Pathology of the kidney

Pathology of the kidney

HUMAN PATHOLOGY Volume 23, No. 9 (September find to be important in any textbook. If there is one complaint to be raised, it is that the index is pr...

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Volume 23, No. 9 (September

find to be important in any textbook. If there is one complaint to be raised, it is that the index is present only at the end of the second volume, instead of at the end of both volumes. I found this two-volume book to be a masterpiece. It is easily readable and extremely well illustrated. It is very authoritative. The material is presented in a manner that allows one to understand the problems of gastrointestinal pathology and how to approach them. It presents differential diagnoses to pathologists and affords them an algorithm of coming to a correct and final diagnosis. This book contains anything and everything a pathologist needs to consult in the everyday practice of gastrointestinal pathology. I would categorically recommend this book to all pathologists (and gastroenterologists). It should be part of every pathology department’s library. I wish to congratulate Drs Lewin, Riddell, and Weinstein on an excellent and well-done job.-HARRY S. COOPER, Professor of Pathology, Hahnemann Hospital, Philadelphia,

Medical PA

College, Hahnemann


Pathobiology of Soft Tissue Tumours. C. D. M. Fletcher and P. H. McKee (eds). New York, NY, Churchill Livingstone, 1990, 358 pages, $98. Pathobiology of Soft Tissue Tumours is a recent addition to the Current Problems in Tumour Pathology series. In this volume there are 16 chapters that have been contributed by 22 authors from around the globe. This book begins with several introductory chapters on the etiology, epidemiology, and current classification of soft tissue tumors. There follows a number of chapters on such varied topics as the biology of the myofibroblast; fibrohistiocytic tumors; Kaposi’s sarcoma; the immunohistochemistry, enzyme chemistry, and electron microscopy of soft tissue tumors; and the grading and staging of sarcomas. It concludes with three chapters on recent developments in benign, pseudosarcomatous, and malignant soft tissue tumors, a chapter on the treatment of soft tissue tumors, and a closing chapter on future prospects. Most of the chapters appear quite current and are well referenced. It is somewhat difficult to define an audience for this book. The chapter on the classification of soft tissue tumors offers a very comprehensive listing of benign and malignant soft tissue tumors. The short comments that follow each entry are often topical and pertinent, and many are potentially useful to the diagnostic surgical pathologist or clinician. For example, the entry that follows well-differentiated liposarcoma raises the current issue of classifying some of these tumors as “atypical lipoma” and gives appropriate references. Similarly, the entry under pleomorphic liposarcoma notes the occasional difficulty in distinguishing this entity from malignant fibrous histiocytoma. The entry under atypical fibroxanthoma emphasizes that this tumor is histologically indistinguishable from pleomorphic malignant fibrous histiocytoma, but occurs more superficially and rarely metastasizes; again, pertinent references are included. A very succinct and informative chapter on benign and malignant fibrohistiocytic tumors places the development of ideas about the histogenesis and classification of these tumors in historic perspective. This is followed by a more practical and diagnostically useful discussion on the morphologic classification of these tumors. This discussion addresses some of the confusion that exists in the current nomenclature (especially for the benign fibrous tumors) and discusses potential diagnostic problems pertaining to benign and malignant fibrous lesions. There are three chapters near the end of the book devoted to recent progress in benign, pseudosarcomatous, and malignant soft tissue tumors. Each of these chapters offers an informative, concise, and well-referenced review of new entities,


