Meeting Reports The Fourth International Conference on Immunopharmacology Thomas W. Klein, Ph.D. University of South Florida Tampa, Florida The Fourth International Conference on Immunopharmacology was held in Osaka, Japan, May 15-19, 1988. It was sponsored by the International Society for Immunopharmacology. The Conference was organized by J. W. Hadden (Tampa, FL), F. Spreafico (Milan, Italy), K. F. Austen (Boston, MA), P. Dukor (Vienna, Austria), D. Willoughby (London, U.K.), L. Chedid (Tampa, FL), Y. Yamamura (Osaka, Japan), and K. Masek (prague, Czechoslovakia). The scientific program consisted of presentations ranging from plenary lectures to symposia to workshop sessions. The first plenary lecture, by R. Good (Tampa, FL), ad-
The International Symposium on Endotoxin Thomas W. Klein 1 Alosi Nowotny2 University of South Florida Tampa, Florida ~ University of Pennsylvania Philadelphia, Pennsylvania2 The International Symposium on Endotoxin was held in Japan at Jichi Medical School, Tochigi-Ken, Japan, May 11-13, 1988. It was co-sponsored by the newly formed International Endotoxin Society and the International Society for Immunopharmacology. The Symposium was organized by M. Nakano (Tochigi, Japan); A. Nowotny, (Philadelphia, PA); and H. Friedman, (Tampa, FL). The scientific program consisted of special lectures, symposia, and poster sessions. The opening special lecture given by S. Kotani (Japan) involved the consideration of
Clinical Immunology Newsletter 9:11,1988
dressed the mechanisms of prevention of autoimmune diseases, cancer, and diseases of aging by nutritional manipulation. The second plenary lecture, by L. Chedid (Tampa, FL), dealt with the subject of immune adjuvants. The third plenary lecture, by K. F. Austen (Boston, MA), considered the influence of the microenvironment on the biochemical characteristics of inflammatory ceils. In addition, two major symposia were scheduled each morning and included the following topics: AIDS, immunopharmacology of neuroendocrine interaction; immunoregulatory molecules, receptors, and their immunopharmacological implications; advances in vaccine development; immunopharmacology of interleukin 6; applications of monoclonal antibodies; transmembrane signalling and chemical mediators; and immunotoxicology. Twenty-six different workshop sessions filled the science program during the afternoons. The workshops were
composed of both poster and oral presentations. Workshop topics included natural product immunomodulators, synthetic immunomodulators, several sessions on lymphokines and monokines and thymic hormones, clinical applications of cytokines, immunopharmacology of inflammation, allergies, immunotoxicology, immune manipulation in infectious diseases, novel vaccines, immunosuppressive agents, endotoxins, new drug delivery systems, therapy for AIDS, and oriental medicine. Over 400 posters were presented, providing a great opportunity for free exchange of ideas, which carried over into the oral sessions presented late each afternoon. Over 800 scientists from over 25 different countries attended the meeting. The Proceedings of this meeting will be published by Pergamon Press (Oxford, UK) and will be entitled "Proceedings of the Fourth Congress on Immunopharmacology" (edited by J. Hadden et al.).
the structural requirements of lipid A for endotoxicity and other biological effects. E. Rietschel (F.R.G.) presented the second special lecture dealing with structure/function relationships of lipid A. The subsequent lecture presented by J. Homma (Japan) provided information on the structure and activity of chemically synthesized lipid A and lipid A analogues. F. Melchers (Switzerland) gave the fourth special lecture defining the influence of lipopolysaccharides on proliferation and maturation of B lymphocytes. In a fifth special lecture, A. Nowotny (U.S.A.) discussed the chemistry and biology of a novel bacterial lipid with selective toxicity for transformed ceils. M. Parant (France) next discussed some aspects of synergy observed between endotoxin and muramyl dipeptide. The final special lecture was presented by D. C. Morrison (U.S.A.), wherein a description and cellular distribution of endotoxin binding sites was discussed. In addition, there were five symposia
on a variety of topics related to endotoxins. The first dealt with the chemcial structure of endotoxins and was chaired by M. Loos (F.R.G.) and S. Iwanaga (Japan). Papers were presented by S. Kusumoto (Japan) on the chemical synthesis of endotoxin and by U. Zahringer (F.R.G.) on the chemical structure of the core region of endotoxin. Additional papers were presented by H. Mayer (F.R.G.) on the observed natural variations of lipid A's, by N. Kasai (Japan) on the immunochemistry of lipid A, and by K. Hisatsune (Japan) on the endotoxins of the noncholera vibrios. The second symposium covered the biological aspects of endotoxin and was chaired by A. Rodloff (F.R.G.) and N. Kato (Japan). Papers were presented by M. Pollack (U.S.A.) and B. J. Appelmelk (The Netherlands) on the definition and utilization of monoclonal antibodies directed against endotoxins. Papers by M. Yoshida (Japan), S. Iwanaga (Japan), and M. Niwa (Japan) dis-
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