The 3rd Annual Scientific Meeting of the Japanese Heart Failure Society Program and Abstracts

The 3rd Annual Scientific Meeting of the Japanese Heart Failure Society Program and Abstracts

The 3rd Annual Scientific Meeting of the Japanese Heart Failure Society - Program and JHFS'99 ~ Abstracts - FUKUOKA [] Dates" October 7 (Thursda...

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The 3rd Annual Scientific Meeting of the Japanese Heart Failure Society - Program

and

JHFS'99 ~

Abstracts

-

FUKUOKA

[] Dates" October 7 (Thursday) - 9 (Saturday), ] 9 9 9 [] Venue" ACROS Fukuoka, Fukuoka, JAPAN [] President Akira Takeshita, M.D., Ph.D. Kyushu University School of Medicine

Contents Welcome Address Organization General Information Map of Central Fukuoka Area The Congress Site & Floor Plan Program at a Glance Scientific Program Abstracts Special Lectures Plenary Sessions YIA Competition Oral Presentations Poster Presentations Author's Index

2 3 4 6 7 10 11 15 21 35 39 51 93

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Dear Colleague: On behalf of the organizing committee of the Japanese Heart Failure Society, we welcome you to the 3rd Annual Scientific Meeting in Fukuoka on October 7 to 9, 1999. Heart failure is a growing public health problem worldwide and has an enormous impact on the prognosis and lifestyles of patients. In recent years impressive strides have been made in understanding the pathophysiology of heart failure at all levels, from molecular changes to the integrated circulatory system. Furthermore, the modalities available for treatment of heart failure have expanded impressively. However, the prognosis of patients with severe heart failure is still grave despite these advancements. It is obvious that we need to put much more efforts to overcome this serious problem of heart failure. It is also obvious that only the cohesive and interacting efforts among Various disciplines may promise a progress. The Heart Failure Society was fou0ded to strengthen our bonds and to renew our enthusiasm and commitment to research on heart failure. The program of the 3rd Annual Scientific Meeting includes the presentations of about 200 original research and of a state-of-the-art review on various issues related to heart failure, which will be given by leading physicians and scientists from abroad and Japan. I hope that you will enjoy the 3rd Annual Meeting of Japanese Heart Failure Society.

Akira Takeshita President The 3rd Annual Meeting of the Japanese Heart Failure Society

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The 3rd Annual Scientific Meeting of the Japanese Heart Failure Society held under the auspices of the Japanese Circulation Society.

Organizing Committee of the Japanese Heart Failure Society President of the Board of Trustees: Shigetake Sasayama, Kyoto University Board of Trustees: (Alphabetical Order) Hisayoshi Fujiwara, Gifu University Shin-ichi Kimata, Tokyo Koseinenkin Hospital Akira Kitabatake, Hokkaido University Hirohide Matsuo, Kagawa Medical University Masunori Matsuzaki, Yamaguchi University Shigetake Sasayama, Kyoto University Kunio Shirato, Tohoku University Yasuro Sugishita, Tsukuba Memorial Hospital Akira Takeshita, Kyushu University Yoshio Yazaki, International Medical Center of Japan Mitsuhiro Yokoyama, Kobe University

Local Organizing Committee Akira Takeshita, President of the 3rd Annual Scientific Meeting of the JHFS' 99 Hiroyuki Tsutsui, Secretary General (Alphabetical Order) Kensuke Egashira Yoshitaka Hirooka Toshihiro Ichiki George Koike Toru Kubota Masahiro Mohri Yuichi Ohara Shinji Sato Hiroaki Shimokawa Hikaru Ueno

Judges for Young Investigator Awards (YIA) (Alphabetical Order) Masao Endo, Yamagata University Yoshihisa Fujiwara, Gifu University Toru Izumi, Kitazato University Kenjirou Kikuchi, Asahikawa Medical University Akira Kitabatake, Hokkaido University Hirohide Matsuo, Kagawa Medical University Takeshi Nakano, Mie University Hirofumi Yasue. Kumamoto University Mitsuhiro Yokoyama, Kobe University

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Dates: October 7 (Thursday) - 9 (Saturday), 1999 Venue: ACROS Fukuoka, Fukuoka, JAPAN Registration/Information The registration and information desks are located at the entrance of Symphony Hall in ACROS Fukuoka. Opening Hours: October 7, Thursday: October 8, Friday: October 9, Saturday:

10:00-18:00 7:30-18:00 7:30-11:00

Venue: The entrance of Symphony Hall, 1st floor, ACROS Fukuoka, Registration Fee: ¥ l O,000 By attending this meeting, qualifying specialists can obtain 1 credit of the Japanese Circulation Society's course of lectures. Name badges must be worn at all times as these serve as the admission pass to all scientific sessions and official activities.