and topical discussions relating recent findings and their impact on the current approaches to established entities. One of the highlights is a welcome summary of the relationship among peripheral neuroepithelioma, Ewing’s sarcoma, and Askin tumors. These three chapters should be of interest to diagnostic surgical pathologists and investigators. The black and white photographs that accompany the discussions of the diagnostic entities are usually relevant to the text and are of high quality. Those that accompany the descriptions of the new entities within the chapter on benign soft tissue tumors are particularly helpful. While appropriate references are made to consistent cytogenetic abnormalities found in some of these entities, the role of certain molecular abnormalities that have been implicated in the oncogenesis of some of these tumors might also have been mentioned. It is unfortunate that a chapter was not included on the molecular biology of these tumors. This book will probably be more useful to those who are involved in investigative work that either directly or indirectly pertains to some aspect of soft tissue tumors. While it should serve well as an overview of this rather complex and very diverse area of human tumor biology, it will probably be more useful as a reference source for those wanting to delve deeper into a particular aspect of the subject. As noted above, certain chapters should also be quite useful to those engaged primarily in diagnostic pathology.-JAMES R. THOMAS, MD, PHD, Assistant Professor, University of Arkansas for Medical Sciences, Little Rock, AR

Pathology of the Kidney. Robert H. Heptinstall (ed). Boston, MA, Little, Brown, 1992, 2,111 pages, 3 volumes, $300. Renal pathologists with well-worn earlier editions of this text will welcome the reorganized and extensively revised fourth edition of Pathology of the Kidney. This book, like previous editions, reflects the extensive experience of Dr Heptinstall and his colleagues. Although Dr Heptinstall has written fewer of the chapters than in previous editions, his colleagues maintain his elegant and readable style. In this edition Dr Heptinstall has turned over authorship of 15 of the 3 1 chapters to his colleagues, including several who have trained under him. The number of pages has been expanded from 1,695 to over 2,100, with extensive reorganization, revision, updating with new material, and new chapters. There are several new authors for this edition. Drs Venkatachalam and Kriz provided a beautifully illustrated compendium of the anatomy of the kidney, Dr Risdon reorganized and consolidated the previous two chapters on development into one chapter, Dr Silva contributed the chapters on acute postinfectious glomerulonephritis and membranoproliferative glomerulonephritis, Dr Schwartz contributed a discussion on membranous glomerulonephritis, and Dr Olsen provided information on the nephrotic syndrome and diabetes mellitus. The expanded knowledge on IgA nephropathy has led to a new chapter by Dr Emancipator on this entity. Dr Hill has extended his contribution to include a chapter on calcium, renal osteodystrophy, and stones. The extensive effort in revising this book is apparent even when picking it up. The page size is larger, allowing formatting in columns. Liberal use of boldface subheadings has allowed easier access to specific sections. Subheadings are listed in the beginning of each chapter, providing easier overview of the material covered, while the index is as complete as it was previously. To avoid serious exertion while lifting this extensive work, the paper stock has been changed to a lighter weight. However, the illustrations are, as before, magnificently reproduced. Although many are retained, new illustrations of the same quality as typical in previous editions abound. The ex-



cellent illustrations and discussion of gross and microscopic features with detailed descriptions of electron microscopic and immunofluorescence findings will be an aid in reaching diagnoses. All chapters have been updated, with many undergoing significant revision and reorganization. References from 1990 are included, which is quite remarkable in a textbook of this size. These are well chosen, with complete coverage of both classic initial descriptions and the most recent experimental work. Much new information has evolved during the 9 years since the previous edition of this book. Although many smallerscope renal pathology texts have been published, this text was the only one that treated renal pathology in a scope comparable to the major clinical nephrology texts. In 1989, a book of comparable scope, Renal Pathology With Renal and Functional Correlations, was edited by Drs Tisher and Brenner. Even since that time, however, new information has appeared that has made its way into this fourth edition of Pathology ofthe Kidney. Entities not discussed previously that are included in this edition include toxicity due to cyclosporine or FK-506, HIV-associated nephropathy, and fibrillary or immunotactoid glomerulonephritis. Examples of new discussions of pathogenesis include those on antineutrophil cytoplasmic antibody (ANCA) and pauci-immune glomerulonephritis, as well as those on the roles of verotoxin, large von Willebrand factor multimers, anti-


