats randomly assigned into 5 groups. Study Design: Carcinogenesis was induced in lower lip by applying DMBA topically, on every other day. The HERP was orally administered to the RP10, RP50 and RP100. After 25 weeks, animals were euthanized for post-mortem removal of the area to histochemical/immunohistochemical analysis. Results: The administration of HERP significantly inhibited of OSCC in 40% of RP50 and RP100. The mean tumor volume seen in TUM1 and TUM2 were significantly bigger than in RP50 and RP100. Eighteen DMBA-induced OSCC showed positivity for Ki-67. The p16INK4A, 70% of the OSCC and 80% of the dysplastic epitheliums were positive. Conclusions: Results suggest that HERP exerts chemopreventive activity on the progression of DMBA-induced epithelial dysplasia to invasive OSCC. Keywords: Extract oil, Brazilian red propolis, carcinogenesis

OSTEOBLASTOMA OF THE MAXILLA: A CASE REPORT Rosa Alejandra Castro Araya1, Juana Olga Salinas Flores1, Iris Espinoza Santander3, Loreto Castellón4, Veronica Palacios Inostroza5, Monica Ramírez2, Carolina Martínez2, Rosa Alejandra Castro Araya2, Verónica Palacios Inostroza2, 1Reference Centre for Health “Cordillera Oriente,” Peñalolen, Santiago de Chile; 2Universidad Católica de Chile, Faculty of Medicine; 3Universidad de Chile, Faculty

ORAL AND MAXILLOFACIAL PATHOLOGY e214 Abstracts

OOOO March 2015

Dentistry; 4Children’s Hospital Dr. Luis Calvo Mackenna; 5 Complejo Asistencial Dr. Sótero del Río

Keywords: Odontogenic RANKL, OPG, IL-1, IL-10

A 16-year-old female was referred for presenting a gradually enlargement mass of the left maxilla since 3 months. The lesion was asymptomatic and covered by normal mucosa, but tooth 2.3 was mobile and sensitive to percussion and tooth 2.4 was displaced. Radiographic examination revealed an ill-defined radiolucency and displacement of teeth 2.3 and 2.4. The lesion extended from tooth 2.2 to 2.4. The CT showed a large expansive mass eroding through the left vestibular cortical. An incisional biopsy was performed and a diagnosis of osteoblastoma was rendered. Later the patient underwent a partial maxillectomy and the histological examination confirmed the diagnosis of osteoblastoma. Keywords: osteoblastoma, aggressive osteoblastoma, Gnathic Maxilla, Osteoblastoma-like osteosarcoma

IMMUNOHISTOCHEMICAL ANALYSIS OF VEGF-C, VEGF-D AND MEASUREMENT OF LYMPHATIC DENSITY IN SALIVARY GLAND NEOPLASMS Clarissa Favero Demeda1, Keila Martha Amorim Barroso1, Cassiano Francisco Weege Nonaka2, Roseana De Almeida Freitas1, Leão Pereira Pinto1, Hébel Cavalcanti Galvão1, Lélia Batista De Souza1, 1Post-Graduate Program of Oral Patology, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Brazil; 2Dentistry Department, State University of Paraíba, Campina Grande, Brazil

METASTASIS OF COLON ADENOCARCINOMA IN ORAL MUCOSA: A CASE REPORT Rosa Alejandra Castro Araya1, Juana Olga Salinas Flores1, Fancy Gaete3, Alejandra Orellana2, Rosa Alejandra Castro Araya2, 1Reference Centre for Health “Cordillera Oriente,” Peñalolen, Santiago de Chile; 2Universidad del Desarrollo, Facultad de Medicina, Santiago de Chile; 3Hospital Luis Tisne, Santiago de Chile Male patient, 72 years old, treated in 2006 for colon cancer, consults for discomfort in the use of his upper denture for one month. Extraoral examination: slight asymmetry on the right side of the face. Intraoral examination: Increased volume in the right retromandibular area and buccal mucosa, indurated, painful to compression, 4  3 cm. Evolution time: unknown, biopsy is taken. Diagnosis: Metastasis of colon adenocarcinoma in oral mucosa. The patient was referred for specialty treatment. Keywords: oral cancer, metastasis, clinical presentation

