P2-124: Risk factors for cerebrovascular disease and cognitive function in the elderly

P2-124: Risk factors for cerebrovascular disease and cognitive function in the elderly

Poster Presentations P2: lower in VD compared with controls. Low HDL-C (⬍ 45 mg/dL) was associated with VD (O.R.: 6.52, C.I. 95%: 1.42-30.70 vs contro...

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Poster Presentations P2: lower in VD compared with controls. Low HDL-C (⬍ 45 mg/dL) was associated with VD (O.R.: 6.52, C.I. 95%: 1.42-30.70 vs controls, and 4.31, C.I. 95%: 0.93-19.82 vs LOAD), after multivariate adjustment. No differences in plasma lipid levels emerged between the two groups. Conclusions: In this cross-sectional study low HDL-C levels are associated with VD, in a sample of older subjects and it is more with chronological age. P2-122

PERIODONTAL DISEASE, ISCHAEMIC STROKE AND COGNITIVE IMPAIRMENT IN NORTH INDIA

Kusum Singh1, Manju Barwar1, Rajesh Bisnoi2, 1PBM Hospital, Bikaner, India; 2S P Medical College, Bikaner, India. Contact e-mail: [email protected]@yahoo.com

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Background: Chronic periodontal disease may increase the risk of cerebro vascular disease. We investigated whether periodontal disease including periodontitis & gingivitis and number of teeth are risk factor for stroke and cognitive impairment. Methods: We performed case control study in 101 patients Examined in 0-7 days after acute ischaemic stroke or TIA and 100 population control with non vascular neurological disease. The individuals mean clinical attachment loss measured at 4 site per tooth served as main indicator for periodontitis and MMSE for cognitive impairment. Results: All patients had higher clinical attachment loss than control (P⬍0.001) The risk of cerebral stroke increase with more severe periodonitis & less no. of teeth. MMSE score was 24 & more in stroke patients at the end of 8 weeks. Patients with severe periodontitis has mean clinical attachment loss more tham 6 mm had a 4.1 times higher (91%) confidential interval (18.4- 10.2) risk of cerebral ischaemia than subject with mild periodontitis. Severe periodontitis and less than 24 teeth (HR ⫽ 1.56 : 95 % CI 1.21 to 1.97) were at higher risk of stroke in younger male compare to male with ⬎ 25 teeth while gingivitis and severe radiological bone loss were independently associated with risk of cerebral ischaemia and cognitive impairment (MMSE ⬎ 24) where as dental caries was not associated with it. Conclusions: Our study indicate that periodontal disease a treatable condition and number of teeth are independent risk factor for cerebral ischaemia and cognitive impairment in younger male patients. P2-123

RISK FACTORS FOR VASCULAR DEMENTIA IN A BRAZILIAN PUBLIC HEALTH CARE SERVICE SPECIALIZING IN COGNITIVE DISORDERS

Jose Ibiapina Siqueira-Neto, Federal University of Ceara, Fortaleza, Brazil. Contact e-mail: [email protected] Background: Vascular dementia (VaD) is the second most common form of dementia. In developing countries we have scarce data about risk factors (RF) for vascular dementia with large number of patients followed during long time and investigated extensively with neuroimaging facilities. Methods: Identification of VaD patients was made in a specialized ambulatory situated in a general hospital utilizing NINDSAIREN criteria between January 1995 and December 2005. 253 charts were seen by the investigators retrospectively. 234 patients were selected to the present analysis. The final classification was fixated by the authors and the same neuroradiologists of our team during a discussion session. The majority (52,1%) of our cases had MRI scan or at least one CT scan made in the emergence unit. Results: A vast proportion (82,9%) of the patients had low education level with 4 years or less of formal studies. The age varied from 29 until 95 years and 145 (62%) were male. Most cases (58,1%) started cognitive symptoms until 70 years. 124 patients (53%) were diagnosed as pure vascular dementia (PVaD) and 110 patients (47%) as “mixed dementia” (MD) or dementia with “definitive vascular component” plus another cause of dementia, mostly dementia that fulfil criteria for probable Alzheimer Disease (AD). In our subjects hypertension was the most prevalent RF compromised 186 patients (79,5%). Among others RF we obtained: 61 (26,1%) Diabetes Mellitus (DM), 39 (16,7%) hyperlipidemia, 108 (46,15%) previous TIA or cerebral infarct (CI), 57 (24,35%) smoking, 46