endothelial cell antibodies, and neuraminidase in hemolytic uremic syndrome. Discussions of pathogenesis are thorough, concise, and scholarly, based on careful analyses and personal experiences. Some minor issues bear mentioning. For some of the newest entities described (notably “immunotactoid” glomerulonephritis) some readers may disagree with generalizations made that are based on the initial reports. For instance, I would question the assertion that most patients with “immunotactoid” glomerulonephritis do not have concomitant systemic disease. Although the chapter on renal transplantation is greatly expanded and contains much information, cyclosplorine nephrotoxicity is discussed only briefly in a few pages in a separate chapter on renal complications of therapeutic agents. An excellent understanding of any subject matter germane to renal pathology will be gained by referring to the appropriate section in this book. For students of renal pathology, including those who have held on to their old editions of this book and those who purchased other books in the interim, this book will be an indispensable reference. This text will remain an essential resource for clinicians, pathologists, and investigators interested in renal pathology and for every medical library.-AGNES FOGO, MD, Assistant Professor of Pathology and Pediatrics, Vanderbilt University Medicat Center, Department of Pathology, Nashville, TN

Neoplasms With Eccrine Differentiation. Pascual Abcnoza and A.


Booksfor reoiew or listing may be sent to Louis M. Fink, MD, Department of Pathology, Universityof Arkansas for Medical Sciences, Laboratq &mice (1 U/LR), John L. McClellan Veterans Hospital, 4300 W 7th St, Little Rock, AR 72205. Books will be reviewed at the discretion of the Book Review Editor. The following books were receivedin June 1992.

Pathology of Bone Marrow. Faramarz Naeim. New York, NY, Igaku-

Bernard Ackerman. Philadelphia, PA. Lee & Febiger. 1990, 500 pages, $129.50. Histology for Pathologists. Stephen S. Sternberg. New York, NY,

Raven, 1,024 pages, $195. Handbook of Clinical Pathology. Julie S. Sandstad, Robert W.

McKenna, and J. H. Keffer. Chicago, IL, ASCP Press, 1992, 270 pages, $30. Biopsy Interpretation of Lymph Nodes (Biopsy Interpretation Series). Steven H. Swerdlow. New York, NY, Raven, 1991, 413

Shoin, 1992, 362 pages, $162.50.



Course: “Concepts

Seminar: “California December 2-5, 1992 in Molecular

Seminars in Pathology”

San Francisco. CA: California Societv of Patholoeists contact California Society of Pathologists, 1303 J St, Suite 250, Sacramento, CA; (916) 446-6001.

Forfurther info&&m,


October 29-November 1, 1992 Bethesda, MD: American Association of Pathologists, Inc For further information, contact The American Association of Pathologists, 9650 Rockville Pike, Bethesda, MD 20814-3993; TEL: (301) 530-7130; FAX: (301) 571-1879.

Symposium: “The Third Annual Rush Symposium on Hepatic and Biliary Disease” October 30, 1992 Chicago, IL: Sections of Digestive Diseases and Transplanta-

Course: “Cutaneous Update”


1993 Skin Cancer

January 22-24, 1993 La Jolla, CA: Scripps Clinic and Research Foundation Forfurther information, contact Department of Academic Affairs, 403C, Scripps Clinic and Research Foundation, 10666 N Torrey Pines Rd, La Jolla, CA 92037; TEL: (619) 554-8556; FAX: (619) 554-6310. Conference:

tion, Rush-Presbyterian-St Luke’s Medical Center I;or further infomation, contact Suzanne Buss, Physician Relations Coordinator, Liver Transplant Program, Rush-Presbyterian-St Luke’s Medical Center, 1653 W Congress Pkwy, Chicago, IL 60612; TEL: (312) 942-6242; FAX: (312) 942-3114.


Third International

March 31-April 3, 1993 Venice, Italy: Cini Foundation,


on Melanoma

S Giorgio Island

Secretary General, c/o Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20122 Milan, Italy; TEL: 39.2.2663992 or 39.2.26680626; FAX: 39.2.26680636. For further


contaxt Dr Mario Santinami,