Reduced Early Inflammation in Response to Hindlimb Ischemia in P2Y2 Receptor Knockout Mice – Potential Mechanism of Reduced Arteriogenesis

Reduced Early Inflammation in Response to Hindlimb Ischemia in P2Y2 Receptor Knockout Mice – Potential Mechanism of Reduced Arteriogenesis

ASSOCIATION FOR ACADEMIC SURGERY AND SOCIETY OF UNIVERSITY SURGEONS—ABSTRACTS 691 N. R. Cormier,1 R. M. O’Keefe,1 W. G. Austen,2,4 M. T. Watkins1,2;...

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ASSOCIATION FOR ACADEMIC SURGERY AND SOCIETY OF UNIVERSITY SURGEONS—ABSTRACTS

691

N. R. Cormier,1 R. M. O’Keefe,1 W. G. Austen,2,4 M. T. Watkins1,2; 1Massachusetts General Hospital - Vascular And Endovascular Surgery, Boston, MA, USA; 2Harvard Medical School, Boston, MA, USA; 3Massachusetts General Hospital - Department Of Interventional Radiology, Boston, MA, USA; 4Massachusetts General Hospital - Depatment Of Surgery, Division Of Plastic And Reconstructive Surgery, Boston, MA, USA

69.7. Low Testosterone Elevates Pro-Inflammatory Interleukin Family Cytokines: A Possible Mechanism for the Potentiation of Vascular Disease in Androgen Deficient Males. B. M. Freeman,1 D. J. Mountain,1 T. C. Brock,1 J. R. Chapman,1 S. S. Kirkpatrick,1 J. D. Arnold,1 S. L. Stevens,1 M. H. Goldman,1 M. B. Freeman,1 F. A. Klein,1 O. H. Grandas1; 1University Of Tennessee Graduate School Of Medicine - Department Of Surgery, Knoxville, TN, USA

69.2. Direct Effect of Monocytes and Macrophages on Vascular Smooth Muscle Cells. S. L. Powell White,1 M. Zuniga,2 E. Hitchner,2 W. Zhou1,2; 1Stanford University Vascular Surgery/Surgery/Medicine, Palo Alto, CA, USA; 2 VA Palo Alto Healthcare Systems - Surgical Services, Palo Alto, CA, USA

69.8. Upregulation of TGF-b in Aortic Adventitial Fibroblasts by Notch Activation: Its Implications in Aortic Aneurysms. Z. Liu,1 Y. Li,1 O. C. Velazquez1; 1University Of Miami - Surgery, Miami, FL, USA

69.3. Hypertension Modulates Sexual Dimorphism of Aortic Aneurysm And Dissection in TGF-B Deficient Mice. B. M. Schmit,1 K. DeSart,1 P. Yang,1 C. Fu,1 S. A. Berceli,1 Z. Jiang1; 1University Of Florida - Division Of Vascular And Endovascular Therapy/Department Of Surgery/College Of Medicine, Gainesville, FL, USA

69.4. Adipose-Derived Stem Cells Overexpressing HIF-1a Promote Wound Healing. W. Hong,1,2 M. S. Hu,1,3 R. C. Rennert,1 M. T. Chung,1 M. Esquivel,1 T. S. Lai,4 A. S. Zimmermann,1 J. Rajadas,1 K. J. Paik,1 S. D. Morrison,1 G. C. Gurtner,1 A. J. Giaccia,5 H. P. Lorenz,1 M. T. Longaker1; 1Stanford University - Division Of Plastic And Reconstructive Surgery/Department Of Surgery, Palo Alto, CA, USA; 2University Of Central Florida - College Of Medicine, Orlando, FL, USA; 3University Of Hawaii Department Of Surgery, Honolulu, HI, USA; 4University Of California - Los Angeles - Department Of Obstetrics And Gynecology, Los Angeles, CA, USA; 5Stanford University - Department Of Radiation Oncology, Palo Alto, CA, USA

