Social Media: A Valuable Tool to Assess Patient Perspectives Regarding Quality of Life

Social Media: A Valuable Tool to Assess Patient Perspectives Regarding Quality of Life

VA L U E I N H E A LT H 1 9 ( 2 0 1 6 ) A 3 4 7 – A 7 6 6 34.4%).  Conclusions: Similar to SQUIRE ITT population, addition of necitumumab to gemc...

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VA L U E I N H E A LT H 1 9 ( 2 0 1 6 ) A 3 4 7 – A 7 6 6

34.4%).  Conclusions: Similar to SQUIRE ITT population, addition of necitumumab to gemcitabine-cisplatin did not have any detrimental effect on HRQoL and was well tolerated in patients with EGFR-expressing tumours. PCN222 Patient Reported Health Utility in HR+/HER2- Advanced/Metastatic Breast Cancer Mitra D1, Wood R2, De Courcy J2, Iyer S1 Real World, Bollington, UK

1Pfizer, Inc., New York, NY, USA, 2Adelphi

Objectives: To assess patient reported health utility among patients with HR+/HER2- advanced/metastatic breast cancer (ABC/MBC) in a real world setting.  Methods: Patients with HR+/HER2- ABC/MBC in 5 major EU countries (N= 613) and the US (N= 126) were recruited into a multicenter study. Health utility was assessed using EQ-5D, a standardized measure of health status that consists of a descriptive system comprising 5 dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression rated at 3 levels (no, some, or extreme problems) and a single index score for health status calculated using countryspecific algorithms. In addition, a visual analogue scale (VAS) measured self-rated health status from ‘0’ (worst imaginable) to ‘100’ (best imaginable). Scores were stratified by sites of metastases and line of therapy, and compared using KruskalWallis tests.  Results: Patients had mean (SD) age of 65.2 (10.6). Majority of patients (83%) had MBC. Mean (SD) EQ-5D index score was 0.73 (0.29) and mean (SD) general health status score was 61.9 (20.7). Patients with both bone and visceral metastases had the lowest (mean [SD]) EQ-5D index score (0.62 [0.34]) compared to those with bone (no visceral) disease (0.69 [0.33]) and visceral (no bone) disease (0.78 [0.26]), p< 0.0001. Patients on 1st line therapy had the highest EQ-5D index score (0.77 [0.26]) compared to those on 2nd (0.69 [0.33]) and 3rd lines or later (0.69 [0.28]), P= 0.0001. No statistically significant differences were observed in the general health status score between lines of therapy or between sites of metastases.  Conclusions: Sites of metastases and lines of therapy have a significant impact on EQ-5D index scores with patients with both bone and visceral metastases and those receiving later lines of therapy reporting significantly worse scores. PCN223 Quality of Life in Patients with Colorectal Cancer in Slovak Republic Poliakova N, Bielik J, Hrda M Trencin University, Trencin, Slovak Republic

