P100 The effect of flavonoids on the prevention of hemoglobin glycosylation

P100 The effect of flavonoids on the prevention of hemoglobin glycosylation

ST4 PosterAbstracts The effect of Ravonolds on the prevention of hemo&bln S. Asgay, Gh. Naderi, N. Sawa~an, M. Boshtam, glycosylatloo M. Rnfie,...

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The effect of Ravonolds on the prevention of hemo&bln S. Asgay,

Gh. Naderi,

N. Sawa~an,

M. Boshtam,


M. Rnfie, A. Alefur,,

Isfaha” Cardiovascular Research Center, Isfaha”, Iran

Sodium chloride intake in Isleha” population M. Boshtam,

M. R&e,

N. Samafaade~on,

Gh. Naderi,

S. Asgay


Cardiovascular Research Center, Isfahan, Iran

Objective: A high glucose concentration has been found to lead to the glycosylation of amino groups of lysine residue in proteins. The addition of reducing agent prevents as well as reverses this reaction. On the other hand flavonoids which are found in plant sources have antioxidant properties. Therefore since the glycosylation of protein is a” oxidation reaction, antioxidants should be able to prevent this reaction. Methods: In this study the best concentration and best time to incubate glucose with Hemoglobin was investigated. T&n the glycosylation degree of Hemoglobin in the vicinity of flavoooids and apart from them was measured by means of a fluorimetric method. Different concentration of flavonoids (Quercetin, Rutin, Kaempferol) were used in this study. Results: The preventing effect on hemoglobin glycosylation by the 3 concentrations; 10, 100,200 pg/ml was estimated as follows: for Rutin: ll%, 27% and 52%, Quercetin: 3%, 37% and 42%, Kaempferol: lo%, 12% and 19%, respectively. Conclusions: So, the in viva effect should be investigated and then plants containing flavonoids can be utilized to prevent or treat complication of diabetes.

Objectives: Hypertension as a major risk factor for coronary artery disease and stroke can be affected with some dietary factors. One of these, factors is sodium chloride (N&l) intake. As hypertension is prevalent in Isfahan population, it seems to be necessary to determine NaCl intake in this population. On the other hand, the best and the most appropriate method, to measure N&l-intake is 24 hour urine collection. Method: So, this descriptive study on 900 persons at the age of 20-60 years in both sexes was done. These subjects were randomly selected from different Isfahan population clusters. The 24-hr urine specimen was collected and BP was measured from each participant, and also questionnaires containing some questions concerning anthropometric characteristics, CAD risk factor, use of some drugs and other confounder for this measurement was completed for them by interview. All persons who were. on an especial diet excluded from stody. Using SPSS software the age-sex based mean of NaCl intake was calculated. Result: The mean sodium chloride intake (g/day) in all age groups has been presented in following table:

Table 13


Age (yr,

MM” 9.23 9.26 9.54 9.23 9.17


The influence of socio-economic condition end education on blood pressure M. Boshtam,

M. Raj%, N. Sawaflade~a~

S. Asgay,

Gh. Naderi

Isfahan Cardiovascular Research Center, Isfahan, Iran Objective: Coronary artery disease (CAD) is one of the fatal diseases in the whole the world. One of the major risk factors of these diseases is hypertension. As socio-economic factors and education seem to be important for occurrence of these diseases so that high prevalence of them has been observed more in low class people than high class one. Method: In a population-based study carried out on 1000 people 20-60 years in Isfahan in 1996-97, the relation of socio-economic factors with blood pressure studied. During home interview, some information about age, sex, occupation, use of contraceptive and antihypertensive drugs, education, history of hypertension, smoking status and the number of cigarettes, the physical activity life style, etc. were obtained by questionnaire. Blood pressure of each participant measured according to standardized WHO criteria after at least 5 minutes of rest from the right arm in lying position. Result: In the following table, the meansystolic and diastolic blood pressure @BP and DBP) (mmHg) in each occupational level has been shown:

30-39 40-49 50-60 Total

P103 Comparison of knowledge and practice of Ishhan people about the CVD risk rnctors N. Samfzadegan

Isfahan Cardiovascular Research Center, Isfahan, Iran

Table 12

Employee Businessman Housewife Farmer Retired Jobless

1.70 1.39 1.34 1.45 1.37

Conclusion: So, as the prevalence of hypertension is high in Isfahan, we must decrease the use of NaCl in our population diet by a good programme.

H. Alikhasi,





(mean k SD) 120.61 f 12.15 119.57 f 9.28 121.16 zt 13.18

(mean f SD) 93.9 * 103.39 77.61 * 8.51 79.61 + 8.95

131.52 + 15.23 115.68 + 15.4

85.15 f 6.67 72.13 f 7.83

In comparing the mean value of SBP and DBP between each level of occupation, separately, the significant difference between low level occupations and SBP, and DPB was observed (P value of T test < 0.05). In addition, the association of education and blood pressure in multiple linear regression model with adjustment for all confounders was investigated which significant relation only for SBP was observed (b = - 1.25, p = 0.042). Conclusion: On the whole, it is considered that in low class people (low in education or low in occupation), the mean of blood pressure is higher than the one in high class one. So, socioeconomic factors have important effect on blood pressure. Therefore it must be noticed in performing programs on cultural factors in order to control hypertension.

Coronary heart diseases (CHD) are the main health problems in developed and developing countries. There are several risk factors that are interfering with CHD. For controling these factors, we must educate the society and before that, it is necessary to determine the degree of primary lmowledge of people about each of the risk factors. This study is done on 2400 people over 14 years of age in Isfahan that have been selected randomly from 40 different cluster of the city. To do this investigation, a questionnaire with several descriptive questions was prepared and was completed by educated question makers. From all these people, 55% were women and 45% were men. The most knowledge about risk factors, was about stresses and emotional problems. As a matter of fact about l/3 of the people mentioned that the first cause of the disease are the stresses. Overall, the knowledge of women and knowledge of the people with higher educations was greater. In nutrition subject, 83% of women and 76% of me” mentioned that liquid oil are the best, but only 22.8% of women and 18.4% of men were consuming liquid oil (p < 0.001). Also 61% of the people mentioned that the best kind of meat is fish, but only 4% of them were using fish once a week Cp < 0.01). Peoples’ knowledge about consequences of overweight and unmobility on CHD were almost good, but their act was different. As a matter of fact 91% of women and 95% of men had complete knowledge about the effect of increasing weight and unmobility, but 71% of women and 43% of men were unmobile. About the correct description of heart attack, more than half of the study population didn’t have correct information and only 5.1% of them knew the correct descrip tion (p = 0.001).