S211 EFFECT OF RHEUMATOID ARTHRITIS ON THE QUALITY OF LIFE – DIFFERENCES BETWEEN A NOVEL BIOLOGICAL THERAPY AND A CONVENTIONAL TREATMENT

S211 EFFECT OF RHEUMATOID ARTHRITIS ON THE QUALITY OF LIFE – DIFFERENCES BETWEEN A NOVEL BIOLOGICAL THERAPY AND A CONVENTIONAL TREATMENT

226 POSTER SESSIONS / European Journal of Pain Supplements 5 (2011) 15–295 During randomized comparative research with four groups – 94 patients at ...

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226

POSTER SESSIONS / European Journal of Pain Supplements 5 (2011) 15–295

During randomized comparative research with four groups – 94 patients at age 46–71 years with expressed painful syndrome (PS) 6–10 points on visually analog scale (VAS), disturbance of function of upper limb duration of disease from 3 to 12 months. First group (n = 27) was injected betamethasone 1 3 with interval 6–7 days. Second group (n = 24) betamethasone was injected twice, then patients received etoricoxib 60 mg/day 1 14. In third (n = 22) and in fourth groups (n = 21) received etoricoxib 60 mg/day and 120 mg/day 1 21. All patients was researched volume of movements, testing was before therapy, in 1, 6 months after therapy. Patients of all groups note subjectively reduction of PS. Reduction of PS and normalization of night dream became perceptible in 62.9% in first group after first injection of betamethasone. Analgesic effect was more expressed in fourth group and was observed on 3–4 day. Proof reduction of PS and improvement of volume of movements in 6 months became perceptible in group with consecutive reception of betamethasone and etoricoxib. Periarticular injections of betamethasone in trigger zones with subsequent peroral etoricoxib are comparable by analgesic effect to reception of etoricoxib of 120 mg within 2 weeks. More expressed analgesic effect and improvement of volume of movements in 6 months has been received in group with consecutive reception of betamethasone and etoricoxib. Disclosure: None declared

S211 EFFECT OF RHEUMATOID ARTHRITIS ON THE QUALITY OF LIFE – DIFFERENCES BETWEEN A NOVEL BIOLOGICAL THERAPY AND A CONVENTIONAL TREATMENT D. Horvath ´ 1 *, N. Csasz ´ ar ´ 2 , A. Hunka3 , G. Poor ´ 3 , N. Pataki2 , P.P. Varga2 . 1 K´ aroli G´ asp´ ar University of the Reformed Church in Hungary, 2 National Center For Spinal Disorders, 3 National Institute of Rheumatology and Phyisiotheraphy, Budapest, Hungary Background and Aims: The aim of the present study was investigating the effect of an autoimmune disease, the rheumatoid arthritis, on the quality of life. Methods: Experiments were carried out on Hungarian subjects. The influential factors of the patients’ state of mind and those of their quality of life were examined comparing two groups. One group included patients having undergone novel biological therapy, while in the other group patients were treated with conventional steroid. In the preliminary study 27 Hungarian subjects (nearly 300 people) were examined. The method was a “Condition Assessing Writing Notebook” including 9 questionnaires: General Data Sheet, Health Status Questionnaire, Health Habits Questionnaire, Spielberger State-Trait Anxiety Inventory, Zung Self-rating Depression Scale, Ways of Coping Questionnaire, Rosenberg Self-Esteem Test, ConnorDavidson Resilience Scale and Schwarzer-Jerusalem General SelfEfficacy Scale. Analyses of data were carried out using Two Sample T-test. Results: The anxiety and depression levels of the subjects differ significantly from those of the Hungarian population. However, there was no difference in terms of self-esteem, resilience and self-efficacy compared to the average Hungarian population. Based on data it was proved that aggravating life experiences influence the state of mind as well. Patients treated with biological therapy were less affected mentally by the disease than the conventionally treated control group. Conclusions: The patients with rheumatoid arthritis are vulnerable to depression and anxiety. These mental disorders can be deleveled by biological therapy. Disclosure: None declared

S212 THE EFFECTIVENESS OF DIFFERENT SCHEMES OF TREATMENT WITH MELOXICAM AND DICLOFENAC SODIUM IN ELDERLY PATIENTS WITH KNEE OSTEOARTHRITIS V. Povoroznyuk *, M. Bystrytska, T. Orlyk, S. Yunusova. Department of Clinical Physiology and Pathology of Locomotor Apparatus, Institute of Gerontology AMS Ukraine, Kyiv, Ukraine Background and Aims: The aim of research was to evaluate the effectiveness of meloxicam (reumoxicam) to release the pain syndrome in comparison with diclofenac sodium in elderly patients with knee osteoarthritis. Methods: The study included 80 patients with knee osteoarthritis, divided into 4 groups included 20 patients. Patients of I and III groups received meloxicam 15 mg per day. Patients of II and IV groups received diclofenac sodium. Patients of I, II groups – 10 day in injection, and III, IV groups – 5 days in injection then 5 days in tablets. The effectiveness of the treatment in patients of different group was evaluated by WOMAC. Results: The patients of the first and third groups marked the significant improvement of their condition in 5 days of treatment, and felt themselves better even in 10 days after discontinuation of the treatment. It wasn’t significant differences in patients of the first and second groups by Womac (F5 = 1.1; p > 0.05; F10 = 0.09; p > 0.05: F20 = 0.2; p > 0.05), and the third and fourth group (F5 = 1.5; p > 0.05; F10 = 1.02; p > 0.05: F20 = 0.8; p > 0.05). Conclusions: Meloxicam significantly reduces the intensity of the pain, stiffness and improves daily activity just in 5-days treatment and remains the effect on the same level through 10 days after discontinuation of treatment and it is comparable to the diclofenac sodium. Disclosure: None declared

S213 IMPAIRED MEDIAN MOTOR AND SENSORY FUNCTION OF THE HANDS IN FEMALES WITH RHEUMATOID ARTHRITIS: COMPARISONS FOR OSTEOARTHRITIS AND HEALTHY CONTROLS F.F. Ayhan, S. Gul, ¨ S. Uyar, H.R. Erdem, P. Borman *. Physical Medicine and Rehabilitation, Ankara Training and Research Hospital, Ankara, Turkey Background and Aims: The symmetrical distribution of synovitis and the spared joints on the paretic side in patients with hemiplegia and polio who later develop RA suggest that neural mechanisms are involved in the pathophysiology of the disease. We aimed to assess the sensory and motor function in the hands of the patients with RA compared to healthy controls and patients with osteoarthritis (OA) and relationship with disease activity parameters and radiographic damage. Methods: 154 females were included to the study. Rheumatologic and radiographic data were recorded. Comprehensive hand evaluation were also performed. Results: 72 female patients with RA (mean age: 55.9±9.5), 43 patients with OA (mean age: 58.9±4.8), and healthy controls with a mean age of 56.6±5.8 years were recruited to the study (p = 0.13). Both quantitative sensory and motor evaluation of the hands were different between groups (p < 0.05). SW monofilament tresholds and classification of SW monofilaments of the both hands were better in patients with RA. Hand deformities were positively correlated with disease activity, disability and CRP, and negatively correlated with pinch strength, and proprioception. Boutonnaire deformity, 2-point discrimination and lateral pinch strength were found to be the most related parameters with radiographic (Larsen) damage in regression analysis. Conclusions: We indicated not only the impaired proprioceptive and cortical sensation but also decreased superficial sensory treshold in rheumatoid hands which were related with structural damage. The latter may indicate the neuropathic component of pain in patients with RA. Disclosure: None declared