69.5. Mesenchymal Stem Cells Potentiate Reparative Processes by Downregulation of Matrix Metalloproteinases 1, 3, and 9 in a Porcine Abdominal Aortic Aneurysm Model. D. K. Han,1 R. O. Tadros,1 B. Rawal,1 A. Patel,1 D. H. Lee,1 V. Gillespie,4 R. Hajjar,3 Z. A. Fayad,2 M. L. Marin,1 P. L. Faries1; 1Mount Sinai Hospital - Vascular Surgery, New York, NY, USA; 2Mount Sinai Hospital Radiology, New York, NY, USA; 3Mount Sinai Hospital Cardiology, New York, NY, USA; 4Mount Sinai Hospital Center For Comparative Medicine And Surgery, New York, NY, USA

69.6. Recurrent Injury of Diabetic Mice Results in a Chronic Wound and Demonstrates that Collagen Production In Diabetic Wounds is Dyregulated at Multiple Gene Levels. R. C. Caskey,1 M. W. Morris,2 C. Zgheib,3 J. Xu,3 W. Dorsett-Martin,2 K. W. Liechty3; 1University Of Pennsylvania - General Surgery, Philadelphia, PA, USA; 2University Of Mississippi - Department Of Surgery, Jackson, Mississippi, USA; 3Nemours Children Hospital - Pediatric Surgery, Orlando, FL, USA

69.9. Mesenchymal Stromal Cells Induce MiR-146a Expression in Diabetic Dermal Fibroblast. J. Xu,1 C. Zgheib,1 J. Hu,1 K. W. Liechty1; 1Nemours Children Hospital - Surgery, Orlando, FL, USA

69.10. Reduced Early Inflammation in Response to Hindlimb Ischemia in P2Y2 Receptor Knockout Mice – Potential Mechanism of Reduced Arteriogenesis. A. J. Shukla,1,2 R. McEnaney,1,2 U. Sachdev,1 E. Tzeng1,2; 1VA Pittsburgh Healthcare System, Pittsburgh, PA, USA; 2University Of Pittsburgh - Surgery, Pittsburgh, PA, USA

69.11. Characterization of Extracellular Signal-regulated Kinase 5 (ERK5) Activation in Human Umbilical Vein Endothelial Cells (HUVECs) Exposed to Disturbed and Uniform Pulsatile Flow. S. Shalaby,1 G. Chitragari,1 B. Sumpio,1 B. Sumpio1; 1Yale University School Of Medicine Vascular Surgery, New Haven, CT, USA

69.12. Increased Monocyte Activity and MMP-9 Concentration is Associated with Increased Expansion Rates in Abdominal Aortic Aneurysms. K. M. Samadzadeh,1 K. C. Chun,3 M. Baker,1 A. Nguyen,1 E. S. Lee2,3; 1Sacramento VA Medical Center - Department Of Research, Mather, CA, USA; 2University Of California - Davis - Department Of Surgery, Sacramento, CA, USA; 3Sacramento VA Medical Center - Department Of Surgery, Mather, CA, USA

69.13. Treatment With a Histone Deacetylase Inhibitor, Valproic acid, is Associated With Increased Platelet Activation in a Large Animal Model of Traumatic Brain Injury and Hemorrhagic Shock. S. E. Dekker,1,3 M. Sillesen,2,4 T. Bambakidis,1 C. Boer,3 P. I. Johansson,4 G. Jin,1 I. Halaweish,1 H. B. Alam1; 1University Of Michigan - Surgery, Ann Arbor, MI, USA; 2Massachusetts General Hospital Trauma, Emergency Surgery, And Surgical Critical Care, Boston, MA, USA; 3UV University Medical Center 4 Anesthesia, Amsterdam, Netherlands; Copenhagen University Hospital - Blood Bank, Copenhagen, Denmark

69.14. Nitric Oxide Mediated Inhibition of Sca-1+ Stem Cell Populations in Diabetes After Vascular Injury. J. R. Streams,1 J. Martinez,1 M. Flynn,1 M. R. Kibbe1; 1Feinberg