Objectives: The incidence of colorectal cancer (CRC) in Slovak Republic is about 3000 cases per year. No study was published about the impact of CRC on quality of life (QoL) and work ability (WA) in patients with CRC in Slovak Republic.  Methods: The sample consisted of 83 patients, 29 women and 54 men, the average age was 67,4 years and weight 74,6 kg. The average duration of disease was 2,73 years. All patients received surgical treatment and 70 had chemotherapy. The patients visited an oncology outpatient clinic 4,82 times a year. The primary method used for analysis was a combined questionnaire consisting of 6 parts: A. Demography, B1. Clinical part, filled out by physician, B2. Clinical part, filled out by patient, C. Quality of life, D. Socio-economic part, E. EQ5DL. F. Special questions. QoL and WA were evaluated on numeric scales from 0 - the worst to 10 - the best. Student-test and chi-squared test were mainly used in results evaluation.  Results: Significant statistical differences in values of QoL were found in various stages: in the time of best health – 8,289, without CRC – 6,687, in the time of diagnosis – 4,205 and in the time of full treatment – 2,217. The results of WA evaluation were following: 8,361 vs 6,711 vs 3,735 vs 1,964. The results of evaluations of QoL and WA were in strong correlation. Foreknowledge of disease (1-the worst, 5-the best) was 3,6, satisfaction with medical care – 4,2. Willingness to pay to be healthy was 232,87 € by average monthly income 421,82 € .  Conclusions: CRC has significant impact on patients‘ QoL and WA. In both areas, there are significant differences in patients‘ assessments in various stages of life and the disease. Treatment has no positive impact on QoL and WA in regards to the progressive characteristics of the disease. PCN224 Social Media: A Valuable Tool to Assess Patient Perspectives Regarding Quality of Life Kalf R1, Makady A2, Ryll B3, Spurrier G4, Goettsch W5 Healthcare Institute (ZIN), Diemen, The Netherlands, 2The National Healthcare Institute (ZIN), Diemen, The Netherlands, 3Melanoma Patient Network Europe, and Uppsala University (Department EBC), Uppsala, Sweden, 4Melanome France, and Melanoma Patient Network Europe, Uppsala, Sweden, 5National Health Care Institute, Diemen, The Netherlands


FACT-M records ‘I have a lack of energy’, while patients rather focus on ‘having enough energy’.  Conclusions: Social media provides a valuable tool in assessing patient perspectives regarding QoL, however results are difficult to generalize to the broader patient population. Differences emerge between what patients and carers consider important for QoL. Melanoma-specific QoL questionnaires available do not seem to correlate well with what patients view as important in QoL. PCN225 Nationwide Survey on The Opinions of Cancer Patients and Personnel on Cost of Metastatic Colorectal Cancer Treatment Sailas L1, Kuoppala J2, Kataja V3 Karelia Health Care District, Joensuu, Finland, 2FIMEA, Kuopio, Finland, 3Central Finland Health Care District, Jyväskylä, Finland


Objectives: Cost of cancer care is rising rapidly due to elevating number of patients and increasing price of cancer medication. We investigated the opinions of cancer patients and personnel on acceptable cost of cancer care provided by national health care service in different outcome-scenarios of metastatic colorectal cancer (mCRC).  Methods: As part of a larger nationwide study the survey included all University and Central Hospitals with cancer centers in Finland. The questionnaire was delivered during a two-week period to all patients visiting Oncology centers, and their personnel. Background information included sex, age and education for all, and, marital and working status, and type and stage of cancer for patients. There were five cost levels from less than 5 000€  /year to more than 100 000€ /year in four scenarios: treatment is curative; survival gain is some years; survival gain is some months; treatment is relieving symptoms with no effect on survival, at case ages 50 or 75.  Results: 291 professionals and 1879 patients answered.1% of personnel and 27% of patients did not want to express their opinion on cost. 45% and 18% of professionals accepted >  100 000€ /year for curative treatment at ages 50 and 75, respectively. Of patients, 19% at both case ages. Gain being years, 62% and 39% of professionals and 34% and 33% of patients chose option > 50 000€ /year. Gain being months, 22% and 49% of professionals and 51% and 52% accepted cost maximum 10 000€ /year at case ages 50 and 75, respectively.  Conclusions: Personnel accepted higher cost of mCRC-treatment than patients. The case’s age affected substantially professionals‘ opinion but not the patients´. In the most usual clinical scenario, ie. patient age closer to 75 than 50 and possible survival gain measured in months, the accepted maximum cost by both patients and personnel does not reflect reality. PCN226 Work Productivity Activity Impairment Loss of Patients with HER2 Metastatic Breast Cancer Bryden P1, Paracha N1, Thuresson P2 1F. Hoffman-La Roche, Basel, Switzerland, 2F. Hoffmann-La Roche Ltd., Basel, Switzerland