tumors,

Odontogenic

cysts,

Objective: To evaluate the expression of VEGF-C and VEGF-D, tumor lymphatic vascular density (LVD) and lymphatic endothelial proliferation (D2-40/Ki-67) in a series of salivary glands tumors. Study Design: The sample consisted of 20 of pleomorphic adenomas (PA), 20 of adenoid cystic carcinomas (AdCC), 20 of mucoepidermoid carcinomas (MEC) and 10 of normal salivary gland tissue. Results: All samples showed positive expression of VEGFC, no differences were found between the groups. However, the group of adenoid cystic carcinoma showed a significant difference in immunoreactivity of VEGF-C by the cribriform and solid pattern (p ¼ 0.004). LVD showed crescent results, with lower values for PA, followed by MEC and AdCC. Most of the cases showed weak immunoreactivity for VEGF-D. Conclusions: Strong expression of VEGF-C indicates that this protein may play an important role in the stimulation of lymphangiogenesis in tumors of salivary gland. However, the weak labeling for VEGF-D suggests otherwise. Keywords: Lymphangiogenesis, VEGF-C, VEGF-D, Immunohistochemical, salivary gland, pathology

IMMUNOEXPRESSION OF OSTEOLYTIC FACTORS IN ODONTOGENIC TUMOR AND CYSTS Roseana De Almeida Freitas, Hébel Cavalcanti Galvão, Lélia Batista De Souza, Leão Pereira Pinto, Melka Coêlho Sá, Felipe Rodrigues De Matos, Ana Luiza Dias Leite De Andrade, Clarissa Favero Demeda, Antonio De Lisboa Lopes Costa, Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil

DELAYED MANAGEMENT OF COMPLICATED CROWN-ROOT FRACTURED MAXILLARY ANTERIOR TOOTH: A CASE REPORT Meltem Derya Akkurt1, Bulent Buyukgural2, 1Kayseri Military Hospital, Dental Clinic, Department of Pediatric Dentistry, Kayseri, Turkey; 2Dental Office, Ankara, Turkey

Objective: The purpose of this study was to investigate the immunoexpression ratio between osteolytic factors stimulating activity (IL-1, RANKL) and inhibitors factors (IL-10, OPG) in radicular cysts (RCs), residual cysts (ReCs), dentigerous cysts (DCs), solid ameloblastomas (SAs) and keratocystic odontogenic tumors (KOTs). Study Design: A total of 20 RCs, 20 ReCs, 20 DCs, 20 KOTs, 18 SAs and 15 dental follicles (DFs) were evaluated. The immunopositive cells were counted in 10 microscopic high-power fields (400) in epithelium and mesenchyme. A comparative analysis of the data was performed using the nonparametric Wilcoxon signed rank test. Results: The results demonstrate that SAs showed higher number of cases with ratio OPGIL1 when compared to other cysts and tumors (P<.05). Conclusions: Our results indicate that imbalance of osteolytic factors stimulating activity (IL-1, RANKL) and inhibitors factors (IL-10, OPG) plays an important role in biological behavior of the studied cysts and tumors. Supported by CNPq.

This case report describes the management of a vertical crown-root fracture in the maxillary right central tooth by surgical, endodontic and conservative treatment. A 10-year-old male child came to our clinic 15 days after having fallen. Clinical and radiological examination showed a complicated crown-root fracture in the incisor tooth. The mobility of the luxated tooth fragments was recorded as grade 1. Until the time of periodontal treatment tooth fragments were cemented with composite restoration in fracture line. Two months after completing the endodontic treatment, under local anesthesia exploratory flap was raised and the coronal part removed. The tooth fragments were attached using a glass ionomer cement. One week after surgery, to meet esthetic requirements for the right maxillary central incisor, the dental treatment was completed with a composite restoration and occlusal adjustment was performed. Clinical and radiographic follow-up after a one-year post-operative period showed no abnormalities. Keywords: Crown-root fracture, Surgical treatment, Composite restoration, Trauma