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ence vasogenic activity. The 832 references cover the experimental work performed from 1812 through 1990, and Klintworth authored 32 of these publications. Normal corneal vascularity and the pathogenesis and sequence of events in vascularization are reviewed in the initial chapters. Subsequent chapters summarize the research of in vitro and in vivo techniques used in the investigation of angiogenesis, the factors that may influence or suppress vasogenic activity, the hypothesis that relates to the pathogenesis, and the potential source and nature of angiogenic factors. Current concepts in relationship to corneal angiogenesis complete the work. The author cautions on the weaknesses and inadequacies of past and current mechanisms for quantitative corneal vascularization and on the difficulties that exist in the quantitation of the in vivo bioassay system for angiogenic factors. Research workers and other readers are reminded to be wary of the interpretation of results. This well-written text with its impressive list of references, list of abbreviations, and flow diagrams is an excellent reference source, not only for those persons with a primary interest in corneal vascularization but also for research workers who are concerned with the general subject of neovascularization. The author challenges readers with the following quote: "I throw down the gauntlet to any investigator who can find a bona fide experimental model of noninflammatory angiogenesis." R. Jean Campbell, M.D. Division of Pathology and Department of Ophthalmology
Textbook of Family Practice, 4th ed, edited by Robert E. Rakel, 1,926 pp, with illus, $125, Philadelphia, W. B. Saunders Company, 1990 When I sat down to review this book, I did not know what to expect. During medical training, a family physician devotes time to many individual specialties, including reading texts of those specialties. I thought this edition would be a survival handbook in the "real world" of family medicine. In many ways it fulfills that role and does more. The biggest surprise was the almost 400 pages of discussion of family practice, including its place in medicine and in the world. This material reinforced my decision to choose family practice, but it is not useful in daily medical practice. This section would be helpful, however, for medical students trying to select a subspecialty or, perhaps, even for those subspecialists who are unaware of the responsibilities of family physicians.
The clinical practice of family medicine is covered in sections that range from oncology and obstetrics to surgical procedures and neurology. In many chapters, the topic is reviewed by both a specialist and a family practitioner. Most chapters completely define the role of a family physician and indicate when consultative services are needed. In some of the sections on surgical intervention, the opinions expressed are somewhat emphatic, but in general the material provides wellbalanced approaches to clinical areas. When I compare this edition with previous editions, subdivision and expansion are evident in two important areascardiology and neurology. These topics are helpful to practicing family physicians who have no immediate subspecialty support. As is expected in an up-to-date edition, more information is also provided on new topics such as Lyme disease and human immunodeficiency virus. The attempt to cover the broad scope of family practice in one text is indeed a formidable task, and this book admirably succeeds in accomplishing that goal. It will definitely be helpful to practicing family physicians and will be a resource for all students and residents in primary-care medicine. Michele A. Hanson, M.D. Department of Family Medicine
Therapeutic Hemapheresis in the 1990s (Current Studies in Hematology and Blood Transfusion, Vol 57), edited by U. E. Nydegger, 282 pp, with illus, $198, Basel, Switzerland, S. Karger, 1990
Therapeutic Hemapheresis in the 1990s, edited by Dr. Nydegger, is a compact publication on the clinical and technologic aspects of therapeutic hemapheresis. It contains 51 illustrations, 48 tables, annotated bibliographies for each of the 15 chapters, and a subject index. This volume is divided into two main sections. The first section, entitled "Plasmapheresis," has 12 chapters that deal with treatment of specific disease conditions, such as idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, T-celllymphotropic virus type I-associated myelopathy, hyperviscosity, and human immunodeficiency virus-related syndromes, and chapters on basic subjects, including the risk-benefit ratio, synergy between plasmapheresis and intravenous immunoglobulin therapy, technology, and low-density lipoprotein apheresis. The second section is devoted to therapeutic cytapheresis and covers ex vivo activation of cells and treatment and prevention of refractoriness to platelet transfusion. The editor indicates in the preface that the purpose of the book is to provide readers with a look into the next few years