Objectives: Work productivity activity impairment (WPAI) can be a valuable tool when considering the wider societal perspective in economic evaluation of health technologies. The objective of this study was to estimate the work productivity lost in women undergoing treatment in the first line metastatic breast cancer setting.  Methods: We combined data from three arms of large phase III study (MARIANNE) for first line treatment in HER2 positive metastatic breast cancer. The following variables were investigated; proportion of patients working stratified by age, hours lost due to health problems and hours lost due to other problems. Outliers were kept in the base-case analysis but removed in sensitivity analysis.  Results: There were a total of 1,062 patients that reported values at baseline. 732 (68.9%) of these subjects were out of work. Increasing the age category increased the proportion out of work; 56.9%, 65.7%, 73.3% 88.9% for the age categories < 45, > = 45 & < 55, > = 55 & < 65 and > 65 respectively. It was found that in average 14.1 working hours were lost per week due ill health. Further 9.7 hrs per week were reported to be lost due to non-health related issues like study participant, holiday etc. Participants reported on a 0 to 10 point visual analogue scale that that the disease affected them on average 2.8 while working.  Conclusions: This study shows that that breast cancer does lower women’s work productivity based upon self-report. However, when considering these results a there are a number of limitations to consider. Participants came from different countries and the unemployment could differ between these. It is not clear how many people gave up work and how many were not in work prior to diagnosis.


Objectives: Explore the potential of social media to assess patient perspectives regarding Quality of Life (QoL).  Methods: A survey was developed with openended questions to assess melanoma patients’ perspectives regarding QoL and actively advertised on social media channels of Melanoma Patient Network Europe (Facebook, Twitter, LinkedIn). Content analysis was performed on responses to identify key themes. Two researchers independently assessed completed surveys. Themes identified were compared to questions used in three current QoL questionnaires (EORTC QLQ-C30, EORTC QLQ-MEL38, FACT-M).  Results: In total, 72 patients with stage I to IV melanoma, and 19 carers completed the survey. Respondents’ demographics differed from the general melanoma patient population (e.g. ~70% of the respondents were female compared to ~50% in the general melanoma patient population) yet demographics largely corresponded to the general social media population. Patients indicated that family, having a normal life, and being able to enjoy life were the three most important aspects of QoL. Carers indicated that being capable, having no or manageable adverse events, and being pain-free were the three most important aspects of QoL for patients. Respondents seem to find some questions from QoL questionnaires relevant (e.g. ‘Have you felt able to carry on with things as normal?’) and others less relevant (e.g. ‘Have you had swelling near your melanoma site?’). Additionally, wording may differ between patients and QoL questionnaires, whereby patients generally use a more positive tone. For example,

CANCER – Health Care Use & Policy Studies PCN227 Factors Influencing Attitudes to Colorectal Cancer Screening Gede N1, Horváthné Kívés Z1, Vajda R1, Pakai A2, Boncz I1, Gyuró M1, Kiss I1 of Pécs, Pécs, Hungary, 2University of Pécs, Zalaegerszeg, Hungary


Objectives: The purpose of our investigation was to explore the attitudes to colorectal cancer of the investigated population, its screening and to identify factors which influence the participation in the screening significantly.  Methods: We conducted a quantitative cross-sectional study in Hungary with self-made questionnaires (socio-demoraphic data, attitude). People between 40-70 years were recruited, the exclusion criterion involved a diagnosed cancerous disease. Data were porcessed by SPSS 22.0 programme. The analysis was performed with descriptive statistics, Odds Ratio, Mann-Whitney tests, regression and factor analyses with 95% probability level (p< 0.05)  Results: 33% of respondents intended to participate in screening only when they experienced symptoms. They were likely to be men (OR= 2.048 95% CI 1.0474.008). 28% of answerers thought that it was necessary to participate in screenings before noticing the symptoms. They had higher education (p< 0,001) and better financial situation (p< 0.001). 29% of respondents were willing to participate in screenings if the doctor recommended that. These people had poor education (p= 0.025) and they saw their doctors frequently (p= 0.04). 9% of the participants were afraid of the result of the screening. Close relatives with colorectal cancer were likely to be found in their