SJÖGREN SINDROME: CLINICAL CHARACTERISTICS AND SEVERITY

SJÖGREN SINDROME: CLINICAL CHARACTERISTICS AND SEVERITY

ABSTRACTS e152 OOOO January 2020 indication for this type of examination for dental treatment evaluated in 3 centers in Brazil. In each center, 2 r...

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ABSTRACTS

e152

OOOO January 2020

indication for this type of examination for dental treatment evaluated in 3 centers in Brazil. In each center, 2 researchers evaluated the images in a consensual way for the diagnosis of SBD, under the supervision of a third researcher who reached a final consensus in case of disagreement of the first two. Results: Among the 17,180 patients, only 15 (0.08%) had SBD, 3 were female and 12 were male. The age range of patients with SBD was 30 to 69 years (mean age 49.2 years). Fourteen cases were diagnosed in the posterior region of the mandible body and 1 case in the ascending branch. Conclusions: According to our results, SBD is an uncommon developmental anomaly most found in middle-aged male patients. It presents a typical radiographic appearance, with panoramic radiography being a valuable tool for the diagnosis of this condition. It is important that dental surgeons be able to diagnose SBD, in order to avoid unnecessary invasive surgical procedures.

QUANTEC (Quantitative Analyses of Normal Tissue Effects in the Clinic) and the complications were classified based on the CTCAE (National Cancer Institute’s Common Criteria Chart of Toxicity). Results: Eleven patients participated, most of them male (89%), with a mean age of 60.2 years. The most frequent tumor site was oropharynx (55%) and the degree of staging IV (64%). Among the participants, 73% were smokers and 82% had a habit of drinking alcohol. The most frequent oral complications were dysphagia (91%), xerostomia (82%), mucositis (54%), and oral pain (54%). For the complications dysphagia, xerostomia, and mucositis, relations were found between the dosimetric data and the development of these; for oral pain, the difference between the groups was not significant. Conclusions: Dosimetric data are directly related to the development of certain oral complications resulting from radiotherapy treatment for malignant head and neck neoplasms.

€ SJOGREN SINDROME: CLINICAL CHARACTERISTICS AND SEVERITY. SONIA SACSAQUISPE, DARIO CHAPA, DANIEL QUISPE and, CRISTINA TELLO

EVALUATION OF HE4 AND SLPI EXPRESSION IN INTRAORAL MUCOEPIDERMOID  CARCINOMAS. DEBORA LIMA PEREIRA,  ^ LYNNE BINGLE, COLIN DAVID BINGLE, FABIO RAMOA  PIRES, MARCIO AJUDARTE LOPES and, PABLO AGUSTIN VARGAS

Objective: The aim of this study was to determine the epidemiology, clinical characteristics, and degree of severity of Sj€ogren syndrome in biopsies of an oral pathology laboratory. Study Design: A retrospective study was performed. Request forms for anatomic-pathologic examination and histopathologic slides were assessed. The data registered included age, sex, clinical characteristics, and degree of severity. Results: Three hundred fifty-seven cases were obtained (2.1% of the total biopsies and 41.71% of the total labial gland biopsies). The mean age was 53 years (range: 13-86 y) with a predominance of women (90.2%) in the fifth decade of life (28.01%). Xerostomia was manifested in 94.67%, while xerophthalmia in 81.52% of cases, the systemic affection predominantly observed was rheumatoid arthritis (34.17%), in addition to systemic sclerosis and lupus erythematosus. The most common degree of severity among the cases was grade 2 (36.42%) and grade 3 in (33.9%) of cases. They also found some lymphoid follicles; it allows for the evaluation of the progress of the disease and early detection of lymphoma. Conclusions: This study shows that 43.98% of cases are diagnosed later in the disease course in Grades 3 and 4, which suggests the diagnosis in advanced stages of the disease.

RADIOTHERAPY DOSIMETRIC DATA AND ORAL COMPLICATIONS IN PATIENTS WITH HEAD AND NECK CANCER. RAYLANE e FARIAS DE ALBUQUERQUE, JAIR CARNEIRO LEAO, ALESSANDRA DE ALBUQUERQUE TAVARES ^ CARVALHO, ROMULO OLIVEIRA DE HOLLANDA VALENTE, ELIANE CRISTINA VIANA REVOREDO, LUIZ ANDRE NADLER LINS and, IGOR HENRIQUE MORAIS SILVA Objective: To study the relation between the dosimetric parameters of the radiotherapy design protocols for head and neck cancers and the acute oral complications resulting from this treatment. Study Design: This was a cross-sectional, quantitative approach. Radiotherapy was planned according to established design protocols. The constraints used were those described in

Human epididymis protein 4 (HE4) and secretory keukocyte protease inhibitor (SLPI) are members of the WFDC family of proteins and have recently been shown to be expressed in normal salivary glands; however, differential expression in mucoepidermoid carcinoma suggests a potential role in tumorigenesis. Objective: To evaluate the immunoexpression of HE4 and SLPI in mucoepidermoid carcinomas and to correlate expression with tumor grade. Study Design: Forty diagnosed mucoepidermoid carcinoma cases were selected and clinical data collected. Hematoxylin and eosin (H&E)-stained sections were reviewed and immunoexpression of HE4 and SLPI was assessed. Results: The sample was composed mostly of female patients (70%), and the mean age was 42.3 years. Histologic analysis showed that 72.5% of cases were low-grade tumors. Immunohistochemical analysis demonstrated 7.6% and 22.9% positivity for HE4 and SLPI, respectively. Most of the stained cells were mucous type, even though SLPI has also shown positivity in some intermediate and epidermoid cells. A significant correlation was found between SLPI expression and tumor grade, with lower expression in intermediate grades. The correlation between SLPI and HE4 was positive and significant. Conclusions: Although HE4 staining was not prominent, SLPI showed consistent staining in mucoepidermoid carcinomas and should be further investigated to elucidate its role in tumorigenesis.

DETECTION OF VIRAL LOAD OF EPSTEINBARR VIRUS AND CYTOMEGALOVIRUS BY POLYMERASE CHAIN REACTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE. ALESSANDRA DE ALBUQUERQUE TAVARES CARVALHO, MARIANA DE MORAES CORREA PEREZ, MARIA EDUARDA CALADO COSTA MARTINS, INGRID CARLA GUEDES DA SILVA, CAMILA CARLA MARIA XIMENES OLIVEIRA, LUIZ ALCINO MONTEIRO e GUEIROS and, JAIR CARNEIRO LEAO