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(19,65%) drinking, 30 (12,8%) atrial fibrillation, 75 (32%) heart disease, and 19 (8,1%) peripheral vascular disease. Conclusions: Among most authors elevated blood pressure is the main RF for VaD that was confirmed in the present work. Other prevalent RF was heart disease and previous cerebral ischemic events with high proportions than observed in the literature. DM and hiperlypidemia were in the range observed in other studies. In conclusion, our results demonstrated that VaD and Mixed dementia in our service is most related with Arterial Hypertension, previous cerebral ischemic events and heart disease. Other observed RF like DM and hyperlipidemia were less prevalent, but still important. P2-124

RISK FACTORS FOR CEREBROVASCULAR DISEASE AND COGNITIVE FUNCTION IN THE ELDERLY

Nicole L. Steibel, Memolab-HMV, POA, Brazil. Contact e-mail: [email protected] Background: The presence of stroke risk factors in the elderly can contribute for cognitive dysfunction. The neuropsychological assessment is useful to demonstrate the profile of these patients on the test. Methods: The cognitive abilities of elderly individuals with different degrees of risk as per the Framingham stroke risk profile were compared. The Framingham stroke risk profile was used to calculate the risk of an ischemic cerebral event. Neuropsychological tests included the Buschke Selective Reminding Test, verbal fluency (animals), clock drawing, Rey Auditory Verbal Learning, digit span and vocabulary. A random and typical population sample was used in the study, selected from the 200 elderly residents in the area surrounding the primary health care facility (Morada das Flores Clinic, Porto Alegre). Forty-six elderly individuals were included in the study. Results: The elderly individuals with a risk profile, had lower memory test performance levels (NF, p⫽0.02) and planning capacity (clock drawing test, p⫽0.03). Diabetes proved to be related to delayed recall performance in the Rey auditory verbal learning test (p⫽0.04). Conclusions: The presence of stroke risk factors in the elderly was associated with worse cognitive performance for memory and executive functions. P2-125

CHARACTERIZATION OF PHOSPHORYLATIONDEPENDENT MONOCLONAL ANTI-TAU ANTIBODIES

Robert Porzig, David Singer, Ralf Hoffmann, Institute of Bioanalytical Chemistry, Centre for Biotechnology and Biomedicine, Leipzig University, Leipzig, Germany. Contact e-mail: [email protected] Background: Senile plaques (SP) and neurofibrillary tangles (NFTs) are the major hallmark in Alzheimer’s disease (AD). NFTs consist mostly of hyperphosphorylated versions of the microtubule- associated tau protein. Whereas many phosphorylation sites have been identified the phosphorylation pattern of these hyperphosphorylated regions is still unclear but bears the promise to identify disease related patterns to develop diagnostic tools or understand the underlying kinase and phosphatase activities. Although many phosphorylation-dependent monoclonal antibodies (mAbs) are available, their exact binding characteristics have not been studied in detail and thus the results of phosphorylation studies relying on such mAbs are often questionable. Methods: Methods used are peptidesynthesis, phosphorylation, native chemical ligation, analyses by immunoblot as well as enzyme linked immunosorbens assay (ELISA). Results: Here we characterize the epitope of mAk AT8 in detail and present also a new strategy to map mAbs in immunoblot analyses. Our data show that mAb AT8 recognizes the double-phosphorylated epitope containing pSer202 and pThr205, which was independent of the phosphorylation status of serine 199. However, mAb AT8 was cross-reactive to two neighbored doublephosphorylated epitopes pSer199/pSer202 and pThr205/pSer 208 in direct and competitive ELISA as well as competitive staining of PHF-tau in