ORAL AND MAXILLOFACIAL PATHOLOGY e68 Abstracts PP - CLINICOPATHOLOGICAL ANALYSIS AND MMP2 EXPRESSION IN PERIAPICAL LESIONS. DANIELLE NOBRE LOPES, ISABEL SCHAUSLTZ PEREIRA FAUSTINO, REBECA DE SOUZA AZEVEDO, ADEMAR TAKAHAMA, JÚNIOR. FACULDADE DE ODONTOLOGIA- CAMPUS UNIVERSITÁRIO DE NOVA FRIBURGO DEPARTAMENTO DE FORMAÇÃO ESPECÍFICA- PATOLOGIA ORAL E ESTOMATOLOGIA UNIVERSIDADE FEDERAL FLUMINENSE. Periapical lesions represent a local immune response to the progression of microorganisms from an infected root canal space to the periapical area that results in bone resorption. During periapical inﬂammation, inﬂammatory cells release matrix metalloproteinases (MMPs) for bone resorption. MMP2 is one of these MMPs, which is probably involved in the development of periapical lesions. The purpose of this study was to evaluate the main clinicopathological features and the immunohistochemical expression of MMP2 in periapical lesions. To do this, 53 periapical lesions were collected and analyzed. The mean age of the patients was 42.2 years with a slightly female predominance. The histopathological examination revealed 29 granulomas and 24 cysts. The radiographic areas of the lesions were measured with a mean of 12.9 mm2, averaging 18.4 mm2 for cysts and 10.8 mm2 for granulomas, but this difference was not statistically signiﬁcant (p¼0.09). The presence of pain was more common in patients with granulomas (p¼0.04), and the MMP2 expression was higher in granulomas (85.2%) than in cysts (75%) (p¼0.003). Periapical granulomas and cysts had a similar frequency and size. The presence of pain was more common in granulomas, and MMP2 may be involved in the development of periapical lesions, mainly in granulomas.
PP ULTRASOUND-DETECTED NEONATAL ORAL MASS: A CASE REPORT OF A CONGENITAL EPULIS FOCUSING ON ITS DIFFERENTIAL DIAGNOSIS. ANDRÉIA FERREIRA DO CARMO, HUGO COSTA NETO, MORGANA DANÚBIA GOMES DE SOUZA, FÁBIO MEDEIROS DE AZEVEDO, HÉBEL CAVALCANTI GALVÃO, MÁRCIA CRISTINA DA COSTA MIGUEL, JOABE DOS SANTOS PEREIRA. FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE. Congenital epulis is a rare benign soft tissue tumor almost exclusively situated on the alveolar ridge of newborns. In recent years, prenatal detection of congenital oral tumors has facilitated differential diagnosis and proper treatment planning through multidisciplinary approach. This is a case report of congenital epulis in a female newborn discovered by obstetric ultrasound at 30 weeks of gestation. Antenatal diagnosis was epignathus. After birth, clinical examination revealed a round, ulcerated, bleeding, soft and pedunculated mass of 4cm in diameter located on the alveolar ridge. After ﬁve days, the lesion was completely removed by simple excision. Histologic examination showed lesional tissue comprising large sheets of polygonal or rounded cells with a centrally placed small dark basophilic nucleus with abundant eosinophilic granular cytoplasm, abutting the overlying parakeratinized stratiﬁed squamous epithelium. Epithelial atrophy was observed. There was no evidence of mitosis or necrosis. These ﬁndings were consistent with the diagnosis of congenital epulis. Epignathus and congenital epulis are both rare; however,
OOOO February 2017 origin, clinical manifestations and histopathology are distinct. Due to the potential risk of neonatal respiratory difﬁculties and feeding associated with these lesions, prenatal detection is valuable for safe childbirth.
PP - LEIOMYOMA OF THE ORAL CAVITY: A CASE REPORT. VICTOR PEREZ TEIXEIRA, JOSÉ NARCISO ROSA ASSUNÇÃO, JÚNIOR, JOÃO ALBERTO LOPES SOUZA, JÚNIOR, RICARDO CAMILLO DE ALMEIDA, CELSO AUGUSTO LEMOS. SCHOOL OF DENTISTRY, METROPOLITAN UNIVERSITY OF SANTOS, SCHOOL OF DENTISTRY, UNIVERSITY OF SÃO PAULO. Leiomyomas are benign smooth muscle tumors that are rare in the head and neck and oral cavity, with only 0.42% occurring in intraoral location. Oral leiomyomas can appear at any age, but the highest prevalence is between 40 and 59 years. They occur more frequently in men, with a 1.43:1 ratio, and usually present slow growing, asymptomatic, submucosal masses in the tongue, hard palate or buccal mucosa. A Caucasian 82-year-old female with unremarkable past medical and familial history was referred to us presenting a growing asymptomatic tongue swelling ﬁrst detected two months before. Intraoral examination showed a single, well-deﬁned, 3 cm large lesion on the right border of tongue, ﬁrm and symptomatic to palpation. CT scan showed a lesion with regular borders surpassing the midline. A biopsy was performed and the histological examination revealed a diagnosis of leiomyoma. Resection under general anesthesia was conducted and the histopathological and immunohistochemical analyses of the specimen conﬁrmed the leiomyoma diagnosis. The patient was kept in postoperative follow-up with no recurrence after 3 months.
PP - ADENOMATOID ODONTOGENIC TUMOR: A CASE REPORT. TAÍSA DOMINGUES BERNARDES SILVA, MARIA ELISA RANGEL JANINI, VALDIR MEIRELLE, JR., THAYLLA NÚÑEZ AMIN DICK, JOSÉ ALEXANDRE CURVELLO, ANA CAROLINA MENEZES, ALINE CORRÊA ABRAHÃO. UNIVERSIDADE FEDERAL DO RIO DE JANEIRO. Adenomatoid odontogenic tumor (AOT) is a benign odontogenic lesion with a slow and non-invasive growth, often affecting the anterior maxillary bone. Radiographically, it shows a radiolucent area with radiopaque spots associated with teeth. We report a case of pain and swelling in the anterior left mandible of a 16year-old girl who presented to the dental clinic of a public college. She had been experiencing the symptoms since 1 month. Clinical examination showed swelling and loss of deﬁnition of the oral vestibule. The panoramic radiographic image showed a welldeﬁned, radiolucent area involving the crown of the retained elements 33 and 34, suggesting a dentigerous cyst. Therefore, the lesion was marsupialized and the material sent for histopathological analysis, which conﬁrmed a dentigerous cyst. The patient did not comply with the post-surgical instructions, resulting in closure of the surgical wound. An additional procedure was performed, and a larger sample specimen was sent for histopathological analysis; the results conﬁrmed adenomatoid odontogenic tumor. Owing to this change in the histopathological report, the patient was referred to a maxillofacial surgeon for total lesion removal. She is currently being treated in the outpatient clinic.