Language Both Japanese and English are the official languages of the Meeting. Presenter can speak Japanese or English.

Meeting Secretariat Hiroyuki Tsutsui, M.D., Ph.D. Secretary General, JHFS' 99 Department of Cardiovascular Medicine Kyushu University School of Medicine 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JAPAN Tel +81-92-642-5360 fax +81-92-642-5374 e-mail [email protected]

The 3rd Annual Scientific Meeting



JHFS

Accommodation Accommodation, local tours and activities may be booked through the following tourist agency.

Japan Travel Bureau (JTB) Asahi-kaikan 10F, 2-8-41 Tenjin, Chuo-ku, Fukuoka 810-0001, JAPAN Tel. +81-92-751-2102 (Japanese), +81-92-735-6111 (English) Fax. +81-92-751-4098 attn.: Ms. Yukie Tashiro and Ms. Mutsumi Nishigabiraki

Commercial Exhibition The exhibition will take place in the lobby of the ACROS Fukuoka during the meeting hours. A professional pharmaceutical and medical laboratory exhibition will be presented. For details, please contact Congress Corporation.

Congress Corporation Chiyoda Seimei Fukuoka Bldg., 1-9-17 Tenjin, Chuo-ku, Fukuoka 810-0001, JAPAN Tel. +81-92-716-7116 Fax. +81-92-716-7143 attn.: Mr. Takanobu Nakayama

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Opening C e r e m o n y

15:00

General A s s e m b l y

15:30 15:45

Poster Presentation

Oral Presentation

Poster Presentation

18:00 Satellite Symposium I New Approaches to Treatment of Heart Failure What can Beta-Blockers Add to Current Therapies?

Satellite S y m p o s i u m II Neurohumoral Control in Heart Failure -Which is important in •emodeling,oatecholamine or angiotensin?-

Morning Lecture I

Morning Lecture I I

Oral Presentation

Oral Presentation

Luncheon S e m i n a r I Therapeutic S~'ategy for Chronic Heart Failure in Japan

Luncheon Seminar II

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Poster Presentation

17:00 Y I A Finalists Competition 18:00 Satellite S y m p o s i u m III Nitric Oxide and Cardiac Disease (Tentative) 19:30

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Luncheon Seminar V Beta Blocker Therapy in Chronic Heart FailureEvidence based Current Sb'a~gy-

Poster Presentation

The 3rd Annual Scientific Meeting • JHFS 11



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I Thursday, October 7, ] 9 9 9 I ] 2:50-] 3:O0 Opening Ceremony Welcome Address

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Akira Takeshita (Kyushu University) 13:00 -15:00

Plenary Session I "Nitric Oxide, Oxidative Stress, and Cytokine in Heart Failure"

(1) Contribution of Nitric Oxide to the Control of Cardiac Oxygen and Substrate Consumption during the Development of Heart Failure Thomas H. Hintze (U.S.A.), Hideo Tada, Kit Ee Loke, Fabio A. Recchia (2) iNOS and Innate Immunity in the Failing Heart. Ralph A. Kelly (U.S.A.) (3) Interaction between Neurohormonesand Cytokines in Heart Failure Douglas L. Mann (U.S.A.), Dinesh Kalra (4) Basis for Increased Production of Oxygen Radicals in Failing Heart Hiroyuki Tsutsui (JAPAN), Tomomi Ide, Akira Takeshita (5) Divergent Pathways of Apoptosis are Mediated by Ischemic and Nonischemic Stresses during Heart Disease. Keith A. Webster (U.S.A.), Nanette H. Bishopric, Piero Anversa

15:00-15:30

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Oral Presentation

15:45 -17:45

Poster Presentation

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18:00 -~-~.00 Satellite Symposium I

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New Approaches to Treatment of Heart Failure -What can Beta-Blockers Add to Current Therapies?

(1) The Effect of Beta-Blockers on Cardiac Remodeling in Congestive Heart Failure Markus Haass (GERMANY) (2) Beta-Adrenergic Receptor Blocker Therapy in Severe Congestive Heart Failure Tsutomu Yoshikawa (JAPAN) (3) Heart Failure Management -2000 Norman Sharpe (NEW ZEALAND)

Satellite Symposium

II

Neurohumoral Control in Heart Failure - Which is important in remodeling, catecholamine or angiotensin? Dorothy E. Vatner, Stephen F. Vatner (U.S.A.), Hidenori Urata (JAPAN)

12 Journalof Cardiac FailureVol. 5 No. 3 Suppl. 2 1999

Friday, October 8, ] 9 9 9 I 8~X3- ~ 5 0

Mornin8 Lecture I Assessment of Left Ventricular Performance in Patients with Heart Failure -What can you tell by Echocardiography? (1) Assessment of LV Performance by Echo and Indication of Medical Management in Patients with Acute Myocardial Infarction Atsushi Yamamuro (JAPAN) (2) Assessment of Global and Regional LV Function with Stress and Contrast Echo Young-Jae Lim (JAPAN)

Mornin8 Lecture

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cAMP up to Date - Adenylyl Cyclase Activator "Colforsin Daropate Hydrochloride" (1) Recent Topics on cAMP - The Specificity of Autonomic Nerve Regulation in the HeartYoshihiro Ishikawa (JAPAN) (2) Does cAMP Accumulation Induced by Adenylyl Cyclase Activation and PDE Inhibition Contribute Differentially to Cardiac Functional Regulation? Masao Endo (JAPAN)

9:00-]0:00

Special Lecture I Myocardial Ischemia and Heart Failure Stephen F. Vatner (U.S.A.)

10:,15 -12:00 Oral Presentation ] L>O0-]

3:20

Luncheon Seminar I Therapeutic Strategy for Chronic Heart Failure in Japan New Insight of Therapeutic Strategy for Chronic Heart Failure Masunori Matsuzaki (JAPAN)

Luncheon Seminar

II

(1) Tc-99m Sestamibi and 1-123 MIBG Myocardial Imaging can Predict Cardiac Event in Heart Failure? Hidero Inada (JAPAN) (2) Prognostic Value of Tc-99m MIBI SPECT Myocardial Perfusion Imaging for the Patient Management (Tentative) Rory Hachamovitch (U.S.A.)

Luncheon Seminar

III

Heart Failure • The Future Disease Burden in the next Millennium - A Therapeutic Challenge David T. Kelly (AUSTRALIA) 13:30 -15:30

Plenary Session II

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"Peripheral Circulation and Exercise Intolerance in Heart Failure" (1) Sympathetic Dysregulation in Heart Failure: Mechanisms, Significance and Therapy Allyn L Mark (U.S.A.) (2) Alterations in Sympathetic Function Following Exercise Training in Experimental Heart Failure Irving H. Zucker (U.S.A.)

The 3rd Annual Scientific Meeting • JHFS 13 (3) Endothelial Dysfunction in Heart Failure: a Target for Therapy? Helmut Drexler (GERMANY) (4) Humoral Adaptation in Heart Failure Masahiko Kinoshita (JAPAN), Takayoshi Tsutamoto, Masayuki Takahashi (5) Skeletal Muscle Abnormalities in Heart Failure: The Need for Anabolic Therapy Stefan D. Anker (U.K.) 15:45 -1 7.130

Oral Presentation ,

1 5 : 4 5 -1 7 : 4 5

Poster Presentation

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17.-OO-18~0 Young Investigator's Award Competition .-

18:00-19:.30 Satellite Symposium

III

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Nitric Oxide and Cardiac Disease (Tentative) Louis J. Ignarro (U.S.A.)

I Saturday, October 9, 1999 I

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Morning Lecture III Effects and Mechanism of Thermal Therapy in Congestive Heart Failure Chuwa Tei (JAPAN)

Morning Lecture IV Arrhythmogenic Substrate in Heart Failure and its Treatment Minoru Horie (JAPAN)

9:00-10:00

Special Lecture

II

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Activation of the Renin Angiotensin Aldosterone System in Patients with Heart Failure due to Systolic Left Ventricular Dysfunction Bertram Pitt (U.S.A.) 1 0 ~ 0 -1 1:30

Oral Presentation

11:30-I 1:50 Young Investigator's Award Ceremony Closing Ceremony ...................................... 1L>OO-13LoO

Luncheon Seminar IV

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Current Topics on the Mechanisms of the Heart Failure The Transition from Hypertrophy to Failure Beverly H. Lorell (U.S.A.)

Luncheon Seminar V

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Beta Blocker Therapy in Chronic Heart Failure - Evidence based Current StrategyThe Role of Beta Blocker Therapy in Heart Failure Based on the Results of MERIT-HF -Including Sub-AnalysisAke Hjalmarson (SWEDEN)